All Clinical Trials

A listing of 23137 clinical trials actively recruiting volunteers for paid trials and research studies in various therapeutic areas.

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Featured Trial

Paid Clinical Studies Nationwide

Recruiting

Nationwide clinical trials offered in your area. Some trials offering up to several thousand dollars in compensation for participation.

Conditions:

Healthy

Healthy Volunteer Study

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* Compensation for time may be available

Featured Trial

Chronic Cough Study

Recruiting

Are you tired of living with chronic cough? The ASPIRE Study is now looking to enroll people from all backgrounds to help research potential new treatment options for chronic cough. You are under no obligation to take part and health insurance is not required. Find out more today! We’d love to hear from you.

Conditions:

Chronic Cough

Refractory or Unexplained Chronic Cough

Cough

Asthma

Allergic Asthma

Learn More

Featured Trial

Studying an Investigational Virus Vaccine

Recruiting

The main objectives of this study are to assess the safety and effectiveness of an investigational vaccine aimed at preventing norovirus, commonly known as the stomach flu. Participants will be randomly assigned to receive either the investigational vaccine or a placebo. Should you express interest, you will be contacted directly by the research site, which will provide further details and answer any questions you may have about study requirements, risks/benefits, and any compensation.

Conditions:

Healthy

Interested in vaccine studies

All Conditions

Preventative Trials

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Featured Trial

Type 2 Diabetes Clinical Trial

Recruiting

Can changing your breakfast improve your type 2 diabetes? If you have an HbA1C of 7.0% or higher, you are invited to participate in an online study at the University of Michigan.

Conditions:

Type 2 Diabetes

Diabetes Mellitus Type 2 in Obese

Diabetes Type Two

Type 2 Diabetes Mellitus

Diabete Type 2

Learn More

Featured Trial

Evaluating an Investigational Treatment for Hidradenitis Suppurativa

Recruiting

The main objectives of this Phase 2 study are to evaluate the safety and effectiveness of an investigational medication in adults with moderate to severe hidradenitis suppurativa (HS), a chronic skin condition. Participants will be randomly assigned to receive the investigational treatment or a placebo. Should you express interest, the research site will contact you directly to provide further details and address any questions you may have about study requirements, risks/benefits, and compensation.

Conditions:

All Conditions

Hidradenitis suppurativa (Skin disorder)

Dermatology

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Featured Trial

Crohn's Disease Clinical Study

Recruiting

Help us study a potential new way to treat Crohn's disease. We are seeking adults living with Crohn's disease to join our latest clinical trial to help us learn more. Eligible participants will receive study-related treatment, assessments, and care at no cost. You will also receive reimbursement for travel while participating. Health insurance is not required to take part.

Conditions:

Crohn's Disease

Crohn Disease

Crohns Disease

Crohn's Disease (CD)

Crohn Colitis

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Technical Development of Cardiovascular Magnetic Resonance Imaging (CMR) Using a Low Specific Absorption Rate (SAR) Scanner System

NCT03331380

Recruiting

Background: Researchers are testing version of a system known as a magnetic resonance imagining (MRI) scanner that uses strong magnetic fields, radio waves and the like to create images of the organs in the body. It uses lower energy levels than other MRI scanners. This may help scan people with metal devices in their body, or in invasive heart procedures using metal tools. Objective: To test a new MRI scanner and software changes to create better pictures. Eligibility: People with disease... Read More

Gender:

ALL

Ages:

Between 18 years and 100 years

Trial Updated:

04/30/2025

Locations: National Institutes of Health Clinical Center, Bethesda, Maryland

Conditions: CAD

Learn More ›

Bedside Ultrasound of Gastric Contents in Pediatric Populations

NCT03520374

Recruiting

Perioperative aspiration of gastric contents is a rare but serious adverse event. The risk of aspiration can be estimated by perioperative evaluation of stomach contents with ultrasound using a validated technique and scoring system. A lack of knowledge or familiarity is frequently cited by anesthesia providers as a rationale for not performing perioperative ultrasound assessments. The purpose of this study is to determine whether novice ultrasonography users (medical students, undergraduates, o... Read More

Gender:

ALL

Ages:

Between 2 years and 60 years

Trial Updated:

04/30/2025

Locations: LPCH/SHC, Stanford, California

Conditions: Gastric Contents

Learn More ›

Reproductive Axis Maturation in the Early Post-Menarchal Years

NCT03986021

Recruiting

Background: Most adult women with irregular periods of unknown cause report symptoms dating back to early adolescence. This study aims to learn how girls' periods change in the 2 years after their first period. We are also looking at girls who may have a condition called PCOS. This will help researchers learn what healthy puberty looks like and how they can spot signs of hormone problems early on. Objective: To learn how long it takes girls to develop regular menstrual cycles after their first period. Eligibility: Healthy girls ages 8-14 who either (1) haven't had their first period but show signs of puberty, such as breast development and hair in the genital area; or (2) had their first period in the past 6 months Girls at risk for PCOS age 8-14 who have a mom or sister with PCOS Girls with irregulat menstrual cycles age 11-17.5 To compare with the girls, we are looking at women \>=18-34 years old with PCOS, Healthy women \>= 18-34 years old without PCOS Design: Both parents or guardians must allow their daughter to participate. They must attend all study visits with her. Participants will first be screened by phone. Those who qualify will be screened in person. They will have a physical exam. They will give blood and urine samples. They will have an ultrasound of their abdomen. They will fill out questionnaires. They will sit in a BOD POD for 6 minutes: This is an egg- shaped machine that takes body measurements. They have the option to provide DNA samples. Participants will have sets of visits at home or at the clinic about every 6 months. The number of visits in each set will depend on their menstrual cycle. Then they will have a final visit. Visits will include repeats of the screening tests. There are additional parts that participants may choose to be involved in depending on how involved they want to be. At home, participants will collect their urine daily to measure hormones. They will keep a diary of their periods. Adults: Women with known PCOS will complete the same Screening Visit as the girls and will collect dried urine specimens at home for 8 weeks; The Healthy control women group will complete the same Screening Visit as the girls and collect dried urine specimens at home for 2 menstrual cycles.... Read Less

Gender:

FEMALE

Ages:

Between 8 years and 34 years

Trial Updated:

04/30/2025

Locations: NIEHS Clinical Research Unit (CRU), Research Triangle Park, North Carolina

Conditions: Reproductive Physiological Processes, Pediatrics, Adolescent Health, Adolescent Development

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A Study to Compare the Blood Levels and Safety of Tazemetostat in Participants With Advanced Cancer and Moderate/Severe Liver Impairment to Participants With Advanced Cancer and Normal Liver Function

NCT04241835

Recruiting

This main aim of this trial will be to study the blood levels (known as pharmacokinetics) of the study drug tazemetostat. The pharmacokinetics of the study drug in participants with advanced solid tumors and moderate or severe hepatic (liver) impairment will be compared with participants with advanced malignancies and normal hepatic function. An advanced malignancy is a cancer that has recurred (come back) after prior treatment or hasn't controlled with treatment. The trial will also study th... Read More

Gender:

ALL

Ages:

18 years and above

Trial Updated:

04/30/2025

Locations: Florida Cancer Specialists & Research Institute, Lake Mary, Florida +17 locations

Conditions: Hepatic Impairment, Advanced Malignant Solid Tumor

Learn More ›

Testing the Addition of Lenalidomide and Nivolumab to the Usual Treatment for Primary CNS Lymphoma

NCT04609046

Recruiting

This phase I trial tests the safety, side effects, best dose and effectiveness of lenalidomide when added to nivolumab and the usual drugs (rituximab and methotrexate) in patients with primary central nervous system (CNS) lymphoma. Lenalidomide may stop or slow primary CNS lymphoma by blocking the growth of new blood vessels necessary for tumor growth. Immunotherapy with monoclonal antibodies, such as nivolumab, may help the body's immune system attack the cancer, and may interfere with the abil... Read More

Gender:

ALL

Ages:

18 years and above

Trial Updated:

