Autism Research Project With Non-Invasive Near-Infrared Light Stimulation
NCT06203938
Recruiting
The investigators have previously shown that the administration of low-level infrared light is a safe and non-invasive procedure which improves cognition and emotion, as well as enhances brain metabolic activity. Based on previous studies, the investigators hypothesize that this methodology, called low-level light therapy or photobiomodulation, could be used to improve behavioral symptoms in individuals with autism spectrum disorder (ASD).
Gender:
ALL
Ages:
Between 4 years and 60 years
Trial Updated:
07/15/2025
Locations: Seay Psychology Building, Room 3.304, Austin, Texas
Conditions: Autism Spectrum Disorder
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A Research Study to Investigate the Effects of CagriSema Compared to Placebo in People With Type 2 Diabetes and Painful Diabetic Peripheral Neuropathy
NCT06797869
Recruiting
This study will look at the effects of CagriSema in people with both type 2 diabetes and painful diabetic peripheral neuropathy, compared to placebo. Participants will either get an active medicine or a "dummy" medicine (placebo). Which treatment participants get is decided by chance. In this study the active, investigational medicine is called CagriSema. Doctors cannot yet prescribe CagriSema. For each participant, the study will last for about 10 months.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/15/2025
Locations: eStudySite, La Mesa, California +49 locations
Conditions: Diabetes Mellitus, Type 2, Diabetic Peripheral Neuropathy
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A Research Study Looking at Long-term Treatment With Etavopivat in People With Sickle Cell Disease or Thalassaemia
NCT06609226
Recruiting
Etavopivat is a new medicine under development for treating blood disorders like sickle cell disease and thalassaemia. Sickle cell disease and thalassaemia are inherited blood disorders that affect haemoglobin. Haemoglobin is the protein that carries oxygen through the body. This study is looking into how safe treatment with etavopivat is and how well it works over a long period of time. The study will last for up to 264 weeks, but it will end earlier if etavopivat is approved in the participant... Read More
Gender:
ALL
Ages:
All
Trial Updated:
07/14/2025
Locations: Univ of Alabama Birmingham, Birmingham, Alabama +95 locations
Conditions: Sickle Cell Disease, Thalassemia
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Researching Engagement With Educational Lifestyle Content
NCT07048483
Recruiting
The goal of this study is to examine how different types of health messages affect people's self efficacy for healthy eating and diet quality. Eligible adult participants with overweight/obesity will be randomized into one of two groups: the intervention group, which will engage with audio-visual messages per week for four weeks, or the control group, which will not engage with any audio-visual messages but will receive written educational materials about healthy eating per week for four weeks.
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
07/13/2025
Locations: Online., Columbia, South Carolina
Conditions: Diet Quality
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CCHS Secure Health-hub Advancing Research Efforts (CCHS SHARE)
NCT06554275
Recruiting
The purpose of this study is to capture longitudinal natural history data in Congenital Central Hypoventilation Syndrome (CCHS). This will include capturing standardized clinical data from standard of care assessments at several CCHS referral centers. Funding source-FDA OOPD
Gender:
ALL
Ages:
All
Trial Updated:
07/11/2025
Locations: Ann & Robert H Lurie Children's Hospital of Chicago, Chicago, Illinois
Conditions: Congenital Central Hypoventilation Syndrome
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Neurocognitive Effects of Non-Invasive Near-Infrared Light Stimulation
NCT05802680
Recruiting
Inattentiveness and impulsivity in healthy adults and individuals with attention deficit hyperactivity disorder (ADHD) diminish these individuals' quality of life. Cortical hypometabolism has been hypothesized to contribute to inattentiveness in ADHD. Transcranial photobiomodulation (tPBM) is a safe and non-invasive modality for activation of the prefrontal cortex. tPBM in healthy adults has been shown to augment brain oxygenation, cognition, and mood. The cognition-enhancing effect of tPBM on s... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/10/2025
Locations: The University of Texas at Austin, Austin, Texas
Conditions: Attention Deficit Hyperactivity Disorder, Attention Difficulties, Attention Deficit, Cognitive Deficit, Wellness
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Protocol for Facilitating the Acquisition of Research Bone Marrow and Blood Samples
NCT01985919
Recruiting
