VibraCool Device to Reduce Pain and Opioid Use After Anterior Cruciate Ligament Reconstruction (ACLR)
NCT06456268
Recruiting
The goal of this project is to test the effects of the VibraCool mechanical stimulation neuromodulatory therapeutic device on post-operative pain and opioid use following anterior crucitate ligament reconstruction (ACLR), and thus residual opioids in circulation.
Gender:
ALL
Ages:
All
Trial Updated:
06/25/2025
Locations: Columbia University Medical Center, New York, New York
Conditions: ACL, Opioid Use, Cryotherapy Effect, Vibration; Exposure, Pain, Postoperative
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Pilot Study of Preoperative Intestinal Training Using Antegrade Ileostomy Infusion
NCT06461559
Recruiting
This research study is being conducted to study the effect of infusing your contents from your ostomy bag back into your intestine to re-train them prior to the ostomy takedown operation, which is a surgery to reverse your ostomy to put your intestine back together. Because your intestine past the ostomy hasn't seen any intestinal content for several weeks to months before the takedown operation, it is no longer used to handling the daily work of processing intestinal content and will take time... Read More
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
06/25/2025
Locations: UC San Diego, La Jolla, California
Conditions: Stoma Ileostomy, Ileostomy; Complications
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The Nuestros Días ("Our Days") Study
NCT06475534
Recruiting
The goal of this observational study is to understand how contextual, individual-level, and cultural factors influence the daily and long-term well-being of caregivers of relatives with memory problems or dementia. The study focuses on caregivers from the Hispanic and Latino community. The main questions it aims to answer are: * What daily factors increase (i.e., risk factors) or decrease (i.e., protective factors) the daily odds of depression and anxiety symptoms reported by caregivers? * How... Read More
Gender:
ALL
Ages:
Between 18 years and 100 years
Trial Updated:
06/25/2025
Locations: The University of Alabama at Birmingham, Birmingham, Alabama
Conditions: Caregiver Burden, Well-Being, Psychological, Stress, Psychological, Depression, Anxiety
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Chronic Subdural Hematoma Treatment With Intra-Arterial Bevacizumab Injection
NCT06510582
Recruiting
The goal of this clinical trial is to test whether infusing bevacizumab into the middle meningeal arteries can be used to treat chronic subdural hematomas (cSDH). The main questions it aims to answer are: * Is bevacizumab infusion safe in cSDH patients? * Is bevacizumab infusion effective in treating cSDH?
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/25/2025
Locations: Cooper University Health Care, Camden, New Jersey
Conditions: Chronic Subdural Hematoma
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FH-FOLR1 Chimeric Antigen Receptor T Cell Therapy for Treating Pediatric Patients With Relapsed or Refractory Acute Myeloid Leukemia
NCT06609928
Recruiting
This phase I trial tests the safety, side effects, and best dose of FH-FOLR1 chimeric antigen receptor (CAR) T cells in treating pediatric patients with FOLR1+ acute myeloid leukemia (AML) that has come back after a period of improvement (recurrent) or has not responded to previous treatment (refractory). CAR T-cell therapy is a type of treatment in which a patient's T cells (a type of immune system cell) are changed in the laboratory so they will attack cancer cells. T cells are taken from a pa... Read More
Gender:
ALL
Ages:
6 years and below
Trial Updated:
06/25/2025
Locations: Fred Hutch/University of Washington/Seattle Children's Cancer Consortium, Seattle, Washington
Conditions: Recurrent Childhood Acute Myeloid Leukemia, Refractory Childhood Acute Myeloid Leukemia
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Evaluation of Efficacy and Safety of Suzetrigine for Pain Associated With Diabetic Peripheral Neuropathy
NCT06628908
Recruiting
The purpose of this study is to evaluate the efficacy, safety, and tolerability of Suzetrigine (SUZ) in participants with pain associated with diabetic peripheral neuropathy (DPN).
