UrbanHEAT: Health Behaviors, Outcomes, and Disparities in Individually Experienced Temperature Across an Urban Community
NCT06778252
Recruiting
We are conducting a research study to learn about how individuals living in Washington, DC perceive and experience temperature. Participation in this study will include: 2 remote visits over the phone and/or computer (these will each last about1.5 to 2 hours) * During the remote visits, you will be asked to respond to a series of surveys, so that we can learn about your life, behaviors, and health 2 weeks of data collection where you will be asked to: * Wear monitoring devices * These w... Read More
Gender:
ALL
Ages:
Between 18 years and 115 years
Trial Updated:
06/25/2025
Locations: National Institute on Minority Health and Health Disparities, Bethesda, Maryland
Conditions: Temperature
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Study of the Esophageal String Test (EST) for the Diagnosis of Helicobacter Pylori
NCT06871579
Recruiting
Background: Helicobacter pylori is a bacterium that infects the lining of the stomach and intestines. It can cause peptic ulcers, cancers, and infections. Current methods of diagnosing H. pylori infections have limitations. Researchers want to test a new method of testing for H. pylori. Objective: To compare the esophageal string test (EST) to standard tests for detecting H. pylori infection. Eligibility: People aged 18 years or older with persistent H. pylori infection. Design: Participa... Read More
Gender:
ALL
Ages:
Between 18 years and 99 years
Trial Updated:
06/25/2025
Locations: National Institutes of Health Clinical Center, Bethesda, Maryland
Conditions: Helicobacter Pylori
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Study of Neuro-Cognitive Correlates of Pediatric Anxiety Disorders
NCT00018057
Recruiting
Study Description: This study examines relations between neurocognitive and clinical features of pediatric anxiety disorders. The study uses neuro-cognitive tasks, functional magnetic resonance imaging (fMRI), as well as magneto- and electro-encephalography (M/EEG). Patients will be studied over one year, before and after receiving either one of two standard-of-care treatments: cognitive behavioral therapy (CBT) or fluoxetine, a serotonin reuptake inhibitor (SSRI). Healthy comparisons will be s... Read More
Gender:
ALL
Ages:
Between 8 years and 65 years
Trial Updated:
06/25/2025
Locations: National Institutes of Health Clinical Center, Bethesda, Maryland
Conditions: Major Depressive Disorder, Anxiety Disorders
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Top-Down Attentional Control of Visual-Processing
NCT01087281
Recruiting
Background: - Previous studies have shown that people with certain types of brain damage may have particular problems paying attention and processing things that they see. Researchers are interested in comparing how people with brain damage and without brain damage process visual images. Objectives: - To better understand the areas of the brain involved in paying attention to things that are seen. Eligibility: - Individuals at least 18 years of age who either have had damage to one or both... Read More
Gender:
ALL
Ages:
Between 18 years and 100 years
Trial Updated:
06/25/2025
Locations: National Institutes of Health Clinical Center, Bethesda, Maryland
Conditions: Focal Brain Lesion, Focal Lesions, fMRI
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Nutrition in Patient With Critical Limb Ischemia
NCT03529019
Recruiting
A prospective pilot study examining nutritional supplements among vascular surgery patients with Critical Limb Ischemia (CLI). CLI patients have a high rate of malnutrition and has the potential to benefit greatly from nutritional intervention. The investigators plan to evaluate nutrition and functional status of patients by assessing objective lab values and the use of the hand grip strength test. Providing perioperative nutritional supplements to patients has potentially improved their nutriti... Read More
Gender:
ALL
Ages:
Between 18 years and 99 years
Trial Updated:
06/25/2025
Locations: Boston Medical Center, Boston, Massachusetts
Conditions: Critical Limb Ischemia, Malnutrition, Nutritional Supplements
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A Study to Compare Blinatumomab Alone to Blinatumomab With Nivolumab in Patients Diagnosed With First Relapse B-Cell Acute Lymphoblastic Leukemia (B-ALL)
NCT04546399
Recruiting
This phase II trial studies the effect of nivolumab in combination with blinatumomab compared to blinatumomab alone in treating patients with B-cell acute lymphoblastic leukemia (B-ALL) that has come back (relapsed). Down syndrome patients with relapsed B-ALL are included in this study. Blinatumomab is an antibody, which is a protein that identifies and targets specific molecules in the body. Blinatumomab searches for and attaches itself to the cancer cell. Once attached, an immune response occu... Read More
Gender:
ALL
Ages:
Between 1 year and 30 years
Trial Updated:
06/25/2025
Locations: Children's Hospital of Alabama, Birmingham, Alabama +207 locations
