A Study of Lebrikizumab (LY3650150) in Participants 6 Months to <18 Years of Age With Moderate-to-Severe Atopic Dermatitis
NCT05559359
Recruiting
The main purpose of this study is to measure the effect, safety and how well the body absorbs lebrikizumab in pediatric participants 6 months to \<18 years of age with moderate-to-severe atopic dermatitis (AD).
Gender:
ALL
Ages:
Between 6 months and 17 years
Trial Updated:
05/19/2025
Locations: Clinical Research Center of Alabama, Birmingham, Alabama +83 locations
Conditions: Atopic Dermatitis, Eczema
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A Ph2 Study of Glofitamab Alone or With Polatuzumab Vedotin, Pirtobrutinib, or Atezolizumab in Richter's Transformation
NCT06043674
Recruiting
This research is being done to evaluate Glofitamab by itself or in combination with Polatuzumab Vedotin, Pirtobrutinib, or Atezolizumab as possible treatments for Chronic Lymphocytic Leukemia (CLL) that has transformed into Richter's Transformation (RT). The names of the study drugs involved in this research study are: * Glofitamab (a T-cell bispecific humanized monoclonal antibody) * Obinutuzumab (a humanized glycoengineered type II anti-CD20 monoclonal antibody) * Polatuzumab vedotin (an ant... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/19/2025
Locations: Brigham and Women's Hospital, Boston, Massachusetts +3 locations
Conditions: Chronic Lymphocytic Leukemia, Richter's Transformation
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Dose Adjusted Chemoradiotherapy in HPV-Associated Oropharynx Cancer of the Elderly
NCT06309225
Recruiting
Previous studies of this type of head and necl cancer have shown high rates of cancer control but result in many short and long term side effects when treated with high dose radiation and chemotherapy. Recently, investigators have noticed similar high rates of cancer control in small numbers of patients who receive less intensive treatments using lower doses of radiation, smaller radiation fields with chemotherapy. It is expected that the side effects of treatment with lower doses of radiation w... Read More
Gender:
ALL
Ages:
Between 65 years and 99 years
Trial Updated:
05/19/2025
Locations: Baptist MD Anderson Cancer Center, Jacksonville, Florida
Conditions: Oropharynx Cancer, Frailty
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Pembrolizumab + Chemotherapy in Newly Diagnosed PCNSL
NCT06475235
Recruiting
This research study is studying if the investigational drug, Pembrolizumab, in combination with chemotherapy helps primary central nervous system lymphoma with acceptable side effects. This research study involves a combination of the below drugs: * Pembrolizumab (a type of monoclonal antibody) * Methotrexate (a type of anti-metabolite) * Temozolomide (a type of alkylating agent) * Rituximab (a type of antibody)
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/19/2025
Locations: Brigham and Women's Hospital, Boston, Massachusetts +1 locations
Conditions: Lymphoma, Primary Central Nervous System Lymphoma
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A Study on Pain After Breast Reconstruction
NCT06627582
Recruiting
The purpose of this study is to find out how common persistent postmastectomy pain (PPMP) is among people who have had a mastectomy and breast reconstruction surgery for their breast cancer. The study will also look at how effective regenerative peripheral nerve interface (RPNI) surgery is for reducing pain from neuropathic PPMP after breast reconstruction.
