Jumpstarting Advance Care Planning With ANAI People
NCT06538493
Recruiting
The older Alaska Native/American Indian (ANAI) population is increasing at twice the rate of the general population with a higher burden of serious illness. Older ANAI adults with serious illness are half as likely to have advance directives (AD), indicating a need for improved access to and utilization of advance care planning (ACP) to ensure that medical care aligns with the values, goals, and preferences of ANAI patients and their families throughout the illness trajectory. The major goals of... Read More
Gender:
ALL
Ages:
40 years and above
Trial Updated:
06/26/2025
Locations: Southcentral Foundation, Anchorage, Alaska
Conditions: Advance Care Planning
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QuantifyHER: Quantitative Immunofluorescence and/or RT-qPCR for Measuring HER2 in HER2-low Metastatic Breast Cancer
NCT06551116
Recruiting
This study will assess whether a quantitative, HER2 assay can accurately and reliably discriminate between responders and non-responders among patients with HER2 IHCI+ metastatic breast cancer who are receiving T-Dxd.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/26/2025
Locations: Smilow Cancer Hospital-Derby Care Center, Derby, Connecticut +33 locations
Conditions: HER2-positive Metastatic Breast Cancer
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Study of Autologous Tumor-Infiltrating Lymphocytes in Pediatric, Adolescent, and Young Adult Participants
NCT06566092
Recruiting
This study is planned to test the safety and tolerability of the TIL regimen. The study will also test how well TIL fights cancer. The study will enroll children, teenagers, and young adults with solid tumors that have returned or are not responding to treatment for whom no effective standard-of-care treatment options exist. Study details include: * The study will last up to 2 years after the TIL infusion (Day 0) for each person. * The treatment will last up to 10 days for each person. * Study... Read More
Gender:
ALL
Ages:
Between 6 months and 21 years
Trial Updated:
06/26/2025
Locations: Children's Hospital of Colorado, Aurora, Colorado +4 locations
Conditions: Soft Tissue Sarcoma, Primary Central Nervous System Carcinoma, Melanoma, Rhabdomyosarcoma, Ewing Sarcoma
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INDV-6001 Multiple-Dose Pharmacokinetic Study
NCT06576843
Recruiting
This is a multicentre, open-label, multiple dose study of INDV-6001 in adult participants with moderate or severe OUD as defined by the Diagnostic and Statistical Manual of Mental Disorders, 5th edition (DSM-5). The current study will evaluate the pharmacokinetics (PK), safety, and tolerability of INDV-6001 following multiple doses in participants with OUD to select optimum dosing regimens for future studies. Prior to receiving INDV-6001, participants will be stabilised on 12-16 mg of transmuco... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
06/26/2025
Locations: Artemis Institute for Clinical Research, San Diego, California +10 locations
Conditions: Moderate to Severe Opioid Use Disorder
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Smart Pillows for Enhancing Sleep Quality
NCT06594627
Recruiting
The purpose of this study is to examine the impact of smart pillows on the sleep quality of individuals who experience a snoring issue and/or obstructive sleep apnea (OSA), as well as their sleep partners. Furthermore, this study will explore whether enhancements in sleep quality positively influence depressive symptoms, physical activity, heart rate, blood oxygen levels, and cognitive functions.
Gender:
ALL
Ages:
50 years and above
Trial Updated:
06/26/2025
Locations: Indiana University, Indianapolis, Indiana
Conditions: Snoring, Obstructive Sleep Apnea
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Cognitive Training and Neuroplasticity in Mild Cognitive Impairment: COGIT-2 Trial
NCT06601933
Recruiting
Effective, clinically meaningful treatments are lacking for patients with mild cognitive impairment (MCI), which is associated with increased risk of transition to dementia. Cognitive training represents an important therapeutic strategy. In a previous study, crossword puzzles were found to be superior to computerized cognitive training on the primary cognitive outcome and function with decreased brain atrophy. Building on these findings, this study will evaluate and compare the impact of high d... Read More
Gender:
ALL
Ages:
Between 55 years and 89 years
Trial Updated:
06/26/2025
Locations: University of Miami Miller School of Medicine, Miami, Florida +3 locations
Conditions: Mild Cognitive Impairment (MCI), Cognitive Training
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A Study of CLN-978, a Subcutaneously Administered CD19-directed T Cell Engager, in Subjects With Systemic Lupus Erythematosus
NCT06613360
Recruiting
Phase 1b, open-label study of CLN-978 administered subcutaneously in patients with Moderate to Severe Systemic Lupus Erythematosus (SLE).
