Psilocybin Therapy for Chronic Low Back Pain
NCT05351541
Recruiting
This study evaluates whether psilocybin therapy helps patients cope with chronic low back pain more effectively. Patients may be recruited at Stanford and University of California San Francisco (UCSF), study procedures will occur at UCSF. Each participant will receive a dose of psilocybin with possibly one or more other drugs. Participants will undergo two preparation sessions, a dosing session, three integration sessions to discuss their psilocybin experience, and several follow up sessions.
Gender:
ALL
Ages:
Between 25 years and 70 years
Trial Updated:
03/17/2025
Locations: University of California San Francisco, San Francisco, California
Conditions: Chronic Low-back Pain
Register for Updates
Brief Cognitive Behavioral Therapy for People with Physical Disabilities
NCT05695430
Recruiting
The purpose of this study is to examine the effectiveness of a psychotherapy (non-medication) treatment, Brief Cognitive Behavioral Therapy for Suicide Prevention, in reducing suicide ideation and attempts for people with physical disabilities.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/17/2025
Locations: The Ohio State Universitty Wexner Medical Center, Columbus, Ohio
Conditions: Suicide, Suicide, Attempted, Suicidal Ideation, Disability Physical, Disability Hearing, Disability, Vision
Register for Updates
Semaglutide Therapy for Alcohol Reduction - Tulsa
NCT05891587
Recruiting
The purpose of this research study is to determine if semaglutide, when compared to placebo, is safe and may reduce alcohol drinking in individuals who endorse symptoms consistent with alcohol use disorder.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/17/2025
Locations: OSU Biomedical Imaging Center, Tulsa, Oklahoma
Conditions: Alcohol Use Disorder
Register for Updates
A Study of a Vaccine in Combination With Beta-glucan in People With Neuroblastoma
NCT06057948
Recruiting
The purpose of this study is to test which treatment schedule of β-glucan with bivalent vaccine is more effective for participants with high-risk neuroblastoma that is in complete remission.
Gender:
ALL
Ages:
All
Trial Updated:
03/17/2025
Locations: Memorial Sloan Kettering at Basking Ridge (Consent only), Basking Ridge, New Jersey +6 locations
Conditions: Neuroblastoma, High-risk Neuroblastoma, Metastatic Neuroblastoma
Register for Updates
Expanding Liver Transplant Immunosuppression Minimization Via Everolimus
NCT06280950
Recruiting
This is a study to determine the safety, efficacy, and tolerability of taking away the anti-rejection medicine, tacrolimus, in liver transplant recipients in conjunction with everolimus monotherapy to preserve renal function. Two hundred - seventy (270) subjects will be randomized 2:1 into one of two groups between 2-3 months post-transplant. Seventy participants will be placed into an observational group and will remain on their current post-transplant medications. The duration of the study fro... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/17/2025
Locations: Mayo Clinic Hospital Arizona (Site #: 71144), Phoenix, Arizona +7 locations
Conditions: Liver Transplant
Register for Updates
A Study of Obexelimab in Patients with Systemic Lupus Erythematosus
NCT06559163
Recruiting
This study aims to examine the efficacy and safety of obexelimab in participants with systemic lupus erythematosus (SLE).
Gender:
ALL
Ages:
Between 18 years and 70 years
Trial Updated:
03/17/2025
Locations: Sierra Pacific Arthritis and Rheumatology Centers, Fresno, California +46 locations
Conditions: Systemic Lupus Erythematosus
Register for Updates
Femoral BMD Change Following Cemented or Cementless Total Knee Arthroplasty
NCT06733597
Recruiting
The purpose of this study is to examine femur bone mineral density (BMD) change before and after surgery in patients receiving cemented or cementless total knee arthroplasty (TKA). performed with manual or robotic methods. 100 participants will be enrolled and can expect to be on study for up to 14 months.
Gender:
ALL
Ages:
55 years and above
Trial Updated:
03/17/2025
Locations: UW School of Medicine and Public Health, Madison, Wisconsin
Conditions: Knee Arthropathy
Register for Updates
A New Clinical Model for the Engagement of Latinx Youth with Suicidal Behavior
NCT06882798
Recruiting
This study will test a model of providing treatment to Latinx/Hispanic youth, who experience suicidal thoughts and behavior, and their caregivers. An affirmative and culturally relevant treatment will be provided to all youth and half of the families will be assigned to the additional support of a community health worker (CHW). Youth symptoms and family engagement to treatment will be followed for nine months. The potential benefit of adding the CHW intervention will be assessed.
Gender:
ALL
Ages:
Between 12 years and 18 years
Trial Updated:
03/17/2025
Locations: Bradley Hasbro Children's Research Center, Providence, Rhode Island
Conditions: Suicide Ideation, Suicidal Behaviors, Depressive Symptoms
Register for Updates
CD22 Redirected Autologous T Cells for ALL
NCT02650414
Recruiting
This is a pilot study to determine the feasibility and safety of a single dose of autologous T cells expressing CD22 chimeric antigen receptors expressing tandem TCR-ζ and 4-1BB signaling domains (CART22/CART22-65s cells) in pediatric and young adult subjects with relapsed or refractory B cell acute lymphoblastic leukemia.
Gender:
ALL
Ages:
Between 1 year and 29 years
Trial Updated:
03/17/2025
Locations: Children's Hospital of Philadelphia, Philadelphia, Pennsylvania
Conditions: B Cell Leukemias, B Cell Lymphomas
Register for Updates
STRIVE Post-Market Registry Study
NCT04302272
Recruiting
This is a single-arm, prospective, multi-center, Registry study to evaluate the long-term safety and effectiveness of the Spiration Valve System (SVS) for the treatment of severe emphysema in a post-market setting.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/17/2025
Locations: Dignity Health St. Joseph's Hospital and Medical Center, Phoenix, Arizona +11 locations
Conditions: Emphysema
Register for Updates
A Study to Evaluate Safety, Drug Levels and Effectiveness of CC-92480 (BMS-986348) in Combination With Other Treatments in Participants With Relapsed or Refractory Multiple Myeloma
NCT05372354
Recruiting
The purpose of this study is to assess the safety, tolerability and preliminary effectiveness of CC-92480 (BMS-986348) in novel therapeutic combinations for the treatment of Relapsed or Refractory Multiple Myeloma (RRMM).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/17/2025
Locations: UAB Comprehensive Cancer Center, Birmingham, Alabama +16 locations
Conditions: Multiple Myeloma
Register for Updates
Tadalafil Effect + Chemotherapy in Resectable Gastric/GEJ Cancer
NCT05709574
Recruiting
The goal of this clinical trial is to assess the ability of Tadalafil alone and in combination with neoadjuvant FLOT (5-Fluorouracil, Oxaliplatin, and Docetaxel) chemotherapy to suppress myeloid derived suppressor cells (MDSCs) in patients with resectable gastric or gastroesophageal junction adenocarcinoma. Resectable means the tumor may be removed through surgical intervention. Neoadjuvant chemotherapy is chemotherapy received before the primary course of treatment i.e.surgical intervention. T... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/17/2025
Locations: Arizona Cancer Center at UMC North/University Medical Center, Tucson, Arizona
Conditions: Gastric Adenocarcinoma, Gastroesophageal Junction Adenocarcinoma
Register for Updates