Functional Magnetic Resonance Imaging Sleep Study With Auditory Stimuli
NCT02629107
Recruiting
Background: An electroencephalogram (EEG) measures the brain s electrical activity. EEG shows that the louder the sound needed to wake a person, the deeper the person s sleep. Researchers are using functional magnetic resonance imaging (fMRI) to study people during sleep so they can view brain activity in 3D. But they still need to correlate fMRI with sound thresholds, like the EEG. Objective: To measure brain activity during sleep using fMRI and EEG. Eligibility: Healthy people ages 18 34... Read More
Gender:
ALL
Ages:
Between 18 years and 34 years
Trial Updated:
06/11/2025
Locations: National Institutes of Health Clinical Center, Bethesda, Maryland
Conditions: Normal Physiology
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Safety and Feasibility of Preoperative and Intraoperative Image-Guided Resection of Gliomas
NCT03542409
Recruiting
This study evaluates the use of specialized magnetic resonance imaging (MRI) techniques including magnetic resonance (MR) perfusion and 2-hydroxyglutarate (2HG) spectroscopy in the surgical treatment of gliomas. Cohort 1 participants will undergo an MR perfusion scan or 2-HG spectroscopy prior to surgery and intra-operatively. Cohort 2 participants will only undergo standard of care imaging and tumor acquisition. Participant participation will end at the completion of surgery and will be trans... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/11/2025
Locations: Huntsman Cancer Institute, Salt Lake City, Utah
Conditions: Brain Tumor Adult
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Vertical Sleeve Gastrectomy and Lifestyle Modification for the Treatment of Non-Alcoholic Steatohepatitis
NCT03587831
Recruiting
Participants meeting study entry criteria are randomized with equal probability to one of two study groups: (1) Lifestyle modification or (2) Vertical Sleeve Gastrectomy (VSG) with Iifestyle modification, followed for 12 months. The primary goal for the trial is to determine if the investigators can recruit, randomize, and retain participants to perform invasive and non-invasive measurements of NASH and fibrosis, deliver lifestyle modification and demonstrate the safety of VSG. The investigators... Read More
Gender:
ALL
Ages:
Between 30 years and 70 years
Trial Updated:
06/11/2025
Locations: University of San Fransisco, San Francisco, California +1 locations
Conditions: NASH - Nonalcoholic Steatohepatitis
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Neuromodulation and Cognitive Training in Opioid Use Disorder
NCT03773523
Recruiting
The relapsing nature of opioid use disorder is a major obstacle to successful treatment. About 90% of those entering treatment will relapse within one year. To improve treatment outcome, new interventions targeting the underlying brain biomarkers of relapse vulnerability hold significant promise in reducing this critical public health problem. Transcranial direct current stimulation (tDCS) is a non-invasive brain stimulation technique that can modulate brain connectivity.
Gender:
ALL
Ages:
Between 18 years and 60 years
Trial Updated:
06/11/2025
Locations: University of Minnesota, Minneapolis, Minnesota
Conditions: Opioid-use Disorder, Opioid Dependence, Opioid Abuse
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Pilot and Feasibility Study of 2'-FL as a Dietary Supplement in IBD Patients Receiving Stable Maintenance Anti-TNF Therapy
NCT03847467
Recruiting
Randomized, placebo-controlled dose-ranging study of 2'-FL in IBD, Crohn's Disease (CD) and ulcerative colitis (UC). The overarching hypothesis is that 2'-FL supplementation in IBD will be safe and well tolerated, while increasing fecal Bifidobacterium abundance and butyrate in a dose dependent manner. The investigators will test 1, 5, or 10 gm 2'-FL compared to 2 gm dextrose placebo as a daily dietary supplement in pediatric and young adult IBD participants in stable remission receiving inflixi... Read More
Gender:
ALL
Ages:
Between 11 years and 25 years
Trial Updated:
06/11/2025
Locations: Connecticut Children's Medical Center, Hartford, Connecticut +2 locations
Conditions: Inflammatory Bowel Diseases, Crohn Disease, Ulcerative Colitis
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89Zr-DFO-Atezolizumab ImmunoPET/CT in Patients With Locally Advanced or Metastatic Renal Cell Carcinoma
NCT04006522
Recruiting
This is an exploratory clinical trial to assess the potential of 89Zr-DFO-Atezolizumab Positron Emission Tomography/Computed Tomography (PET/CT) scans in patients with locally advanced or metastatic renal cell carcinoma (RCC). This open label, nontherapeutic trial will test the correlation of 89Zr-DFO-Atezolizumab immunoPET/CT with programmed death-ligand 1 (PD-L1) expression and the response to immune checkpoint inhibitor therapy in patients with RCC. There will be two cohorts, one made up of p... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/11/2025
