All Clinical Trials

A listing of 23115 clinical trials actively recruiting volunteers for paid trials and research studies in various therapeutic areas.

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Featured Trial

Healthy Participants Needed (Colonoscopy + Cancer Screening)

Recruiting

Earn $325 - $475 in electronic payment card compensation for your time and effort by participating in a clinical study to develop a blood test that may one day help screen for colon cancer. Take a quick quiz to see if you qualify.

Conditions:

Healthy

Healthy Volunteers

Healthy Subjects

Healthy Volunteer

Healthy Participants

Learn More

Featured Trial

Buy Retatrutide Online Through Celia

Recruiting

Retatrutide (formerly M25) is an investigational peptide being studied for its potential in supporting weight management and metabolic health. It acts on GLP-1, GIP, and glucagon receptors to influence appetite, energy regulation, and fat metabolism.

Conditions:

Healthy

Learn More

Featured Offer

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Policy Lab has partnered with OnlineSemaglutide.org to offer trusted access to tirzepatide and other GLP-1 medications, including generic alternatives to Ozempic® and Wegovy®.

Semaglutide and Tirzepatide are advanced GLP-1 medications designed to support weight management and metabolic health. They work by targeting GLP-1 receptors in the body, helping regulate appetite, improve blood sugar control, and support sustainable weight loss (up to 22% of body weight).

Get $50 off your first order using promo code: policy-lab-50

Conditions:

Overweight

Overweight and Obesity

Obesity

Weight Loss

Morbid Obesity

Learn More

Featured Trial

Birth Control Clinical Research Study

Recruiting

Living with obesity and looking for a birth control option that is right for you? Clinical trials are now enrolling women with a body mass index (BMI) of 30 or more in the area to help study a potential new progestin-only contraceptive patch. Participating in research studies can help advance birth control options. Don’t let financial stress hold you back. All study-related assessments, care, and study patch are available at no cost. You may also be reimbursed for study-related travel.

Conditions:

Obesity

Overweight

Overweight and Obesity

Learn More

Featured Trial

Depression Clinical Trial

Recruiting

Join us in researching a potential investigational treatment for Depression. Reimbursement for study-related expenses may be available to you.

Qualifying participants:
•Are between 18-65
•Have been experiencing a major depressive episode for at least a month

Conditions:

Depression

Major Depressive Disorder

Depressive Disorder

Depressive Symptoms

Depressive Disorder

Learn More

Featured Offer

Ketamine Therapy—At Home, Clinician-Guided (Innerwell)

If you’re exploring options besides a clinical trial, Innerwell provides at-home ketamine therapy with medical oversight and structured support. Ketamine-assisted treatment may help “reset” rigid stress and mood patterns, and some people feel relief within a few sessions. Your care team works with you to tailor treatment and track progress every step of the way. Proven effective for Anxiety, PTSD, Depression, Addiction, and other disease areas.

Conditions:

Anxiety

Anxiety Disorders

Generalized Anxiety Disorder

Depression

Learn More

A Study to Assess the Relative Bioavailability of Oral ABBV-932 in Healthy Adult Participants

NCT06849791

Recruiting

This study will assess the relative bioavailability and effect of food on pharmacokinetics of ABBV-932 oral administration in healthy adult participants.

Gender:

ALL

Ages:

Between 18 years and 65 years

Trial Updated:

08/21/2025

Locations: Acpru /Id# 266649, Grayslake, Illinois

Conditions: Healthy Volunteer

Learn More ›

Low-Dose Danazol for the Treatment of Telomere Related Diseases

NCT03312400

Recruiting

Background: DNA is a structure in the body. It contains data about how the body develops and works. Telomeres are found on the end of chromosomes in DNA. Some people with short telomeres or other gene changes can develop diseases of the bone marrow, lung, and liver. Researchers want to see if low doses of the hormone drug danazol can help. Objective: To study the safety and effect of low dose danazol. Eligibility: People ages 3 and older with a telomere disease who have either very short te... Read More

Gender:

ALL

Ages:

Between 3 years and 99 years

Trial Updated:

08/21/2025

Locations: National Institutes of Health Clinical Center, Bethesda, Maryland

Conditions: Telomere Disease

Learn More ›

A Study of Adagrasib Plus Pembrolizumab Plus Chemotherapy vs. Placebo Plus Pembrolizumab Plus Chemotherapy in Participants With Previously Untreated Non-squamous Non-small Cell Lung Cancer With KRAS G12C Mutation (KRYSTAL-4)

NCT06875310

Recruiting

This is a trial to evaluate the efficacy, safety, and tolerability of adagrasib plus pembrolizumab plus platinum-doublet chemotherapy versus placebo plus pembrolizumab plus platinum-doublet chemotherapy in participants with previously untreated, locally advanced or metastatic NSCLC with KRAS G12C mutation

Gender:

ALL

Ages:

18 years and above

Trial Updated:

08/21/2025

Locations: Local Institution - 0347, Birmingham, Alabama +328 locations

Local Institution - 0347, Birmingham, Alabama

Local Institution - 0581, Fullerton, California

Local Institution - 0202, Long Beach, California

Local Institution - 0643, Newport Beach, California

Local Institution - 0666, Orange, California

Local Institution - 0623, Santa Barbara, California

Local Institution - 0442, Denver, Colorado

Local Institution - 0651, Gainesville, Florida

Local Institution - 0621, Palm Bay, Florida

Local Institution - 0377, Tamarac, Florida

Local Institution - 0647, Tampa, Florida

Local Institution - 0392, Fort Eisenhower, Georgia

Local Institution - 0031, Marietta, Georgia

Local Institution - 0665, Arlington Heights, Illinois

Local Institution - 0423, Munster, Indiana

Local Institution - 0366, Edgewood, Kentucky

Local Institution - 0566, Louisville, Kentucky

Local Institution - 0644, Shreveport, Louisiana

Local Institution - 0385, Columbia, Maryland

Local Institution - 0019, Boston, Massachusetts

Local Institution - 0437, Worcester, Massachusetts

Local Institution - 0618, White Plains, New York

Local Institution - 0624, Asheville, North Carolina

Local Institution - 0672, Salisbury, North Carolina

Local Institution - 0620, Columbus, Ohio

Local Institution - 0657, York, Pennsylvania

Local Institution - 0658, Greenville, South Carolina

Local Institution - 0652, Laredo, Texas

Local Institution - 0622, San Antonio, Texas

Instituto Alexander Fleming, Ciudad Autónoma de Buenos Aires, Buenos Aires

IDIM - Instituto de Investigaciones Metabólicas, Ciudad de Buenos Aires, Buenos Aires

