A First-in-human Dose Escalation and Expansion Study to Evaluate the Safety, and Tolerability of AZD8421 Alone or in Combination in Participants With Selected Advanced or Metastatic Solid Tumors
NCT06188520
Recruiting
This study is designed to evaluate AZD8421 alone and in combination with selected targeted anti-cancer drugs in patients with ER+HER2- advanced breast cancer, and patients with metastatic high-grade serious ovarian cancer.
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
05/14/2025
Locations: Research Site, Saint Louis, Missouri +13 locations
Conditions: ER+ HER2- Advanced Breast Cancer, High-grade Serous Ovarian Cancer (HGSOC)
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Stress Management Program
NCT06526585
Recruiting
This study will test the immediate and long term (post 4 weeks of daily practice) effectiveness of two breathwork practices, cyclic sighing and box breathing, in comparison to hypnosis and an audiobook about stress, on psychological and physiological variables.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/14/2025
Locations: Psychiatry & Behavioral Sciences, Stanford, California
Conditions: Stress, Anxiety
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A Phase 2b, Randomized, Double-blind, Active-controlled Study of Single Dose CVXGA Intranasal COVID-19 Vaccine in Adults
NCT06742281
Recruiting
The purpose of this trial is to assess the safety and relative efficacy of CVXGA (CVXGA50), a KP.2 containing vaccine, compared to COMIRNATY® (COVID-19 Vaccine, mRNA; 2024-2025 Formula), a currently approved COVID-19 vaccine in the prevention of symptomatic, RT-PCR-confirmed SARS-CoV-2 infection. The trial will enroll up to 10016 healthy participants.
Gender:
ALL
Ages:
Between 18 years and 100 years
Trial Updated:
05/14/2025
Locations: Pinnacle Research Group, LLC, Anniston, Alabama +54 locations
Conditions: COVID-19
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Multiple Ascending Dose Phase 1 Study of ALA-3000
NCT06965569
Recruiting
This is a randomized, double-blind, placebo-controlled, multiple-dose study of ALA-3000 designed to evaluate the safety, tolerability, pharmacokinetics and preliminary efficacy in subjects with treatment-resistant depression (TRD).
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
05/14/2025
Locations: Pillar Clinical Research, Little Rock, Arkansas +3 locations
Conditions: Treatment Resistant Depression
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Radiation Therapy and Rituximab in Treating Patients With Stage I-II Grade 1 or Grade 2 Follicular Lymphoma
NCT01473628
Recruiting
This randomized phase I/II trial studies radiation therapy and rituximab in treating patients with stage I-II grade 1 or grade 2 follicular lymphoma. Radiation therapy uses high energy x-rays to kill cancer cells. Immunotherapy with monoclonal antibodies, such as rituximab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Giving radiation therapy with rituximab may kill more cancer cells.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/14/2025
Locations: M D Anderson Cancer Center, Houston, Texas
Conditions: Ann Arbor Stage I Grade 1 Follicular Lymphoma, Ann Arbor Stage I Grade 2 Follicular Lymphoma, Ann Arbor Stage II Grade 1 Follicular Lymphoma, Ann Arbor Stage II Grade 2 Follicular Lymphoma
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Electrical DN as an Adjunct to Eccentric Exercise, Stretching + MT for Achilles Tendinopathy
NCT03968614
Recruiting
The purpose of this research is to compare two different approaches for treating patients with achilles tendinopathy: eccentric exercise, stretching and manual therapy VS Electric dry needling, eccentric exercise, stretching and manual therapy. Physical therapists commonly use all of these techniques to treat achilles tendinopathy. This study is attempting to find out if one treatment strategy is more effective than the other.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/14/2025
Locations: Prisma Health - Research PT Specialists, Columbia, South Carolina
Conditions: Achilles Tendinopathy
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Adapting for Latinx Populations an Intervention That Involves Discussing and Sharing Patients' Health-Related Values
NCT04942717
Recruiting
The purpose of this study is to translate and tailor for Latinx participants a program called Communicating with Oncology Nurses about Values from the Outset (CONVO). In CONVO, routine cancer care for each participant includes a discussion between the nurse and participant about the participant's health-related values.
