Multicenter Study of Lumateperone for the Treatment of Irritability Associated With Autism Spectrum Disorder (ASD) in Pediatric Patients
NCT06706674
Recruiting
This is a multicenter, randomized, double-blind, placebo-controlled study in pediatric patients aged 5 to 17 years with a primary diagnosis of irritability associated with Autism Spectrum Disorder (ASD) based on Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition Text Revision (DSM-5-TR) and confirmed by the Kiddie Schedule for Affective Disorders and Schizophrenia Present and Lifetime Version (K-SADS-PL).
Gender:
ALL
Ages:
Between 5 years and 17 years
Trial Updated:
07/03/2025
Locations: Clinical Site, Little Rock, Arkansas +38 locations
Conditions: Irritability Associated With Autism Spectrum Disorder
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The Effect of Non-invasive Brain Stimulation rTMS on Hand Muscles in Chronic Stroke Patients.
NCT06765642
Recruiting
The study is about using a brain stimulation technique called rTMS (Repetitive Transcranial Magnetic Stimulation) to help improve hand muscles in people who had a stroke. Researchers want to understand how this device can help stroke patients use their hands better.
Gender:
ALL
Ages:
21 years and above
Trial Updated:
07/03/2025
Locations: Duke University Medical Center, Durham, North Carolina
Conditions: Stroke, Stroke Patients, Arm Weakness as a Consequence of Stroke, Brain Stimulation, Transcranial Magnetic Stimulation Repetitive, Transcranial Magnetic Stimulation, Motor Learning, Chronic Stroke Patients, Chronic Stroke Survivors
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A Study of TAK-411 in Adults With Chronic Inflammatory Demyelinating Polyradiculoneuropathy (CIDP)
NCT06798012
Recruiting
CIDP is an autoimmune disease. This means that the body's germ fighting (immune) system attacks itself. In CIDP, the immune system attacks the protective covering around the nerves called myelin. Over time, these nerves lose their ability to send signals to the muscles in the body. This leads to muscle weakness and loss of sensation in arms and legs among other symptoms. Participants with CIDP can be treated with a protein called immunoglobulin (or IG). TAK-411 is a special type of immune globu... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/03/2025
Locations: University of California San Diego, La Jolla, California +21 locations
Conditions: Chronic Inflammatory Demyelinating Polyradiculoneuropathy (CIDP)
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A Study to Assess the Adverse Events of Intramuscular Injections of AGN-151586 and OnabotulinumtoxinA in Adult Participants for the Change of Glabellar Lines (GL)
NCT06834789
Recruiting
The objective of this Phase 1 study is to assess the safety and efficacy of single treatment of AGN-151586 and of OnabotulinumtoxinA in the glabellar complex of participants with moderate to severe glabellar lines (GL).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/03/2025
Locations: Investigate MD /ID# 270771, Scottsdale, Arizona +7 locations
Conditions: Glabellar Lines
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Hyperpolarized Xenon-129 MRI in Idiopathic Pulmonary Fibrosis
NCT06853145
Recruiting
Idiopathic pulmonary fibrosis has a poor prognosis with limited treatment options. The Investigator hypothesize hyperpolarized Xe129-MRI can be performed in patients with IPF and repeated over time which will detect deficiencies related to perfusion in the lung.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/03/2025
Locations: Snyder Building 480 Ray C. Hunt Drive, Charlottesville, Virginia
Conditions: Idiopathic Pulmonary Fibrosis
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Pre-malignant States to Hematologic Malignancies in Firefighters
NCT06870760
Recruiting
The purpose of the study is to evaluate if firefighter exposure to hazardous compounds will increase the incidence of premalignant hematological states which subsequently increases the risk of the development of hematologic malignancies, and potentially other pathophysiological consequences.