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
06/25/2025
Locations: Pinnacle Research Group, LLC, Anniston, Alabama +74 locations
Conditions: Diabetic Peripheral Neuropathic Pain
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Family Connections
NCT06662357
Recruiting
The Family Connections study, is intended to disrupt disparities in mental health treatment access for children at-risk for childhood trauma (ACEs) and/or serious emotional disturbance (SED). "Family Connections" will use mobile clinical and family support teams to improve mental health outcomes. This clinical innovation, nested in an integrated system-of-care will be piloted for children, ages 3-18 yrs., with SED who receive primary care through Cambridge Health Alliance.
Gender:
ALL
Ages:
Between 3 years and 18 years
Trial Updated:
06/25/2025
Locations: Cambridge Health Alliance, Cambridge, Massachusetts
Conditions: Emotional Disturbance, Behavior Disorders in Children
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Rehabilitation Outcomes Study
NCT06674889
Recruiting
This pilot health services interventional study aims to prospectively assess the effectiveness of a pre-treatment rehabilitation (prehabilitation) program across a diverse cohort of adult cancer patients via a randomized pilot trial. Upon screening and identification of high-risk features through a central navigation process, patients referred to oncology clinics will be approached to participate in tailored prehabilitation interventions. The study will track and analyze functional outcomes and... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/25/2025
Locations: The N.C. Cancer Hospital, Chapel Hill, North Carolina
Conditions: Cancer, Malignant Tumor
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Outcomes of Low-Risk Endometrial Cancer With Isolated Tumor Cells in the Sentinel Lymph Nodes: A Prospective, Multicenter, Single-Arm Observational Study
NCT06689956
Recruiting
This study evaluates whether isolated tumor cells in the first lymph nodes near the tumor can tell researchers something important about the future of patients with a certain type of endometrial (uterine) cancer.
Gender:
ALL
Ages:
All
Trial Updated:
06/25/2025
Locations: Mayo Clinic in Rochester, Rochester, Minnesota +19 locations
Conditions: FIGO Grade 1 Endometrial Endometrioid Adenocarcinoma, FIGO Grade 2 Endometrial Endometrioid Adenocarcinoma, Stage IA1 Endometrial Cancer FIGO 2023, Stage IA2 Endometrial Cancer FIGO 2023
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NT-101 Topical Ophthalmic Solution in Patients With Wet AMD
NCT06704009
Recruiting
Phase 1/2 Trial NT-101 Topical Ophthalmic Solution in Patients with Wet Age-Related Macular Degeneration (AMD)
Gender:
ALL
Ages:
50 years and above
Trial Updated:
06/25/2025
Locations: Elman Retina Group, Rosedale, Maryland +3 locations
Conditions: Wet Age Related Macular Degeneration, Wet AMD
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Brain-Gut Yoga for Functional Dyspepsia and Gastroparesis (FD-GP)
NCT06732453
Recruiting
The purpose of this research study is to assess whether using a yoga-based intervention in practice is feasible (possible) and acceptable to patients with Functional Dyspepsia and/or Gastroparesis (FD-GP).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/25/2025
Locations: Atrium Health Gastroenterology and Hepatology Kenilworth, Charlotte, North Carolina
Conditions: Functional Dyspepsia, Gastroparesis
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Comparing Radiation Therapy to Usual Care for Patients With High-Risk Bone Asymptomatic Metastases
NCT06745024
Recruiting
This phase III trial compares the effect of adding radiation therapy to usual care on the occurrence of bone-related complications in cancer patients with high-risk bone metastases that are not causing symptoms (asymptomatic). High-risk bone metastases are defined by their location (including hip, shoulder, long bones, and certain levels of the spine), or size (2 cm or larger). These bone metastases appear to be at higher risk of complications such as fracture, spinal cord compression, and/or pa... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/25/2025
Locations: Fairbanks Memorial Hospital, Fairbanks, Alaska +278 locations
Conditions: Metastatic Malignant Neoplasm in the Bone, Metastatic Malignant Solid Neoplasm
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