Moving Beyond Inflammation as a Therapeutic Target for Crohn's Disease
NCT06976853
Recruiting
The purpose of this research study is to evaluate what type of treatment will be beneficial for people with Crohn's disease and difficult to treat inflammation in the small bowel. Current therapies are used to control the inflammation due to Crohn's disease in your digestive tract. In some patients, those therapies are not sufficient to fully treat the disease. This objective of this study is to evaluate the efficacy of a different type of therapy, tirzepatide, that may promote healing of the af... Read More
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
06/05/2025
Locations: Cedars-Sinai Medical Center, Beverly Hills, California +2 locations
Conditions: Crohn Disease (CD)
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Testing the Effectiveness and Implementation of a Meditation App for Youth in the Legal System
NCT06997120
Recruiting
The goals of this hybrid type 2 randomized controlled trial (RCT) are to evaluate the effectiveness and individual-level implementation of a 1-month app-based meditation program with youth on probation in Cook County, IL. The primary questions it is designed to answer are: 1. Is the meditation app associated with improvements in behavioral health outcomes including cannabis use problems? 2. Do improvements in emotion regulation appear to mediate the effects of the meditation app on these behavi... Read More
Gender:
ALL
Ages:
Between 13 years and 20 years
Trial Updated:
06/05/2025
Locations: University of Illinois at Chicago, Chicago, Illinois
Conditions: Behavioral Health
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Prepping for The Talk: Helping Trusted Adults and Youth Talk About Sexual Health
NCT07011563
Recruiting
The goal of this study is to help young people talk to trusted adults (including their parents, but also other adults) about sexual health more openly and honestly- including how to prevent sexually transmitted diseases like HIV - while also respecting a young person's right to privacy. If youth don't have a parent they can talk to about sexual health, we want to help them find a trusted adult to talk to. We also want to help youth take control of their own health by learning about different way... Read More
Gender:
MALE
Ages:
Between 14 years and 17 years
Trial Updated:
06/05/2025
Locations: Rhode Island Hospital, Providence, Rhode Island
Conditions: HIV Prevention, Sexual Health
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INTEGRATED CHILDHOOD ACTIVITY AND NUTRITION (ICAN) STUDY
NCT07011602
Recruiting
This study is a multi-functional integrated research and education project to prevent losses in academic achievement, cognitive function, and behavioral health among at-risk youth. The study tests the effects of a 8-week nutrition and physical activity-based program (Integrated Childhood Activity and Nutrition \[ICAN\]) to prevent summer learning loss. Outcomes include standardized academic achievement as well as executive function among 6-10-year-olds affected by poverty. The nutrition componen... Read More
Gender:
ALL
Ages:
Between 6 years and 11 years
Trial Updated:
06/05/2025
Locations: Bloomington Public Schools District 87, Bloomington, Illinois
Conditions: Achievement, Weight Change, Cognition, Fitness, Nutrition Status
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Effects of Dietary Nitrate in Women With Secondary Amenorrhea
NCT07019129
Recruiting
Excessive exercise, disordered attitudes toward eating, physical and psychological stress, and/or hormonal imbalances may result in cessation of menstruation (secondary amenorrhea). The accompanying lack of estrogen may impair muscle power and oxygen recovery after exercise by reducing nitric oxide levels. The purpose of this study is to determine whether ingestion of beetroot juice containing nitrate, an alternative source of nitric oxide, can help reverse these changes.
Gender:
FEMALE
Ages:
Between 18 years and 44 years
Trial Updated:
06/05/2025
Locations: Indiana University Indianapolis, Indianapolis, Indiana
Conditions: Secondary Amenorrhea
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Evaluation of Tau-Pathology in Sporadic and LRRK2 Parkinson's Disease
NCT07020026
Recruiting
The study aims to evaluate the burden of tau pathology in people with Sporadic and LRRK2 PD via in vivo imaging using the tau tracer, \[18F\]PI-2620, and a high resolution PET camera, NeuroEXPLORER.
Gender:
ALL
Ages:
Between 45 years and 85 years
Trial Updated:
06/05/2025
Locations: Institute for Neurodegenerative Disorders / XingImaging, LLC, New Haven, Connecticut
Conditions: Parkinson's Disease
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Assessment of Stroke Volume in Shock Using Echocardiography Versus Bioreactive Impedance
NCT07020637
Recruiting
This study aims to evaluate the correlation between stroke volume measurements obtained by transthoracic echocardiography and bioreactance-based noninvasive cardiac output monitoring. The primary objective is to assess the level of agreement between these two modalities in critically ill patients.
