Radioembolization Trial Utilizing Eye90 Microspheres™ for the Treatment of Hepatocellular Carcinoma (HCC)
Recruiting
This is a prospective, multi-center, open-label study to evaluate the effectiveness and safety of Eye90 microspheres® in the treatment of subjects with unresectable Hepatocellular Carcinoma (HCC). Eye90 microspheres is a medical device containing yttrium-90 (Y-90), a radioactive material, and provides local radiation brachytherapy for the treatment of liver tumors.
Gender:
ALL
Ages:
Between 18 years and 99 years
Trial Updated:
07/23/2025
Locations: The University of Arizona Cancer Center, Tucson, Arizona +20 locations
Conditions: Hepatocellular Carcinoma, Hepatocellular Carcinoma Non-resectable, Liver Cancer
Outpatient Buprenorphine Induction With Psilocybin for Opioid Use Disorder
Recruiting
This study will examine the effect of a single high dose of psilocybin therapy (30 mg) versus a very low dose (1 mg) as an adjunctive therapy to individuals undergoing standard-of-care outpatient buprenorphine treatment for Opioid use disorder (OUD). The participants will have previously undergone buprenorphine induction before. Effects of adjunctive psilocybin will be determined for longitudinal outcomes of opioid abstinence, compliance with outpatient buprenorphine maintenance, quality of life... Read More
Gender:
ALL
Ages:
Between 21 years and 70 years
Trial Updated:
07/23/2025
Locations: Johns Hopkins Center for Psychedelic and Consciousness Research, Baltimore, Maryland
Conditions: Opioid Use Disorder
IMC-F106C Regimen Versus Nivolumab Regimens in Previously Untreated Advanced Melanoma (PRISM-MEL-301)
Recruiting
This is a phase 3, randomized, controlled study of brenetafusp (IMC-F106C) plus nivolumab compared to standard nivolumab regimens in HLA-A\*02:01-positive participants with previously untreated advanced melanoma.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/23/2025
Locations: University of Arizona, Tucson, Arizona +173 locations
Conditions: Advanced Melanoma
Pilot Window of Opportunity Trial (POET)
Recruiting
The proposed clinical trial with TPST-1495 can help people with two types of cancer, Endometrial Cancer (EC) and Colorectal Carcinoma (CRC), who need surgery. The investigator plans to evaluate how well TPST-1495 works against these cancers by checking blood samples and tumor tissues taken before and after the treatment to see if it is an effective treatment option to help the immune system fight against cancer.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/23/2025
Locations: OU Health Stephenson Cancer Center, Oklahoma City, Oklahoma
Conditions: Colorectal Carcinoma (CRC), Endometrial Carcinoma (EC)
A Study to Evaluate the Safety and Effectiveness Transdermal Compress Device in Participants With Transfemoral Amputations
Recruiting
The purpose of this study is to evaluate the safety and effectiveness of the Transdermal Compress device in participants with Transfemoral Amputations.
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
07/23/2025
Locations: UC Davis Medical Center, Sacramento, California +8 locations
Conditions: Prosthesis and Implants
QTX3034 in Patients With KRAS G12D Mutation
Recruiting
Phase 1 study to determine the safety and tolerability of QTX3034 as a single agent or in combination with cetuximab.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/23/2025
Locations: UCLA Hematology/Oncology, Los Angeles, California +13 locations
Conditions: Solid Tumors
Efficacy and Safety of Phentermine/Topiramate in Youth With Hypothalamic Obesity
Recruiting
Hypothalamic obesity (HO) refers to the substantial weight gain that often complicates hypothalamic brain tumors. Children with this treatment-recalcitrant form of obesity have excess rates of metabolic sequelae compared to otherwise healthy children with similar obesity, and later experience excess mortality related to cardiometabolic disease. In this pilot trial, our objective is to gather key preliminary data about phentermine/topiramate (Ph/T) that is FDA-approved for "common" obesity but ha... Read More
Gender:
ALL
Ages:
Between 6 years and 28 years
Trial Updated:
07/23/2025
Locations: The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania +1 locations
Conditions: Hypothalamic Obesity, Hypothalamic Tumor, Craniopharyngioma
A Study of Meaning-Centered Psychotherapy for Caregivers to People With Cancer
Recruiting
Participants will complete 1 set of questionnaires about 2 weeks before beginning their Meaning-Centered Psychotherapy for Caregivers/MCP-C or standard Supportive Psychotherapy for Caregivers/SP-C sessions. These questionnaires will ask about participants' sense of meaning and purpose in life, spiritual well-being, depression and/or anxiety, and social support. Participants will then be assigned to receive either MCP-C or SP-C for 7 sessions. Participants will complete additional sets of questio... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/23/2025
Locations: University of Miami (Data Collection AND Data Analysis), Miami, Florida +7 locations
Conditions: Caregiver Burden, Caregiver Burnout, Caregiver Stress Syndrome
The Happiest Baby, Inc. SNOO Postmarket Surveillance Study
Recruiting
This postmarket surveillance study will evaluate the safety of the SNOO Smart Sleeper Bassinet when used for infants who are at high risk for Sudden Unexpected Infant Death (SUID). This study will survey 1000 caregivers of high-risk infants to examine the frequency of death or serious injury occurring in the SNOO Bassinet.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/23/2025
Locations: Happiest Baby, Inc., Los Angeles, California
Conditions: Infant Death, Serious Injury
VR Pilot for Pancreatitis
Recruiting
The purpose of the research is to test the feasibility and preliminary impact of a home-based, standardized, gut-directed, virtual reality cognitive behavioral therapy (VR CBT) on clinical and functional outcomes of patients with chronic pancreatitis (CP) pain. The primary research procedures are questionnaires and biometric Fitbit data. The study will enroll adult patients with CP.
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
07/23/2025
Locations: Cedars-Sinai Medical Center, Los Angeles, California
Conditions: Chronic Pancreatitis, Recurrent Pancreatitis
A Study Comparing Venetoclax and Azacitidine Plus Cusatuzumab to Venetoclax and Azacitidine in Newly Diagnosed AML Ineligible for Intensive Therapy
Recruiting
The goal of this clinical trial is to learn if participants treated with the experimental drug cusatuzumab added to venetoclax and azacitidine works to treat acute myeloid leukemia (AML) compared to venetoclax and azacitidine. Venetoclax and azacitidine are drugs commonly used to treat AML in patients that are unable to receive chemotherapy to treat AML. The main question the clinical trial aims to answer is does cusatuzumab added to venetoclax and azacitidine prolong the length of time particip... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/23/2025
Locations: Banner MD Anderson, Gilbert, Arizona +30 locations
Conditions: Leukemia, Myeloid, Acute
Dime La VerDAD: Verify, Debunk, and Disseminate
Recruiting
Dime La VerDAD is an innovative social media capacity-building program that empowers promotores de salud to debunk vaccine misinformation through the use of personal narratives on social media. The core of the implementation strategy consists of augmenting training and self-efficacy for natural community champions, "promotores de salud" from the Hispanic community as trusted messengers to debunk vaccination misinformation. The study will leverage existing community relationships in Chicago and a... Read More
Gender:
ALL
Ages:
Between 18 years and 99 years
Trial Updated:
07/23/2025
Locations: Rush University, Chicago, Illinois +3 locations
Conditions: Misinformation, Influenza, COVID-19, Vaccine Hesitancy, Communication Research, Health Behavior