Comparing Cooling and/or Compression Approaches of Limbs for Prevention of Chemotherapy-Induced Peripheral Neuropathy
NCT05642611
Recruiting
This phase III trial compares the effect of 3 study approaches in preventing chemotherapy-induced peripheral neuropathy: 1) cryocompression, 2) continuous compression, and 3) low cyclic compression. Taxane chemotherapy drugs, such as paclitaxel or docetaxel, can cause a nerve disorder called peripheral neuropathy, which can cause numbness, tingling, or pain in the arms and legs. The 3 study approaches will use a device, called the Paxman Limb Cryocompression System, made of wraps that cool and/o... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/27/2025
Locations: University of Alabama at Birmingham Cancer Center, Birmingham, Alabama +28 locations
Conditions: Malignant Solid Neoplasm
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Blinded Efficacy and Safety Study of CAL02 IV Plus SOC in Subjects With Severe Community-Acquired Bacterial Pneumonia
NCT05776004
Recruiting
This is a placebo-controlled study to evaluate the addition of CAL02 to standard of care in treating hospitalized subjects diagnosed with severe community acquired bacterial pneumonia (SCABP) requiring critical care measures
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/27/2025
Locations: UCSF Hospital, Fresno, California +94 locations
Conditions: Pneumonia, Bacterial
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The Effect of Semantic Support on Word Learning
NCT05921214
Recruiting
The goal of this clinical trial is to compare word learning outcomes in late talking toddlers who are taught different types of words. The main question it aims to answer is if teaching words that come from categories that children already know (e.g., animals) will aid overall word learning. Children will take part in the Vocabulary Acquisition and Usage for Late Talkers (VAULT) word learning treatment and be taught words from more familiar or less familiar categories to see which group learns m... Read More
Gender:
ALL
Ages:
Between 2 years and 4 years
Trial Updated:
03/27/2025
Locations: University of Arizona, Tucson, Arizona
Conditions: Language Development Disorders
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Patient-Directed Antimicrobial Duration in Acute Uncomplicated Pyelonephritis
NCT06127160
Recruiting
This pilot study will randomize 40 female patients with acute uncomplicated pyelonephritis to receive standard duration of therapy versus patient-directed antimicrobial duration (PDAD). The primary objectives of this pilot trial are to determine the feasibility and safety of conducting a full-scale multi-center randomized controlled trial.
Gender:
FEMALE
Ages:
Between 18 years and 55 years
Trial Updated:
03/27/2025
Locations: Olive View - UCLA Medical Center, Sylmar, California +1 locations
Conditions: Pyelonephritis Acute
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Effect of Raised End-Tidal pCo2 on Choroidal Volume
NCT06275308
Recruiting
This study is to investigate the relationship between arterial carbon dioxide (CO2) concentration and vitreous pressure on the choroidal volume by integrated intraoperative OCT imaging under eye exams under anesthesia.
Gender:
ALL
Ages:
8 years and below
Trial Updated:
03/27/2025
Locations: University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania
Conditions: Intraocular Pressure
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The Influence of Chardonnay Marc Intake on Gut and Cardiometabolic Health
NCT06476795
Recruiting
Recently a dietary recommendation of 400 - 600 mg/ day has been proposed for the reduced risk of developing cardiovascular disease. Dietary flavanols can be obtained from the intake of foods such as tea, cocoa, wine, berries and apples. Incorporating Chardonnay Marc (the skins and seeds of Chardonnay grapes) into the diet can be an additional source of dietary flavanols. Like other flavanol-rich foods, Chardonnay Marc provides fiber and polysaccharides that may benefit gut health. This study see... Read More
Gender:
FEMALE
Ages:
Between 45 years and 70 years
Trial Updated:
03/27/2025
Locations: University of California, Davis, Davis, California
Conditions: Cardiovascular Diseases, Adiposity, Cardiometabolic Syndrome
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Vortioxetine for the Treatment of Mood and Cognitive Symptoms in Frontotemporal Dementia
NCT06604520
Recruiting