Local Institution - 0584, Pilar, Buenos Aires

Hospital Italiano de Buenos Aires, ABB, Ciudad Autónoma De Buenos Aires

Local Institution - 0571, Buenos Aires, Ciudad Autónoma De Buenos Aires

Clinica Adventista Belgrano, Caba, Ciudad Autónoma De Buenos Aires

Sanatorio Plaza, Rosario, Santa Fe

Local Institution - 0126, Canberra, Australian Capital Territory

Tamworth Hospital, North Tamworth, New South Wales

Orange Hospital, Orange, New South Wales

Princess Alexandra Hospital, Brisbane, Queensland

Lyell McEwin Hospital, Elizabeth Vale, South Australia

Frankston Hospital, Frankston, Victoria

Northern Hospital, Melbourne, Victoria

Latrobe Regional Health, Traralgon, Victoria

Joondalup Health Campus, Joondalup, Western Australia

Klinikum Wels-Grieskirchen GmbH, Wels, Oberösterreich

Medizinische Universität Graz, Graz, Steiermark

Kepler Universitätsklinikum, Linz, Not set

Medizinische Universität Wien, Wien, Not set

Local Institution - 0673, Wien, Not set

UZ Brussel, Brussels, Bruxelles-Capitale, Région De

Cliniques universitaires Saint-Luc, Brussels, Bruxelles-Capitale, Région De

Jessa Ziekenhuis, Hasselt, Limburg

AZ Maria Middelares, Gent, Oost-Vlaanderen

UZ Leuven, Leuven, Vlaams-Brabant

Centre Hospitalier Universitaire de Liège - Domaine Universitaire du Sart Tilman, Liège, Not set

Local Institution - 0257, Salvador, Bahia

Local Institution - 0242, Vitória, Espírito Santo

Local Institution - 0244, Belo Horizonte, Minas Gerais

Local Institution - 0235, Ijui, Rio Grande Do Sul

Local Institution - 0233, Porto Alegre, Rio Grande Do Sul

Local Institution - 0238, Santa Cruz do Sul, Rio Grande Do Sul

Local Institution - 0243, Porto Velho, Rondonia

Local Institution - 0237, Blumenau, Santa Catarina

Local Institution - 0245, Itajaí, Santa Catarina

Local Institution - 0240, Barretos, São Paulo

Local Institution - 0254, Sao Paulo, São Paulo

Local Institution - 0241, São Carlos, São Paulo

Local Institution - 0239, São José do Rio Preto, São Paulo

Local Institution - 0236, Rio de Janeiro, Not set

Local Institution - 0258, São Paulo, Not set

Local Institution - 0629, Panagyurishte, Pazardzhik

Local Institution - 0628, Sofia, Sofia (stolitsa)

Complex Oncology Center - Ruse EOOD, Ruse, Not set

Trakia Hospital, Stara Zagora, Not set

Local Institution - 0074, Halifax, Nova Scotia

Local Institution - 0559, Montreal, Quebec

Bradfordhill, Recoleta, Región Metropolitana De Santiago

FALP, Santiago, Región Metropolitana De Santiago

The First Afflilated Hospital of Bengbu Medical College, Bengbu, Anhui

Anhui Provincial Hospital, Hefei, Anhui

Beijing Cancer hospital, Beijing, Beijing

Local Institution - 0491, Beijing, Beijing

Local Institution - 0397, Beijing, Beijing

Chongqing University Cancer Hospital, Chongqing, Chongqing

Local Institution - 0362, Fuzhou Fujian, Fujian

The First Affiliated hospital of Xiamen University, Xiamen, Fujian

The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong

The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong

Cancer Hospital of Shantou University Medical College, Shantou, Guangdong

Cancer Hospital Chinese Academy of Medical Sciences. Shenzhen Center, Shenzhen, Guangdong

