Novel Approaches for Improving Vascular Function in Veterans With HFpEF
NCT06312748
Recruiting
This project will evaluate the impact of L-Citrulline, tetrahydrobiopterin (BH4), and atorvastatin administration on physical capacity and vascular function in Veterans with heart failure with preserved ejection fraction (HFpEF).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/16/2025
Locations: VA Salt Lake City Health Care System, Salt Lake City, UT, Salt Lake City, Utah
Conditions: Inflammation, Heart Failure With Preserved Ejection Fraction
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A Study of Auxora in Patients With AKI and Injurious Lung "Crosstalk"
NCT06374797
Recruiting
Approximately 150 patients with acute kidney injury (AKI) associated with acute hypoxemic respiratory failure (AHRF) will be randomized at up to 40 sites. Patients will be randomly assigned to either Auxora or matching placebo. Study drug infusions will occur every 24 hours for five consecutive days for a total of five infusions.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/16/2025
Locations: University of Alabama, Birmingham, Alabama +36 locations
Conditions: Acute Kidney Injury
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Stereotactic Body Radiation Therapy Plus Androgen Receptor Pathway Inhibitor and Androgen Deprivation Therapy for Treatment of Metastatic, Recurrent Hormone-Sensitive Prostate Cancer, DIVINE Trial
NCT06378866
Recruiting
This phase II trial studies the effects of stereotactic body radiation therapy (SBRT) and the timing of treatment with androgen receptor pathway inhibitor (ARPI) plus androgen deprivation therapy (ADT) in treating patients with hormone sensitive prostate cancer that has spread from where it first started to other places in the body (metastatic), and that has come back after a period of improvement (recurrent). SBRT is a type of external radiation therapy that uses special equipment to position a... Read More
Gender:
MALE
Ages:
18 years and above
Trial Updated:
06/16/2025
Locations: Mayo Clinic in Arizona, Phoenix, Arizona +1 locations
Conditions: Recurrent Castration-Sensitive Prostate Carcinoma, Stage IVB Prostate Cancer AJCC v8, Recurrent Prostate Cancer, Castration-resistant Prostate Cancer
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Cardiopulmonary Monitoring in Lung Cancer Patients Receiving Combined Thoracic Radiotherapy and Immunotherapy
NCT06410300
Recruiting
The overall purpose of this study is to evaluate cardiopulmonary toxicity in patients with lung cancer (NSCLC or SCLC) undergoing combined thoracic radiotherapy ± chemotherapy and immunotherapy through timed monitoring and blood sample collection and to identify correlative biomarkers for predicting cardiopulmonary adverse events.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/16/2025
Locations: University of Missouri - Ellis Fischel Cancer Center, Columbia, Missouri +2 locations
Conditions: Lung Cancer
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Evaluating Intuitive 3D Models in Preoperative Surgical Planning for Thoracic and Colorectal Procedures.
NCT06434727
Recruiting
The Study Objective: To evaluate the clinical utility of a 3D model with 2D CT/MRI scans during simulated preoperative surgical planning of open, laparoscopic, or robotic-assisted anatomic lung resection (segmentectomy, lobectomy) or Lower Anterior Resection (LAR) procedures.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/16/2025
Locations: Our Lady of the Lake Regional Medical Center, Baton Rouge, Louisiana +3 locations
Conditions: Thoracic, Colorectal Disorders
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NeuroTrainer Cognitive Training For Academic Focus
NCT06512974
Recruiting
This clinical trial aims to evaluate the feasibility and efficacy of NeuroTrainer cognitive training in improving attentional and executive control functions in students with and without attention-related difficulties.
Gender:
ALL
Ages:
Between 11 years and 17 years
Trial Updated:
06/16/2025
Locations: Marquette Senior High School, Marquette, Michigan +2 locations
Conditions: ADHD - Combined Type, ADHD Predominantly Inattentive Type, ADHD, Predominantly Hyperactive - Impulsive
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Lower Extremity Elevation to Minimize Hemodynamic Instability During Induction of General Anesthesia
NCT06513169
Recruiting
The purpose of this study is to determine if lower extremity elevation (LEE) will reduce the incidence of postinduction hypotension, to compare the utilization of vasoactive medications after induction in patients with LEE and patients without LEE and to determine if LEE will increase measured cardiac output
Gender:
ALL
Ages:
Between 18 years and 70 years
Trial Updated:
06/16/2025
Locations: The University of Texas Health Science Center at Houston, Houston, Texas
Conditions: Post Induction Hypotension
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A Dose Range-Finding Study to Assess the Efficacy and Safety of Multiple Dose Levels of AZD8630 in Adults With Uncontrolled Asthma at Risk of Exacerbations
NCT06529419
Recruiting
A dose range-finding study to assess the efficacy and safety of multiple dose levels of AZD8630 administered via a dry powder inhaler in adults with uncontrolled asthma at risk of exacerbations, receiving medium -to -high dose inhaled corticosteroid (ICS)/long-acting β2-agonist (LABA).
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
06/16/2025
Locations: Research Site, Mesa, Arizona +231 locations
Conditions: Asthma
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REgulatory T Cell Therapy to Achieve Immunosuppression REduction
NCT06552169
Recruiting
The goal of this multi-national, multi-center, open-label, randomized Phase 2 trial is to determine the safety and efficacy of administering expanded regulatory T cells (TRK-001) to prevent allograft rejection in living donor renal transplant recipients. Enrolled subjects will be randomized to one of 2 study arms: Arm 1 subjects will receive standard of care immunosuppression Arm 2 subjects will receive initial standard of care (SOC) immunosuppression and a single infusion of TRK-001. Three m... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
06/16/2025
Locations: Northwestern Memorial Hospital, Chicago, Illinois +3 locations
Conditions: Kidney Transplantation
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Psyllium in Pediatric IBS
NCT06639984
Recruiting
The goal of this clinical trial is to learn if a fiber (psyllium) can change the way bacteria use fructans (a type of sugar) and whether psyllium can help decrease childhood irritable bowel syndrome (IBS) symptoms when eating fructans. The main questions it aims to answer are: Aim 1: The effect of psyllium at two doses given with a fructan meal on microbial fructan fermentation (intracolonic pH; H2 gas production; gut microbiome composition; fecal short-chain fatty acids, lactate, glycomics).... Read More
Gender:
ALL
Ages:
Between 12 years and 17 years
Trial Updated:
06/16/2025
Locations: Duke University, Durham, North Carolina
Conditions: Irritable Bowel Syndrome
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QTX3544 in Patients With Advanced Solid Tumors With KRAS G12V Mutations
NCT06715124
Recruiting
Phase 1 study to determine the safety, tolerability, and anti-tumor activity of QTX3544 as a single agent or in combination with cetuximab.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/16/2025
Locations: Sarah Cannon Research Institute, Denver, Colorado +9 locations
Conditions: Advanced Solid Tumors
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Enhancing Telemedicine for T2D
NCT06740435
Recruiting
The goal of this pilot clinical trial is to assess feasibility of an intervention to deliver comprehensive, high-quality diabetes care through telemedicine among adults with type 2 diabetes who use insulin and have multiple chronic health conditions. The main question it aims to answer is: Is an enhanced telemedicine intervention for type 2 diabetes compared to usual telemedicine care feasible? Researchers will compare the enhanced telemedicine intervention to usual telemedicine care to see if... Read More
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
06/16/2025
Locations: University of Pittsburgh, Pittsburgh, Pennsylvania
Conditions: Type 2 Diabetes
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