04/30/2025

Locations: Cedars Sinai Medical Center, Los Angeles, California +47 locations

Cedars Sinai Medical Center, Los Angeles, California

UCSF Medical Center-Parnassus, San Francisco, California

UM Sylvester Comprehensive Cancer Center at Coral Gables, Coral Gables, Florida

UM Sylvester Comprehensive Cancer Center at Deerfield Beach, Deerfield Beach, Florida

University of Miami Miller School of Medicine-Sylvester Cancer Center, Miami, Florida

UM Sylvester Comprehensive Cancer Center at Kendall, Miami, Florida

UM Sylvester Comprehensive Cancer Center at Plantation, Plantation, Florida

Iowa Methodist Medical Center, Des Moines, Iowa

UI Health Care Mission Cancer and Blood - Des Moines Clinic, Des Moines, Iowa

Broadlawns Medical Center, Des Moines, Iowa

Mercy Medical Center - Des Moines, Des Moines, Iowa

Iowa Lutheran Hospital, Des Moines, Iowa

Trinity Regional Medical Center, Fort Dodge, Iowa

Methodist West Hospital, West Des Moines, Iowa

LSU Health Baton Rouge-North Clinic, Baton Rouge, Louisiana

Our Lady of the Lake Physician Group, Baton Rouge, Louisiana

MaineHealth Maine Medical Center - Portland, Portland, Maine

MaineHealth Maine Medical Center- Scarborough, Scarborough, Maine

MaineHealth Cancer Care and IV Therapy - South Portland, South Portland, Maine

Hickman Cancer Center, Adrian, Michigan

Toledo Clinic Cancer Centers-Monroe, Monroe, Michigan

Siteman Cancer Center at West County Hospital, Creve Coeur, Missouri

Washington University School of Medicine, Saint Louis, Missouri

Siteman Cancer Center-South County, Saint Louis, Missouri

Siteman Cancer Center at Christian Hospital, Saint Louis, Missouri

Siteman Cancer Center at Saint Peters Hospital, Saint Peters, Missouri

Overlook Hospital, Summit, New Jersey

Northwell Health/Center for Advanced Medicine, Lake Success, New York

North Shore University Hospital, Manhasset, New York

NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center, New York, New York

NYP/Weill Cornell Medical Center, New York, New York

State University of New York Upstate Medical University, Syracuse, New York

UNC Lineberger Comprehensive Cancer Center, Chapel Hill, North Carolina

Ohio State University Comprehensive Cancer Center, Columbus, Ohio

Toledo Clinic Cancer Centers-Toledo, Toledo, Ohio

University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma

Rhode Island Hospital, Providence, Rhode Island

Medical University of South Carolina, Charleston, South Carolina

UT Southwestern/Simmons Cancer Center-Dallas, Dallas, Texas

Huntsman Cancer Institute/University of Utah, Salt Lake City, Utah

West Virginia University Healthcare, Morgantown, West Virginia

Marshfield Medical Center-EC Cancer Center, Eau Claire, Wisconsin

Gundersen Lutheran Medical Center, La Crosse, Wisconsin

Marshfield Medical Center-Marshfield, Marshfield, Wisconsin

Marshfield Medical Center - Minocqua, Minocqua, Wisconsin

Marshfield Medical Center-Rice Lake, Rice Lake, Wisconsin

Marshfield Medical Center-River Region at Stevens Point, Stevens Point, Wisconsin

Marshfield Medical Center - Weston, Weston, Wisconsin

Conditions: Primary Diffuse Large B-Cell Lymphoma of the Central Nervous System

Learn More ›

Canakinumab for the Prevention of Lung Cancer, the Can-Prevent-Lung Trial

NCT04789681

Recruiting

This phase II trial studies the effects of canakinumab in preventing lung cancer in patients who have high-risk pulmonary nodules. Canakinumab is a monoclonal antibody that may interfere with the ability of tumor cells to grow and spread. Giving canakinumab may prevent the development of lung cancer.

Gender:

ALL

Ages:

18 years and above

Trial Updated:

04/30/2025

Locations: M D Anderson Cancer Center, Houston, Texas

Conditions: Lung Carcinoma, Stage I Lung Cancer AJCC v8, Stage IA1 Lung Cancer AJCC v8, Stage IA2 Lung Cancer AJCC v8, Stage IA3 Lung Cancer AJCC v8, Stage IB Lung Cancer AJCC v8, Stage II Lung Cancer AJCC v8, Stage IIA Lung Cancer AJCC v8, Stage IIB Lung Cancer AJCC v8, Stage III Lung Cancer AJCC v8, Stage IIIA Lung Cancer AJCC v8, Stage IIIB Lung Cancer AJCC v8, Stage IIIC Lung Cancer AJCC v8

Learn More ›

A Study to Evaluate Efficacy and Safety of an Investigational Drug Named Volixibat in Patients With Itching Caused by Primary Biliary Cholangitis

NCT05050136

Recruiting

The purpose of this clinical research study is to learn more about the use of the study medicine, volixibat, for the treatment of pruritus (itching) associated with Primary Biliary Cholangitis (PBC), and to assess the possible impact on the disease progression of PBC.

Gender:

ALL

Ages:

18 years and above

Trial Updated:

04/30/2025

Locations: Southern California Research Center, Coronado, California +90 locations

Southern California Research Center, Coronado, California

Science 37, Inc (Remote-homebased Telemedicine), Culver City, California

Cedars Sinai Medical Center, Los Angeles, California

University of Colorado, Aurora, Colorado

Covenant Metabolic Specialists, Fort Myers, Florida

UF Hepatology Research at CTRB, Gainesville, Florida

UF Health Gastroenterology- Emerson, Jacksonville, Florida

IHS Health, Kissimmee, Florida

Schiff Center for Liver Diseases, Miami, Florida

Advanced Research Institute, Inc, New Port Richey, Florida

Covenant Research and Clinics, LLC, Sarasota, Florida

Tampa General Hospital, Tampa, Florida

Southeast Clinical Research Center, Dalton, Georgia

Northwestern University, Chicago, Illinois

Loyola University Health System - Loyola Outpatient Center, Maywood, Illinois

University of Iowa Hospitals & Clinics, Iowa City, Iowa

Ochsner Clinic Foundation-Baton Rouge, Baton Rouge, Louisiana

LSU Health Science Center Shreveport, Shreveport, Louisiana

Beth Israel Deaconess, Boston, Massachusetts

Mayo Clinic, Rochester, Minnesota

Jackson Liver and GI Specialists, Jackson, Mississippi

CHI Health Clinic (Alegent Creighton Clinic)- Gastroenterology-Bergan, Omaha, Nebraska

Cleveland Clinic - Main Campus, Cleveland, Ohio

Einstein Healthcare Network - Einstein Medical Center, Philadelphia, Pennsylvania

Methodist Le Bonheur Healthcare, Memphis, Tennessee

Galen Medical Group, P.C, Tennessee, Tennessee

Amel Med LLC, Austin, Texas

Soma Clinical Trials, Denison, Texas

Liver Associates of Texas, Houston, Texas

Velocity Clinical Research, Waco, Texas

University of Utah Health Care, Salt Lake City, Utah

MedStar Health Research Institute, Fairfax, Virginia

Bon Secours Liver Institute of Hampton Roads Mary Immaculate Hospital, Newport News, Virginia

Bon Secours Richmond Community Hospital LLC d/b/a Bon Secours Liver Institute of Richmond, Richmond, Virginia

Liver Institute Northwest, Seattle, Washington

Hospital de Alta Complejidad En Red El Cruce, Florencio Varela, Buenos Aires

Glenny Corp S.A, Caba, Not set

Universitair Ziekenhuis Antwerpe UZA, Antwerp, Not set

Cliniques Universitaires Saint-Luc, Brussel, Not set

UZ Gent, Gent, Not set

Centro de Pesquisa Clínica da Bahiana Saúde, Salvador, Bahia

Centro de Pesquisas Clínicas do HC/UFMG-EBSERH, Belo Horizonte, Minas Gerais

Hospital de Clínicas de Porto Alegre, Porto Alegre, RS

Fundação Oswaldo Ramos, São Paulo, Not set

Gordon and Leslie Diamond Health Care Centre, Division of Gastroenterology, Vancouver, British Columbia