This clinical research protocol is intended to allow for bone marrow aspirate/biopsy and blood specimens to be collected for research purposes, specifically allowing subjects the option of sedation during the bone marrow procedure. Samples will be banked for future research related to cancer and other diseases. Researchers hope this protocol will improve the collection of research correlative and translational biopsy specimens for clinical research.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/10/2025
Locations: Abramson Cancer Center of the University of Pennsylvania, Philadelphia, Pennsylvania
Conditions: No Restrictions on Diagnosis
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Cereset Research for Caregivers
NCT05209438
Recruiting
Caregivers experience high levels of prolonged stress that can lead to chronic problems with health, including increased risk of cardiovascular disease that is linked to autonomic dysregulation. Heart rate variability (HRV), measures of autonomic cardiovascular regulation, is decreased (worse) in caregivers. Autonomic function is linked to lateralization in the brain, and emerging neuromodulation methods that target lateralized signals in the brain, like Cereset (CR), may be able to improve hear... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/09/2025
Locations: Wake Forest University Health Sciences, Winston-Salem, North Carolina
Conditions: Caregivers
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Hemophagocytic Lymphohistiocytosis (HLH) Evaluation and Research of Clinical, ImmUnoLogic and TranscriptomE Study
NCT06339177
Recruiting
Background: Hemophagocytic lymphohistiocytosis (HLH) is a disease caused by disrupted immune function. People with HLH are prone to fevers and illnesses, which can be fatal. Some people develop a genetic form of this disease (pHLH), but researchers do not understand why some other people develop a nongenetic form (sHLH). They also do not have good ways to diagnose and treat sHLH. Objective: To learn about sHLH and why some people get it and others do not. Eligibility: Adults aged 18 years a... Read More
Gender:
ALL
Ages:
Between 18 years and 120 years
Trial Updated:
07/08/2025
Locations: National Institutes of Health Clinical Center, Bethesda, Maryland
Conditions: Lymphohistiocytosis, Hemophagocytic, Secondary Hemophagocytic Lymphohistiocytosis, Macrophage Activation Syndrome, Hyperinflammatory Syndromes
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The Purpose of This Research Study is to See if Combining Gemcitabine, Cisplatin and Durvalumab Chemotherapy Treatments With a Direct Tumor Therapy Yittrium-90 (Y-90) Will Work Better Together to Shrink Tumors and Control Cancer
NCT05422690
Recruiting
The purpose of this research is to see if combining gemcitabine, cisplatin and Durvalumab chemotherapy treatments with a direct tumor therapy called Yittrium-90, will work better together to shrink the tumor and control cancer.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/07/2025
Locations: Keary Janet, Fairfax, Virginia
Conditions: Intrahepatic Cholangiocarcinoma
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Prospective Multicenter Research on Donor and Recipient Management Strategies to Improve Lung Transplant Outcomes
NCT06399302
Recruiting
This project aims to collect detailed clinical data, blood samples, and patient-reported outcomes from 2,600 lung transplant candidates, donors, and recipients at Lung Transplant Centers. The goal is to create a robust resource for various research objectives, including studying the impact of variations in donor and medical practices on clinical outcomes. The project also seeks to identify serum biomarkers associated with or predictive of specific post-transplant complications and conditions.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/03/2025
Locations: University of California Los Angeles, Los Angeles, California +16 locations
Conditions: Lung Transplant; Complications, Lung Transplant; Infection or Inflammation, Lung Transplant Rejection, Lung Transplant Failure
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Human Biospecimen Procurement Protocol: Biorepository to Support Translational Research to Identify Disease Mechanism(s)
NCT02543996
Recruiting
Background: Studies show that rare genetic variants might lead to diseases. Researchers want to collect blood and tissue samples so they can study them and better understand diseases. Objective: To collect blood and tissue samples for studies to identify underlying causes of disease. Eligibility: People of all ages Design: Participants will have blood and/or tissue samples collected. Samples can be collected at the NIH Clinical Center. Participants doctors can collect the samples and sen... Read More
Gender:
ALL
Ages:
Between 1 month and 100 years
Trial Updated:
07/03/2025
Locations: National Institutes of Health Clinical Center, Bethesda, Maryland
Conditions: Undiagnosed Diseases, Cardiovascular Disease
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