ShenZhen People's Hospital, Shenzhen, Guangdong

Guangxi Medical University Affiliated Tumor Hospital, Nanning, Guangxi

Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei

Harbin Medical University Cancer Hospital, Harbin, Heilongjiang

Nanyang City Center Hospital, Nanyang, Henan

The First Affiliated Hospital of Xinxiang Medical University, Xinxiang, Henan

Tongji Hospital Tongji Medical,Science & Technology, Wuhan, Hubei

Local Institution - 0398, Changsha, Hunan

Local Institution - 0371, Nanjing, Jiangsu

The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu

Northern Jiangsu People's Hospital, Yangzhou, Jiangsu

The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi

The First Hospital of Jilin University, Changchun, Jilin

The First Hospital of China Medical University, Shenyang, Liaoning

Shengjing Hospital of China Medical University, Shenyang, Liaoning

Local Institution - 0493, Shenyang, Liaoning

Shandong Cancer Hospital, Jinan, Shandong

LinYi Cancer Hospital, Linyi, Shandong

Local Institution - 0470, Shanghai, Shanghai

Local Institution - 0381, Shanghai, Shanghai

Shanxi Cancer Hospital, Taiyuan, Shanxi

West China Hospital, Sichuan University, Cheng Du, Sichuan

Sichuan Cancer hospital, Chengdu, Sichuan

Tianjin Medical University General Hospital, Tianjin, Tianjin

Local Institution - 0462, Hangzhou, Zhejiang

Sir Run Run Shaw Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang

Zhejiang Cancer Hospital, Hangzhou, Zhejiang

Taizhou Hospital of Zhejiang Province, Linhai, Zhejiang

Shanghai East Hospital, Shanghai, Not set

Local Institution - 0580, Medellín, Antioquia

Local Institution - 0171, Rionegro, Antioquia

Local Institution - 0191, Puerto Colombia, Atlántico

Local Institution - 0253, Valledupar, Cesar

Local Institution - 0167, Montería, COR

Local Institution - 0671, Bogota, Cundinamarca

Local Institution - 0189, Bogotá, Distrito Capital De Bogotá

Local Institution - 0170, Floridablanca, Santander

Local Institution - 0173, Cali, Valle Del Cauca

Local Institution - 0619, Dubrovnik, Dubrovačko-neretvanska Županija

Local Institution - 0664, Rijeka, Primorsko-goranska Županija

Local Institution - 0639, Split, Splitsko-dalmatinska Županija

Local Institution - 0567, Osijek, Not set

Local Institution - 0585, Zagreb, Not set

Local Institution - 0159, Mulhouse, Alsace

Centre François Baclesse, Caen, Calvados

Centre Georges François Leclerc, Dijon, Côte-d'Or

CHRU de Brest, Brest, Finistère

Institut Régional du Cancer Montpellier, Montpellier, Hérault

Chu Grenoble Alpes, La Tronche, Isère

Local Institution - 0560, Angers, Maine-et-Loire

Centre Hospitalier Régional Universitaire de Nancy - Hôpitaux de Brabois, Vandoeuvre lès Nancy, Meurthe-et-Moselle

Local Institution - 0636, Marseille, Provence-Alpes-Côte-d'Azur

CHU d'Amiens-Picardie - Hôpital Sud, Amiens, Somme

Gustave Roussy, Villejuif, Val-de-Marne

Hôpital Ambroise Paré, Boulogne-Billancourt, Not set

Chu Gabriel Montpied, Clermont-Ferrand, Not set

Centre Hospitalier Universitaire de Limoges - Hôpital Dupuytren, Limoges, Not set

Assistance Publique Hôpitaux de Marseille - Hôpital Nord, Marseille, Not set

Local Institution - 0133, Paris, Not set

Hopitaux Universitaires Paris Centre-Hopital Cochin, Paris, Not set

Hôpital Nord Guillaume-et-René-Laennec / CHU de Nantes, Saint-Herblain, Not set

Klinikum Esslingen, Esslingen, Baden-Württemberg

Local Institution - 0670, Ulm, Baden-Württemberg

Klinikum der Ludwig-Maximilians-Universitaet Muenchen, München, Bayern

Centrum für Hämatologie und Onkologie Bethanien, Frankfurt, Hessen

Local Institution - 0535, Gießen, Hessen

Praxis Onkologie am Raschplatz, Hannover, Niedersachsen

Pius Hospital Oldenburg, Oldenburg, Niedersachsen

Evangelisches Krankenhaus Herne - Eickel, Herne, Nordrhein-Westfalen

Klinikum Köln-Merheim, Köln, Nordrhein-Westfalen

Local Institution - 0522, Halle, Sachsen-Anhalt

Malteser Krankenhaus St. Franziskus-Hospital, Flensburg, Schleswig-Holstein

Local Institution - 0524, Gera, Thüringen

Universitätsklinikum Jena, Jena, Thüringen

Vivantes Klinikum Neukölln, Berlin, Not set

Evangelische Lungenklinik Berlin, Berlin, Not set

Local Institution - 0675, Halle, Not set

Local Institution - 0528, Hemer, Not set

Local Institution - 0517, Stuttgart, Not set

Universitaetsklinikum Wuerzburg, Wuerzburg, Not set

Errikos Dunant Hospital Center, Athens, Attikí

Thoracic General Hospital of Athens "I Sotiria", Athens, Attikí

University General Hospital of Larissa, Larissa, Thessalía

Queen Mary Hospital, Hksar, Not set

Local Institution - 0144, Gyöngyös, Heves

Local Institution - 0157, Tatabánya, Komárom-Esztergom

Local Institution - 0593, Kaposvár, Somogy

Local Institution - 0143, Farkasgyepu, Veszprém

Local Institution - 0151, Budapest, Not set

Local Institution - 0140, Budapest, Not set

Petz Aladar Egyetemi Oktato Korhaz, Győr, Not set

Local Institution - 0222, Visakhapatnam, Andhra Pradesh

Local Institution - 0312, New Delhi, Delhi

Local Institution - 0511, New Delhi, Delhi

Local Institution - 0135, New Delhi, Delhi

Local Institution - 0136, Ahmedabad, Gujarat

Local Institution - 0230, Ahmedabad, Gujarat

Local Institution - 0155, Thiruvananthapuram, Kerala

Local Institution - 0154, Mumbai, Maharashtra

Local Institution - 0226, Bhubaneswar, Odisha

Local Institution - 0224, Madurai, Tamil Nadu

Local Institution - 0663, Hyderabad, Telangana

Local Institution - 0153, Varanasi, Uttar Pradesh

Local Institution - 0161, Howrah, West Bengal

Local Institution - 0221, Kolkata, West Bengal

Local Institution - 0661, Hyderabad, Not set

Local Institution - 0102, Cork, Not set

Mater Private Hospital - Dublin, Dublin, Not set

St. James's Hospital, Dublin, Not set

Local Institution - 0100, Dublin, Not set

Beaumont Hospital, Dublin, Dublin, Not set

Rabin Medical Center, Petah Tikva, HaMerkaz

Sheba Medical Center, Ramat Gan, HaMerkaz

Yitzhak Shamir Medical Center, Zerifin, HaMerkaz

Hadassah Medical Center, Jerusalem, Yerushalayim

Local Institution - 0613, Haifa, Ḥeifā

IRCCS - Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori", Meldola, Emilia-Romagna