University Hospital, LHSC, London, Ontario

University of Alberta, Edmonton, Not set

CHU Grenoble - Hôpital MICHALLON, Grenoble, Not set

Hopital Claude Huriez-Digestive system disease clinic, Lille, Not set

CHU de NICE- Hospital L'Archet 2, Nice, Not set

Hospital Saint Antoine, Paris, Not set

Nouvel Hospital Civil, Strasbourg, Not set

Hospital Paul Brousse- APHP, Villejuif, Not set

Klinikum Chemnitz gGmbH, Chemnitz, Not set

Universitätsklinikum Frankfurt am Main, Frankfurt, Not set

Medizinische Hochschule Hannover (MHH), Hanover, Not set

Universitätsklinikum Schleswig-Holstein, Kiel, Not set

University Hospital Munster, Münster, Not set

University Hospital Tübingen Medical clinic, Tubingen, Not set

St. Josefs-Hospital Wiesbaden, Wiesbaden, Not set

Hillel Yaffe Medical Center, Hadera, Not set

Rambam Medical Center, Haifa, Not set

Carmel Medical Center, Haifa, Not set

Shaare Zedek Medical Center, Jerusalem, Not set

Hadassah Medical Center - Ein Karem, Liver Institute Kiryat Hadassah POB 12000, Jerusalem, Not set

Galilee Medical Center, Nahariyya, Not set

Rabin Medical Center, Petach Tikva, Not set

Sheba Medical Center, Ramat Gan, Not set

The Tel Aviv Sourasky Medical Center, Tel Aviv, Not set

Universita Politecnica delle Marche- Ospedali Riuniti, Ancona, Not set

Fondazione Ca Granda, Milano, Not set

ASST Grande Ospedale Metropolitano Niguarda, Milano, Not set

Fondazione IRCCS San Gerardo dei Tintori, Monza, Not set

Azienda Ospedale-Università di Padova, Padova, Not set

Azienda Ospedaliero Universitaria Pisana (AOUP), Pisa, Not set

Istituto Clinico Humanitas, Rozzano, Not set

National Hospital Organization Nagasaki Medical Center, Ōmura, Nagasaki

Ehime University Hospital, Ehime, Not set

Toranomon Hospital, Tokyo, Not set

Juntendo University Hospital, Tokyo, Not set

Amstedam University Medical Centers, Amsterdam, Not set

Radboudumc, Nijmegen, Not set

Erasmus medical center, Rotterdam, Not set

Hospital Clínic de Barcelona, Barcelona, Not set

Hospital Universitari Parc Tauli, Barcelona, Not set

Hospital General Universitario Gregorio Maranon, Madrid, Not set

Hospital Universitario Virgen del Rocio, Sevilla, Not set

University Hospital Southampton NHS Foundation Trust, Southampton, Hampshire

Belfast Health & Social Care Trust (BHSCT) Royal Victoria Hospital, Belfast, Not set

King's College Hospital NHS Foundation Trust, London, Not set

Nottingham University Hospitals NHS Trust, Nottingham, Not set

Conditions: Primary Biliary Cholangitis, PBC

Learn More ›

Tiragolumab and Atezolizumab for the Treatment of Relapsed or Refractory SMARCB1 or SMARCA4 Deficient Tumors

NCT05286801

Recruiting

This phase I/II trial studies how well tiragolumab and atezolizumab works when given to children and adults with SMARCB1 or SMARCA4 deficient tumors that have either come back (relapsed) or do not respond to therapy (refractory). SMARCB1 or SMARCA4 deficiency means that tumor cells are missing the SMARCB1 and SMARCA4 genes, seen with some aggressive cancers that are typically hard to treat. Immunotherapy with monoclonal antibodies, such as tiragolumab and atezolizumab, may help the body's immune... Read More

Gender:

ALL

Ages:

12 months and above

Trial Updated:

04/30/2025

Locations: Children's Hospital of Alabama, Birmingham, Alabama +39 locations

Children's Hospital of Alabama, Birmingham, Alabama

Children's Hospital Los Angeles, Los Angeles, California

Children's Hospital of Orange County, Orange, California

Lucile Packard Children's Hospital Stanford University, Palo Alto, California

UCSF Medical Center-Mission Bay, San Francisco, California

Children's Hospital Colorado, Aurora, Colorado

Children's National Medical Center, Washington, District of Columbia

Children's Healthcare of Atlanta - Arthur M Blank Hospital, Atlanta, Georgia

Lurie Children's Hospital-Chicago, Chicago, Illinois

University of Chicago Comprehensive Cancer Center, Chicago, Illinois

Riley Hospital for Children, Indianapolis, Indiana

Johns Hopkins University/Sidney Kimmel Cancer Center, Baltimore, Maryland

National Institutes of Health Clinical Center, Bethesda, Maryland

Dana-Farber Cancer Institute, Boston, Massachusetts

C S Mott Children's Hospital, Ann Arbor, Michigan

University of Minnesota/Masonic Cancer Center, Minneapolis, Minnesota

Children's Mercy Hospitals and Clinics, Kansas City, Missouri

Washington University School of Medicine, Saint Louis, Missouri

NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center, New York, New York

Memorial Sloan Kettering Cancer Center, New York, New York

New York Medical College, Valhalla, New York

Duke University Medical Center, Durham, North Carolina

Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio

Nationwide Children's Hospital, Columbus, Ohio

Oregon Health and Science University, Portland, Oregon

Children's Hospital of Philadelphia, Philadelphia, Pennsylvania

Children's Hospital of Pittsburgh of UPMC, Pittsburgh, Pennsylvania

Saint Jude Children's Research Hospital, Memphis, Tennessee

Vanderbilt University/Ingram Cancer Center, Nashville, Tennessee

UT Southwestern/Simmons Cancer Center-Dallas, Dallas, Texas

Cook Children's Medical Center, Fort Worth, Texas

Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center, Houston, Texas

Primary Children's Hospital, Salt Lake City, Utah

Seattle Children's Hospital, Seattle, Washington

Children's Hospital of Wisconsin, Milwaukee, Wisconsin

Sydney Children's Hospital, Randwick, New South Wales

Queensland Children's Hospital, South Brisbane, Queensland

Royal Children's Hospital, Parkville, Victoria

Hospital for Sick Children, Toronto, Ontario

Centre Hospitalier Universitaire Sainte-Justine, Montreal, Quebec

Conditions: Atypical Teratoid/Rhabdoid Tumor, Epithelioid Sarcoma, Kidney Medullary Carcinoma, Malignant Solid Neoplasm, Poorly Differentiated Chordoma, Recurrent Atypical Teratoid/Rhabdoid Tumor, Recurrent Chordoma, Recurrent Epithelioid Sarcoma, Recurrent Kidney Medullary Carcinoma, Recurrent Rhabdoid Tumor, Refractory Atypical Teratoid/Rhabdoid Tumor, Refractory Chordoma, Refractory Epithelioid Sarcoma, Refractory Kidney Medullary Carcinoma, Refractory Rhabdoid Tumor, Rhabdoid Tumor, Recurrent Malignant Solid Neoplasm, Refractory Malignant Solid Neoplasm

Learn More ›

Open-Label Umbrella Study To Evaluate Safety And Efficacy Of Elacestrant In Various Combination In Patients With Metastatic Breast Cancer

NCT05563220

Recruiting

This is a multicenter, Phase 1b/2 trial. The phase 1b part of the trial aims to determine the RP2D of elacestrant when administered in combination with alpelisib, everolimus, palbociclib, abemaciclib, and ribociclib. The Phase 2 part of the trial will evaluate the efficacy and safety of the various combinations in patients with ER+/HER2- advanced/metastatic breast cancer.

