ED Observation for Opioid Use Disorder
NCT05064826
Recruiting
This is a multicenter, randomized clinical comparative effectiveness trial (RCT) in which patients with untreated OUD presenting to a Northwell Health Emergency Department (ED), NYULH-Brooklyn, NYULH-Tisch, and Bellevue Hospital will be randomized (1:1) to be managed clinically through either a standard ED visit or an extended visit through ED observation (EDOU).
Gender:
ALL
Ages:
Between 18 years and 100 years
Trial Updated:
03/26/2025
Locations: Rutgers University-University Hospital, Newark, New Jersey +5 locations
Conditions: Opiod Use Disorder
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Tempus Sculptor Study: Small Cell Lung Cancer (SCLC) Observational Study
NCT05257551
Recruiting
The study is a non-interventional evaluation of participants with SCLC who will receive diagnostic and (where possible) post-progression tumor tissue profiling, alongside plasma ctDNA biomarker profiling in addition to their standard of care therapy and disease surveillance.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/26/2025
Locations: Cancer and Blood Specialty Clinic, Los Alamitos, California +10 locations
Conditions: Small Cell Lung Cancer
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Low-Dose Interleukin-2 and Pembrolizumab for the Treatment of Stage IV Non-Small Cell Lung Cancer
NCT05493566
Recruiting
This early phase 1 trial will investigate the combination of low-dose interleukin-2 (IL-2) and pembrolizumab in patients with previously untreated stage IV non-small cell lung cancer (NSCLC). Preclinical data demonstrate reinvigoration of exhausted T cells into an effector-like phenotype with improved anti-tumor activity in response to this combination. This study will evaluate T cell function as well as clinical outcomes associated with this combination therapy.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/26/2025
Locations: Emory University/Winship Cancer Institute, Atlanta, Georgia
Conditions: Lung Non-Small Cell Carcinoma, Stage IV Lung Cancer AJCC v8, Stage IVA Lung Cancer AJCC v8, Stage IVB Lung Cancer AJCC v8
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INTERCOSTAL NERVE BLOCK: Efficacy of CINB for Patients With Multiple Rib Fractures
NCT05642026
Recruiting
This is a prospective, randomized, non-blinded study comparing CINB plus medical therapy versus standard medical care (non-steroidals and opioids intravenous/oral inpatient and oral outpatient) alone for patients with multiple rib fractures. The objective of this study is to analyze the effect of continuous intercostal nerve block (CINB) in the treatment of patients admitted to the adult trauma service with rib fractures. The effectiveness of CINB as adjunctive treatment will be compared to stan... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/26/2025
Locations: University of Kentucky Medical Center, Lexington, Kentucky
Conditions: Rib Fractures
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Window-of-Opportunity Trial of Ulixertinib for MAPK-Activated Low-Grade Gliomas in Adults
NCT05804227
Recruiting
To learn if the study drug, ulixertinib, can cross over the blood-brain barrier in patients with recurrent brain tumors
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/26/2025
Locations: M D Anderson Cancer Center, Houston, Texas
Conditions: Gliomas
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Increasing the Feasibility, Impact, and Equity of the Medicare Annual Wellness Visit (AWV)
NCT05910736
Recruiting
The goal of this study is to improve the use of preventive health services by implementing a multilevel intervention to stimulate Annual Wellness Visit use in diverse practices across the United States. This is a stepped wedge cluster randomized controlled trial. The intervention will be implemented in a total of 24 primary care practices over 24 months. Every 3 months, 6 practices will receive the intervention. Electronic health record (EHR) data extractions will be used to collect outcomes in... Read More
Gender:
ALL
Ages:
50 years and above
Trial Updated:
03/26/2025
Locations: Banner Health, Phoenix, Arizona +2 locations
Conditions: Preventive Health Services
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A Long-Term Study of Elafibranor in Adult Participants With Primary Biliary Cholangitis
NCT06016842
Recruiting
The participants of this study will have confirmed Primary Biliary Cholangitis (PBC) and cirrhosis (scarring of the liver). PBC is a slowly progressive disease, characterised by damage to the bile ducts in the liver, leading to a build-up of bile acids which causes further damage. The liver damage in PBC may lead to cirrhosis. PBC may also be associated with multiple symptoms. Many patients with PBC may require liver transplant or may die if the disease progresses and a liver transplant is not... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/26/2025
Locations: Arizona Liver Health, Tucson, Arizona +129 locations
Conditions: Primary Biliary Cholangitis (PBC)
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A Study Evaluating the Presence and Concentration of BRIUMVI™ (Ublituximab) in Breast Milk
NCT06143514
Recruiting
The primary objective of the lactation study is to characterize the presence and concentration of BRIUMVI™ in breast milk among breastfeeding participants who receive BRIUMVI™ therapeutically for the treatment of relapsing forms of multiple sclerosis (RMS).
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
03/26/2025
Locations: PROVIDE Virtual Research Coordination Center, Wilmington, North Carolina
Conditions: Relapsing Multiple Sclerosis
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Study of CG0070 After Transurethral Resection in Patients With IR NMIBC
NCT06253845
Recruiting
Investigators will evaluate the safety of CG0070 for the treatment of patients with Intermediate-Risk Non-Muscle Invasive Bladder Cancer (IR NMIBC).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/26/2025
Locations: Moffitt Cancer Center, Tampa, Florida
Conditions: Non-muscle Invasive Bladder Cancer
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Effects of Watermelon or Low-fat Cookie Consumption on Wellness
NCT06323070
Recruiting
The objective of the proposed research is to determine the effects of fresh watermelon consumption on physiological indicators of wellness regarding sexual, skin and gut health in adults.
Gender:
ALL
Ages:
Between 18 years and 50 years
Trial Updated:
03/26/2025
Locations: School of Exercise and Nutritional Sciences, San Diego, California
Conditions: Overweight and Obesity
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Turkey Tail Mushroom for Treating Post-Menopausal Women With HER2-Negative ER-Positive Breast Cancer Undergoing Surgery
NCT06450873
Recruiting
This phase II trial tests how well turkey tail mushroom (TTM) works in treating post-menopausal women with HER2-negative, estrogen receptor (ER)-positive breast cancer undergoing surgery. TTM is a common mushroom. In traditional Chinese medicine, it is used for enhancing function and removing toxins, as well as for cancer, hepatitis, and infections. There is previous evidence of significant tumor shrinkage occurring in the 2-month window between diagnosis and surgery in women who have taken TTM.... Read More
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
03/26/2025
Locations: Mayo Clinic in Arizona, Scottsdale, Arizona
Conditions: Estrogen Receptor-Positive Breast Carcinoma, HER2-Negative Breast Carcinoma
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A Phase 2 Study Evaluating Olutasidenib in Combination With Hypomethylating Agents in Patients With IDH1-mutated Higher-risk Myelodysplastic Syndromes, Chronic Myelomonocytic Leukemia, or Advanced Myeloproliferative Neoplasm
NCT06597734
Recruiting
To learn if olutasidenib, when combined with a drug called a hypomethylating agent (HMA) can help to control MDS, CMML, and/or MPN. The safety of the drug combination will also be studied.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/26/2025
Locations: MD Anderson Cancer Center, Houston, Texas
Conditions: Chronic Myelomonocytic Leukemia, Advanced Myeloproliferative Neoplasms, IDH1-mutated Higher-Risk Myelodysplastic Syndromes
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