Conditions: Down Syndrome, Recurrent B Acute Lymphoblastic Leukemia
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A Study to Look at the Health Outcomes of Patients With COVID-19 and Influenza
NCT05160636
Recruiting
The main purpose of this study is to understand: * the symptoms of COVID-19 or influenza- health-related outcomes of people with COVID-19 or influenza (influenza only included in updated study analyses) * the potential effects of COVID-19 vaccines in people with COVID-19 This study will enroll participants who are: * 18 years or older * reported to have symptoms with tests that have confirmed illness. The tests can be taken at any of CVS pharmacy COVID-19 or influenza test sites. The study w... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/25/2025
Locations: CVS Health, Woonsocket, Rhode Island
Conditions: COVID-19, Coronavirus Disease 2019, Influenza
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Observational Study of Advanced Data Analytics in Genetic Conditions
NCT05657405
Recruiting
Background: The genes a person is born with can sometimes cause serious diseases. Genetic diseases are rare, but they can have a big impact on the people they affect. Researchers have already made great strides in understanding how some genes cause disease. But they would like to have even better tools to analyze and understand genetic data. To create these new tools, they need to gather health and genetic data from a lot of people. Objective: This natural history study will gather medical in... Read More
Gender:
ALL
Ages:
Between 1 day and 120 years
Trial Updated:
06/25/2025
Locations: National Institutes of Health Clinical Center, Bethesda, Maryland
Conditions: Genetic Conditions
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Somatic Mosaicism in Twins Discordant for Childhood Cancer
NCT06054295
Recruiting
Somatic mosaicism in cancer associated genes is one potential explanation for discordance in childhood cancer that has not been fully explored to date. This pilot study will focus on twins with central nervous system (CNS) tumors who are identified through the Children's Oncology Group's Project: EveryChild (PEC) registry or volunteer.
Gender:
ALL
Ages:
18 years and below
Trial Updated:
06/25/2025
Locations: University of Minnesota, Minneapolis, Minnesota
Conditions: Pediatric Central Nervous System Tumor, Central Nervous System Tumor, Discordant Twin, Somatic Mutation
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Effects of Urolithin A Supplementation on Glucose Metabolism in Healthy Adults 55 >= Years Old: A Randomized Triple-Masked Controlled Clinical Trial
NCT06274749
Recruiting
Background: As people age, the cells in the pancreas that produce insulin begin to release less of this hormone, and levels of blood glucose (sugar) rise. This can lead to illnesses such as diabetes. Urolithin A (UA) is a natural nutritional supplement that may improve how the body controls blood glucose. Objective: To learn if UA improves levels of insulin and other hormones that help control blood glucose. Eligibility: People aged 55 years and older with a body mass index of 27 or higher.... Read More
Gender:
ALL
Ages:
Between 55 years and 100 years
Trial Updated:
06/25/2025
Locations: National Institute of Aging, Clinical Research Unit, Baltimore, Maryland
Conditions: Healthy Volunteer
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A Proof-of-concept Study of Lunsekimig Compared With Placebo in Adults With Chronic Rhinosinusitis With Nasal Polyps
NCT06454240
Recruiting
This is a parallel, Phase 2, 2-arm, multicenter, randomized, double-blind, placebo-controlled, proof-of-concept study for treatment of CRSwNP. The purpose of this study is to assess the efficacy, safety, and tolerability of add-on therapy with subcutaneous lunsekimig in adult participants (aged 18 to 70 years, inclusive) with CRSwNP who are inadequately controlled on intranasal corticosteroid treatment. Participants with and without co-morbid asthma will be included in the study, and lung funct... Read More
Gender:
ALL
Ages:
Between 18 years and 70 years
Trial Updated:
06/25/2025
Locations: Modena Allergy + Asthma Site Number : 8400005, La Jolla, California +27 locations
Conditions: Chronic Rhinosinusitis With Nasal Polyps
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Family Connections
NCT06662357
Recruiting
The Family Connections study, is intended to disrupt disparities in mental health treatment access for children at-risk for childhood trauma (ACEs) and/or serious emotional disturbance (SED). "Family Connections" will use mobile clinical and family support teams to improve mental health outcomes. This clinical innovation, nested in an integrated system-of-care will be piloted for children, ages 3-18 yrs., with SED who receive primary care through Cambridge Health Alliance.
Gender:
ALL
Ages:
Between 3 years and 18 years
Trial Updated:
06/25/2025
Locations: Cambridge Health Alliance, Cambridge, Massachusetts
Conditions: Emotional Disturbance, Behavior Disorders in Children
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