A.O.R.N. Ospedale dei Colli - Monaldi V., Naples, Napoli

Local Institution - 0070, Orbassano, Piemonte

Local Institution - 0071, Bari, Puglia

Local Institution - 0068, Rome, Roma

Azienda Ospedaliera Universitaria Careggi, Firenze, Toscana

Ospedale San Martino, Genova, Not set

Local Institution - 0073, Padova, Not set

Local Institution - 0156, Parma, Not set

Local Institution - 0543, Pavia, Not set

Local Institution - 0556, Varese, Not set

Local Institution - 0607, Nagoya, Aichi

Local Institution - 0305, Nagoya, Aichi

Local Institution - 0298, Sapporo, Hokkaido

Local Institution - 0304, Kanazawa, Ishikawa

Local Institution - 0302, Sagamihara, Kanagawa

Local Institution - 0369, Yokohama, Kanagawa

Local Institution - 0301, Sendai, Miyagi

Local Institution - 0306, Kashihara, Nara

Local Institution - 0368, Kurashiki, Okayama

Local Institution - 0642, Hirakata, Osaka

Local Institution - 0303, Hidaka, Saitama

Local Institution - 0300, Ina-machi, Saitama

Local Institution - 0606, Hamamatsu, Shizuoka

Local Institution - 0299, Shimotsuga, Tochigi

Local Institution - 0674, Bunkyo ku, Tokyo

Local Institution - 0343, Toyoma, Toyama

Local Institution - 0542, Iwakuni, Yamaguchi

Local Institution - 0307, Akashi, Not set

Local Institution - 0346, Aomori, Not set

Local Institution - 0310, Fukuoka, Not set

Local Institution - 0367, Fukushima, Not set

Local Institution - 0308, Kumamoto, Not set

Local Institution - 0297, Osaka, Not set

Local Institution - 0309, Osaka, Not set

Chungbuk National University Hospital, Cheongju-si, Chungcheongbuk-do [Chungbuk]

Gachon University Gil Medical Center, Namdong-gu, Incheon-gwangyeoksi [Incheon]

Pusan National University Yangsan Hospital, Yangsan, Kyǒngsangnam-do

Pusan National University Hospital, Busan, Pusan-Kwangyǒkshi

Severance Hospital, Yonsei University Health System, Seoul, Seoul-teukbyeolsi [Seoul]

Konkuk University Medical Center, Seoul, Seoul-teukbyeolsi [Seoul]

The Catholic Univ. of Korea Seoul St. Mary's Hospital, Seoul, Seoul-teukbyeolsi [Seoul]

Korea University Guro Hospital, Seoul, Seoul-teukbyeolsi [Seoul]

Local Institution - 0583, Saltillo, Coahuila

Local Institution - 0176, Mexico City, DIF

Local Institution - 0579, Pachuca, Hidalgo

Local Institution - 0178, Guadalajara, Jalisco

Local Institution - 0591, Monterrey, Nuevo León

Local Institution - 0175, Chihuahua, Not set

Local Institution - 0181, Puebla, Not set

Local Institution - 0638, Puebla, Not set

Local Institution - 0180, Veracruz, Not set

Local Institution - 0615, Maastricht, Limburg

Nederlands Kanker Instituut Antoni van Leeuwenhoek (NKI AVL), Amsterdam, Noord-Holland

Local Institution - 0205, Wrocław, Dolnośląskie

Uniwersytecki Szpital Kliniczny Nr 4 w Lublinie, Lublin, Lubelskie

Szpital Specjalistyczny im. Henryka Klimontowicza, Gorlice, Małopolskie

Pratia MCM Krakow, Kraków, Małopolskie

Med-Polonia Sp. z o. o., Poznan, Wielkopolskie

Centrum Onkologii im. Prof. Franciszka Lukaszczyka, Bydgoszcz, Not set

Local Institution - 0078, Katowice, Not set

Szpital Specjalistyczny w Prabutach Spolka z o.o., Prabuty, Not set

Local Institution - 0509, Lisbon, Lisboa

Instituto Portugês de Oncologia de Coimbra Francisco Gentil, Coimbra, Not set

Centro Hospitalar do Porto - Hospital de Santo António, Porto, Not set

SC Memorial Healthcare International SRL, Bucharest, București

Institutul Oncologic Bucuresti, Bucharest, București

Cardiomed SRL Cluj-Napoca, Cluj-Napoca, Cluj

SC Radiotherapy Center Cluj SRL, Florești, Cluj

Ovidius Clinical Hospital OCH, Ovidiu, Constanța

Centrul de Oncologie "Sfântul Nectarie", Craiova, Dolj

Spitalul Municipal Schuller Ploiești, Ploiești, Prahova

Cabinet Medical Oncomed, Timișoara, Timiș

Institutul Oncologic Cluj, Cluj, Not set

Affidea Constanța, Constanța, Not set

S.C. Centrul de Oncologie Euroclinic S.R.L., Iași, Not set

Institutul Regional de Oncologie, Iași, Not set

Local Institution - 0614, Jeddah, Makkah Al Mukarramah

Local Institution - 0602, Riyadh, Not set

Local Institution - 0562, Riyadh, Not set

Local Institution - 0499, A Coruña, A Coruña [La Coruña]

Local Institution - 0506, Santiago de Compostela, A Coruña [La Coruña]

Hospital Universitari Vall d'Hebron, Barcelona, Barcelona [Barcelona]

Local Institution - 0497, Hospitalet, Barcelona [Barcelona]

Local Institution - 0505, Barcelona, Catalunya [Cataluña]

Hospital Son Llàtzer, Palma, Illes Balears [Islas Baleares]

Hospital General Universitario Gregorio Marañon, Madrid, Madrid, Comunidad De

Hospital Universitario Ramón y Cajal, Madrid, Madrid, Comunidad De

Hospital Universitario 12 de Octubre, Madrid, Madrid, Comunidad De

Hospital Universitario Puerta de Hierro Majadahonda, Majadahonda, Madrid, Comunidad De

