Data Collection Protocol for the Development of CHLOE-OQ, an AI Model for Assessing Oocytes Quality.
NCT06928337
Recruiting
This data collection protocol is aimed to allow the reliable and robust development (training, verification, and validations) of CHLOE technology-based applications as well as improve the machine learning stage of released devices/applications. Additionally, a simulated use assessments will be conducted to ensure the correct and easy use of the CHLOE applications.
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
04/07/2025
Locations: The World Egg and Sperm Bank, Scottsdale, Arizona
Conditions: Fertility Disorders
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Primary Care-based Study of an Online Workshop for Family Caregivers of PLWD
NCT06928467
Recruiting
Many family and friend caregivers of persons living with dementia experience depression, stress, and other adverse health consequences due to the responsibilities of their caregiving role. These caregivers express a desire for education and support. The overarching goal of this project is to improve education and support for caregivers of persons living with dementia so that they can take better care of themselves and also their person living with dementia. Building Better Caregivers workshop i... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/07/2025
Locations: University of California, San Francisco, San Francisco, California +1 locations
Conditions: Family Caregivers, Dementia, Self-management, Depression, Internet-based Intervention
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PLAN Intervention to Enhance Engagement of Latino Cancer Patients in Advanced Care Planning
NCT04889144
Recruiting
This trial tests whether Planning for Your Advance Care Needs (PLAN) intervention works to enhance Latino patients' understanding of and engagement in advanced care planning. The PLAN intervention may be an effective method to help people with cancer plan for and talk about advance care planning (the care they would want if they were unable to communicate) with their loved ones and doctors.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/04/2025
Locations: Weill Cornell Medicine, New York, New York +3 locations
Conditions: Locally Advanced Malignant Solid Neoplasm, Metastatic Malignant Solid Neoplasm
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Platform Study of Immunotherapy Combinations in Colorectal Cancer Liver Metastases
NCT06300463
Recruiting
The goal of this clinical trial is to to learn about different combinations of immunotherapy in patients with colorectal cancer whose cancer has spread to their liver and are planning to have surgery to remove tumor metastases from their liver. The main questions it aims to answer are: * whether these combinations of immunotherapy change the tumor microenvironment in the liver * whether these combinations of immunotherapy are safe and effective when used in colorectal cancer with liver metastas... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/04/2025
Locations: Weill Cornell Medicine/NewYork-Presbyterian Hospital, New York, New York
Conditions: Colorectal Cancer Metastatic, Liver Metastases, Colorectal Cancer
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Implementation of Naturalistic Developmental Behavioral Intervention (NDBI) Through Coaching Caregivers of Young Autistic Children
NCT06923553
Recruiting
Naturalistic developmental behavioral interventions (NDBIs) are a newer class of evidence-based interventions for young autistic children to promote their positive developmental or behavioral outcomes. These are often delivered by family members or other natural change agents given the emphasis on naturalistic transactions between an adult and a child. Despite the emerging evidence, there are practical difficulties that hinder wider dissemination and implementation of NDBIs, including low level... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/04/2025
Locations: University of Texas Austin, Austin, Texas
Conditions: Implementation Research
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A Study Evaluating the Efficacy and Safety of Adjuvant Giredestrant Compared With Physician's Choice of Adjuvant Endocrine Monotherapy in Participants With Estrogen Receptor-Positive, HER2-Negative Early Breast Cancer (lidERA Breast Cancer)
NCT04961996
Recruiting
This is a Phase III, global, randomized, open-label, multicenter, study evaluating the efficacy and safety of adjuvant giredestrant compared with endocrine therapy of physician's choice in participants with medium- and high-risk Stage I-III histologically confirmed estrogen receptor (ER)-positive and human epidermal growth factor receptor 2 (HER2)-negative early breast cancer. In addition, an open-label exploratory substudy will explore the safety and efficacy of giredestrant in combination wit... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/04/2025
Locations: Southern Cancer Center, Daphne, Alabama +701 locations
Conditions: Early Breast Cancer
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Reducing Obesity Using Social Ties Program
NCT06335810
Recruiting
This trial aims to test the feasibility and acceptability of addressing interpersonal barriers to weight-related behavior change. Specifically, the study will test if, by including up to two friends, family members, or co-workers in a lifestyle intervention for weight loss, the person enrolled in the study loses more weight than someone whose friends, family members, or co-workers were not invited to participate.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/04/2025
Locations: Weill Cornell Medicine, New York, New York
Conditions: Obesity
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Choline Dose Ranging in Postmenopausal Women
NCT06924541
Recruiting
This study will use a randomized placebo-controlled trial to examine smaller doses of choline and whether a signal in the brain is detectable using fMRI. This study will examine if an even smaller doses of choline can show these similar brain activation and connectivity patterns to the 1650 mg dose. This will be a dose ranging study of 550 mg and 1100 mg oral choline compared to placebo.
