Sequential and Comparative Evaluation of Pain Treatment Effectiveness Response
NCT04142177
Recruiting
VETERANS ONLY. Chronic low back pain (cLBP) is common. Most Americans will have at least one episode of low back pain in their lifetimes. Approximately 50% of all US Veterans have chronic pain, and CLBP is the most common type of pain in this population. This study will use a sequential randomized, pragmatic, 2-step comparative effectiveness study design. The main goal is to identify the best approach for treating cLBP using commonly recommended non-surgical and non-pharmacological options. The... Read More
Gender:
ALL
Ages:
All
Trial Updated:
05/15/2025
Locations: Phoenix VA Health Care System, Phoenix, AZ, Phoenix, Arizona +18 locations
Conditions: Chronic Low Back Pain
Register for Updates
A Study to Compare Two Surgical Procedures in Individuals With BRCA1 Mutations to Assess Reduced Risk of Ovarian Cancer
NCT04251052
Recruiting
This clinical trial evaluates how well two surgical procedures (bilateral salpingectomy and bilateral salpingo-oophorectomy) work in reducing the risk of ovarian cancer for individuals with BRCA1 mutations. Bilateral salpingectomy involves the surgical removal of fallopian tubes, and bilateral salpingo-oophorectomy involves the surgical removal of both the fallopian tubes and ovaries. This study may help doctors determine if the two surgical procedures are nearly the same for ovarian cancer risk... Read More
Gender:
FEMALE
Ages:
Between 35 years and 50 years
Trial Updated:
05/15/2025
Locations: University of Alabama at Birmingham Cancer Center, Birmingham, Alabama +508 locations
Conditions: Ovarian Carcinoma
Register for Updates
NBTXR3 and Radiation Therapy for the Treatment of Inoperable Recurrent Non-small Cell Lung Cancer
NCT04505267
Recruiting
This phase I trial investigates the best dose and side effects of NBTXR3 when given together with radiation therapy for the treatment of non-small cell lung cancer that cannot be treated by surgery (inoperable) and has come back (recurrent). NBTXR3 is a radio-enhancer designed to increase the radiotherapy energy dose deposition inside tumor cells. Radiation therapy uses high energy x-rays to kill tumor cells and shrink tumors. Giving NBTXR3 and radiation therapy may increase radiation-dependent... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/15/2025
Locations: M D Anderson Cancer Center, Houston, Texas
Conditions: Recurrent Lung Non-Small Cell Carcinoma, Stage I Lung Cancer AJCC v8, Stage IA1 Lung Cancer AJCC v8, Stage IA2 Lung Cancer AJCC v8, Stage IA3 Lung Cancer AJCC v8, Stage IB Lung Cancer AJCC v8, Stage II Lung Cancer AJCC v8, Stage IIA Lung Cancer AJCC v8, Stage IIB Lung Cancer AJCC v8, Stage III Lung Cancer AJCC v8, Stage IIIA Lung Cancer AJCC v8, Stage IIIB Lung Cancer AJCC v8, Stage IIIC Lung Cancer AJCC v8, Unresectable Lung Non-Small Cell Carcinoma
Register for Updates
Role of Diet on the Microbiome of the Digestive System
NCT04666727
Recruiting
This study is to learn more about how diet affects the microbiome (bacteria and microorganisms) of the digestive system. Researchers want to learn if this, in turn, has an effect on if and how people then develop colorectal cancer.