Gender:

ALL

Ages:

18 years and above

Trial Updated:

04/30/2025

Locations: Dothan Hematology and Oncology, Dothan, Alabama +116 locations

Dothan Hematology and Oncology, Dothan, Alabama

Mayo Clinic - Arizona, Phoenix, Arizona

Highlands Oncology Group, Springdale, Arkansas

OPN Healthcare (Arcadia Location), Arcadia, California

Glendale Adventist, Glendale, California

OPN Healthcare (Los Alamitos Location), Los Alamitos, California

Cedars Sinai, Los Angeles, California

UCLA UCLA Hem/Onc - Clinical Research Unit, Los Angeles, California

UCSF Helen Diller Family Comprehensive Cancer Center, San Francisco, California

TOI Clinical Research, Whittier, California

Rocky Mountain Cancer Centers, Lone Tree, Colorado

Yale School Of Medicine - Smilow Cancer Hospital - Breast Center, New Haven, Connecticut

George Washington Cancer Center, Washington, District of Columbia

Advent Health (Florida Hospital) - Altamonte Springs, Altamonte Springs, Florida

Mayo Clinic - Jacksonville, Jacksonville, Florida

Ocala Oncology, Ocala, Florida

Northside Hospital Atlanta Cancer Care, Cumming, Georgia

Northwestern Feinberg Scholl of Medicine Prentice Women's Hospital, Chicago, Illinois

Fort Wayne Medical Oncology and Hematology, Fort Wayne, Indiana

MD Alliance for Multispecialty Research, LLC, Merriam, Kansas

New England Cancer Specialists, Scarborough, Maine

Johns Hopkins School of Medicine, Baltimore, Maryland

Massachusetts General Hospital, Boston, Massachusetts

Dana Farber Cancer Institute, Boston, Massachusetts

Barbara Ann Karmanos Cancer Institute, Detroit, Michigan

Minnesota Oncology Hematology, Minneapolis, Minnesota

Mayo Clinic - Rochester, Rochester, Minnesota

Washington University School of Medicine in St. Louis, Saint Louis, Missouri

Astera Cancer Care, East Brunswick, New Jersey

Summit Medical Group, Florham Park, New Jersey

Cooperman Barnabas Medical Center, New Brunswick, New Jersey

NYU Langone Health, New York, New York

New York Cancer and Blood Specialists, Port Jefferson Station, New York

W&IH of RI Breast Health Center of Women and Infants Hospital of Rhode Island, Providence, Rhode Island

Sarah Cannon Research Institute / Tennessee Oncology, Nashville, Tennessee

Texas Oncology - Baylor Charles A. Sammons Cancer Center, Dallas, Texas

MD Anderson Cancer Center Texas, Houston, Texas

UT Health San Antonio, San Antonio, Texas

Inova Schar Cancer Institute, Fairfax, Virginia

Virginia Cancer Specialists, Fairfax, Virginia

Virginia Oncology Associates, Norfolk, Virginia

Cancer Care Northwest, Spokane Valley, Washington

Northwest Medical Specialties (Nwms) - Puyallup - Medical Oncology (Rainier Hematology-Oncology)/Exigent Research Network; LLC, Tacoma, Washington

University of WI - Carbone Cancer Center (Phase II only), Madison, Wisconsin

Centro Medico Austral, Buenos Aires, Not set

Hospital Britanico De Buenos Aires, Buenos Aires, Not set

Cemaic - Centro De Especialidades Medicas Ambulatorias E Investigacion Clinica, Cordoba, Not set

Centro Oncologico Riojano Integral (Cori), La Rioja, Not set

Macquarie University, Sydney, Not set

Institut Jules Bordet, Anderlecht, Not set

Grand Hôpital de Charleroi - Site Notre Dame, Charleroi, Not set

Universitaire Ziekenhuizen (Uz) Leuven - Campus Gasthuisberg - Multidisciplinair Borstcentrum (Multidisciplinary Breast Center) (Mbc), Leuven, Not set

Algemeen Ziekenhuis Nikolaas; VITAZ; Oncologie Klinisch Studiecentrum, Sint-Niklaas, Not set

ACCG - Hospital Araujo Jorge, Goiania, Not set

Clinica Neoplasias Litoral, Itajai, Not set

Hospital Sao Lucas da PUCRS, Porto Alegre, Not set

Centro Gaucho Integrado de Oncologia; Hematologia; Ensino e Pesquisa - Hospital Mae de Deus/AESC, Porto Alegre, Not set

Hospital Sirio-Libanes (HSL) - Centro De Oncologia - Sao Paulo, Sao Paulo, Not set

Nemocnice Horovice Hospital, Hořovice, Not set

Fakultni Nemocnice Olomouc, Olomouc, Not set

Centre Hospitalier Lyon SUD- HCL, Lyon, Not set

Centre de Cancérologie du Grand Montpellier, Montpellier, Not set

Centre de Cancérologie du Grand Montpellier, Rouen, Not set

Centre Hospitalier Universitaire (Chu) De Toulouse - Institut Universitaire Du Cancer De Toulouse-Oncopole (Iuct-Oncopole) (Institut Claudius Regaud), Toulouse, Not set

Institut Gustave-Roussy-Umr 981, Villejuif, Not set

Universitaetsklinikum Mannheim, Mannheim, Baden-Wuerttemberg

Technischen Universitaet Muenchen (TUM), Klinikum Rechts der Isar, Muenchen, Bayern

Universitatskinikum Carl Gustav Carus Dresden, Dresden, Sachsen

Marienhospital Bottrop, Bottrop, Not set

Universitatskinikum Carl Gustav Carus Dresden, Dresden, Not set

Kliniken Essen-Mitte (KEM), Essen, Not set

Gesundheit Nordhessen Klinikum Kassel, Kassel, Not set

Universitaetsklinikum Tuebingen, Tübingen, Not set

Semmelweis Egyetem Klinikai Kozpont - Onkologiai Intezet, Budapest, Not set

Orszagos Onkologiai Intezet, Budapest, Not set

Samson Assuta Ashdod University Hospital - The Institute of Oncology, Ashdod, Not set

Rambam Heath, Haifa, Not set

Shaare Zedek Medical Center, Jerusalem, Not set

Davidoff Rabin Medical Center, Petah Tikva, Not set

Sheba Medical Center; Center Israel, Ramat Gan, Not set

ASST degli Spedali Civili di Brescia, Brescia, Not set

Azienda Ospedaliera "Istituti Ospitalieri" Di Cremona, Cremona, Not set

Istituto Europeo di Oncologia (IEO), Milano, Not set

Istituto Nazionale Tumori "Fondazione PASCALE", Napoli, Not set

Azienda Ospedaliero-Universitaria Pisana, Pisa, Not set

Ospedale Infermi di Rimini - Azienda Unita Sanitaria Locale Della Romagna, Rimini, Not set

Seoul National University Bundang Hospital, Seongnam-si, Not set

Asan Medical Center, Seoul, Not set

Gangnam Severance Hospital, Seoul, Not set

The Catholic University of Korea - Seoul St. Mary's Hospital, Seoul, Not set

Korea University Anam Hospital, Seoul, Not set

Ulsan University Hospital, Ulsan, Not set

Centre Hospitalier De L'Ardenne, Libramont, Not set

Klinika Onkologii; Wojskowy Instytut Medyczny - Państwowy Instytut Badawczy, Warszawa, Mazowieckie

Przychodnia Lekarska "Komed" Roman Karaszewski, Konin, Not set

Med-Polonia Sp. Z o.o., Poznań, Not set

Instytut Centrum Zdrowia Matki Polki, Łódź, Not set

Complejo Hospitalario Universitario A Coruna, A Coruña, Not set

Hospital Universitari Vall d'Hebron, Barcelona, Not set

Hospital Clinic Barcelona, Barcelona, Not set

Hospital General Universitario Gregorio Maranon, Madrid, Not set

IOB Madrd Institute of Oncology Hospital Beata Maria Ana de Jesus, Madrid, Not set

