First-in-Human Assessment of Safety, Biodistribution and Pharmacokinetics of 18F-Fluoro-1-Naphthol (18F-4FN) for PET Imaging
NCT05335811
Recruiting
18F-4FN represents a novel PET agent for imaging inflammation. Acute inflammatory signaling through the TLR axis recruits neutrophils and macrophages to inflammatory sites. Both cells activate the production of high energy reactive oxygen species/reactive nitrogen species (RONS), setting off a cascade that can be leveraged to detect the presence of these inflammatory cells by molecular imaging. 18F-4FN is efficiently oxidized by high energy RONS, leading to retention and accumulation in human ne... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/17/2025
Locations: MD Anderson Cancer Center, Houston, Texas
Conditions: Endocrine Neoplasia
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Assoc. of Genomic Polymorphisms With Cancer Cachexia in Subjects With Panc Adenocarcinoma
NCT05376592
Recruiting
A major complication of pancreatic adenocarcinoma (PDAC) is cancer cachexia (CC) which is a complex syndrome characterized by skeletal muscle mass loss (with or without loss of fat mass) and progressive functional impairment not reversible by conventional nutritional support. It is estimated to occur in over 75% of patients with advanced PDAC, the highest incidence of all solid tumors, and contributes significantly to poor outcomes and mortality. Though there is overlap amongst the pathophysiolo... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/17/2025
Locations: Levine Cancer Institute, Charlotte, North Carolina +1 locations
Conditions: Pancreas Adenocarcinoma, Cachexia
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A Study of Amivantamab Monotherapy and in Addition to Standard-of-Care Chemotherapy in Participants With Advanced or Metastatic Colorectal Cancer
NCT05379595
Recruiting
The purpose of this study is to assess the anti-tumor activity of amivantamab as a monotherapy (Cohorts A, B, and C), to characterize the safety of amivantamab when added to standard-of care (SoC) chemotherapy in participants with metastatic colorectal cancer (mCRC) (Ph2 cohorts), and to assess the recommended phase 2 combination dose (RP2CD) of amivantamab when added to SoC chemotherapy (Ph1b cohorts).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/17/2025
Locations: O Neal Comprehensive Cancer Center at UAB, Birmingham, Alabama +52 locations
Conditions: Advanced or Metastatic Colorectal Cancer
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Effect of Validated Skills Simulation With the Miya Model
NCT05418764
Recruiting
Simulation training with the Miya Model will improve Operating Room performance of Vaginal Hysterectomy (VH) in novice surgeons and this phase of the study is designed to test that.
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
07/17/2025
Locations: Wake Forest University Health Sciences, Winston-Salem, North Carolina
Conditions: Vaginal Hysterectomy
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Coconut Oil to Prevent Mouth Sores in Pediatric Patients Receiving High Dose Chemotherapy
NCT05441813
Recruiting
The purpose of this study is to learn if virgin coconut oil (VCO) mouth rinse can help prevent oral mucositis. The Study Investigator will compare standard of care mucositis prevention rinses with the VCO mouth rinse added to the standard of care mucositis prevention rinses. The severity of oral mucositis between the 2 groups will be evaluated. Some of the standard of care rinses that can be used to prevent mucositis are normal saline, Benadryl (diphenhydramine), Mylanta, lidocaine, or other com... Read More
Gender:
ALL
Ages:
Between 7 years and 26 years
Trial Updated:
07/17/2025
Locations: Atrium Health Levine Children's Hospital, Charlotte, North Carolina
Conditions: Oral Mucositis
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The Neural Underpinnings of Depression and Cannabis Use in Young People Living With HIV
NCT05453513
Recruiting
To elucidate mechanisms of substance use disorders (SUD) and comorbid mental illnesses in people living with HIV (PLWH), the study team seeks to investigate reward and pain circuitry in cannabis use and depression comorbidity, two highly prevalent conditions in PLWH. The study team proposes a tightly integrative study to test the overall hypothesis that cannabis use and depression in young PLWH have an additive effect, inducing both reward deficits and pain hypersensitivity, and that this patter... Read More
Gender:
ALL
Ages:
Between 18 years and 59 years
Trial Updated:
07/17/2025
Locations: University of Miami, Miami, Florida
Conditions: Hiv, Depression, Cannabis Use Disorder
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Expiratory Muscle Strength Training for Hypernasal Speech in Children
NCT05492266
Recruiting
When the soft palate does not move enough because of a cleft palate or for unknown reasons, this can lead to a speech difference called velopharyngeal insufficiency. The purpose of this research study is to test if soft palate exercises using a hand help breathing device will help improve the ability of the soft palate to close the area between the throat and nose and help improve speech.