Gender:
ALL
Ages:
45 years and above
Trial Updated:
05/15/2025
Locations: M D Anderson Cancer Center, Houston, Texas
Conditions: Colorectal Carcinoma
Register for Updates
Categorized PT for Non-arthritic Hip and Groin Pain
NCT04720846
Recruiting
There is currently limited literature on a categorized physical therapy protocol for management of hip pain. Only a handful of studies have looked at the treatment of osteoarthritis of the hip with a standardized physical therapy treatment, primarily looking at manual therapy versus exercise therapy protocols. However, there are no studies observing the effect of a standardized physical therapy program on patients presenting with non-arthritic hip and groin pain. Based on the gap in the literatu... Read More
Gender:
ALL
Ages:
Between 18 years and 60 years
Trial Updated:
05/15/2025
Locations: Hospital for Special Surgery, New York, New York
Conditions: Hip Pain, Groin Pain
Register for Updates
Evaluating the Implementation and Impact of Navigator-delivered ePRO System
NCT04809740
Recruiting
1) Evaluate implementation of navigator-delivered Home ePRO for all cancer patients across multiple practice sites; 2) examine the barriers, facilitators, and implementation strategies used in implementing navigator-delivered Home ePRO; and 3) assess the impact of Home ePRO on clinical and utilization outcomes.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/15/2025
Locations: University of Alabama at Birmingham, Birmingham, Alabama +1 locations
Conditions: Cancer
Register for Updates
A Phase 1/2/3 Study of UX701 Gene Therapy in Adults With Wilson Disease
NCT04884815
Recruiting
The primary objectives of this study are to evaluate the safety of single IV doses of UX701 in patients with Wilson disease, to select the UX701 dose with the best benefit/risk profile based on the totality of safety and efficacy data and to evaluate the effect of UX701 on copper regulation.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/15/2025
Locations: University of California Los Angeles, Los Angeles, California +16 locations
Conditions: Wilson Disease
Register for Updates
Angiotensin II in Liver Transplantation
NCT04901169
Recruiting
The purpose of this study is to determine the efficacy and safety of Angiotensin II as a second-line vasopressor (drug that raises the blood pressure) during liver transplantation.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/15/2025
Locations: University of California, San Francisco, San Francisco, California
Conditions: Liver Transplant; Complications, Vasoplegia
Register for Updates
EUS-RFA PANCARDINAL-1 Trial
NCT04990609
Recruiting
The objectives of this study are to determine the feasibility, tolerability, and treatment effect of endoscopic ultrasound (EUS) radiofrequency ablation (RFA) plus standard-of-care neoadjuvant chemotherapy (NAC) in the treatment of pancreatic ductal adenocarcinoma (PDAC). Endoscopic ultrasound (EUS) radiofrequency ablation (RFA) and neoadjuvant chemotherapy (NAC) will be performed before tumor resection surgery, with the goal of shrinking a tumor or stopping the spread of cancer so that surgery... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/15/2025
Locations: Memorial Hermann Hospital, Houston, Texas
Conditions: Pancreatic Ductal Adenocarcinoma (PDAC)
Register for Updates
Autologous Mitochondrial Transplant for Cerebral Ischemia
NCT04998357
Recruiting
The investigators propose to infuse healthy autologous mitochondria into cerebral vessels supplying brain tissue experiencing ischemia in patients who undergo standard-of- care endovascular reperfusion therapy.
Gender:
ALL
Ages:
Between 18 years and 85 years
Trial Updated:
05/15/2025
Locations: Harborview Medical Center, Seattle, Washington
Conditions: Cerebral Ischemia
Register for Updates
Biorepository and Registry for Plasma Exchange Patients
NCT05004493
Recruiting
Patients who have immune mediated diseases commonly undergo plasma exchange (PLEX) procedures to remove pathological substances, typically believed to be antibodies. At our facility about 400 of these procedures are performed annually on 40-60 different patients. These procedures are considered within the standard of care for these patients and are covered by insurance. This study will not influence the treatment plan for subjects who participate in this study. The goal of the study is to collec... Read More
Gender:
ALL
Ages:
Between 12 years and 99 years
Trial Updated:
05/15/2025
Locations: DeGowin blood Center, Iowa City, Iowa
Conditions: Antibody-mediated Rejection, NMO Spectrum Disorder, TTP, CIDP
Register for Updates
Late Onset Alzheimer's Disease
NCT05010603
Recruiting
The goal of this study is to is to focus on the genetic influences on Alzheimer's Disease (AD) risk. The investigators are looking for families and/or individuals (affected or unaffected) of any ethic background (African American, Caucasian, and Hispanics) with a family history of AD and willing to participate.
Gender:
ALL
Ages:
55 years and above
Trial Updated:
05/15/2025
Locations: University of Washington, Washington, District of Columbia +11 locations
Conditions: Alzheimer Disease
Register for Updates