Hospital Clinico San Carlos, Madrid, Not set

Hospital Universitario 12 de Octubre, Madrid, Not set

Hospital Universitario La Paz, Madrid, Not set

Hospital Universitario Virgen de la Victoria, Malaga, Not set

NEXT Madrid, Pozuelo de Alarcon, Not set

Fundacion Instituto Valeciano De Oncologia, Valencia, Not set

Hospital Clinico Universitario de Valencia, Valencia, Not set

Hospital Arnau De Vilanova, Valencia, Not set

Abdurrahman Yurtaslan Oncology Hospital, Ankara, Not set

Ankara Bilkent City Hospital, Bilkent Campus, Universiteler Mh. (old: Ankara Yildirim Beyazit Universitesi), Ankara, Not set

The Clatterbridge Cancer Centre NHS Foundation Trust, Liverpool, Not set

Liverpool Hospital, Liverpool, Not set

North Middlesex University Hospital, London, Not set

Sarah Cannon Research Institute UK; Ltd, London, Not set

University College London Hospitals NHS Foundation Trust; The London Clinic - Main Hospital, London, Not set

Conditions: Breast Cancer, Metastatic Breast Cancer

Learn More ›

Testing Different Amounts of the Combination of Drugs M1774 and ZEN-3694 for the Treatment of Recurrent Ovarian and Endometrial Cancer

NCT05950464

Recruiting

This phase Ib trial tests the safety, side effects, and best dose of M1774 when given with ZEN-3694 in treating patients with ovarian and endometrial cancer that has come back (recurrent). M1774 and ZEN-3694 may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. M1774 and ZEN-3694 combined together has demonstrated to be better than either drug alone in killing ovarian tumor cells.

Gender:

FEMALE

Ages:

18 years and above

Trial Updated:

04/30/2025

Locations: Augusta University Medical Center, Augusta, Georgia +13 locations

Conditions: Endometrial Carcinoma, Endometrial Clear Cell Adenocarcinoma, Endometrial Endometrioid Adenocarcinoma, Ovarian Clear Cell Adenocarcinoma, Ovarian Endometrioid Adenocarcinoma, Ovarian High Grade Serous Adenocarcinoma, Platinum-Resistant Ovarian Carcinoma, Endometrial Low Grade Endometrioid Adenocarcinoma, Ovarian Low Grade Endometrioid Adenocarcinoma

Learn More ›

Study of Opevesostat (MK-5684) Versus Alternative NHA in mCRPC (MK-5684-003)

NCT06136624

Recruiting

This is a phase 3, randomized, open-label study of opevesostat compared to alternative abiraterone acetate or enzalutamide in participants with metastatic castration-resistant prostate cancer (mCRPC) with respect to overall survival (OS) and to radiographic progression-free survival (rPFS) per Prostate Cancer Working Group (PCWG) Modified Response Evaluation Criteria In Solid Tumors (RECIST 1.1) as assessed by blinded independent central review (BICR) in participants with mCRPC previously treate... Read More

Gender:

ALL

Ages:

All

Trial Updated:

04/30/2025

Locations: University of California, Irvine (UCI) Health - UC Irvine Medical Center ( Site 0040), Orange, California +274 locations

University of California, Irvine (UCI) Health - UC Irvine Medical Center ( Site 0040), Orange, California

Stanford Cancer Center ( Site 0036), Palo Alto, California

Kaiser Permanente Riverside Medical Center ( Site 0099), Riverside, California

Anschutz Cancer Pavilion ( Site 0046), Aurora, Colorado

University of Colorado Health - Highlands Ranch Hospital ( Site 0111), Highlands Ranch, Colorado

Colorado Clinical Research ( Site 0067), Lakewood, Colorado

University of Colorado Health - Lone Tree Medical Center ( Site 0112), Lone Tree, Colorado

Yale-New Haven Hospital-Yale Cancer Center ( Site 0064), New Haven, Connecticut

Bruce W. Carter Veterans Affairs Medical Center ( Site 0082), Miami, Florida

University of Miami Hospital and Clinics, Sylvester Cancer Center ( Site 0051), Miami, Florida

University of Illinois at Chicago ( Site 0105), Chicago, Illinois

University of Chicago Medical Center ( Site 0045), Chicago, Illinois

University of Iowa ( Site 0047), Iowa City, Iowa

University of Kentucky Chandler Medical Center ( Site 0048), Lexington, Kentucky

Baltimore Veterans Affairs Medical Center ( Site 0069), Baltimore, Maryland

Greenebaum Comprehensive Cancer Center ( Site 0049), Baltimore, Maryland

Henry Ford Hospital ( Site 0015), Detroit, Michigan

M Health Fairview Clinics and Surgery Center ( Site 0019), Minneapolis, Minnesota

Metro-Minnesota Community Clinical Oncology ( Site 0014), Saint Louis Park, Minnesota

Washington University School of Medicine-Internal Medicine/Oncology ( Site 0062), Saint Louis, Missouri

University Of Nebraska Medical Center-Oncology/Hematology ( Site 0095), Omaha, Nebraska

Comprehensive Cancer Centers of Nevada ( Site 0010), Las Vegas, Nevada

Rutgers Cancer Institute of New Jersey ( Site 0033), New Brunswick, New Jersey

James J. Peters VA Medical Center ( Site 0088), Bronx, New York

University Hospitals Cleveland Medical Center ( Site 0043), Cleveland, Ohio

Oregon Health and Science University ( Site 0028), Portland, Oregon

VA Portland Health Care System ( Site 0058), Portland, Oregon

AHN Allegheny General Hospital ( Site 0001), Pittsburgh, Pennsylvania

Ralph H. Johnson VA Health Care System (RHJVAHCS)-Urology ( Site 0083), Charleston, South Carolina

Avera Cancer Institute - Pierre ( Site 0118), Pierre, South Dakota

Avera Cancer Institute- Research ( Site 0094), Sioux Falls, South Dakota

Avera Cancer Institute - Yankton ( Site 0117), Yankton, South Dakota

SCRI Oncology Partners ( Site 7000), Nashville, Tennessee

Texas Oncology - Central/South Texas ( Site 8003), Austin, Texas

Texas Oncology - Gulf Coast ( Site 8002), Houston, Texas

University of Virginia Health System ( Site 0054), Charlottesville, Virginia

VCU Health Adult Outpatient Pavillion ( Site 0061), Richmond, Virginia

Blue Ridge Cancer Care ( Site 0004), Roanoke, Virginia

Fred Hutchinson Cancer Center ( Site 0013), Seattle, Washington

MEDICAL COLLEGE OF WISCONSIN ( Site 0020), Milwaukee, Wisconsin

Hospital Británico de Buenos Aires-Oncology ( Site 0202), Ciudad autónoma de Buenos Aires, Buenos Aires

Instituto de Investigaciones Clínicas Mar del Plata ( Site 0201), Mar del Plata, Buenos Aires

Asociación de Beneficencia Hospital Sirio Libanés ( Site 0205), Buenos Aires, Caba

Instituto Alexander Fleming-Alexander Fleming ( Site 0206), Ciudad Autónoma de Buenos Aires, Caba

Sanatorio Parque ( Site 0208), Rosario, Santa Fe

Hospital Aleman-Oncology ( Site 0207), Buenos Aires, Not set

Fundacion Centro Oncologico de Integración Regional-Medical Oncology ( Site 0204), Mendoza, Not set

Dubbo Hospital ( Site 0235), Dubbo, New South Wales

Macquarie University-MQ Health Clinical Trials Unit ( Site 0234), Macquarie University, New South Wales

Westmead Hospital ( Site 0232), Westmead, New South Wales

Princess Alexandra Hospital-Cancer Care Serices ( Site 0237), Brisbane, Queensland

Peter MacCallum Cancer Centre-Parkville Cancer Clinical Trials Unit (PCCTU) ( Site 0230), Melbourne, Victoria

Ordensklinikum Linz GmbH Elisabethinen-Urologie ( Site 0276), Linz, Oberosterreich

Klinikum Wels-Grieskirchen GmbH ( Site 0279), Wels, Oberosterreich

Medizinische Universität Graz-Innere Medizin Klin. Abt. Onkologie ( Site 0280), Graz, Steiermark

Obras Sociais Irma Dulce ( Site 0302), Salvador, Bahia

Hospital Santa Rita de Cassia-Centro de Pesquisa Clínica ( Site 0320), Vitoria, Espirito Santo