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
05/19/2025
Locations: Memoral Sloan Kettering Basking Ridge (Limited Protocol Activities), Basking Ridge, New Jersey +6 locations
Conditions: Mastectomy, Mastectomy Patient, Mastectomy and Breast Reconstruction, Breast Reconstruction, Breast Reconstruction After Mastectomy, Postmastectomy Pain
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CT-95 in Advanced Cancers Associated With Mesothelin Expression
NCT06756035
Recruiting
This is a Phase 1a/1b open-label, dose escalation study to evaluate the safety and efficacy of CT-95 (study drug), a humanized T cell engaging bispecific antibody targeting Mesothelin, in subjects with advanced solid tumors associated with Mesothelin expression.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/19/2025
Locations: Context Investigational Site, Hackensack, New Jersey +1 locations
Conditions: Mesothelin-Expressing Tumors, Epithelial Ovarian Cancer, Malignant Pleural Mesothelioma, Advanced, Malignant Peritoneal Mesothelioma, Advanced, Pancreatic Adenocarcinoma Advanced or Metastatic, Lung Adenocarcinoma Metastatic, Cholangiocarcinoma Advanced, Cholangiocarcinoma Non-resectable, Mesothelin-expressing Advanced Cancers, Mesothelin-positive Advanced Malignant Solid Tumors, Colorectal Cancer
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Effects of Anakinra in Subjects With Corticosteroid-resistant/Intolerant Meniere's Disease and Autoimmune Inner Ear Disease
NCT03587701
Recruiting
A Phase II randomized, placebo controlled study design of anakinra (Kineret) in corticosteroid-resistant or intolerant Meniere's disease (CR-MD)and corticosteroid-resistant or intolerant autoimmune inner ear disease (CR-AIED) patients. Patients will be randomized by a 2:1 allocation to anakinra or placebo for 42 continuous days. After day 42, a second placebo-controlled period will begin for an additional 42 days. This will be followed by a 264 day observation period, during which, hearing decli... Read More
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
05/19/2025
Locations: Northwell Health, Hearing& Speech Center, New Hyde Park, New York
Conditions: Autoimmune Inner Ear Disease, Meniere's Disease
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Study of Sacituzumab Govitecan in Participants With Advanced or Metastatic Solid Tumor and Moderate Liver Impairment
NCT04617522
Recruiting
The goals of this clinical study are to learn more about the safety and dosing of the study drug, sacituzumab govitecan-hziy, in participants with solid tumors and moderate liver problems.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/19/2025
Locations: Pacific Shores Medical Group, Long Beach, California +9 locations
Conditions: Advanced or Metastatic Solid Tumor, Liver Failure
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Genetic Collection Protocol
NCT05272319
Recruiting
This study involves the one-time collection of whole blood or saliva samples for the extraction and storage of DNA for use in ongoing and future ChiLDReN studies.
Gender:
ALL
Ages:
Between 24 hours and 25 years
Trial Updated:
05/19/2025
Locations: Children's Hospital of Los Angeles, Los Angeles, California +12 locations
Conditions: Liver Diseases
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Effects of a Physical Therapy Intervention on Motor Delay in Infants Admitted to a Neonatal Intensive Care Unit
NCT05568264
Recruiting
Study Aims Pilot study: Due to the large recruitment goal and length of the project, the study team/PIs will evaluate the first cohort of 6-10 participants to refine study procedures and study-related materials. If no major modifications are made to the protocol as a result of this evaluation, data from these participants will be included for analysis. Aim 1: Evaluate the efficacy of an early, evidence-based, clinical experience-based therapeutic intervention (from the NICU to 12-months correc... Read More
Gender:
ALL
Ages:
Between 33 weeks and 48 weeks
Trial Updated:
05/19/2025
Locations: Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois +2 locations
Conditions: Motor Delay, Premature Birth, Intraventricular Hemorrhage, Hypoxic-Ischemic Encephalopathy, Bronchopulmonary Dysplasia
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Effects of Acupuncture on Perceived Stress and Health in Military Service Members
NCT06044714
Recruiting
The goal of this is to investigate the effect of a Manual Standardized Stress Acupuncture (MSSA) protocol as an adjunct treatment to a short-term mindfulness therapy for perceived stress and general health in service members (i.e., active duty military personnel and veterans). The specific aims of this study are Aim 1) To evaluate the effectiveness of a brief MSSA as an adjunct treatment with a short-term Mindfulness-Based Stress Reduction (MBSR) compared with MBSR alone for perceived stress an... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
05/19/2025
Locations: Naval Medical Center, San Diego, San Diego, California
Conditions: Perceived Stress
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A Study of Opportunistic Salpingectomy to Prevent Ovarian Cancer
NCT06312124
Recruiting
The purpose of this study is to find out how many participants are interested in a surgical preventive procedure after watching an educational video. Before and after watching the video, participants will complete questionnaires in the clinic.
Gender:
FEMALE
Ages:
45 years and above
Trial Updated:
05/19/2025
Locations: Johns Hopkins University (Data Collection Only), Baltimore, Maryland +9 locations
Conditions: Surgery
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