First in Human Study of TORL-1-23 in Participants With Advanced Cancer
NCT05103683
Recruiting
This first-in-human study will evaluate the safety, tolerability, pharmacokinetics, and antitumor activity of TORL-1-23 in patients with advanced cancer
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/09/2025
Locations: Providence Medical Foundation, Fullerton, California +12 locations
Conditions: Advanced Solid Tumor, Ovarian Cancer, Endometrial Cancer, NSCLC
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Non-invasive Functional Assessment and Pathogenesis of Morquio A
NCT05284006
Recruiting
Morquio A disease is a devastating systemic skeletal disease in which detailed progression and pathogenesis remain unknown. The proposed project aims to establish a non-invasive objective assessment that can be applicable to all ages of patients to better understand the progress of their disease and the most serious clinical problems (cervical instability and stenosis, tracheal obstruction, hyperlaxity of joints, hip dysplasia, and small lung capacity). The outcome of this project will lead to a... Read More
Gender:
ALL
Ages:
All
Trial Updated:
05/09/2025
Locations: Nemours Children's Health, Delaware Valley, Wilmington, Delaware
Conditions: Mucopolysaccharidosis IV Type A, Morquio A Syndrome, MPS IVA
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A 2-Part Study to Learn Whether Litifilimab (BIIB059) Injections Can Improve Symptoms of Adult Participants Who Have Active Cutaneous Lupus Erythematosus (AMETHYST)
NCT05531565
Recruiting
In this study, researchers will learn more about a study drug called litifilimab (BIIB059) in participants with cutaneous lupus erythematosus (CLE). The study will focus on participants who have either active subacute CLE or chronic CLE, or both. They may also have systemic lupus erythematosus (SLE). The participants did not respond to antimalarial therapy or had problems with the treatment that made it hard to continue. The main objective of the study is to learn about the effect litifilimab h... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/09/2025
Locations: Pinnacle Research Group, LLC, Anniston, Alabama +255 locations
Conditions: Subacute Cutaneous Lupus Erythematosus, Chronic Cutaneous Lupus Erythematosus
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Assessment of Functional and Symptom Outcomes for Survivors of Paranasal Sinus, Nasopharyngeal and Skull Base Tumors
NCT05733091
Recruiting
To learn about the symptoms and changes our patients experience while receiving treatment for sinonasal or nasopharyngeal cancer
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/09/2025
Locations: M D Anderson Cancer Center, Houston, Texas
Conditions: Tumors
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Localized Body Cooling Technology on Sleep and Metabolism in African, American With Overweight and Obesity
NCT05849181
Recruiting
The goal of this study is to see the effect that a cooling pillow pad called Moona has on sleep quality.
Gender:
ALL
Ages:
Between 21 years and 50 years
Trial Updated:
05/09/2025
Locations: University of Chicago, Chicago, Illinois
Conditions: Overweight or Obesity
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Intensive Multi-Couple Therapy for PTSD Versus Relationship Education in Military Couples
NCT06047691
Recruiting
The goal of this clinical trial is to test an abbreviated, intensive, multi-couple group version of cognitive-behavioral conjoint therapy for PTSD (AIM-CBCT for PTSD) in an active military and veteran population. The main questions it aims to answer are: * Does AIM-CBCT for PTSD improve PTSD symptoms? * Does AIM-CBCT for PTSD improve associated symptoms (e.g., depression), romantic partner distress, and couple relationship satisfaction? Participants will participate in a two-day retreat in whi... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/09/2025
Locations: University of Texas Health Science Center at San Antonio, San Antonio, Texas
Conditions: Posttraumatic Stress Disorder
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Definitive Radiation for High-Risk Spine Metastases
NCT06165419
Recruiting
This study is looking at whether patients with cancer that has aggressively spread to the spine can be treated with stereotactic body radiation therapy only and avoid a large spine surgery
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/09/2025
Locations: Stony Brook University Hospital, Stony Brook, New York
Conditions: Metastatic Cancer, Metastatic Lung Cancer, Metastatic Breast Cancer, Metastatic Tumor, Metastatic Tumor of Bone, Metastatic Tumor to the Spine, Spine Metastases, Metastasis
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Gut Oxalate Absorption in Calcium Oxalate Stone Disease
NCT06331546
Recruiting
The goal of this clinical trial study is to test if patients with idiopathic calcium oxalate kidney stones have an increased absorption of dietary oxalate, which would lead to increased urinary excretion of oxalate. The study will recruit adult patients with a history of calcium oxalate kidney stones and healthy volunteers without kidney stones. Participants will * ingest fixed diets containing low and moderately high amounts of oxalate for 5 days at a time * ingest a soluble form of oxalate... Read More
Gender:
ALL
Ages:
Between 18 years and 70 years
Trial Updated:
05/09/2025
Locations: University of Alabama at Birmingham, Birmingham, Alabama +1 locations
Conditions: Kidney Stone, Kidney Calculi, Urolithiasis, Urolithiasis, Calcium Oxalate, Nephrolithiasis, Nephrolithiasis, Calcium Oxalate, Oxalate Urolithiasis, Oxaluria, Healthy
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Pancreatic Enzyme Replacement Therapy for Acute Pancreatitis-Associated Exocrine Pancreatic Insufficiency
NCT06477159
Recruiting
This study aims to evaluate if a 6-month course of pancrelipase (CREON) treatment improves symptoms of exocrine pancreatic insufficiency (EPI) after an attack of acute pancreatitis. Diagnosis of EPI is measured by a fecal elastase value of \<200, and patients must have a qualifying symptom burden based on the EPI symptom tracker survey. Blood and stool will be analyzed as part of this study, and other surveys of health status will be used to track improvement of symptoms.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/09/2025
Locations: University of Southern California, Los Angeles, California +4 locations
Conditions: Exocrine Pancreatic Insufficiency
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Phase 1 Dose Escalation and Dose Expansion Trial of NP-101 in Patients With Solid Tumors
NCT06563375
Recruiting
To evaluate the safety and preliminary efficacy of NP-101 in patients with solid tumors.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/09/2025
Locations: MD Anderson Cancer Center, Houston, Texas
Conditions: Solid Tumor
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Mirikizumab Real World Protocol
NCT06696014
Recruiting
The goal of this observational study is to learn about how effective mirikizumab (Omvoh) is when treating patients with ulcerative colitis (UC) Does mirikizumab (Omvoh) lead to a reduction in symptoms at intervals throughout one year? Participants being prescribed mirikizumab (Omvoh) as part of their regular medical care for UC will answer online survey questions about their bowel habits for 1 year.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/09/2025
Locations: South Denver Gastroenterology, P.C., Denver, Colorado +4 locations
Conditions: Ulcerative Colitis
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A Study of TAK-360 in Adults With Idiopathic Hypersomnia
NCT06812078
Recruiting
Idiopathic Hypersomnia (IH) is a condition where people feel extremely sleepy during the day, especially in the morning, even if they sleep a lot at night. They may have trouble waking up in the morning, no matter how much they sleep (sometimes more than 11 hours per day), and they can't help feeling tired, even after taking daytime naps. Because of this sleepiness, they may have trouble focusing, thinking clearly, or keeping up with daily activities. They may also have symptoms like dizziness o... Read More
Gender:
ALL
Ages:
Between 18 years and 70 years
Trial Updated:
05/09/2025
Locations: Takeda Site 11, Redwood City, California +28 locations
Conditions: Idiopathic Hypersomnia
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