Hospital Felicio Rocho ( Site 0317), Belo Horizonte, Minas Gerais

Hospital Mario Penna ( Site 0309), Belo Horizonte, Minas Gerais

Hospital Universitário Evangélico Mackenzie-Centro de Oncologia Mackenzie ( Site 0314), Curitiba, Parana

Clínica de Neoplasias Litoral ( Site 0305), Itajai, Santa Catarina

Hospital Universitário São Francisco de Assis - Bragança Paulista ( Site 0308), Bragança Paulista, Sao Paulo

A. C. Camargo Cancer Center ( Site 0310), São Paulo, Sao Paulo

Cross Cancer Institute ( Site 0332), Edmonton, Alberta

The Ottawa Hospital - General Campus-The Ottawa Hospital Cancer Centre ( Site 0336), Ottawa, Ontario

Sunnybrook Research Institute ( Site 0331), Toronto, Ontario

Princess Margaret Cancer Centre ( Site 0330), Toronto, Ontario

Centre Intégré de Santé et de Services Sociaux de la Montérégie-Centre ( Site 0328), Greenfield Park, Quebec

Centre Hospitalier de l'Université de Montréal ( Site 0326), Montréal, Quebec

Centre intégré de cancérologie du CHU de Québec Université Laval, Hôpital de l'Enfant-Jésus ( Site 0, Quebec City, Quebec

Centre intégré universitaire de santé et de services sociaux de l'Estrie - Centre Hospitalier Univer, Sherbrooke, Quebec

IC La Serena Research ( Site 0356), La Serena., Coquimbo

Clinical Research Chile SpA ( Site 0358), Valdivia, Los Rios

Clinica Universidad Catolica del Maule-Oncology ( Site 0355), Talca, Maule

FALP ( Site 0353), Santiago, Region M. De Santiago

Pontificia Universidad Catolica de Chile-Hemato-Oncology ( Site 0354), Santiago, Region M. De Santiago

Bradfordhill-Clinical Area ( Site 0351), Santiago, Region M. De Santiago

Bradford Hill Norte ( Site 0357), Antofagasta, Not set

Second Affiliated hospital of Anhui Medical University-Urology ( Site 0408), Hefei, Anhui

Peking University First Hospital-Urology ( Site 0390), Beijing, Beijing

Beijing Friendship Hospital Affiliate of Capital University ( Site 0396), Beijing, Beijing

Beijing Cancer hospital-Urinary Surgery ( Site 0395), Beijing, Beijing

The First Affiliated Hospital of Chongqing Medical University ( Site 0427), Chongqing, Chongqing

Chongqing University Cancer Hospital ( Site 0416), Chongqing, Chongqing

Southwest Hospital of Third Military Medical University ( Site 0420), Chongqing, Chongqing

Chongqing Three Gorges Central Hospital's ( Site 0426), Chongqing, Chongqing

The First Affiliated Hospital Of Fujian Medical University-Urology ( Site 0414), Fuzhou, Fujian

The First Affiliated hospital of Xiamen University-Urology ( Site 0415), Xiamen, Fujian

The First Affiliated Hospital of Guangzhou Medical University ( Site 0412), Guangzhou, Guangdong

Sun Yat-sen University Cancer Center-Internal medicine ( Site 0413), Guangzhou, Guangdong

Tongji Hospital Tongji Medical,Science & Technology ( Site 0407), Wuhan, Hubei

Hubei Cancer Hospital-Urinary surgery ( Site 0406), Wuhan, Hubei

Hunan Cancer Hospital ( Site 0405), Changsha, Hunan

First Huai'an Hospital Affiliated to Nanjing Medical University ( Site 0436), Huaian, Jiangsu

Nanjing Drum Tower Hospital The Affiliated Hospital of Nanjing University Medical School-Urology ( S, NanJing, Jiangsu

Affiliated hospital of Jiangnan university ( Site 0434), Wuxi, Jiangsu

Jiangxi Cancer Hospital ( Site 0386), Nanchang, Jiangxi

The Second Affiliated Hospital of Xi'an Jiaotong University ( Site 0394), XI An, Shaanxi

The First Affiliated Hospital of Xi'an Jiaotong University-Oncology ( Site 0393), Xi'an, Shaanxi

Yantai Yuhuangding Hospital ( Site 0397), Yantai, Shandong

Fudan University Shanghai Cancer Center-Urology department ( Site 0376), Shanghai, Shanghai

Huadong Hospital Affiliated to Fudan University-Urology ( Site 0388), Shanghai, Shanghai

West China Hospital, Sichuan University-Urology Surgery ( Site 0417), Cheng Du, Sichuan

The Third People's Hospital of Chengdu (CDTPH) ( Site 0428), Chengdu, Sichuan

Nanchong Central Hospital-urology ( Site 0422), Nanchong, Sichuan

Suining Central Hospital ( Site 0437), Suining, Sichuan

Tianjin Medical University Cancer Institute & Hospital ( Site 0392), Tianjin, Tianjin

The Second Hospital of Tianjin Medical University ( Site 0391), Tianjin, Tianjin

Xinjiang Medical University Cancer Hospital - Urumqi-Urology ( Site 0419), Urumqi, Xinjiang

The Second Affiliated Hospital Of Kunming Medical University ( Site 0429), Kunming, Yunnan

Yunnan Province Cancer Hospital ( Site 0418), Kunming, Yunnan

Zhejiang Provincial People's Hospital-Urology ( Site 0378), Hangzhou, Zhejiang

Zhejiang Cancer Hospital ( Site 0435), Hangzhou, Zhejiang

The First Hospital of Jiaxing-urology ( Site 0380), Jiaxing, Zhejiang

The First Affiliated Hospital of Ningbo University ( Site 0383), Ningbo, Zhejiang

The First Affiliated Hospital of Wenzhou Medical University-Urology Surgery ( Site 0379), Wenzhou, Zhejiang

Sociedad De Oncología y Hematología Del Cesar SAS-Oncology ( Site 0502), Valledupar, Cesar

IMAT S.A.S ( Site 0504), Monteria, Cordoba

Clinica Colsanitas S.A, Sede Clínica Universitaria Colombia-Center Investigator ( Site 0501), Bogota, Distrito Capital De Bogota

Fundación Cardiovascular de Colombia ( Site 0503), Piedecuesta, Santander

Fundación Valle del Lili ( Site 0505), Cali, Valle Del Cauca

Clínica Imbanaco S.A.S ( Site 0509), Cali, Valle Del Cauca

Masarykuv onkologicky ustav-Klinika komplexni onkologicke pece ( Site 0553), Brno, Brno-mesto

Fakultni nemocnice Ostrava-Klinika onkologicka ( Site 0554), Ostrava, Moravskoslezsky Kraj

Fakultni nemocnice Olomouc-Onkologicka klinika ( Site 0555), Olomouc, Olomoucky Kraj

Fakultni nemocnice v Motole-Onkologicka klinika 2. LF UK a FN Motol ( Site 0551), Praha, Praha 5

Rigshospitalet ( Site 0576), Copenhagen, Hovedstaden

Odense Universitetshospital-Department of oncology ( Site 0579), Odense, Syddanmark

Vejle Sygehus ( Site 0578), Vejle, Syddanmark

Tampereen yliopistollinen sairaala ( Site 0604), Tampere, Pirkanmaa

Kuopion Yliopistollinen Sairaala ( Site 0603), Kuopio, Pohjois-Savo

Turku University Hospital-Department of Oncology ( Site 0601), Turku, Varsinais-Suomi

Institut de cancérologie Strasbourg Europe (ICANS) ( Site 0627), Strasbourg, Alsace

Centre Hospitalier Universitaire de Nîmes - Institut de Cancérologie du Gard - Hôpital Universitaire, Nîmes, Gard

Centre Eugène Marquis Rennes - Centre de Lutte Contre le Cancer ( Site 0632), Rennes, Ille-et-Vilaine

Centre Jean Perrin - Centre Régional de Lutte contre le Cancer d'Auvergne ( Site 0629), Clermont-Ferrand, Puy-de-Dome

