Auricular VNS Following Intracerebral Hemorrhage
NCT06799390
Recruiting
This study will evaluate whether non-invasive auricular vagal nerve stimulation lowers inflammatory markers, and improves outcomes following intracerebral hemorrhage.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/24/2025
Locations: Washington University School of Medicine, Saint Louis, Missouri
Conditions: Intracerebral Hemorrhage
Register for Updates
Transcranial Magnetic Stimulation for Methamphetamine Use Disorder in PLWH
NCT06830980
Recruiting
The purpose of this study is to learn more about how accelerated theta burst stimulation affects methamphetamine craving and brain activity. Theta burst stimulation is a unique transcranial magnetic stimulation (TMS) paradigm that is efficient and potent.
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
03/24/2025
Locations: UK Department of Psychiatry, Lexington, Kentucky +1 locations
Conditions: Methamphetamine Use Disorders, HIV
Register for Updates
A Trial of the Efficacy and Safety of SEP-363856 in Acutely Psychotic Participants With Schizophrenia
NCT06894212
Recruiting
This is a Phase 3, Multicenter, Randomized, Double-blind, Placebo-controlled Trial to Determine the the Efficacy and Safety of SEP-363856 in Acutely Psychotic Participants with Schizophrenia
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
03/24/2025
Locations: Clinical Research Site # 145, Bentonville, Arkansas +10 locations
Conditions: Schizophrenia
Register for Updates
Longitudinal Sexual and Reproductive Health Study of Women with Breast Cancer and Lymphoma
NCT01788839
Recruiting
The purpose of this study is to see how cancer treatment affects sexual and reproductive function. The patient will also be asked to participate in blood draws to see if and how cancer treatment affects the ovaries and the ability to have children (fertility). These blood draws are optional and the patient can still participate in the questionnaire portion of the study even if they choose not to have their blood drawn.
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
03/24/2025
Locations: Memorial Sloan Kettering Basking Ridge, Basking Ridge, New Jersey +6 locations
Conditions: Breast Cancer, Lymphoma, Hodgkin's Lymphoma
Register for Updates
Investigations of Dementia in Parkinson Disease
NCT02763683
Recruiting
The purpose of this study is to use a brain imaging method called Pittsburgh B (PIB) Positron Emission Tomography (PET) and Vesicular Cholinergic Transport (VAT) PET to determine dementia subtypes in patients with Parkinson disease (PD). The ultimate goal of this project is to be able to identify individuals with PD who are at risk of developing dementia, and to distinguish the underlying cause of dementia.
Gender:
ALL
Ages:
50 years and above
Trial Updated:
03/24/2025
Locations: Washington University in St. Louis, Saint Louis, Missouri
Conditions: Parkinsons
Register for Updates
Edwards PASCAL CLASP IID/IIF Pivotal Clinical Trial
NCT03706833
Recruiting
To establish the safety and effectiveness of the Edwards PASCAL Transcatheter Valve Repair System in patients with degenerative mitral regurgitation (DMR) who have been determined to be at prohibitive risk for mitral valve surgery by the Heart Team, and in patients with functional mitral regurgitation (FMR) on guideline directed medical therapy (GDMT)
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/24/2025
Locations: The University of Alabama at Birmingham, Birmingham, Alabama +101 locations
Conditions: Degenerative Mitral Valve Disease, Mitral Regurgitation, Mitral Insufficiency, Functional Mitral Regurgitation
Register for Updates
American Indian Chronic Renal Insufficiency Cohort Study (AI-CRIC Study)
NCT04185844
Recruiting
Despite many advances in our understanding of the natural history and progression of chronic kidney disease (CKD) and cardio vascular disease (CVD) in the parent CRIC study over the past 15 years, important questions about key risk factors for these diseases remain unanswered in the AI population. To address this burden of CKD in AI communities Investigators formed a consortium of investigators with extensive experience in conducting research of chronic diseases including diabetes, cardiovascula... Read More
Gender:
ALL
Ages:
Between 21 years and 80 years
Trial Updated:
03/24/2025
Locations: NIDDK-Phoenix Epidemiology and Clinical Research, Phoenix, Arizona +2 locations
Conditions: Diabetes Mellitus, Chronic Kidney Diseases, Heart Diseases, Cardiovascular Diseases
Register for Updates
Ultrasound-based Blood-brain Barrier Opening and Albumin-bound Paclitaxel and Carboplatin for Recurrent Glioblastoma
NCT04528680
Recruiting
Paclitaxel is among the most active agents against glioblastoma in preclinical models. However, its clinical use has been hampered by the blood-brain barrier (BBB). In this trial we will implant a novel device with 9 ultrasound emitters allowing to temporarily and reversibly open the BBB immediately prior to chemotherapy infusion with albumin-bound paclitaxel. In the phase 1 component, increasing doses of chemotherapy will be delivered as long deemed safe based on the prior patient not experien... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/24/2025
Locations: Northwestern Memorial Hospital, Chicago, Illinois
Conditions: Glioblastoma, Gliosarcoma, GBM, Glioblastoma Multiforme, Glioblastoma, IDH-wildtype, Recurrent Glioblastoma
Register for Updates
Long-Chain Fatty Acid Oxidation Disorders In-Clinic Disease Monitoring Program
NCT04632953
Recruiting
The primary objective of this study is to assess the long-term safety, including pregnancy, infant, and lactation outcomes, of patients with LC-FAOD who are enrolled in the DMP.
Gender:
ALL
Ages:
All
Trial Updated:
03/24/2025
Locations: Phoenix Children's Hospital, Phoenix, Arizona +15 locations
Conditions: Long-chain Fatty Acid Oxidation Disorders (LC-FAOD)
Register for Updates
Capivasertib + CDK4/6i + Fulvestrant for Advanced/Metastatic HR+/HER2- Breast Cancer (CAPItello-292)
NCT04862663
Recruiting
A Phase Ib/III Open-label, Randomised Study of Capivasertib plus CDK4/6 Inhibitors and Fulvestrant versus CDK4/6 Inhibitors and Fulvestrant in Hormone Receptor-Positive and Human Epidermal Growth Factor Receptor 2-Negative Locally Advanced, Unresectable or Metastatic Breast Cancer (CAPItello-292)
Gender:
ALL
Ages:
Between 18 years and 99 years
Trial Updated:
03/24/2025
Locations: Research Site, Tucson, Arizona +277 locations
Conditions: Locally Advanced (Inoperable) or Metastatic Breast Cancer
Register for Updates
Effects of Pregnancy-Specific Anxiety on Placental Inflammatory and Oxidative Stress Response and Birth Outcomes
NCT04993742
Recruiting
Explore the associations of prenatal maternal anxiety to placental histologic findings, and the pro-inflammatory, anti-inflammatory, and immunoregulatory cells found in the placenta and determine the effect of maternal anxiety on the association between placental molecular changes on pregnancy and birth and infant outcomes.
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
03/24/2025
Locations: Joint Base San Antonio, San Antonio, Texas
Conditions: Placental Dysfunction, Prenatal Stress
Register for Updates
Comparing Two Ways to Manage Head and Neck Lymphedema
NCT05182229
Recruiting
This randomized clinical trial aims to compare clinic-based CDT and home-based (a hybrid model) CDT on changes in the severity of lymphedema, symptom burden, functional status, and healthcare utilization in HNC survivors with lymphedema.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/24/2025
Locations: University of Pennsylvania, Philadelphia, Pennsylvania +2 locations
Conditions: Head and Neck Cancer, Lymphedema
Register for Updates