Gender:
ALL
Ages:
Between 40 years and 49 years
Trial Updated:
07/03/2025
Locations: Levine Cancer Institute, Charlotte, North Carolina
Conditions: Clonal Hematopoiesis of Indeterminate Potential, Monoclonal Gammopathy, Non Hodgkin Lymphoma, Leukemia, Multiple Myeloma, Plasma Cell Disorder
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BFRT for Subacromial Pain
NCT06873113
Recruiting
The goal of this pilot clinical trial is to learn if blood flow restriction training is safe and feasible in patients with subacromial pain. The main questions the investigators aim to answer are: * What problems do participants with shoulder pain encounter when training with blood flow restriction? * Is it feasible to apply blood flow restriction training as part of a physical therapy intervention? * What are some preliminary effects of blood flow restriction training on the recovery of should... Read More
Gender:
ALL
Ages:
Between 18 years and 50 years
Trial Updated:
07/03/2025
Locations: University of Florida, Gainesville, Florida
Conditions: Shoulder Pain
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Actívatexto: Advancing Smoking Cessation and Physical Activity Among Latinos
NCT06926608
Recruiting
The purpose of this randomized controlled trial is to assess the efficacy of Actívatexto (Aim 1) and the mediators of the presumed treatment effect (Aim 2) among Latino adults who smoke. Actívatexto is a mobile intervention that integrates four components: 1) a text messaging program that promotes both smoking cessation and physical activity, 2) wearable devices to monitor physical activity, 3) smoking cessation pharmacotherapy \[i.e., nicotine replacement therapies (NRT)\], and 4) an online das... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/03/2025
Locations: University of Rochester Medical Center, Rochester, New York
Conditions: Smoking, Smoking Cessation, Physical Inactivity
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Efficacy and Safety of Petrelintide in Participants With Overweight or Obesity and Type 2 Diabetes (ZUPREME 2)
NCT06926842
Recruiting
The main purpose of this study is to investigate efficacy and safety of three doses of petrelintide versus placebo in participants with overweight or obesity and type 2 diabetes.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/03/2025
Locations: Cullman Clinical Trials - Family Medicine, Cullman, Alabama +24 locations
Conditions: Overweight, Type 2 Diabetes, Obesity
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Effects of Distinct Nebraska-Dry Bean Market Classes on Gut Microbiota
NCT06935435
Recruiting
Beans are well known for their health benefits. Many of these benefits relate to gut health, as many of the nutrients found in beans support beneficial microbes that live in the gut. However, beans have a lot of genetic diversity. This diversity has led to different bean market classes with different colors, sizes, and nutrient profiles. Differences between bean market classes may trigger different effects on gut microbes and health, but this is poorly understood. The goal of the pilot clinical... Read More
Gender:
ALL
Ages:
Between 19 years and 50 years
Trial Updated:
07/03/2025
Locations: Nebraska Food for Health Center, Lincoln, Nebraska
Conditions: Dietary Intervention, Gut Microbiota
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A Study of 2 Doses of EYE103 Compared With Ranibizumab (0.5 mg) in Participants With DME
NCT06957080
Recruiting
EYE-RES-103 is a randomized, double masked pivotal study to evaluate the efficacy and safety of 2 dose levels of EYE103 in comparison with the active control, ranibizumab, in patients with diabetic macular edema (DME). In the first year, all 3 treatment groups will be treated every 4 weeks with either EYE103 or ranibizumab. Beginning at Year 2, the frequency of treatment for participants will shift based on a personalized treatment interval algorithm. Approximately 960 participants will be ent... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/03/2025
Locations: Scottsdale, AZ, Scottsdale, Arizona +116 locations
Conditions: Diabetic Macular Edema (DME)
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Real-time NOMA Evaluation
NCT06996626
Recruiting
Alerts related to outlier clinician behavior are generated in real-time by an intelligent system continuously scraping EHR (electronic health record) data. These alerts are passed to the bedside and their potential impact on bedside clinical behavior is evaluated.
Gender:
ALL
Ages:
Between 18 years and 100 years
Trial Updated:
07/03/2025
Locations: UPMC Montefiore, Pittsburgh, Pennsylvania +1 locations
Conditions: Critical Illness
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