The goal of this clinical trial is to learn if vortioxetine improves mood symptoms and cognition in patients with early-stage behavioral variant Frontotemporal Dementia (bvFTD). The main questions this study aims to answer are: 1. Do individuals with mood symptoms and bvFTD have brain changes and cognitive profiles that differ compared to individuals without bvFTD? 2. Do mood symptoms and cognition improve following treatment with vortioxetine? Researchers will also determine whether there are... Read More
Gender:
ALL
Ages:
45 years and above
Trial Updated:
03/27/2025
Locations: The Johns Hopkins Hospital, Baltimore, Maryland
Conditions: Fronto-temporal Dementia, Fronto-temporal Lobar Dementia, Frontotemporal Degeneration, Frontotemporal Dementia (FTD), Frontotemporal Dementia, Behavioral Variant, Frontotemporal Dementia
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NT-101 Topical Ophthalmic Solution in Patients With Wet AMD
NCT06704009
Recruiting
Phase 1/2 Trial NT-101 Topical Ophthalmic Solution in Patients with Wet Age-Related Macular Degeneration (AMD)
Gender:
ALL
Ages:
50 years and above
Trial Updated:
03/27/2025
Locations: Elman Retina Group, Rosedale, Maryland +3 locations
Conditions: Wet Age Related Macular Degeneration, Wet AMD
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Transcranial Magnetic Stimulation (TMS) Effects Using Magnetoencephalography (MEG) Study
NCT06770556
Recruiting
Alcohol use disorder (AUD) is a complex chronic brain disease characterized by compulsive alcohol use, loss of control over drinking, and negative emotional states. Extensive research has identified the general neural circuitry underlying AUD. There is an exciting opportunity to intervene in AUD using neuromodulation. Transcranial magnetic stimulation (TMS) offers a non-invasive method to modulate brain activity, making it a promising tool for investigating, modulating, and potentially treating... Read More
Gender:
ALL
Ages:
Between 21 years and 65 years
Trial Updated:
03/27/2025
Locations: Wake Forest University Health Sciences, Winston-Salem, North Carolina
Conditions: Alcohol Use Disorder, Alcohol Dependence, Alcohol Consumption
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A Study to Investigate the Safety, Tolerability, and Drug Levels of BMS-986419 (Part 1) and the Effects Multiple Doses of BMS-986419 on Cardiac Repolarization (Part 2) in Healthy Participants
NCT06846866
Recruiting
The purpose of this study is to investigate the safety, tolerability, and pharmacokinetics of BMS-986419 (Part 1) and the effects of multiple doses of BMS-986419 on cardiac repolarization (Part 2) in healthy participants.
Gender:
ALL
Ages:
Between 18 years and 55 years
Trial Updated:
03/27/2025
Locations: Celerion, Tempe, Arizona
Conditions: Healthy Volunteers
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The Effects of Drug Candidate CS1 on Lung Structure and Function Utilizing FRI
NCT06907693
Recruiting
Explore the impact of drug candidate CS1 on pathological vascular remodeling of small pulmonary arteries in the disease pulmonary arterial hypertension (PAH). This sub-study for CS1-004 aims to utilize FRI, an innovative, non-invasive imaging technology to visualize how long-term use of CS1 influences structural changes in pulmonary arteries. This sub-study seeks to provide valuable insights into the potential of CS1 to transform PAH treatment in some patients enrolled in the Expanded Access Pro... Read More
Gender:
ALL
Ages:
All
Trial Updated:
03/27/2025
Locations: Prisma Health, Greenville, South Carolina
Conditions: Pulmonary Arterial Hypertension
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Morphea in Adults and Children (MAC) Cohort Study: A Morphea Registry and DNA Repository
NCT01808937
Recruiting
The Morphea in Adults and Children (MAC) cohort is the first registry for both children and adults with morphea (also known as localized scleroderma) in the country. The purpose of the registry is to learn more about morphea, specifically: * How morphea behaves over time * How frequently specific problems occur along with morphea (for example, arthritis) * Whether morphea has an autoimmune background
Gender:
ALL
Ages:
90 years and below
Trial Updated:
03/27/2025
Locations: UT Southwestern Medical Center - Department of Dermatology, Dallas, Texas
Conditions: Scleroderma, Localized, Morphea, Frontal Linear Scleroderma en Coup de Sabre, Scleroderma, Circumscribed, Scleroderma, Linear
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