Gender:
ALL
Ages:
Between 18 years and 90 years
Trial Updated:
06/05/2025
Locations: University Medical Center Southern Nevada, Las Vegas, Nevada
Conditions: Shock Hemodynamic Monitoring Stroke Volume Measurement Passive Leg Raising Critical Illness
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[68Ga]Ga DOTA-5G as a Diagnostic Imaging Agent for Metastatic/Advanced Invasive Lobular Breast Cancer (LBC)
NCT07020806
Recruiting
This is a prospective study using \[68Ga\]Ga DOTA-5G PET/CT imaging in patients diagnosed with metastatic/advanced invasive lobular breast cancer (LBC).
Gender:
ALL
Ages:
Between 18 years and 89 years
Trial Updated:
06/05/2025
Locations: University of California Davis, Sacramento, California
Conditions: Metastatic Lobular Breast Carcinoma
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Collection of Blood and Urine Samples in Patients Receiving Radiation Therapy for Glioblastoma Multiforme
NCT00083512
Recruiting
This study will collect blood and urine samples from patients undergoing radiation therapy for glioblastoma multiforme (a type of brain tumor) to investigate the effects of this treatment on blood cells and certain proteins. The information from this study may help scientists develop new tests to measure radiation exposure and find new ways to treat cancer with radiation, and help determine which kinds of patients or tumors respond better to radiation therapy. Two proteins of particular interest... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/04/2025
Locations: National Institutes of Health Clinical Center, Bethesda, Maryland
Conditions: Glioblastoma Multiforme
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Evaluation of Branch Endografts in the Treatment of Aortic Aneurysms
NCT01524211
Recruiting
Zenith t-Branch Study Cohort: The purpose of this study is to collect information on the Cook Zenith t-Branch endovascular stent-graft system and the Terumo Arch Branch for the treatment of aortic aneurysms. Terumo Arch Branch Study Cohort: The purpose of this additional study arm to the current IDE clinical trial is to collect a priori information on the Terumo Arch Branch Endograft for the treatment of proximal thoracic aortic pathologies that cannot be treated with conventional thoracic endo... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/04/2025
Locations: Baptist Health South Florida|Boca Raton Regional Hospital (BRRH), Boca Raton, Florida
Conditions: Thoracoabdominal Aortic Aneurysm, Aortic Arch Aneurysm
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Experimental Infection of Hookworm-naïve Adults With Dermally-applied Infectious Necator Americanus Hookworm Larvae
NCT01940757
Recruiting
An experimental hookworm infection model is being developed to provide early proof-of-concept that a hookworm vaccine targeting the blood-feeding pathway of adult hookworms is feasible and efficacious. The proposed model consists of vaccinating healthy, hookworm-naïve adults with a candidate hookworm vaccine, followed by challenging them with the investigational product, Necator americanus Larval Inoculum to assess the effect of vaccination on infection. The first proposed study will be a feasib... Read More
Gender:
ALL
Ages:
Between 18 years and 45 years
Trial Updated:
06/04/2025
Locations: George Washington University Medical Faculty Associates, Washington, District of Columbia
Conditions: Hookworm Infection
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Integrated Cancer Repository for Cancer Research
NCT02012699
Recruiting
The iCaRe2 is a multi-institutional resource created and maintained by the Fred \& Pamela Buffett Cancer Center to collect and manage standardized, multi-dimensional, longitudinal data and biospecimens on consented adult cancer patients, high-risk individuals, and normal controls. The distinct characteristic of the iCaRe2 is its geographical coverage, with a significant percentage of small and rural hospitals and cancer centers. The iCaRe2 advances comprehensive studies of risk factors of cancer... Read More
Gender:
ALL
Ages:
Between 19 years and 110 years
Trial Updated:
06/04/2025
Locations: Advent Health, Greenwood Village, Colorado +46 locations
Conditions: Pancreatic Cancer, Thyroid Cancer, Lung Cancer, Esophageal Cancer, Thymus Cancer, Colon Cancer, Rectal Cancer, Anal Cancer, Bile Duct Cancer, Duodenal Cancer, Gallbladder Cancer, Gastric Cancer, Liver Cancer, Small Intestine Cancer, Peritoneal Surface Malignancies, Familial Adenomatous Polyposis, Lynch Syndrome, Bladder Cancer, Kidney Cancer, Penile Cancer, Prostate Cancer, Testicular Cancer, Ureter Cancer, Urethral Cancer, Hypopharyngeal Cancer, Laryngeal Cancer, Lip Cancer, Oral Cavity Cancer, Nasopharyngeal Cancer, Oropharyngeal Cancer, Paranasal Sinus Cancer, Nasal Cavity Cancer, Salivary Gland Cancer, Skin Cancer, Mesothelioma, Breast Cancer, Leukemia, Melanoma, Sarcoma, Unknown Primary Tumor, Multiple Myeloma, Ovarian Cancer, Endometrial Cancer, Vaginal Cancer, Neuroendocrine Tumors, Plasma Cell Dyscrasia, Healthy Control, Gastrointestinal Stromal Tumors, Central Nervous System Tumor, Central Nervous System Cancer
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