Locations: UT Southwestern Medical Center, Dallas, Texas
Conditions: Renal Cell Carcinoma
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A Study of E7386 in Combination With Other Anticancer Drug(s) in Participants With Solid Tumor
NCT04008797
Recruiting
The primary objective of this study is to assess the safety and tolerability and to determine the recommended Phase 2 dose (RP2D) of E7386 in combination with other anticancer drug(s), and to determine the optimal dose of E7386 in combination with lenvatinib in endometrial carcinoma (EC) (for EC Dose Optimization Part only).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/11/2025
Locations: UAMS, Little Rock, Arkansas +107 locations
Conditions: Neoplasms, Carcinoma, Hepatocellular, Liver Neoplasms, Colorectal Neoplasms, Endometrial Neoplasms
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Enhanced Spatial Targeting in ECT Utilizing FEAST
NCT04099342
Recruiting
The purpose of this research study is to find an alternative version of ECT that reduces the negative side effects (mainly memory loss) while still providing patients with relief from depressive symptoms. Previous forms of ECT may use Bilateral (electrodes on both sides of the head) or Right Unilateral (RUL) (electrodes on one side of the head). Our research focuses on adjusting the placement of electrodes on one side of the head in order to better stimulate the Prefrontal Cortex (PFC) of the br... Read More
Gender:
ALL
Ages:
Between 22 years and 90 years
Trial Updated:
06/11/2025
Locations: University of Minnesota, Minneapolis, Minnesota
Conditions: Treatment Resistant Depression
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PCS in Severe Treatment Resistant Depression
NCT04124341
Recruiting
This research study is designed to test if electrical stimulation of the surface of the brain in the frontal region will help treat depressive symptoms. Participants receive intermittent electrical stimulation to the brain, which involves surgically placing electric leads in between the tough fibrous membrane covering the surface of the brain and the surface of the brain itself. This type of stimulation is referred to as bilateral subdural prefrontal cortical stimulation (PCS) because it will sp... Read More
Gender:
ALL
Ages:
Between 22 years and 70 years
Trial Updated:
06/11/2025
Locations: University of Minnesota, Minneapolis, Minnesota
Conditions: Treatment Resistant Depression
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Facial Affect Sensitivity Training for Young Children With Callous-unemotional Traits
NCT04159168
Recruiting
The goal of this study is to test a novel intervention for children ages 6-11 with elevated callous-unemotional (CU) traits. Conduct problems are among the most prevalent and costly mental health conditions of childhood, and a common antecedent to adult psychiatric disorders. An established risk factor for early, persistent, and severe youth misconduct is the presence of CU traits. CU traits (e.g., lack of empathy or guilt, shallow affect) are analogous to the core affective features of adult ps... Read More
Gender:
ALL
Ages:
Between 6 years and 11 years
Trial Updated:
06/11/2025
Locations: Center for Youth Development and Intervention (CYDI), Tuscaloosa, Alabama
Conditions: Affective Symptoms, Empathy
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Characterizing Variability in Hearing Aid Outcomes in Among Older Adults With Alzheimer's Dementia
NCT04240561
Recruiting
This current translational project, funded by NIH, aims to better understand the impact of various signal modification strategies for older adults with Alzheimer's dementia and its potential precursor, known as amnestic mild cognitive impairment. The investigators hypothesize that adults with Alzheimer's dementia represent an extreme case of restricted cognitive ability, such that very low working memory capacity and overall reduced cognitive capacity will limit benefit from advanced signal proc... Read More
Gender:
ALL
Ages:
Between 50 years and 90 years
Trial Updated:
06/11/2025
Locations: Northwestern University, Chicago, Illinois +1 locations
Conditions: Hearing Loss, Sensorineural, Dementia of Alzheimer Type, Amnestic Mild Cognitive Impairment
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Brain Connections for Arm Movement After Stroke
NCT04286516
Recruiting
The purpose of this study is to use Transcranial Magnetic Stimulation (TMS) while subjects are making reaching movements in a robotic arm device in order to discover how different brain areas control movement before and after stroke and when these brain areas are most sensitive to TMS.
Gender:
ALL
Ages:
Between 45 years and 90 years
Trial Updated:
06/11/2025
Locations: VA Pittsburgh Healthcare System University Drive Division, Pittsburgh, PA, Pittsburgh, Pennsylvania
Conditions: Stroke, Brain Disease, Central Nervous System Diseases, Nervous System Diseases, Cardiovascular Diseases
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