Gender:
ALL
Ages:
Between 18 years and 70 years
Trial Updated:
06/26/2025
Locations: Cullinan Investigative Site, Avondale, Arizona +10 locations
Conditions: SLE, SLE (Systemic Lupus)
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HB-adMSCs vs Placebo for the Treatment of Juvenile Idiopathic Arthritis
NCT06623240
Recruiting
Methodology: Randomized, double-blind, AB/BA cross-over study with a washout period of 12 weeks. Treatment Duration: 8 weeks per group General Objectives: To assess the efficacy and safety of multiple intravenous infusions of allogeneic HB-adMSCs by improving signs and symptoms of juvenile idiopathic arthritis in this subject population. Number of Subjects: 66 (6 subjects in Cohort 1 and 60 subjects in Cohort 2) Indication: Juvenile Idiopathic Arthritis
Gender:
ALL
Ages:
Between 2 years and 16 years
Trial Updated:
06/26/2025
Locations: Hope Biosciences Research Foundation, Sugar Land, Texas
Conditions: Juvenile Idiopathic Arthritis (JIA)
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A Precision Medicine Approach (SMMART-ACT) for the Treatment of Patients With Advanced Sarcoma, Prostate, Breast, Ovarian or Pancreatic Cancer
NCT06630325
Recruiting
This phase II trial tests the how well a precision medicine approach (serial measurements of molecular and architectural response to therapy \[SMMART\])-adaptive clinical treatment \[ACT\]) works in treating patients with sarcoma, prostate, breast, ovarian or pancreatic cancer that may have spread from where it first started to nearby tissue, lymph nodes, or distant parts of the body (advanced). SMMART testing uses genetic and protein tests to learn how cancer changes and to understand what drug... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/26/2025
Locations: OHSU Knight Cancer Institute, Portland, Oregon
Conditions: Advanced Breast Carcinoma, Advanced Malignant Solid Neoplasm, Advanced Ovarian Carcinoma, Advanced Pancreatic Carcinoma, Advanced Prostate Carcinoma, Advanced Sarcoma, Anatomic Stage III Breast Cancer AJCC v8, Anatomic Stage IV Breast Cancer AJCC v8, Stage III Ovarian Cancer AJCC v8, Stage III Pancreatic Cancer AJCC v8, Stage III Prostate Cancer AJCC v8, Stage IV Ovarian Cancer AJCC v8, Stage IV Pancreatic Cancer AJCC v8, Stage IV Prostate Cancer AJCC v8
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Addressing Barriers to Care for Substance Use Disorder Trial
NCT06729957
Recruiting
The Addressing Barriers to Care for Substance Use Disorder Trial (ABC-SUD) is a cluster-randomized crossover trial, with clinicians (care coordinators) as the unit of randomization. This study will be conducted in a mental health access center within the Washington region of Kaiser Permanente. As part of usual care, patients contact the mental health access center and speak to a care coordinator to obtain an appointment with or contact information for potential venues to obtain treatment for su... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/26/2025
Locations: Kaiser Permanente Washington, Seattle, Washington
Conditions: Drug Use Disorders, Alcohol-Related Disorders, Substance Use Disorder (SUD)
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A Study to Evaluate the Effects of Lithium, Valproic Acid, and Lamotrigine on the Pharmacokinetics of KarXT and Effects of KarXT on the Pharmacokinetics of Lithium, Valproic Acid, and Lamotrigine in Healthy Participants
NCT06729970
Recruiting
The purpose of this study is to evaluate the effects of lithium, valproic acid, and lamotrigine on the single-dose pharmacokinetics (PK) of KarXT and the effect of KarXT on the single-dose PK of lithium, valproic acid, and lamotrigine in healthy participants.
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
06/26/2025
Locations: CenExel Collaborative Neuroscience Research, LLC - Los Alamitos, Los Alamitos, California
Conditions: Healthy Volunteers
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A Study of TLN-254 in Participants With Relapsed or Refractory T-cell Lymphoma
NCT06733441
Recruiting
The primary purpose of this study is to evaluate the anti-tumor activity of TLN-254 monotherapy in participants with relapsed or refractory T-cell lymphoma.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/26/2025
Locations: Washington University School of Medicine, St. Louis, Missouri +3 locations
Conditions: Lymphoma
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