A Study to Evaluate the Efficacy and Safety of AVTX-009 in Patients With Moderate to Severe Hidradenitis Suppurativa
NCT06603077
Recruiting
The main purpose of this study is to evaluate the efficacy and safety of AVTX-009 compared with placebo in patients with moderate to severe Hidradenitis Suppurativa (HS).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/17/2025
Locations: Clinical Site 1022, Scottsdale, Arizona +71 locations
Conditions: Hidradenitis Suppurativa
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A Nutrition & Exercise Prehabilitation Intervention on Inflammatory Biomarkers in AI Cancer Patients
NCT06644560
Recruiting
The purpose of this study is to assess the feasibility of a prehab intervention among American Indian (AI) patients diagnosed with obesity-related cancer and measure inflammatory biomarkers to evaluate the preliminary impact of the trial intervention. The central hypothesis is that this community-informed prehab intervention will demonstrate feasibility, patient acceptability, and modulation of host and tumor-microenvironment inflammatory biomarkers. Aim 1: Implement the prehab translational cl... Read More
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
07/17/2025
Locations: University of Arizona Cancer Center, Tucson, Arizona
Conditions: Cancer, Obesity
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A Follow-on Study for Second-Eye Treatment for Participants Previously Treated With Gene Therapy for X-Linked Retinitis Pigmentosa (XLRP)
NCT06646289
Recruiting
The purpose of this study is to assess the safety and tolerability of subretinal delivery of Adeno-associated Virus Vector (AAV5 hRKp.RPGR) gene therapy in adults and children with X-linked retinitis pigmentosa.
Gender:
MALE
Ages:
5 years and above
Trial Updated:
07/17/2025
Locations: Massachusetts Eye and Ear Infirmary, Boston, Massachusetts +1 locations
Conditions: X-Linked Retinitis Pigmentosa
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A Study of JNJ-89402638 for Metastatic Colorectal Cancer
NCT06663319
Recruiting
The purpose of this study is to determine the putative recommended phase 2 dose(s) (RP2Ds) of JNJ-89402638 and to determine the safety of JNJ-89402638 at the RP2D(s) in participants with metastatic colorectal cancer.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/17/2025
Locations: University of Colorado Denver Anschultz Medical Campus, Aurora, Colorado +7 locations
Conditions: Unresectable Metastatic Colorectal Cancer
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A Long-term Extension (LTE) Study of Guselkumab in Pediatric Participants
NCT06663332
Recruiting
The purpose of this study is to evaluate long-term safety of subcutaneous guselkumab in pediatric participants with moderately to severely active ulcerative colitis, or moderately to severely active Crohn's disease, or juvenile psoriatic arthritis (jPsA).
Gender:
ALL
Ages:
3 years and above
Trial Updated:
07/17/2025
Locations: University of Utah, Salt Lake City, Utah +10 locations
Conditions: Crohns Disease, Colitis, Ulcerative, Arthritis, Psoriatic, Arthritis, Juvenile
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A Study of ETHIZIA Versus SURGICEL Original in Controlling Soft Tissue Bleeding During Open Surgery
NCT06664788
Recruiting
The objective of this clinical investigation is to evaluate the safety and efficacy of ETHIZIA to control minimal, mild, or moderate soft tissue bleeding during open surgery when compared to SURGICEL Original in the percentage of cases achieving hemostasis at 3 minutes after product application, and without re-bleeding up to 10 minutes after application.
Gender:
ALL
Ages:
22 years and above
Trial Updated:
07/17/2025
Locations: Keck Hospital of USC, Los Angeles, California +6 locations
Conditions: Hemostasis, Hemostatic Techniques
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A Study of JNJ-90301900 in Combination With Chemoradiation Followed by Consolidation Immunotherapy for Non-Small Cell Lung Cancer (NSCLC)
NCT06667908
Recruiting
The purpose of this study is to determine whether JNJ-90301900 added to concurrent platinum-based doublet chemotherapy with radiation therapy (cCRT) followed by consolidation immunotherapy (cIT) can improve objective response rate (ORR; that is percentage of participants whose best response is complete response or partial response during the study) in participants with locally advanced and unresectable stage III non-small cell lung cancer.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/17/2025
Locations: University of Connecticut Health Center, Farmington, Connecticut +10 locations
Conditions: Carcinoma, Non-Small-Cell Lung
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A Study to Assess How the Drug Moves Through the Body, Adverse Events, and Tolerability of Oral ABBV-722 Capsules of Single and Multiple Ascending Doses in Adult Participants and Single Doses in Adult Asian Participants
NCT06673238
Recruiting
This is a Phase 1, first-in-human study to investigate safety, tolerability, and pharmacokinetics of ABBV-722 after oral dosing in healthy adult participants.
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
07/17/2025
Locations: Acpru /Id# 270279, Grayslake, Illinois
Conditions: Healthy Volunteer
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Investigating The Role of Noise Correlations in Learning
NCT06673303
Recruiting
A fundamental problem in neuroscience is how the brain computes with noisy neurons. An advantage of population codes is that downstream neurons can pool across multiple neurons to reduce the impact of noise. However, this benefit depends on the noise associated with each neuron being independent. Noise correlations refer to the covariance of noise between pairs of neurons, and such correlations can limit the advantages gained from pooling across large neural populations. Indeed, a large body of... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/17/2025
Locations: Brown University, Providence, Rhode Island
Conditions: Noise Correlations, Learning Quality
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Avacopan in Crescentic Immunoglobulin A Nephropathy (IgAN)
NCT06676579
Recruiting
The purpose of this study is to evaluate the efficacy and safety of Avacopan together with low-dose glucocorticoid in the treatment of patients with crescentic Imunoglobulin A Nephropathy (IgAN) and high risk of progression.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/17/2025
Locations: Mayo Clinic in Florida, Jacksonville, Florida +1 locations
Conditions: IgA Nephropathy (IgAN)
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Food Provision in Prenatal Care
NCT06711627
Recruiting
The overarching research question is: "Does the provision of healthy food during pregnancy reduce the proportion of women who experience excessive gestational weight gain compared with standard of care (SoC)?" To answer this question, the investigators will conduct a randomized controlled trial with 400 pregnant women. Participants will be randomized 1:1 to either the Food Provision arm or the SoC arm, with approximately 200 participants per arm. Participants randomized to the SoC arm will recei... Read More
Gender:
FEMALE
Ages:
Between 16 years and 44 years
Trial Updated:
07/17/2025
Locations: UAMS Institute for Community Health Innovation, Springdale, Arkansas
Conditions: Pregnancy Complications, Excessive Gestational Weight Gain
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Study With Omecamtiv Mecarbil (CK-1827452) to Treat Chronic Heart Failure With Severely Reduced Ejection Fraction
NCT06736574
Recruiting
The purpose of this study is to find out if the investigational drug called omecamtiv mecarbil can reduce the risk of the effects of heart failure, like hospitalization, transplantation, or death in patients with heart failure and severely reduced ejection fraction.
Gender:
ALL
Ages:
Between 18 years and 85 years
Trial Updated:
07/17/2025
Locations: Advanced Cardiovascular, LLC, Alexander City, Alabama +62 locations
Conditions: Heart Failure, Heart Failure With Reduced Ejection Fraction
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