Gender:
ALL
Ages:
21 years and above
Trial Updated:
05/14/2025
Locations: SBH Health System, Bronx, New York +4 locations
Conditions: Solid Tumor, Solid Tumor, Adult, Solid Tumor, Unspecified, Adult
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A Study Comparing Perioperative Stress Reduction vs. Standard of Care in Ovarian Cancer (PRESERVE)
NCT05429970
Recruiting
The purpose of this study is to see if propranolol and etodolac along with mind-body resilience training/MBRT and music therapy help participants who are experiencing physiological stress before, during, and after primary debulking surgery/PDS or IDS and also if it's better than the standard-of-care approach (no intervention for reducing stress).
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
05/14/2025
Locations: Memorial Sloan Kettering Basking Ridge (Limited Protocol Activities), Basking Ridge, New Jersey +6 locations
Conditions: Ovarian Cancer, Ovarian Carcinoma, Stage II Ovary Cancer, Stage II Ovarian Cancer, Stage III Ovary Cancer, Stage III Ovarian Cancer, Stage IV Ovary Cancer, Stage IV Ovarian Cancer, Epithelial Ovarian Cancer, Fallopian Tube Cancer, Stage II Fallopian Tube Cancer, Stage III Fallopian Tube Cancer, Stage IV Fallopian Tube Cancer, Primary Peritoneal Carcinoma
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An Informational and Supportive Care Intervention for Patients With Locally Advanced Rectal Cancer
NCT05914766
Recruiting
The aim of this study is to evaluate the feasibility and acceptability of conducting a randomized trial of a brief psychoeducational intervention versus enhanced usual care for patients with locally advanced rectal cancer who are initiating neoadjuvant multimodality treatment.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/14/2025
Locations: Massachusetts General Hospital, Boston, Massachusetts +1 locations
Conditions: Rectal Cancer, Self Efficacy
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Artesunate Ointment for the Treatment of Anal HSIL in HIV-negative Participants
NCT06206564
Recruiting
This is a phase II double blind, placebo-controlled, randomized study of artesunate ointment for the treatment of HIV-negative men and women who have anal high grade squamous intraepithelial lesions (anal HSIL)
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/14/2025
Locations: Anal Dysplasia Clinic MidWest, Chicago, Illinois +1 locations
Conditions: Anal High-grade Squamous Intraepithelial Lesion, Anal HSIL, Anal HPV Infection, AIN
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Study to Evaluate the Effects of NMRA-323511 Among Healthy Elderly and Adults With Agitation Associated With Dementia Due to Alzheimer's Disease
NCT06546995
Recruiting
This study consists of 2 parts, Part A and Part B. Part A is a single center, randomized, double-blind, placebo-controlled cohort designed to evaluate the safety, tolerability, and pharmacokinetics (PK) of NMRA-323511 among healthy elderly. Part B is a multicenter, randomized, double-blinded, placebo-controlled, parallel-group cohort to evaluate the safety, tolerability, and efficacy of NMRA-323511 among adults with Agitation Associated with Dementia due to Alzheimer's Disease. Part A consists... Read More
Gender:
ALL
Ages:
Between 55 years and 90 years
Trial Updated:
05/14/2025
Locations: Neumora Investigator Site, Chandler, Arizona +24 locations
Conditions: Alzheimer's Disease, Healthy Elderly
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Measurable Residual Disease Detection Using Tumor-Informed ctDNA Surveillance After Curative-Intent Treatment in HPV-Independent Squamous Cell Carcinoma of the Head and Neck
NCT06744296
Recruiting
This study will test the ability of a personalized blood test to determine which head and neck cancer patients will have a recurrence after treatment.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/14/2025
Locations: Massachusetts Eye and Ear, Boston, Massachusetts
Conditions: Squamous Cell Carcinoma of Head and Neck
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