Urinary Microbiome Changes Following Administration of 500 Mg of NDS-446 in Women with Dry OAB At 12 Weeks
NCT05557279
Recruiting
The purpose of this study is to learn about how the use of 500 mg of dried cranberry powder extract (NDS-446) changes the bacteria that normal reside in the bladder of women who don't have urinary leakage problems but do have problems with urinary urgency and frequency.
Gender:
FEMALE
Ages:
Between 18 years and 99 years
Trial Updated:
03/03/2025
Locations: Loyola Medical Center, Maywood, Illinois
Conditions: Overactive Bladder
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Two Fraction Prostate SBRT With DIL SIB
NCT05864196
Recruiting
Phase I/Ib, single arm trial of Two-Fraction Stereotactic Body Radiation Therapy (SBRT) with an MRI directed, dominant intraprostatic lesion (DIL), simultaneous integrated boost (SIB) based on genomic classification in the treatment of localized prostate cancer. The primary purpose of this study is to determine the feasibility and safety of two fraction SBRT in patients with localized prostate cancer.
Gender:
MALE
Ages:
18 years and above
Trial Updated:
03/03/2025
Locations: NYU Langone Hospital - Long Island, Mineola, New York +1 locations
Conditions: Prostate Cancer
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Phase 2 Study of SAR444656 in Adult Participants With Moderate to Severe Atopic Dermatitis
NCT06058156
Recruiting
This is a multinational, multicenter, double-blind, placebo-controlled, parallel-group Phase 2, 4-arm study in adult participants with moderate to severe AD who are inadequately controlled with topical therapies or for whom such topical therapies are inadvisable and who are candidates for systemic therapy. Participants will be randomized to receive SAR444656 dose 1, dose 2, dose 3 or matching placebo. Participants who meet inclusion/exclusion criteria will be stratified for randomization by se... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/03/2025
Locations: Clear Dermatology & Aesthetics Center Site Number: 8400003, Scottsdale, Arizona +27 locations
Conditions: Atopic Dermatitis
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Safety and Effectiveness of Endoscopic Intestinal Re-Cellularization Therapy in Individuals With Type II Diabetes
NCT06267391
Recruiting
This study is designed to evaluate the safety and effectiveness of endoscopic intestinal re-cellularization therapy in individuals with type 2 diabetes (T2D) inadequately controlled on non-insulin glucose-lowering medications.
Gender:
ALL
Ages:
Between 22 years and 70 years
Trial Updated:
03/03/2025
Locations: University of Alabama, Birmingham, Alabama +44 locations
Conditions: Type 2 Diabetes Mellitus, Type2diabetes, Diabetes Mellitus, Type 2, Diabetes, Type 2 Diabetes
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Testing Proton Craniospinal Radiation Therapy Versus the Usual Radiation Therapy for Leptomeningeal Metastasis, RADIATE-LM Trial
NCT06500481
Recruiting
This phase III trial compares proton craniospinal irradiation (pCSI) to involved-field radiation therapy (IFRT) for the treatment of breast or non-small cell lung cancer that has spread from where it first started to the cerebrospinal fluid filled space that surrounds the brain and spinal cord (leptomeningeal metastasis). Patients with leptomeningeal metastasis (LM) may develop multiple areas of nervous system (neurologic) impairment that can be life-threatening. Radiation therapy (RT) effective... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/03/2025
Locations: University of Arkansas for Medical Sciences, Little Rock, Arkansas +7 locations
Conditions: Anatomic Stage IV Breast Cancer AJCC v8, Metastatic Breast Carcinoma, Metastatic Lung Non-Small Cell Carcinoma, Metastatic Malignant Neoplasm in the Leptomeninges, Stage IV Lung Cancer AJCC v8
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A Multi-Level Trauma-Informed Approach to Increase HIV Pre-exposure Prophylaxis Initiation Among Black Women
NCT06703060
Recruiting
U.S. epidemiological data indicates that Black women are a high-risk HIV disparity group, yet initiation of novel prevention strategies like pre-exposure prophylaxis (PrEP) among this group is stagnant. Socio-structural challenges like intimate partner violence and gendered racism can constrain PrEP access among Black women, but few implementation studies have mitigated these challenges to improve PrEP initiation. The proposed research aims to implement and assess the effectiveness, implementati... Read More
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
03/03/2025
Locations: Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland
Conditions: HIV Prevention, PrEP, Women, Intimate Partner Violence (IPV)
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Leveraging Video Logs as a Bridge to Pre-exposure Prophylaxis (PrEP) With Tailored Messaging to Black Women and Their Healthcare Providers in Texas.
