Cardiovascular and Neurovascular Regulation in GWI
NCT04586049
Recruiting
Brain blood flow regulation and autonomic dysfunction will be measured in Veterans with and without Gulf War Illness who served in the Gulf War between 1990 and 1992.
Gender:
ALL
Ages:
Between 45 years and 68 years
Trial Updated:
03/31/2025
Locations: University of Wisconsin-Madison, Madison, Wisconsin
Conditions: Brain Blood Flow, Neurovascular Control
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Ketorolac in Upper Extremity Tendinopathy and Arthropathy
NCT05292339
Recruiting
Osteoarthritis (OA) and inflammatory conditions of the tendons and joints of the shoulder, elbow, hand, and wrist are common yet disabling diseases. Standard management utilizes conservative measures to minimize pain and improve function. Conservative pharmacological management commonly includes corticosteroid and ketorolac injections which have been well investigated as a modality of pain control and improved function in large joint OA. However, fewer studies yielding mixed results on the durat... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/31/2025
Locations: Emory Saint Joseph's Hospital, Atlanta, Georgia +3 locations
Conditions: Osteoarthritis, Tendinopathy, Arthropathy
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Adipose-derived MSC to Treat Rejection in Kidney Transplant Recipients
NCT05456243
Recruiting
This research study is being done to learn if an experimental treatment of infusing allogeneic adipose-derived mesenchymal stromal cells (allo-A-MSC ) directly into the renal artery is safe and can help reduce inflammation in the transplanted kidney and treat rejection.
Gender:
ALL
Ages:
Between 18 years and 70 years
Trial Updated:
03/31/2025
Locations: Mayo Clinic, Rochester, Minnesota
Conditions: Kidney Transplant
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Evaluate Pharmacokinetics and Safety of Slow Release DHEA
NCT05623059
Recruiting
This is a study to look at pharmacokinetic levels of different doses of slow release DHEA in subjects with asthma.
Gender:
ALL
Ages:
Between 18 years and 50 years
Trial Updated:
03/31/2025
Locations: Riley Hospital for Children, Indianapolis, Indiana +1 locations
Conditions: Asthma, Genotype
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TriNav Infusion System for the Evaluation of Fidelity Between 99mTc-MAA and Y90-Microspheres Hepatic Distribution for Dosimetry Treatment Planning
NCT05743842
Recruiting
To learn if using the TriNav Infusion System (TriNav catheter) for the injection of the surrogate/test dose during the planning part of the radioembolization procedure and your actual treatment with the radioactive microspheres match each other better than the standard catheter.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/31/2025
Locations: MD Anderson Cancer Center, Houston, Texas
Conditions: Liver Cancer
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A Study of Pulmonary Hypertension Peripheral Limitations
NCT05968859
Recruiting
The investigators are doing this research study to compare whole body aerobic training with isolated leg training (with weights) and its impact on effectiveness in symptoms and quality of life in patients with Pulmonary Arterial Hypertension (PAH).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/31/2025
Locations: Mayo Clinic in Rochester, Rochester, Minnesota
Conditions: Pulmonary Arterial Hypertension, Healthy
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AZD0486 as Monotherapy in B-cell Acute Lymphoblastic Leukaemia
NCT06137118
Recruiting
This is a Phase 1/2, global multicentre, open-label, single-arm, dose escalation and dose optimisation study of AZD0486 to evaluate the safety, tolerability, and efficacy of AZD0486 monotherapy in participants with R/R B ALL who have received ≥ 2 prior lines of therapies. The study will consist of 3 parts. Part A monotherapy dose escalation. Part B dose optimisation. Part C Dose expansion at the recommended phase 2 dose (RP2D)
Gender:
ALL
Ages:
Between 12 years and 80 years
Trial Updated:
03/31/2025
Locations: Research Site, Birmingham, Alabama +61 locations
Conditions: B-cell Acute Lymphoblastic Leukemia (B-ALL)
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Radicle Clarity 24: A Study of Health and Wellness Products on Cognitive Function and Related Health Outcomes
NCT06294431
Recruiting
A randomized, double-blind, placebo-controlled direct-to-consumer study of health and wellness products on cognitive function and related health outcomes
Gender:
ALL
Ages:
Between 21 years and 105 years
Trial Updated:
03/31/2025
Locations: Radicle Science, Inc, Del Mar, California
Conditions: Cognitive Function
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Registry for Stage 2 Type 1 Diabetes
NCT06481904
Recruiting
Stage 2 Type 1 Diabates (T1D) is an early stage of T1D characterized by dysglycemia but not yet leading to clinical symptoms. Progression of the disease to Stage 3 (clinical T1D), leads to overt hyperglycemia requiring eventually exogenous insulin. TZIELD® (teplizumab-mzwv) has been approved to delay onset of stage 3 T1D, by the United States (US) Food and Drug Administration (FDA) for adults and children aged 8 years and older with Stage 2 T1D. The purpose of this study is to collect general... Read More
Gender:
ALL
Ages:
All
Trial Updated:
03/31/2025
Locations: University of Chicago Medical Center- Site Number : 8400017, Chicago, Illinois +21 locations
Conditions: Type 1 Diabetes
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A Study of a Potential Disease Modifying Treatment in Individuals at Risk for or With a Type of Early Onset AD Caused by a Genetic Mutation
NCT06647498
Recruiting
The purpose of this research study is to test the study drug, referred to as remternetug, to determine its effectiveness for the study treatment of asymptomatic (at risk) Alzheimer disease in individuals with AD-causing mutations. This study will also investigate the effects of remternetug on biomarkers (measures of the disease including brain scans, blood and spinal fluid tests), examine safety data to identify any potential benefits or risks, and examine how well participants can tolerate remt... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/31/2025
Locations: University of Alabama in Birmingham, Birmingham, Alabama +34 locations
Conditions: Alzheimers Disease, Dementia, Alzheimers Disease, Familial
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A Study to Assess Sulbactam-durlobactam in Pediatric Patients With Acinetobacter Baumannii-calcoaceticus Complex Infection
NCT06801223
Recruiting
The goal of this clinical trial is to investigate the use of Sulbactam-Durlobactam (SUL-DUR) in pediatric patients and is being conducted to collect pharmacokinetic (PK) and safety data to enable the identification of appropriate pediatric dosing regimens for patients with Acinetobacter baumannii-calcoaceticus complex (ABC) infections
Gender:
ALL
Ages:
Between 1 day and 18 years
Trial Updated:
03/31/2025
Locations: University of Texas Medical Branch at Galveston, Galveston, Texas
Conditions: Acinetobacter Baumannii-calcoaceticus Complex Infection (ABC)
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Rehydration With a Trace Mineral Supplement
NCT06858904
Recruiting
It is well established that post-exercise rehydration with electrolyte solutions is more effective than plain water. However, most commercially available drinks are high in electrolytes but lack some essential trace minerals. This study aims to examine the impact of a higher-electrolyte sports drink compared with a low-electrolyte, trace-mineral-rich solution and water on the time course and extent of rehydration after exercise-induced dehydration.
Gender:
ALL
Ages:
Between 18 years and 55 years
Trial Updated:
03/31/2025
Locations: Hydration Science Lab, Phoenix, Arizona
Conditions: Dehydration (Physiology)
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