Safety, Effectiveness, and Pharmacokinetics of BNT327 in Combination With Chemotherapy and Other Investigational Agents for Lung Cancer
NCT06712316
Recruiting
This is a Phase 2/3, multisite, randomized, open-label study in participants with first-line non-small cell lung cancer (NSCLC). This study includes two substudies (substudy A and substudy B) that will recruit participants according to histological subtypes due to differences in chemotherapy choice for standard-of-care and type of NSCLC.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/15/2025
Locations: Alaska Oncology and Hematology, LLC, Anchorage, Alaska +46 locations
Conditions: Non-small Cell Lung Cancer
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A Study of TAK-360 in Adults With Narcolepsy Without Cataplexy (NT2)
NCT06952699
Recruiting
Narcolepsy without cataplexy or Narcolepsy Type 2 (NT2) is a lifelong condition that makes people very sleepy during the day, regardless of how much sleep they get at night. People with NT2 may fall asleep suddenly, have trouble staying awake during the day, or may not be able to sleep well at night. They may have difficulty thinking clearly, paying attention, or remembering things, during the day. These symptoms can make daily activities like driving, working, or caring for their families chall... Read More
Gender:
ALL
Ages:
Between 18 years and 70 years
Trial Updated:
05/15/2025
Locations: Takeda Site 14, Redwood City, California +29 locations
Conditions: Narcolepsy Type 2
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Fludarabine Based RIC for Bone Marrow Failure Syndromes
NCT02928991
Recruiting
This is a pilot study to determine whether fludarabine-based reduced intensity conditioning (RIC) regimens facilitate successful donor engraftment of patients with acquired aplastic anemia (AA) and Inherited bone marrow failure (iBMF) syndromes undergoing Matched related donor bone marrow transplant (MRD-BMT).
Gender:
ALL
Ages:
22 years and below
Trial Updated:
05/15/2025
Locations: Children's Hospital of Philadelphia, Philadelphia, Pennsylvania
Conditions: Bone Marrow Failure Syndromes
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Categorized PT for Non-arthritic Hip and Groin Pain
NCT04720846
Recruiting
There is currently limited literature on a categorized physical therapy protocol for management of hip pain. Only a handful of studies have looked at the treatment of osteoarthritis of the hip with a standardized physical therapy treatment, primarily looking at manual therapy versus exercise therapy protocols. However, there are no studies observing the effect of a standardized physical therapy program on patients presenting with non-arthritic hip and groin pain. Based on the gap in the literatu... Read More
Gender:
ALL
Ages:
Between 18 years and 60 years
Trial Updated:
05/15/2025
Locations: Hospital for Special Surgery, New York, New York
Conditions: Hip Pain, Groin Pain
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Change in Stroke Volume Index After Diuresis for Patients With Decompensated Heart Failure
NCT05240651
Recruiting
This is a prospective cohort study for 50 patients admitted to the cardiac care unit requiring clinically-indicated diuretic therapy for congestive heart failure. The purpose of this study is to assess the role of non-invasive cardiac output monitoring (NICOM) with the Starling Fluid Management System (Baxter Medical, Deerfield, IL) in determining volume status in patients with acute decompensated heart failure requiring intravenous diuretic therapy.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/15/2025
Locations: NYU Langone Health, New York, New York
Conditions: Acute Decompensated Heart Failure
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StableEyes With Active Neurofeedback
NCT05622344
Recruiting
The investigators have developed a self-administered rehabilitation tool that incrementally guides the user to increase head motion to mitigate motion sickness and enhance postural recovery following centrifugation or unilateral vestibular nerve deafferentation surgery.
Gender:
ALL
Ages:
Between 21 years and 70 years
Trial Updated:
05/15/2025
Locations: Johns Hopkins University, Baltimore, Maryland +1 locations
Conditions: Vestibular Disorder, Vestibular Schwannoma, Space Motion Sickness, Motion Sickness
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Reminder Messages for Lung Cancer Screening
NCT05952778
Recruiting
To test lung cancer screening reminder messages to help adults who 1) 50 to 80 years of age, 2) smoke or have smoked, and 3) do not have history of lung cancer by self-report.
Gender:
ALL
Ages:
Between 40 years and 80 years
Trial Updated:
05/15/2025
Locations: M D Anderson Cancer Center, Houston, Texas
Conditions: Skin Flaps, Lung Cancer
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SW-682 in Advanced Solid Tumors
NCT06251310
Recruiting
This is a first-in-human (FIH), Phase 1a/1b open-label, multicenter, dose escalation and dose expansion study of SW-682 in adult participants with metastatic or unresectable advanced solid tumors with or without Hippo pathway alterations that are refractory to, or have progressed, during or after appropriate prior systemic anticancer therapy, including chemotherapy, immunotherapy, radiation therapy or targeted therapy, or for which no treatment is available, or prior standard of care (SOC) thera... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/15/2025
Locations: SpringWorks Clinical Trial Site, Scottsdale, Arizona +8 locations
Conditions: Advanced Solid Tumor, Mesothelioma, Malignant
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Prebiotic Food-enriched Diet (PreFED) to Enhance the Microbiome and Response to First-line Immunotherapy in Unresectable Melanoma
NCT06466434
Recruiting
To learn about the possible effects of a prebiotic food-enriched diet (PreFED) targeting the gut microbiome in participants with melanoma who are starting immune checkpoint blockade (ICB) therapy.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/15/2025
Locations: MD Anderson Cancer Center, Houston, Texas
Conditions: Unresectable Melanoma
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Study of 68Ga-R10602
NCT06745804
Recruiting
A phase 1 imaging study of 68Ga-R10602 in hormone-receptor positive breast cancer.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/15/2025
Locations: Indiana University Melvin and Bren Simon Cancer Center, Indianapolis, Indiana +2 locations
Conditions: Locoregionally Recurrent Hormone-receptor Positive Breast Cancer, Metastatic Hormone Receptor Positive Breast Cancer
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AI-Enhanced App-based Intervention for Adolescent E-cigarette Cessation
NCT06965296
Recruiting
The goal of this quasi-experimental study is to test if a smartphone app can help adolescents aged 14-20 quit e-cigarettes. The main questions it aims to answer are: * Can the app help adolescents manage cravings and increase their readiness to quit? * Does the personalized and real-time support provided by the app improve their success in quitting e-cigarettes? Researchers will compare two groups: an immediate-intervention group that starts using the app right away and a delayed-intervention... Read More
Gender:
ALL
Ages:
Between 14 years and 20 years
Trial Updated:
05/15/2025
Locations: University at Buffalo, School of Nursing, Buffalo, New York
Conditions: Nicotine Dependence, Cigarettes
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Clinical Trial to Evaluate the Safety and Efficacy of MeRT Treatment in Post-Traumatic Stress Disorder
NCT02990793
Recruiting
The purpose of this study is to evaluate the safety and efficacy of individualized, Biometrics-guided Magnetic e-Resonance Therapy (MeRT) treatment of Post-Traumatic Stress Disorder
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
05/15/2025
Locations: BrainHealth Solutions, Costa Mesa, California +7 locations
Conditions: Postconcussive Symptoms, Traumatic Brain Injury, PostTraumatic Stress Disorder
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