Testing Olaparib for One or Two Years, With or Without Bevacizumab, to Treat Ovarian Cancer
NCT06580314
Recruiting
This phase III trial compares the effect of olaparib for one year versus two years, with or without bevacizumab, for the treatment of BRCA 1/2 mutated or homologous recombination deficient stage III or IV ovarian cancer. Olaparib is a polyadenosine 5'-diphosphoribose polymerase (PARP) enzyme inhibitor and may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Bevacizumab is in a class of medications called antiangiogenic agents. It works by stopping the format... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/15/2025
Locations: University of Alabama at Birmingham Cancer Center, Birmingham, Alabama +510 locations
Conditions: Fallopian Tube Endometrioid Adenocarcinoma, Fallopian Tube High Grade Serous Adenocarcinoma, FIGO Stage III Ovarian Cancer 2014, FIGO Stage IV Ovarian Cancer 2014, Ovarian Carcinoma, Primary Peritoneal Endometrioid Adenocarcinoma, Primary Peritoneal High Grade Serous Adenocarcinoma, Ovarian High Grade Serous Adenocarcinoma, Ovarian High Grade Endometrioid Adenocarcinoma
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At-Home taVNS - Stroke Rehab
NCT06616831
Recruiting
Early evidence suggests the benefits of post-stroke motor rehabilitation may be enhanced by applying electrical stimulation to the ear. This study aims to test the new approach of pairing ear stimulation with motor rehabilitation in the home setting in stroke survivors with upper limb motor function deficits.
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
05/15/2025
Locations: Medical University of South Carolina, Charleston, South Carolina
Conditions: Stroke, Stroke, Ischemic, Stroke Hemorrhagic
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Group Exposure Workshops for Socially Anxious Undergraduates
NCT06673407
Recruiting
The purpose of the study is to investigate the effects of four versions of a workshop for social anxiety and public speaking stress. All participants are current University of Colorado Boulder undergraduate students. Participation in this research study lasts for approximately 8 weeks, and includes a pre-workshop questionnaire, 3 weekly workshop sessions (ranging from 2 to 3 hours each, including a 5-minute post-session questionnaire), a post-workshop questionnaire, and a 1-month follow-up quest... Read More
Gender:
ALL
Ages:
Between 18 years and 30 years
Trial Updated:
05/15/2025
Locations: Renee Crown Wellness Institute and Department of Psychology & Neuroscience, University of Colorado Boulder, Boulder, Colorado
Conditions: Social Anxiety Disorder, Public Speaking Fear, Public Speaking Anxiety, Social Fear
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Colorectal Metastasis to Liver Extraction With Auxiliary Transplant and Delayed Resection
NCT06698146
Recruiting
Liver transplantation (LT) has become an accepted treatment for selected patients with unresectable liver metastases due to colorectal cancer (CRLM). The goal of this study is to look at and compare the clinical results of all the different approved methods (living vs. Deceased, whole organ vs. Split, one staged vs. Two staged) used to perform a standard liver transplant procedure for recipients with CRLM. Investigators will look at things like different procedure results, recovery in the hospit... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/15/2025
Locations: Northwestern University-Comprehensive Transplant Center, Chicago, Illinois
Conditions: Liver Transplant Surgery, Colorectal Cancer Metastatic, Colon Cancer Liver Metastases
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Pilot of a Trial Enrollment Diversity Dashboard
NCT06795139
Recruiting
The goal of this study is to test the feasibility of a data visualization tool called the Trial Enrollment Diversity Dashboard (TEDD) to ensure participant diversity in acute leukemia trial enrollment.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/15/2025
Locations: Dana-Farber Cancer Institute, Boston, Massachusetts
Conditions: Leukemia, Acute Leukemia
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Improving Parental Support in Hypospadias Care
NCT06832280
Recruiting
The proposed study will enroll parent-child pairs and is designed to obtain new knowledge and improve hypospadias care. Parent-child pairs will be randomized into different groups over 36 months and participate for at least 6 months.