Centre Hospitalier de la Côte Basque ( Site 0633), Bayonne, Pyrenees-Atlantiques

Gustave Roussy ( Site 0626), Villejuif, Val-de-Marne

Hôpital Européen Georges Pompidou ( Site 0628), Paris, Not set

klinikum rechts der isar der technischen universität münchen-Urologische Klinik und Poliklinik ( Sit, Munich, Bayern

HELIOS Kliniken Schwerin ( Site 0694), Schwerin, Mecklenburg-Vorpommern

Universitätsklinikum Bonn-Klinik und Poliklinik für Urologie und Kinderurologie ( Site 0680), Bonn, Nordrhein-Westfalen

Universitätsklinikum Münster - Albert Schweitzer Campus-Klinik für Urologie ( Site 0678), Münster, Nordrhein-Westfalen

Universitätsklinikum Schleswig-Holstein-Klinik für Urologie ( Site 0691), Lubeck, Schleswig-Holstein

Universitätsklinikum Jena-Klinik und Poliklinik für Urologie ( Site 0682), Jena, Thuringen

Charité Universitaetsmedizin Berlin - Campus Mitte ( Site 0679), Berlin, Not set

Universitaetsklinikum Hamburg-Eppendorf-Onkologisches Zentrum ( Site 0705), Hamburg, Not set

Queen Mary Hospital ( Site 0727), Hksar, Not set

Prince of Wales Hospital ( Site 0730), Shatin, Not set

Bacs-Kiskun Varmegyei Oktatokorhaz-Onkoradiologiai Kozpont ( Site 0752), Kecskemét, Bacs-Kiskun

Nograd Varmegyei Szent Lazar Korhaz-Onkologia es Sugarterapias Osztaly ( Site 0761), Salgótarján, Nograd

Országos Onkológiai Intézet-Urogenitális Tumorok és Klinikai Farmakológiai Osztály ( Site 0756), Budapest, Pest

Debreceni Egyetem Klinikai Kozpont-Onkológiai Klinika ( Site 0758), Debrecen, Not set

St. Vincent's University Hospital ( Site 0802), Dublin, Not set

Tallaght University Hospital ( Site 0801), Dublin, Not set

Emek Medical Center ( Site 0830), Afula, Not set

Rambam Health Care Campus-Oncology Division ( Site 0826), Haifa, Not set

Hadassah Medical Center ( Site 0833), Jerusalem, Not set

Meir Medical Center. ( Site 0832), Kfar Saba, Not set

Rabin Medical Center ( Site 0828), Petah Tikva, Not set

Sheba Medical Center ( Site 0827), Ramat Gan, Not set

IRCCS - Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori"-Oncologia Medica ( Site 08, Meldola, Emilia-Romagna

Fondazione IRCCS Istituto Nazionale dei Tumori-Struttura Complessa Oncologia Medica 1 ( Site 0877), Milan, Lombardia

Ospedale San Raffaele-Oncologia Medica ( Site 0876), Milano, Not set

Toho University Sakura Medical Center ( Site 0906), Sakura, Chiba

Ehime University Hospital ( Site 0918), Toon, Ehime

Hospital of the University of Occupational and Environmental Health, Japan ( Site 0921), Kitakyushu, Fukuoka

Kurume University Hospital ( Site 0920), Kurume, Fukuoka

Asahikawa Medical University Hospital ( Site 0901), Asahikawa, Hokkaido

Sapporo Medical University Hospital ( Site 0902), Sapporo, Hokkaido

Hokkaido University Hospital ( Site 0931), Sapporo, Hokkaido

Kobe University Hospital ( Site 0914), Kobe, Hyogo

Kanazawa Medical University Hospital ( Site 0909), Uchinada, Ishikawa

Kagawa University Hospital ( Site 0917), Kita, Kagawa

Yokohama City University Medical Center ( Site 0908), Yokohama, Kanagawa

National Hospital Organization Nagasaki Medical Center ( Site 0923), Ōmura, Nagasaki

Nara Medical University Hospital ( Site 0915), Kashihara, Nara

Nanbu Tokushukai Hospital ( Site 0930), Shimajiri, Okinawa

Kansai Medical University Hospital ( Site 0912), Hirakata, Osaka

Bell Land General Hospital ( Site 0913), Sakai, Osaka

The University of Osaka Hospital ( Site 0911), Suita, Osaka

Saga-Ken Medical Centre Koseikan ( Site 0922), Saga-shi, Saga

The Jikei University Hospital ( Site 0907), Minato, Tokyo

Akita University Hospital ( Site 0904), Akita, Not set

Kyushu University Hospital ( Site 0919), Fukuoka, Not set

Fukushima Medical University Hospital ( Site 0933), Fukushima, Not set

Gifu University Hospital ( Site 0910), Gifu, Not set

Hiroshima University Hospital ( Site 0916), Hiroshima, Not set

Kagoshima University Hospital ( Site 0929), Kagoshima, Not set

National Hospital Organization Kumamoto Medical Center ( Site 0924), Kumamoto, Not set

Miyazaki Prefectural Miyazaki Hospital ( Site 0927), Miyazaki, Not set

University of Miyazaki Hospital ( Site 0926), Miyazaki, Not set

Nagano Municipal Hospital ( Site 0932), Nagano, Not set

National Hospital Organization Oita Medical Center ( Site 0925), Oita, Not set

Asan Medical Center-Oncology ( Site 1402), Songpagu, Seoul

Seoul National University Hospital-Oncology ( Site 1401), Seoul, Not set

Severance Hospital, Yonsei University Health System-Medical oncology ( Site 1404), Seoul, Not set

Samsung Medical Center ( Site 1405), Seoul, Not set

Hospital Sultan Ismail ( Site 1081), Johor Bahru, Johor

University Malaya Medical Centre ( Site 1077), Lembah Pantai, Kuala Lumpur

Sarawak General Hospital-Radiotherapy Unit ( Site 1076), Kuching, Sarawak

National Cancer Institute ( Site 1079), Putrajaya, Wilayah Persekutuan Putrajaya

Hospital Kuala Lumpur-Radiotherapy and Oncology ( Site 1078), Kuala Lumpur, Not set

Quemex Medical and Research ( Site 1112), Mexico City, Distrito Federal

CIO - Centro de Inmuno-Oncología de Occidente ( Site 1103), Guadalajara, Jalisco

Filios Alta Medicina ( Site 1106), Monterrey, Nuevo Leon

Medical Care and Research SA de CV ( Site 1108), Merida, Yucatan

Centro de Investigacion Clinica de Oaxaca ( Site 1109), Oaxaca, Not set

Medische Centrum Leeuwarden ( Site 1172), Leeuwarden, Fryslan

Radboudumc-Medical Oncology ( Site 1152), Nijmegen, Gelderland

Zuyderland Medical Centre-Trialbureau Interne Geneeskunde ( Site 1163), Sittard-Geleen, Limburg

VieCuri Medisch Centrum ( Site 1173), Venlo, Limburg

ETZ Elisabeth-Internal Medicine ( Site 1160), Tilburg, Noord-Brabant

Nederlands Kanker Instituut - Antoni van Leeuwenhoek - NKI-AVL ( Site 1153), Amsterdam, Noord-Holland

Amsterdam UMC, locatie VUmc ( Site 1156), Amsterdam, Noord-Holland

Spaarne Gasthuis - Hoofddorp-Oncology ( Site 1170), Hoofddorp, Noord-Holland

Meander Medisch Centrum ( Site 1157), Amersfoort, Utrecht

Haga Ziekenhuis locatie Leyweg-Oncology ( Site 1164), Den Haag, Zuid-Holland

Franciscus Gasthuis & Vlietland, Locatie Vlietland ( Site 1151), Schiedam, Zuid-Holland

Tauranga Hospital-Bay of Plenty Clinical Trials Unit ( Site 1201), Tauranga, Bay Of Plenty

Dunedin Hospital-Southern Blood and Cancers Service ( Site 1203), Dunedin, Otago

Akershus Universitetssykehus-Onkologisk avdeling ( Site 1227), Lørenskog, Akershus