NCT06864689
Recruiting
The primary objective of this R34 proposal is to increase willingness for PrEP initiation and PrEP initiation among Cisgender Black Women (CBW) and increase willingness to prescribe/refer pre-exposure prophylaxis (PrEP) to CBW among healthcare providers (HCPs) in Houston/Harris County, a high priority Ending the HIV Epidemic (EHE) jurisdiction.
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
03/03/2025
Locations: University of Texas Medical Branch, Galveston, Galveston, Texas
Conditions: HIV Prevention
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Confocal Laser Endomicroscopy As an Imaging Biomarker for the Diagnosis of Pancreatic Cystic Lesions
NCT03492151
Recruiting
The study schema is shown in Figure 4. (A) All patients referred to one of the participating academic centers for EUS evaluation of the PCL will be enrolled in the protocol if they satisfy inclusion criteria. Patient consent will be obtained during the clinic visit or prior to their EUS. EUS-guided nCLE imaging is first performed (B) followed by EUS-guided FNA and aspiration of cyst fluid. The cyst fluid is analyzed for CEA and cytology. As per institutional standard of care, the cyst fluid is a... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/03/2025
Locations: Mayo Clinic Scottsdale Campus, Scottsdale, Arizona +9 locations
Conditions: Pancreatic Cyst
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Pembrolizumab, Ibrutinib and Rituximab in PCNSL
NCT04421560
Recruiting
This research study is evaluating a combination therapy of 3 drugs as possible treatments for recurrent primary central nervous system lymphoma (PCNSL). The three drugs being used in the study are: * Pembrolizumab (MK3475) * Ibrutinib * Rituximab (or biosimilar)
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/03/2025
Locations: Dana Farber Cancer Institute, Boston, Massachusetts +1 locations
Conditions: Primary Central Nervous System Lymphoma, Recurrent Cancer, Refractory Cancer, Relapsed Cancer
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Long Term Evaluation of Safety and Efficacy of Tildrakizumab in Patients With Psoriatic Arthritis
NCT04991116
Recruiting
An open label phase 3 study
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/03/2025
Locations: Sunpharma site no 50, Dothan, Alabama +92 locations
Conditions: Psoriatic Arthritis
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Autologous CAR T-Cells Targeting the GD2 Antigen for Lung Cancer
NCT05620342
Recruiting
This is a phase 1, single-center, open-label study that enrolls adult subjects with extensive stage lung cancer or stage IV non-small cell lung cancer that is platinum-refractory and received PD-1 and/or PD-L1 therapy. The purpose of this study is to test the safety of using a new treatment called autologous T lymphocyte chimeric antigen receptor cells against the GD2 antigen (iC9-GD2.CAR.IL-15 T cells) in subjects with lung cancer. How much (dose) of the iC9-GD2.CAR.IL-15 T cells are safe to us... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/03/2025
Locations: Lineberger Comprehensive Cancer Center, Chapel Hill, North Carolina
Conditions: Lung Cancer, Small Cell Lung Carcinoma, Non Small Cell Lung Cancer
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Bridging the Health Disparities Gap in Decision-Making Among Limited English Proficient (LEP) Patients with Pelvic Floor Disorders
NCT05871268
Recruiting
Understanding a patient's decision-making preference can help physicians meet their expectations and may increase patient satisfaction with the decision-making process.
Gender:
FEMALE
Ages:
Between 18 years and 99 years
Trial Updated:
03/03/2025
Locations: Loyola University Medical Center, Maywood, Illinois
Conditions: Preferred Level of Involvement in Decision Making LEP Patients
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