Local Institution - 0669, Pontevedra, Pontevedra [Pontevedra]

Hospital Arnau de Vilanova, Valencia, València

Hospital Clinico San Carlos, Madrid, Not set

H.R.U Málaga - Hospital General, Málaga, Not set

Hospital Universitario Virgen Del Rocio, Sevilla, Not set

Local Institution - 0495, València, Not set

Kantonsspital Münsterlingen - Spital Thurgau AG, Münsterlingen, Not set

Chi Mei Hospital - Liouying Branch, Tainan City, Tainan

Tri-Service General Hospital, Taipei City, Taipei

Taipei Medical University Shuang Ho Hospital, New Taipei, Not set

National Cheng Kung University Hospital, Tainan, Not set

National Taiwan University Hospital, Taipei, Not set

Local Institution - 0565, Muang, Khon Kaen

Local Institution - 0563, Bangkok, Krung Thep Maha Nakhon

Local Institution - 0564, Hatyai, Songkhla

Local Institution - 0548, Stanbul, İstanbul

Local Institution - 0199, Izmir, Karsiyaka, İzmir

Local Institution - 0197, Adana, Not set

Local Institution - 0201, Ankara, Not set

Local Institution - 0194, Ankara, Not set

Local Institution - 0198, Ankara, Not set

Local Institution - 0550, Istanbul, Not set

Local Institution - 0549, Istanbul, Not set

Local Institution - 0200, Izmir, Not set

University College London Hospital, London, London, City Of

Guy's & St Thomas' NHS Foundation Trust, London, London, City Of

Heartlands Hospital, Birmingham, Not set

Local Institution - 0545, Guildford, Not set

The Royal Surrey County Hospital, Guildford, Not set

Local Institution - 0093, Manchester, Not set

Conditions: Carcinoma, Non-Small-Cell Lung

Learn More ›

Natural History and Development of Spondyloarthritis

NCT01422694

Recruiting

Background: - Spondyloarthritis (SpA) is a group of bone and joint disorders that may cause back and joint pain and stiffness. In some cases, SpA can lead to abnormal bone growth affecting the joints and spine. Some patients have SpA without ever developing these growths, while others develop them after only a few years. Researchers are interested in studying people with SpA and their relatives to determine which people are more likely to develop more severe conditions. Objectives: - To ident... Read More

Gender:

ALL

Ages:

2 years and above

Trial Updated:

08/21/2025

Locations: National Institutes of Health Clinical Center, Bethesda, Maryland

Conditions: Arthritis, Spondylitis, Ankylosing

Learn More ›

Stone and Laser Therapies Post-Market Study (SALT)

NCT06982235

Recruiting

The objective of the SALT Study is to obtain post-market safety and device performance data for Boston Scientific's Stone and BPH study devices used during a diagnostic and/or therapeutic urinary tract procedure (e.g., transurethral or percutaneous access routes) or benign prostatic hyperplasia (BPH) treatment.

Gender:

ALL

Ages:

All

Trial Updated:

08/21/2025

Locations: University of Miami Hospital, Miami, Florida

Conditions: Benign Prostate Hypertrophy(BPH), Renal Calculi, Ureteral Stones, Kidney Stones, Calculi, Urinary, Urinary Tract Procedure

Learn More ›

Radiation Medication (Radium-223 Dichloride) Versus Radium-223 Dichloride Plus Radiation Enhancing Medication (M3814) Versus Radium-223 Dichloride Plus M3814 Plus Avelumab (a Type of Immunotherapy) for Advanced Prostate Cancer Not Responsive to Hormonal Therapy

NCT04071236

Recruiting

This phase I/II trial studies the best dose of M3814 when given together with radium-223 dichloride or with radium-223 dichloride and avelumab and to see how well they work in treating patients with castrate-resistant prostate cancer that had spread to other places in the body (metastatic). M3814 may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Radioactive drugs, such as radium-223 dichloride, may carry radiation directly to tumor cells and not harm norm... Read More

Gender:

MALE

Ages:

18 years and above

Trial Updated:

08/21/2025

Locations: City of Hope Comprehensive Cancer Center, Duarte, California +29 locations

City of Hope Comprehensive Cancer Center, Duarte, California

Los Angeles General Medical Center, Los Angeles, California

USC / Norris Comprehensive Cancer Center, Los Angeles, California

UC Irvine Health/Chao Family Comprehensive Cancer Center, Orange, California

University of California Davis Comprehensive Cancer Center, Sacramento, California

UM Sylvester Comprehensive Cancer Center at Aventura, Aventura, Florida

UM Sylvester Comprehensive Cancer Center at Coral Gables, Coral Gables, Florida

UM Sylvester Comprehensive Cancer Center at Deerfield Beach, Deerfield Beach, Florida

University of Miami Miller School of Medicine-Sylvester Cancer Center, Miami, Florida

UM Sylvester Comprehensive Cancer Center at Kendall, Miami, Florida

UM Sylvester Comprehensive Cancer Center at Plantation, Plantation, Florida

Emory University Hospital Midtown, Atlanta, Georgia

Emory University Hospital/Winship Cancer Institute, Atlanta, Georgia

Emory Saint Joseph's Hospital, Atlanta, Georgia

University of Kansas Clinical Research Center, Fairway, Kansas

University of Kansas Cancer Center, Kansas City, Kansas

University of Kansas Cancer Center-Overland Park, Overland Park, Kansas

University of Kansas Hospital-Westwood Cancer Center, Westwood, Kansas

University of Kentucky/Markey Cancer Center, Lexington, Kentucky

Wayne State University/Karmanos Cancer Institute, Detroit, Michigan

Siteman Cancer Center at West County Hospital, Creve Coeur, Missouri

University of Kansas Cancer Center at North Kansas City Hospital, North Kansas City, Missouri

