Positive Affect Treatment for Adolescents with Early Life Adversity
NCT06273137
Recruiting
Youth exposed to early life adversity (ELA) are known to be at greater risk for depression and suicidality and account for almost half of the youth suffering from psychiatric diseases today. Youth exposed to ELA consistently report symptoms of anhedonia as well as dysregulated positive affect. The present project will test the efficacy of PAT in a sample of ELA-exposed adolescents in order to determine whether PAT increases positive affect, and subsequently symptoms of depression. For the initia... Read More
Gender:
ALL
Ages:
Between 12 years and 16 years
Trial Updated:
03/17/2025
Locations: University of California Irvine, Irvine, California
Conditions: Depression
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Adaptive Use of Nicotine Substitution to Maintain Smoking Reduction/Abstinence in Nicotine Responders
NCT06554873
Recruiting
To determine whether smokers who initially respond (within 2 weeks) to nicotine products (including nicotine replacement therapy, e-cigarettes, nicotine pouches) by reducing their smoking by ≥50% can be successfully maintained on use of these noncombustible nicotine alternatives to cigarettes for 6 months, and whether this results in sustained smoking reduction/abstinence.
Gender:
ALL
Ages:
Between 22 years and 65 years
Trial Updated:
03/17/2025
Locations: Rose Research Center, Charlotte, North Carolina +1 locations
Conditions: Smoking Cessation, Harm Reduction
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Feasibility of Video Gaming Technology for Arm Recovery Early Post-stroke
NCT06691880
Recruiting
The investigators are investigating ways to incorporate new technologies that can enhance functional outcome after neurological insult into the patient recovery space. In order to accelerate the translation of these technologies to patient care spaces, the investigators need to identify the locations that are feasible for its use. Currently the investigators are using video game technologies that are used to maximize motor recovery of impaired upper extremities after neurological insult in the o... Read More
Gender:
ALL
Ages:
Between 21 years and 90 years
Trial Updated:
03/17/2025
Locations: Johns Hopkins Hospital, Baltimore, Maryland
Conditions: Subacute Stroke, Acute Stroke
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A Study of Botensilimab and Balstilimab for Rectal Adenocarcinoma
NCT06843434
Recruiting
The purpose of this study is to find out whether the combination of botensilimab and balstilimab (BOT/BAL) is a safe and effective treatment that causes few or mild side effects for people with mismatch repair proficient (MMRp)/microsatellite stable (MSS) locally advanced rectal adenocarcinoma. The investigators will also find out whether BOT/BAL is an effective treatment when given in combination with standard chemotherapy.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/17/2025
Locations: Memorial Sloan Kettering Basking Ridge (Limited Protocol Activities), Basking Ridge, New Jersey +6 locations
Conditions: Microsatellite Stable Rectal Carcinoma, Locally Advanced Rectal Adenocarcinoma
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Neurocognition in Patients With Multiple Brain Metastases Treated With Radiosurgery
NCT03184038
Recruiting
This phase II trial studies the neurological function in patients with multiple brain metastases undergoing stereotactic radiosurgery (SRS) or stereotactic body radiation therapy (SBRT). Stereotactic body radiation therapy uses special equipment to position a patient and deliver radiation to tumors with high precision. This method can kill tumor cells with fewer doses over a shorter period and cause less damage to normal tissue. Assessment of neurocognitive function may help show that SRS preser... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/17/2025
Locations: Jefferson Health New Jersey, Sewell, New Jersey +1 locations
Conditions: Metastatic Malignant Neoplasm in the Brain, Metastatic Malignant Solid Neoplasm
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Assessment of N-Acetylcysteine as Therapy for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome
NCT04542161
Recruiting
Chronic fatigue syndrome/myalgic encephalomyelitis (ME/CFS) is an unexplained multisymptom/multisystem disorder for which there are currently no validated treatments. The present exploratory clinical trial aims to advance our understand of the mechanisms of in situ GSH synthesis control through assessment of the response of brain GSH and plasma markers of oxidative stress to different doses of NAC in comparison to placebo, as a potential treatment for ME/CFS that would provide neuroprotection ag... Read More
Gender:
ALL
Ages:
Between 21 years and 60 years
Trial Updated:
03/17/2025
Locations: Weill Cornell Medicine, New York, New York
Conditions: Chronic Fatigue Syndrome, Myalgic Encephalomyelitis
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Metabolic Mechanisms Induced by Enteral DHA and ARA Supplementation in Preterm Infants
NCT05380401
Recruiting
A comprehensive analysis of the impact of exogenous enteral DHA and ARA supplementation on lipid metabolism including the production of downstream derived mediators and how this impacts important biological pathways such as metabolism, inflammation, and organogenic factors.
