Digital Limited Interaction Efficacy Trial of LifeSkills Mobile to Reduce HIV Incidence in YTW
NCT05018611
Recruiting
The LifeSkills Mobile app will be evaluated in a randomized controlled trial (RCT) among 5,000 young transgender women (YTW), ages 16-29 in the United States (U.S.). Study findings will demonstrate if the intervention will reduce HIV incidence.
Gender:
MALE
Ages:
Between 16 years and 29 years
Trial Updated:
02/18/2025
Locations: UCLA, Los angeles, California
Conditions: HIV Prevention
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Comparison of Methods of Pulmonary Blood Flow Augmentation in Neonates: Shunt Versus Stent (The COMPASS Trial)
NCT05268094
Recruiting
COMPASS is a prospective multicenter randomized interventional trial. Participants with ductal-dependent pulmonary blood flow will be randomized to receive either a systemic-to-pulmonary artery shunt or ductal artery stent. Block randomization will be performed by center and by single vs. two ventricle status. Participants will be followed through the first year of life.
Gender:
ALL
Ages:
Between 1 day and 30 days
Trial Updated:
02/18/2025
Locations: University of Alabama, Birmingham, Alabama +23 locations
Conditions: Congenital Heart Disease in Children
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Factors in Learning and Plasticity: Macular Degeneration
NCT05454124
Recruiting
A greater understanding of plasticity after central vision loss can inform new therapies for treating low vision and has the potential to benefit millions of individuals suffering from low vision. The treatment of low vision is particularly relevant to the mission of the NEI to support research on visual disorders, mechanisms of visual function, and preservation of sight. The comparison of different training and outcome factors is in line with the NIMH RDOC framework and studies in an aging popu... Read More
Gender:
ALL
Ages:
Between 18 years and 89 years
Trial Updated:
02/18/2025
Locations: UAB, Birmingham, Alabama
Conditions: Central Visual Impairment, Macular Degeneration
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Heated Intraperitoneal Chemotherapy Followed by Niraparib for Ovarian, Primary Peritoneal and Fallopian Tube Cancer
NCT05659381
Recruiting
Patients will be registered prior to, during or at the completion of neoadjuvant chemotherapy (Paclitaxel 175 mg/m2 IV over 3 hours and Carboplatin AUC 6 IV on Day 1 every 21 days for 3-4 cycles). Registered patients who progress during neoadjuvant chemotherapy will not be eligible for iCRS and will be removed from the study. Following completion of neoadjuvant chemotherapy, interval cytoreductive surgery (iCRS) will be performed in the usual fashion in both arms. Patients will be randomized at... Read More
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
02/18/2025
Locations: City of Hope, Duarte, California +50 locations
Conditions: Stage III Ovarian Cancer, Stage IV Ovarian Cancer, Stage III Primary Peritoneal Cancer, Stage IV Primary Peritoneal Cancer, Stage III Fallopian Tube Cancer, Stage IV Fallopian Tube Cancer
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Wakaya: Rising Up for Choctaw Youth Health
NCT05818384
Recruiting
Investigators will conduct a two-group randomized waitlist-control trial to assess the efficacy of the Wakaya: Rising Up for Choctaw Youth Health program on improving physical activity, reducing sedentary behaviors and improving healthful eating habits as well as delaying or reducing alcohol, tobacco and other drug use. Wakaya is an experiential, outdoor, nature-based program grounded in Choctaw values. It is a multi-level intervention that increases individual motivation and leadership skills t... Read More
Gender:
ALL
Ages:
Between 12 years and 19 years
Trial Updated:
02/18/2025
Locations: Choctaw Nation of Oklahoma, Durant, Oklahoma +1 locations
Conditions: Obesity, Adolescent, Healthy Nutrition, Sedentary Behavior, Drug Abuse
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Prospective Study to Determine the Safety and Effectiveness of a Connective Tissue Allograft Active Matrix (AM) Vs. Standard of Care in Arthroscopic Rotator Cuff Repair
NCT05894265
Recruiting
The purpose of this study is to see how well the ActiveMatrix® graft works at improving healing and function of the shoulder following rotator cuff repair surgery
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
02/18/2025
Locations: The University of Texas Health Science Center at Houston, Houston, Texas
Conditions: Rotator Cuff Tears