Gender:
ALL
Ages:
Between 5 years and 17 years
Trial Updated:
07/17/2025
Locations: UPMC Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania
Conditions: Velopharyngeal Insufficiency, Velopharyngeal Incompetence Due to Cleft Palate, Inadequate Velopharyngeal Closure, Palatopharyngeal Incompetence, Hypernasality
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A Study of Amivantamab in Participants With Advanced or Metastatic Solid Tumors Including Epidermal Growth Factor Receptor (EGFR)-Mutated Non-Small Cell Lung Cancer
NCT05498428
Recruiting
The purpose of this study is to assess the anti-tumor activity and safety of amivantamab which will be administered as a co-formulation with recombinant human hyaluronidase PH20 (rHuPH20) (subcutaneous co-formulation \[SC-CF\]) in combination treatment (all cohorts except Cohort 4) and to characterize the safety of amivantamab SC-CF (Cohort 4).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/17/2025
Locations: University of California at San Diego, La Jolla, California +109 locations
Conditions: Carcinoma, Non-small-Cell Lung
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Safety and Effectiveness of the Genio® bilAteral Stimulation for Treatment of Complete Concentric CollapsE and OSA.
NCT05592002
Recruiting
The solution offered by the Genio System to treat OSA patients with CCC using bilateral HGNS has a favorable risk-benefit ratio, as demonstrated by evidence from 2 studies.
Gender:
ALL
Ages:
Between 22 years and 75 years
Trial Updated:
07/17/2025
Locations: Colorado ENT & Allergy, Colorado Springs, Colorado +15 locations
Conditions: Sleep Apnea, Obstructive
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A Study of JNJ-79635322 in Participants With Relapsed or Refractory Multiple Myeloma or Previously Treated Amyloid Light-chain (AL) Amyloidosis
NCT05652335
Recruiting
The primary purpose of this study is to identify the recommended phase 2 dose (RP2D\[s\]) and schedule(s) to be safe for JNJ-79635322 in Part 1 (dose escalation), and to characterize the safety and tolerability of JNJ-79635322 at the RP2D(s) selected and in disease subgroups in Part 2 (dose expansion).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/17/2025
Locations: City of Hope, Duarte, California +28 locations
Conditions: Relapsed or Refractory Multiple Myeloma, Previously Treated Amyloid Light-chain (AL) Amyloidosis
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A Study of the Effects of Oxytocin in Adults With Binge-eating Disorder
NCT05664516
Recruiting
This study evaluates the impact of intranasal oxytocin vs placebo in patients with binge eating disorder or episodes of binging. We hypothesize that 8 weeks of intranasal oxytocin vs placebo will improve clinical outcomes \[reduction in bingeing frequency\], and have a satisfactory safety and tolerability profile. We will also explore the predictive value of changes in homeostatic appetite, reward sensitivity, and impulse control, the identified underlying mediators, as assessed 4 weeks into the... Read More
Gender:
ALL
Ages:
Between 18 years and 70 years
Trial Updated:
07/17/2025
Locations: Neuroendocrine Unit Research Center, Boston, Massachusetts
Conditions: Binge-eating Disorder
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The Effects of Medicaid Policy Interventions on Racial Equity in Severe Maternal Morbidity
NCT05678699
Recruiting
The goal of this study is to learn about the effects of structural inventions, such as equity-focused Medicaid polices, on severe maternal morbidity (SMM) and mortality and maternal health. The main questions it aims to answer are: 1. What is the effect of Medicaid healthcare quality interventions on SMM? 2. What is the effect of Medicaid healthcare quality interventions + doula care? 3. What are Medicaid beneficiaries' experiences in receiving services and the potential impact of integration o... Read More
Gender:
ALL
Ages:
All
Trial Updated:
07/17/2025
Locations: University of Pittsburgh School of Public Health, Pittsburgh, Pennsylvania
Conditions: Severe Maternal Morbidity, Maternal Death
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