Sykehuset Østfold Kalnes ( Site 1228), Sarpsborg, Ostfold

St. Olavs Hospital-Kreftklinikken ( Site 1231), Trondheim, Sor-Trondelag

Instituto Regional de Enfermedades Neoplasicas del Centro (IREN CENTRO) ( Site 1258), Concepcion, Junin

Clínica Sánchez Ferrer ( Site 1261), Trujillo, La Libertad

Aliada-Oncologìa ( Site 1257), Lima, Not set

IPOR Instituto Peruano de Oncología & Radioterapia-Centro de Investigación ( Site 1254), Lima, Not set

Oncosalud-Clinical Research ( Site 1260), Lima, Not set

INSTITUTO NACIONAL DE ENFERMEDADES NEOPLASICAS-Medical Oncology ( Site 1256), Lima, Not set

Centrum Onkologii im. Prof. Franciszka Lukaszczyka-Ambulatorium Chemioterapii ( Site 1302), Bydgoszcz, Kujawsko-pomorskie

Regionalny Szpital Specjalistyczny im. dr. Władyslawa Biegańskiego ( Site 1316), Grudziadz, Kujawsko-pomorskie

Wojewodzki Szpital Zespolony im Ludwika Rydygiera w Toruniu ( Site 1304), Torun, Kujawsko-pomorskie

Mazowiecki Szpital Wojewódzki w Siedlcach-Siedleckie Centrum Onkologii ( Site 1310), Siedlce, Mazowieckie

Swietokrzyskie Centrum Onkologii, Samodzielny Publiczny Zakl-Klinika Onkologii Klinicznej, Dzial Ch, Kielce, Swietokrzyskie

Szpital Wojewódzki im. Mikoaja Kopernika w Koszalinie-Oddzial Dzienny Chemioterapii ( Site 1303), Koszalin, Zachodniopomorskie

Zachodniopomorskie Centrum Onkologii ( Site 1311), Szczecin, Zachodniopomorskie

Puerto Rico Medical Research Center LLC ( Site 1354), Hato Rey, Not set

Ad-Vance Medical Research-Research ( Site 1353), Ponce, Not set

Pan American Center for Oncology Trials - Ciudadela ( Site 1351), San Juan, Not set

National University Hospital ( Site 1376), Singapore, Central Singapore

National Cancer Centre Singapore ( Site 1377), Singapore, Central Singapore

Tan Tock Seng Hospital-Medical Oncology ( Site 1378), Singapore, Central Singapore

Hospital Jerez de la Frontera ( Site 1427), Jerez de la Frontera, Cadiz

Hospital Universitario Ramón y Cajal-Medical Oncology ( Site 1431), Madrid, Madrid, Comunidad De

Hospital Universitario 12 de Octubre-Medical Oncology ( Site 1433), Madrid, Madrid, Comunidad De

Complexo Hospitalario Universitario de Ourense ( Site 1426), Ourense, Orense

Fundación Instituto Valenciano de Oncología-Oncologico ( Site 1430), Valencia, Valenciana, Comunitat

Hospital Lucus Augusti-Oncology ( Site 1432), Lugo, Not set

HOSPITAL UNIVERSITARIO VIRGEN DEL ROCIO-Medical Oncology ( Site 1428), Sevilla, Not set

Karolinska Universitetssjukhuset Solna ( Site 1478), Stockholm, Stockholms Lan

Akademiska sjukhuset-Blod- och tumörsjukdomar ( Site 1477), Uppsala, Uppsala Lan

Sahlgrenska Universitetssjukhuset ( Site 1479), Gothenburg, Vastra Gotalands Lan

China Medical University Hospital-Department of Urology ( Site 1503), Taichung, Not set

National Cheng Kung University Hospital-Urology ( Site 1502), Tainan, Not set

National Taiwan University Hospital-Urology ( Site 1506), Taipei, Not set

Taipei Veterans General Hospital ( Site 1505), Taipei, Not set

Chang Gung Medical Foundation-Linkou Branch-Medical Oncology ( Site 1504), Taoyuan, Not set

Faculty of Medicine - Khon Kaen University ( Site 1526), Muang, Khon Kaen

Chulalongkorn University ( Site 1530), Bangkok, Krung Thep Maha Nakhon

Faculty of Medicine Siriraj Hospital ( Site 1531), Bangkok, Krung Thep Maha Nakhon

Songklanagarind hospital ( Site 1527), Hatyai, Songkhla

Baskent University Dr. Turgut Noyan Research and Training Center-ONCOLOGY ( Site 1554), Adana, Not set

Gulhane Egitim Arastirma Hastanesi ( Site 1558), Ankara, Not set

Hacettepe Universite Hastaneleri-oncology hospital ( Site 1551), Ankara, Not set

Memorial Ankara Hastanesi-Medical Oncology ( Site 1557), Ankara, Not set

Ankara Bilkent Şehir Hastanesi-Medical Oncology ( Site 1552), Ankara, Not set

Istanbul Universitesi Cerrahpasa-Medical Oncology ( Site 1555), Istanbul, Not set

TC Saglik Bakanligi Goztepe Prof. Dr. Suleyman Yalcin Sehir Hastanesi-oncology ( Site 1553), Istanbul, Not set

Addenbrooke's Hospital ( Site 1605), Cambridge, Cambridgeshire

The Royal Cornwall Hospital ( Site 1610), Truro, England

The Beatson West of Scotland Cancer Centre ( Site 1603), Glasgow, Glasgow City

Charing Cross Hospital-Oncology Research ( Site 1606), London, Hammersmith And Fulham

University College London Hospital ( Site 1612), London, London, City Of

The Christie NHS Foundation Trust ( Site 1608), Manchester, Not set

Conditions: Prostate Cancer Metastatic

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Placebo Impacts Sleep and Pain Modulation in Chronic Pain

NCT06225817

Recruiting

The goal of this free-choice parallel design clinical trial is to examine the potential beneficial effects of using open-label placebo (OLP) in improving chronic pain related outcomes and sleep quality in people with temporomandibular disorders. This study will enroll a cohort of participants with temporomandibular disorders (TMD) which lasts for more than 3 months. The main questions it aims to answer are: 1. Will participants with TMD be more likely to take open-label placebo pills if they are introduced to the effects of placebo (e.g., going through an expectation management session)? 2. Will taking open-label placebo plus expectation management improve chronic pain related outcomes, such as chronic pain intensity, interference, levels of anxiety and depression, in the cohort of TMD? 3. Will open-label placebo plus expectation management improve sleep quality in participants suffering from TMD? To answer the above questions, participants with TMD will be randomly assigned to three groups: 1. Open-label placebo plus expectation management group, where participants will complete a 1-hour discussion session about their expectations toward open-lable placebo intervention, and then take 1 open-labe placebo pill per day for a total of 45 days. 2. Open-label placebo only group where participants will be asked to take open-label placebo pills, one pill per day, for a total of 45 days. 3. standard of care group where participants will maintain their usual care without introducing open-label placebo to them during the 45 days monitoring. Researchers will compare the chronic pain intensity, interference, mood, anxiety, and sleep quality between the open-label placebo group and the wait-list group. Daily chronic pain will be measured using visual analog scale (VAS) ranging from 0=no pain at all to 100=maximum tolerable pain. Chronic pain interference using Patient-Reported Outcomes Measurement Information System (PROMIS) pain interference and pain behavior. Anxiety and depression will be measured using PROMIS-anxiety, and PROMIS-depression scales respectively. Finally, sleep quality will be quantified using the objective measurement Motion Watch during the 45 days intervention and monitoring. In order to have a rigorous measurement of the baseline pain and sleep fluctuation, this study will include a 7-day phenotyping period before the starting of the 45-day intervention and monitoring. During the 7-day phenotyping period, participants will record their daily chronic pain and sleep quality using polysomnography. Read Less

Gender:

ALL

Ages:

Between 18 years and 88 years

Trial Updated:

04/30/2025

Locations: University of Maryland Baltimore School of Nursing, Baltimore, Maryland

Conditions: Headache, Chronic Pain

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