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The HAPPINESS Trial: cHAnging the Perceived Pain INtensity in divErSe Populations With Spinal Cord Injury
NCT06140355
Recruiting
Chronic neuropathic pain affects 69% of adults with spinal cord injury (SCI). Current treatment options are limited (primarily pain medications) with insufficient benefits and significant risks for addiction and adverse effects. Of the available mind and body approaches, Qigong is the most accessible for adults with SCI with evidence for effectiveness in reducing pain, but there is insufficient evidence to make recommendations for adults with SCI. Thus, the feasibility of Qigong in SCI needs to... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/18/2025
Locations: University of Miami, Miami, Florida +2 locations
Conditions: Spinal Cord Injuries
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Study of Ravulizumab in Immunoglobulin A Nephropathy (IgAN)
NCT06291376
Recruiting
The primary objective of this study to evaluate efficacy of ravulizumab compared with placebo on proteinuria reduction and change in eGFR in adult participants with IgAN who are at risk of disease progression.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/18/2025
Locations: Research Site, Alabaster, Alabama +311 locations
Conditions: Immunoglobulin A Nephropathy, IgAN
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A Plant-Based Whole-Foods Meal Delivery Service for Patients With Multiple Myeloma Undergoing Autologous Hematopoietic Cell Transplant
NCT06559709
Recruiting
This clinical trial evaluates the impact of a plant-based whole-foods delivery service on the microbiome in patients with multiple myeloma undergoing an autologous hematopoietic cell transplant. An autologous hematopoietic cell transplant is a procedure in which blood-forming stem cells (cells from which all blood cells develop) are removed, stored, and later given back to the same person. Loss of microbial diversity within the intestinal tract has been associated with poor outcomes for patients... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/18/2025
Locations: Fred Hutch/University of Washington Cancer Consortium, Seattle, Washington
Conditions: Multiple Myeloma
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Lisaftoclax (APG-2575) Combined With Azacytidine (AZA) in the Treatment of Patients With Higher-risk Myelodysplastic Syndrome (GLORA-4).
NCT06641414
Recruiting
A global multicenter, randomized, double-blind, placebo-controlled, pivotal phase III study. To evaluate overall survival (OS) of Lisaftoclax (APG-2575) combined with azacitidine (AZA) vs. placebo combined with azacitidine in newly diagnosed patients with HR-MDS.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/18/2025
Locations: MD Anderson Cancer Center, Houston, Texas +1 locations
Conditions: Higher-risk Myelodysplastic Syndrome
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Evaluation of the Abbott i-STAT TBI Biomarker Test
NCT06766435
Recruiting
According to the Centers for Disease Control and Prevention, approximately 200,000 hospitalizations occurred in 2020 related to Traumatic Brain Injury (TBI), which does not include many TBIs treated only in emergency departments, urgent care, primary care, or that are not evaluated by a clinician. Head CT is a critical component of care for severe TBI, however in mild TBI there is practice variation with a wider risk to benefit estimation for obtaining head CT imaging. Potential disadvantages of... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/18/2025
Locations: Mount Sinai Morningside, New York, New York +2 locations
Conditions: Traumatic Brain Injury
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Drawing and Anxiety Study
NCT06838351
Recruiting
Anxiety is among the most common emotional difficulties impacting well-being, highlighting the need for approachable anxiety-reduction tools. Both mindfulness and art-based interventions have been shown to decrease anxiety symptoms. These studies integrate these approaches via a novel guided drawing intervention, and tests effects on anxiety (pre/post drawing and at one-week follow-up) and physiological regulation (respiratory sinus arrhythmia). This registration includes two separate interventi... Read More
Gender:
ALL
Ages:
Between 13 years and 25 years
Trial Updated:
02/18/2025
Locations: Penn State University, University Park, Pennsylvania
Conditions: Anxiety
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