Washington University School of Medicine, Saint Louis, Missouri

Siteman Cancer Center-South County, Saint Louis, Missouri

Siteman Cancer Center at Saint Peters Hospital, Saint Peters, Missouri

Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center, Lebanon, New Hampshire

Laura and Isaac Perlmutter Cancer Center at NYU Langone, New York, New York

Ohio State University Comprehensive Cancer Center, Columbus, Ohio

Thomas Jefferson University Hospital, Philadelphia, Pennsylvania

UT Southwestern/Simmons Cancer Center-Dallas, Dallas, Texas

Conditions: Metastatic Malignant Neoplasm in the Lymph Nodes, Metastatic Castration-Resistant Prostate Carcinoma, Metastatic Malignant Neoplasm in the Bone, Stage IVB Prostate Cancer AJCC v8

Learn More ›

A Study of INCB123667 in Participants With Platinum-Resistant Ovarian Cancer With Cyclin E1 Overexpression

NCT07023627

Recruiting

This study will evaluate the safety and efficacy of INCB123667 in Participants With Platinum-Resistant Ovarian Cancer (PROC) With Cyclin E1 Overexpression.

Gender:

FEMALE

Ages:

Between 18 years and 99 years

Trial Updated:

08/21/2025

Locations: Usa Health Mitchell Cancer Institute, Mobile, Alabama +73 locations

Usa Health Mitchell Cancer Institute, Mobile, Alabama

Uams Winthrop P Rockefeller Cancer Institute, Little Rock, Arkansas

University of California, Los Angeles Medical Center, Los Angeles, California

Scripps Healthscripps Mercy Hospital Prebys Cancer Center, San Diego, California

Mount Sinai Comprehensive Cancer Center, Miami Beach, Florida

Sylvester Comprehensive Cancer Center, Miami, Florida

Northeast Georgia Medical Center Gainesville, Gainesville, Georgia

Parkview Research Center, Fort Wayne, Indiana

Indiana University Melvin and Bren Simon Cancer Center, Indianapolis, Indiana

Community Health Network, Inc., Indianapolis, Indiana

University of Iowa Hospital and Clinics, Iowa City, Iowa

Norton Cancer Institute, Louisville, Kentucky

Trials365, Llc, Shreveport, Louisiana

Greater Baltimore Medical Center, Baltimore, Maryland

Massachusetts General Hospital, Boston, Massachusetts

St Joseph Mercy Hospital-Gynecologic Oncology Clinic, Ypsilanti, Michigan

Minnesota Oncology-Minneapolis, Minneapolis, Minnesota

Washington University, Saint Louis, Missouri

St. Vincent Regional Hospital - West End Clinic, Billings, Montana

Methodist Hospital Methodist Estabrook Cancer Center, Omaha, Nebraska

John Theurer Cancer Center, Hackensack University Medical Center, Hackensack, New Jersey

Laura and Isaac Perlmutter Cancer Center, New York, New York

University of Rochester, James P. Wilmot Cancer Center, Rochester, New York

State University of New York Upstate Medical Unive, Syracuse, New York

Oncology Hematology Care, Inc, Cincinnati, Ohio

The Mark H Zangmeister Cancer Center Ohio, Columbus, Ohio

Medical University of South Carolina, Charleston, South Carolina

Texas Oncology-Austin Center, Austin, Texas

Houston Methodist Cancer Center, Houston, Texas

Cancer Care Center of South Texas-Medical Center, San Antonio, Texas

Texas Oncology-Tyler, Tyler, Texas

Utah Cancer Specialists, Salt Lake City, Utah

Virginia Cancer Specialists, Pc, Fairfax, Virginia

Carilion Clinic, Roanoke, Virginia

West Virginia University, Morgantown, West Virginia

Froedtert & the Medical College of Wisconsin, Milwaukee, Wisconsin

Blacktown Cancer & Haematology Centre-Blacktown Hospital, Blacktown, New South Wales

Concord General Repatriation Hospital, Concord, New South Wales

Burnside War Memorial Hospital - the Brian Fricker Oncology Centre, Adelaide, South Australia

Hobart Hospital-Royal Hobart Hospital, Hobart, Tasmania

Cancer Research Sa (Crsa), Adelaide, Not set

Southern Oncology Clinical Research Unit, South Australia, Not set

Hopital Universitaire de Bruxelles (H.U.B)/ Academisch Ziekenhuis Brussel, Brussels, Not set

Cliniques Universitaires St Luc Ucl, Brussels, Not set

Az Groeninge Campus Kennedylaan, Kortrijk, Not set

Universitair Ziekenhuis Leuven, Leuven, Not set

Chu Liege, Liège, Not set

Hyogo Cancer Center, Akashi-shi, Not set

Saitama Medical University International Medical Center, Hidaka-shi, Not set

The Cancer Institute Hospital of Jfcr, Koto-ku, Not set

Kurume University Hospital, Kurume, Not set

Shikoku Cancer Center, Matsuyama-city, Not set

Hokkaido University Hospital, Sapporo, Not set

Shizuoka Cancer Center, Sunto-gun, Not set

Panoncology Trials, San Juan, Not set

Hospital Universitario Vall D'Hebron, Barcelona, Not set

Hospital Clinic de Barcelona (Hospital Clinic I Provincial), Barcelona, Not set

Instituto Catalan de Oncologia - Hospital Duran I Reynals, Barcelona, Not set

Institut Catala D'Oncologia Girona, Girona, Not set

Clinica Universidad de Navarra - Sede Madrid, Madrid, Not set

Hospital Universitario La Paz, Madrid, Not set

Hospital Universitario Virgen de La Arrixaca, Múrcia, Not set

Hospital Clinico Universitario de Valencia (Instituto de Investigacion Sanitaria Incliva), Valencia, Not set

Istituto Oncologico Della Svizzera Italiana (Iosi) Di Bellinzona, Bellinzona, Not set

Hopital Du Valais-Geneva University Hospitals - Hug, Geneve, Not set

Centre Hospitalier Universitaire Vaudois Lausanne (Chuv) - Centre Du Cancer Lausanne-Batiment Hospit, Lausanne, Not set