Gender:
ALL
Ages:
36 weeks and below
Trial Updated:
03/17/2025
Locations: University of California, Los Angeles (UCLA), Los Angeles, California +6 locations
Conditions: Premature
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E-Cigarettes for Harm Reduction in Smokers With Opioid Use Disorder
NCT05722561
Recruiting
The purpose of this an open-label, randomized controlled trial study is to compare the effectiveness of electronic cigarettes (e-cigarettes/e-cigs) versus telehealth motivational counseling with combination nicotine replacement therapy (NRT) + telehealth counseling on combustible cigarettes smoking reduction among persons with opioid use disorder (OUD) in methadone and buprenorphine treatment programs (opioid use disorder treatment programs (OUDTP)). OUDTP patients are a population with exceptio... Read More
Gender:
ALL
Ages:
Between 21 years and 75 years
Trial Updated:
03/17/2025
Locations: Albert Einstein College of Medicine, Bronx, New York +1 locations
Conditions: Opioid Use Disorder, Cigarette Smoking
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Comparison of Anti-coagulation and Anti-Platelet Therapies for Intracranial Vascular Atherostenosis- Magnetic Resonance Imaging
NCT05907629
Recruiting
CAPTIVA-MRI is an observational multimodal MR imaging study that is ancillary to the CAPTIVA trial \[a 3-arm, double-blind Phase III trial conducted at approximately 115 StrokeNet sites randomizing patients with stroke attributed to 70-99% intracranial atherosclerotic stenosis (ICAS) to aspirin plus ticagrelor, clopidogrel, or rivaroxaban.\] The primary goal of this ancillary study is to determine if MRI biomarkers can potentially identify ICAS patients who fail best medical management. The CAPT... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/17/2025
Locations: University of Alabama Hospital, Birmingham, Alabama +12 locations
Conditions: Stroke, Intracranial Atherosclerotic Stenosis (ICAS)
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Study of Lurbinectedin in Combination With Doxorubicin Versus Doxorubicin Alone as First-line Treatment in Participants With Metastatic Leiomyosarcoma
NCT06088290
Recruiting
The primary objective of this phase IIb/III study is to evaluate whether the combination of lurbinectedin plus doxorubicin given as first line treatment for metastatic leiomyosarcoma (LMS) prolongs the progression-free survival (PFS) by Independent Review Committee (IRC) when compared to doxorubicin administered as a single agent.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/17/2025
Locations: Mayo Clinic Hospital - Phoenix, Phoenix, Arizona +75 locations
Conditions: Leiomyosarcoma
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Expanding Liver Transplant Immunosuppression Minimization Via Everolimus
NCT06280950
Recruiting
This is a study to determine the safety, efficacy, and tolerability of taking away the anti-rejection medicine, tacrolimus, in liver transplant recipients in conjunction with everolimus monotherapy to preserve renal function. Two hundred - seventy (270) subjects will be randomized 2:1 into one of two groups between 2-3 months post-transplant. Seventy participants will be placed into an observational group and will remain on their current post-transplant medications. The duration of the study fro... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/17/2025
Locations: Mayo Clinic Hospital Arizona (Site #: 71144), Phoenix, Arizona +7 locations
Conditions: Liver Transplant
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A Study of Obexelimab in Patients with Systemic Lupus Erythematosus
NCT06559163
Recruiting
This study aims to examine the efficacy and safety of obexelimab in participants with systemic lupus erythematosus (SLE).
Gender:
ALL
Ages:
Between 18 years and 70 years
Trial Updated:
03/17/2025
Locations: Sierra Pacific Arthritis and Rheumatology Centers, Fresno, California +46 locations
Conditions: Systemic Lupus Erythematosus
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