Gender:
ALL
Ages:
All
Trial Updated:
05/15/2025
Locations: Indiana University, Indianapolis, Indiana +1 locations
Conditions: Hypospadias
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Ritual Synbiotic+, a Dietary Supplement Designed to Impact Gastrointestinal Health, Mood, and Behavior in Women
NCT06834984
Recruiting
The aim of this study is to determine how regular consumption of Synbiotic+, a dietary supplement that contains prebiotics, probiotics, and postbiotics, impacts functional gastrointestinal health, markers of intestinal inflammation and immune health, and influences mood and behavior. The primary outcome will be to assess gastrointestinal health using bowel movement tracking, self-report and objective assessments of gastrointestinal symptom severity, stool levels of short chain fatty acids, chang... Read More
Gender:
FEMALE
Ages:
Between 25 years and 65 years
Trial Updated:
05/15/2025
Locations: Colorado State University Food and Nutrition Clinical Research Laboratory, Fort Collins, Colorado
Conditions: Gastrointestinal Disease Symptoms
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Pulsed Electromagnetic Field Treatment With Dementia Patients
NCT06862557
Recruiting
An open label pilot study in mild to moderate AD/ADRD patients to assess the effects of treatment with ECHS AD/ADRD pulsed electromagnetic treatment device on disease progression. Enrolled patients will receive active devices. They will treat themselves at home three times a day for 15 minutes over 120 days. Primary end point is the The Alzheimer's Disease Assessment Scale-Cognitive Subscale. Participants will be followed-up for 9 months post-treatment.
Gender:
ALL
Ages:
Between 50 years and 100 years
Trial Updated:
05/15/2025
Locations: University of Miami, Boca Raton, Florida
Conditions: Alzheimer's Disease, Lewy Body Dementia, Vascular Dementia
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ZTE MRI Pulse Sequence Use for Visualization of Bone Cement, Breast Biopsy Markers
NCT06873802
Recruiting
This study is being done to determine if a clinically available MRI sequence called ZTE imaging better visualizes breast biopsy markers made of bone cement compared to the currently used breast biopsy markers made of metal.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/15/2025
Locations: Mayo Clinic in Rochester, Rochester, Minnesota
Conditions: Breast Carcinoma
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Sweet Corn and Carotenoids
NCT06892444
Recruiting
This study will assess the effect of daily yellow and white sweet corn intake on serum lutein and zeaxanthin concentrations. Skin carotenoid levels using the Veggie Meter will be assessed, and gastrointestinal symptoms and changes in fecal microbiota during a 4-week intervention period will be monitored.
Gender:
ALL
Ages:
Between 18 years and 90 years
Trial Updated:
05/15/2025
Locations: University of Florida, Gainesville, Florida
Conditions: Carotenoids
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Breastmilk in Response to a Bout of Exercise
NCT06892483
Recruiting
The purpose of this study is to unveil the mechanistic benefits of a bout of postpartum maternal exercise on infant health that are provided by breastmilk.
Gender:
FEMALE
Ages:
Between 18 years and 45 years
Trial Updated:
05/15/2025
Locations: Mayo Clinic, Rochester, Minnesota
Conditions: Infant Development, Obesity, Childhood, Diabetes, Childhood-Onset
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Communication About Sexual Health in Gynecologic Cancer
NCT06904339
Recruiting
The goal of this clinical trial is to learn if an educational video and workbook can help gynecologic cancer patients talk to their cancer providers about sexual health concerns. The main questions it aims to answer are: 1. Do gynecologic cancer patients who take part in the educational program and get a resource booklet talk to their cancer clinicians more about sexual health concerns than patients who get a resource booklet alone? 2. Do gynecologic cancer patients who take part in the educat... Read More
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
05/15/2025
Locations: Fox Chase Cancer Center, Philadelphia, Pennsylvania
Conditions: Gynecologic Cancers
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