Kantonsspital Baselland (Ksbl) - Standort Liestal - Medizinische Universitatsklinik, Liestal, Not set

Kantonsspital - Onkologisches Ambulatorium, St. Gallen, Not set

Western General Hospital - Lothian Health Board, Edinburgh, Not set

St Bartholomew'S Hospital, London, Not set

Guy'S Hospital - Guy'S & St Thomas' Nhs Foundation Trust, London, Not set

Royal Marsden Hospital (Sutton) - Royal Marsden Nhs Foundation Trust, London, Not set

Hammersmith Hospital - Imperial College Healthcare Nhs Trust, London, Not set

The Christie Nhs Foundation Trust, Manchester Greater, Not set

Conditions: Ovarian Cancer

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Testing What Happens When an Immunotherapy Drug (Pembrolizumab) is Given by Itself Compared to the Usual Treatment of Chemotherapy With Radiation After Surgery for Recurrent Head and Neck Squamous Cell Carcinoma

NCT04671667

Recruiting

This phase II trial studies the effect of pembrolizumab alone compared to the usual approach (chemotherapy \[cisplatin and carboplatin\] plus radiation therapy) after surgery in treating patients with head and neck squamous cell carcinoma that has come back (recurrent) or patients with a second head and neck cancer that is not from metastasis (primary). Radiation therapy uses high energy radiation or protons to kill tumor cells and shrink tumors. Cisplatin is in a class of medications known as p... Read More

Gender:

ALL

Ages:

Between 18 years and 79 years

Trial Updated:

08/21/2025

Locations: University of Alabama at Birmingham Cancer Center, Birmingham, Alabama +160 locations

University of Alabama at Birmingham Cancer Center, Birmingham, Alabama

University of Arkansas for Medical Sciences, Little Rock, Arkansas

Kaiser Permanente-Anaheim, Anaheim, California

Kaiser Permanente-Bellflower, Bellflower, California

UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care, Irvine, California

UC San Diego Moores Cancer Center, La Jolla, California

Kaiser Permanente Los Angeles Medical Center, Los Angeles, California

Kaiser Permanente-Ontario, Ontario, California

UC Irvine Health/Chao Family Comprehensive Cancer Center, Orange, California

Sutter Cancer Centers Radiation Oncology Services-Roseville, Roseville, California

Sutter Roseville Medical Center, Roseville, California

California Protons Cancer Therapy Center, San Diego, California

Smilow Cancer Center/Yale-New Haven Hospital, New Haven, Connecticut

Yale University, New Haven, Connecticut

Smilow Cancer Hospital Care Center-Trumbull, Trumbull, Connecticut

Smilow Cancer Hospital Care Center - Waterford, Waterford, Connecticut

MedStar Washington Hospital Center, Washington, District of Columbia

UM Sylvester Comprehensive Cancer Center at Coral Gables, Coral Gables, Florida

UM Sylvester Comprehensive Cancer Center at Deerfield Beach, Deerfield Beach, Florida

University of Florida Health Science Center - Gainesville, Gainesville, Florida

University of Miami Miller School of Medicine-Sylvester Cancer Center, Miami, Florida

UM Sylvester Comprehensive Cancer Center at Plantation, Plantation, Florida

Moffitt Cancer Center-International Plaza, Tampa, Florida

Moffitt Cancer Center - McKinley Campus, Tampa, Florida

Moffitt Cancer Center, Tampa, Florida

Emory Proton Therapy Center, Atlanta, Georgia

Emory University Hospital Midtown, Atlanta, Georgia

Emory University Hospital/Winship Cancer Institute, Atlanta, Georgia

Memorial Health University Medical Center, Savannah, Georgia

Northwestern University, Chicago, Illinois

John H Stroger Jr Hospital of Cook County, Chicago, Illinois

University of Illinois, Chicago, Illinois

Carle at The Riverfront, Danville, Illinois

Cancer Care Specialists of Illinois - Decatur, Decatur, Illinois

Decatur Memorial Hospital, Decatur, Illinois

Northwestern Medicine Cancer Center Kishwaukee, DeKalb, Illinois

Carle Physician Group-Effingham, Effingham, Illinois

Crossroads Cancer Center, Effingham, Illinois

Northwestern Medicine Cancer Center Delnor, Geneva, Illinois

Northwestern Medicine Lake Forest Hospital, Lake Forest, Illinois

Carle Physician Group-Mattoon/Charleston, Mattoon, Illinois

Loyola University Medical Center, Maywood, Illinois

HSHS Saint Elizabeth's Hospital, O'Fallon, Illinois

Southern Illinois University School of Medicine, Springfield, Illinois

Springfield Clinic, Springfield, Illinois

Springfield Memorial Hospital, Springfield, Illinois

Carle Cancer Center, Urbana, Illinois

The Carle Foundation Hospital, Urbana, Illinois

Northwestern Medicine Cancer Center Warrenville, Warrenville, Illinois

Reid Health, Richmond, Indiana

UI Health Care Mission Cancer and Blood - Ankeny Clinic, Ankeny, Iowa

Heartland Oncology and Hematology LLP, Council Bluffs, Iowa

Methodist Jennie Edmundson Hospital, Council Bluffs, Iowa

Iowa Methodist Medical Center, Des Moines, Iowa

UI Health Care Mission Cancer and Blood - Des Moines Clinic, Des Moines, Iowa

Broadlawns Medical Center, Des Moines, Iowa

Iowa Lutheran Hospital, Des Moines, Iowa

UI Health Care Mission Cancer and Blood - Waukee Clinic, Waukee, Iowa

Methodist West Hospital, West Des Moines, Iowa

University of Kansas Cancer Center, Kansas City, Kansas

University of Kansas Cancer Center-Overland Park, Overland Park, Kansas

University of Kansas Hospital-Indian Creek Campus, Overland Park, Kansas

University of Kansas Hospital-Westwood Cancer Center, Westwood, Kansas

University of Kentucky/Markey Cancer Center, Lexington, Kentucky

The James Graham Brown Cancer Center at University of Louisville, Louisville, Kentucky