Gender:
FEMALE
Ages:
Between 50 years and 65 years
Trial Updated:
04/04/2025
Locations: University of Vermont, Burlington, Vermont
Conditions: Menopause
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Biomarker Profiling in Individuals at Risk for Prion Disease
NCT05124392
Recruiting
We are doing this research to identify biomarkers in individuals who are at-risk for familial prion disease. We hope to use these biomarkers to predict timing of disease onset in pre-symptomatic individuals and to guide the direction of future clinical trials.
Gender:
ALL
Ages:
Between 18 years and 85 years
Trial Updated:
04/04/2025
Locations: Alzheimer's Clinical and Translational Research Unit, Charlestown, Massachusetts
Conditions: CJD (Creutzfeldt Jakob Disease), Prion Diseases, GSS, FFI, Familial Fatal Insomnia
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Somatostatin-Receptors (SSTR)-Agonist [212Pb]VMT-alpha-NET in Metastatic or Inoperable SSTR+ Gastrointestinal Neuroendocrine Tumor and Pheochromocytoma/Paraganglioma Previously Treated With Systemic Targeted Radioligand Therapy
NCT06427798
Recruiting
Background: Gastrointestinal neuroendocrine tumors (GI NET) are a type of cancer that affects the stomach and intestines; pheochromocytoma/paragangliomas (PPGL) are tumors that grow in or near the adrenal glands. Both of these types of tumor have high levels of a protein called somatostatin receptors (SSTR) on their surfaces. Researchers want to test a treatment that targets SSTR. Objective: To test a drug (\[212Pb\]VMT-alpha-NET) in people with GI NET or PPGL. The drug has 2 components: a pr... Read More
Gender:
ALL
Ages:
Between 18 years and 120 years
Trial Updated:
04/04/2025
Locations: National Institutes of Health Clinical Center, Bethesda, Maryland
Conditions: Somatostatin Receptor Positive, Gastrointestinal Neuroendocrine Tumors, Pheochromocytoma, Paragangliomas
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Comprehensive Molecular and Clinical Evaluation of Pediatric and Adult MDS
NCT05350748
Recruiting
Background: Myelodysplastic syndromes (MDS) occur when the cells that make blood cells are abnormal. There are limited treatment options for MDS. Researchers want to learn more through this natural history study so they can develop better treatments. Objective: To study the natural course of MDS and MDS/myeloproliferative neoplasms (MPN) and collect biological samples that can help researchers understand the disease. Eligibility: People with suspected or confirmed MDS or MDS/MPN. Healthy do... Read More
Gender:
ALL
Ages:
Between 1 day and 120 years
Trial Updated:
04/04/2025
Locations: National Institutes of Health Clinical Center, Bethesda, Maryland
Conditions: Myelodysplastic Syndromes
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Efficacy and Safety of Obefazimod in Subjects With Moderately to Severely Active Crohn's Disease
NCT06456593
Recruiting
This study has 3 treatment phases, a 12-Week Induction Phase, a 40-Week Maintenance Phase, and a 48-Week Extension Phase. The objective is to evaluate the efficacy and safety of obefazimod compared to placebo as induction and maintenance therapy in subjects with moderately to severely active CD after inadequate response (no response, loss of response, or intolerance) to conventional therapies and/or advanced therapies. The primary objective for the 48-Week Extension Phase is to evaluate the sa... Read More
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
04/04/2025
Locations: IMC Gulf Coast Gastroenterology, PC, Fairhope, Alabama +140 locations
Conditions: Moderately to Severely Active Crohn Disease
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