UofL Health Medical Center Northeast, Louisville, Kentucky

Maryland Proton Treatment Center, Baltimore, Maryland

University of Maryland/Greenebaum Cancer Center, Baltimore, Maryland

Central Maryland Radiation Oncology in Howard County, Columbia, Maryland

UM Baltimore Washington Medical Center/Tate Cancer Center, Glen Burnie, Maryland

Tufts Medical Center, Boston, Massachusetts

University of Michigan Comprehensive Cancer Center, Ann Arbor, Michigan

Wayne State University/Karmanos Cancer Institute, Detroit, Michigan

Weisberg Cancer Treatment Center, Farmington Hills, Michigan

Sanford Joe Lueken Cancer Center, Bemidji, Minnesota

University of Mississippi Medical Center, Jackson, Mississippi

Saint Francis Medical Center, Cape Girardeau, Missouri

Siteman Cancer Center at West County Hospital, Creve Coeur, Missouri

University of Kansas Cancer Center - North, Kansas City, Missouri

University of Kansas Cancer Center - Lee's Summit, Lee's Summit, Missouri

University of Kansas Cancer Center at North Kansas City Hospital, North Kansas City, Missouri

Washington University School of Medicine, Saint Louis, Missouri

Mercy Hospital South, Saint Louis, Missouri

Siteman Cancer Center-South County, Saint Louis, Missouri

Siteman Cancer Center at Christian Hospital, Saint Louis, Missouri

Mercy Hospital Saint Louis, Saint Louis, Missouri

Siteman Cancer Center at Saint Peters Hospital, Saint Peters, Missouri

Mercy Hospital Springfield, Springfield, Missouri

Benefis Sletten Cancer Institute, Great Falls, Montana

Logan Health Medical Center, Kalispell, Montana

Community Medical Center, Missoula, Montana

Nebraska Cancer Specialists/Oncology Hematology West PC - MECC, Omaha, Nebraska

Nebraska Methodist Hospital, Omaha, Nebraska

Oncology Associates PC, Omaha, Nebraska

University of New Mexico Cancer Center, Albuquerque, New Mexico

Montefiore Medical Center-Einstein Campus, Bronx, New York

Montefiore Medical Center - Moses Campus, Bronx, New York

Mount Sinai Union Square, New York, New York

Mount Sinai Chelsea, New York, New York

Mount Sinai Hospital, New York, New York

University of Rochester, Rochester, New York

Stony Brook University Medical Center, Stony Brook, New York

Wilmot Cancer Institute at Webster, Webster, New York

Randolph Hospital, Asheboro, North Carolina

Cone Health Cancer Center, Greensboro, North Carolina

Annie Penn Memorial Hospital, Reidsville, North Carolina

Sanford Bismarck Medical Center, Bismarck, North Dakota

Sanford Roger Maris Cancer Center, Fargo, North Dakota

Indu and Raj Soin Medical Center, Beavercreek, Ohio

Dayton Physicians LLC-Miami Valley South, Centerville, Ohio

Miami Valley Hospital South, Centerville, Ohio

Cleveland Clinic Foundation, Cleveland, Ohio

Premier Blood and Cancer Center, Dayton, Ohio

Dayton Physician LLC - Englewood, Dayton, Ohio

Miami Valley Hospital North, Dayton, Ohio

Atrium Medical Center-Middletown Regional Hospital, Franklin, Ohio

Dayton Physicians LLC-Atrium, Franklin, Ohio

Miami Valley Cancer Care and Infusion, Greenville, Ohio

Greater Dayton Cancer Center, Kettering, Ohio

Kettering Medical Center, Kettering, Ohio

Upper Valley Medical Center, Troy, Ohio

Cancer Centers of Southwest Oklahoma Research, Lawton, Oklahoma

University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma

Clackamas Radiation Oncology Center, Clackamas, Oregon

Providence Cancer Institute Clackamas Clinic, Clackamas, Oregon

Providence Newberg Medical Center, Newberg, Oregon

Providence Portland Medical Center, Portland, Oregon

Providence Saint Vincent Medical Center, Portland, Oregon

UPMC Altoona, Altoona, Pennsylvania

Geisinger Medical Center, Danville, Pennsylvania

UPMC Hillman Cancer Center Erie, Erie, Pennsylvania

UPMC Cancer Center at UPMC Horizon, Farrell, Pennsylvania

Geisinger Medical Oncology-Lewisburg, Lewisburg, Pennsylvania

UPMC Hillman Cancer Center - New Castle, New Castle, Pennsylvania

Thomas Jefferson University Hospital, Philadelphia, Pennsylvania

Fox Chase Cancer Center, Philadelphia, Pennsylvania

Jefferson Torresdale Hospital, Philadelphia, Pennsylvania

Temple University Hospital, Philadelphia, Pennsylvania

UPMC-Saint Margaret, Pittsburgh, Pennsylvania

University of Pittsburgh Cancer Institute (UPCI), Pittsburgh, Pennsylvania

UPMC-Shadyside Hospital, Pittsburgh, Pennsylvania

UPMC-Passavant Hospital, Pittsburgh, Pennsylvania

Geisinger Wyoming Valley/Henry Cancer Center, Wilkes-Barre, Pennsylvania

UPMC Memorial, York, Pennsylvania

Medical University of South Carolina, Charleston, South Carolina

Avera Cancer Institute, Sioux Falls, South Dakota

Sanford USD Medical Center - Sioux Falls, Sioux Falls, South Dakota

Avera Cancer Institute at Yankton, Yankton, South Dakota

Vanderbilt University/Ingram Cancer Center, Nashville, Tennessee

Huntsman Cancer Institute/University of Utah, Salt Lake City, Utah

VCU Massey Cancer Center at Stony Point, Richmond, Virginia

VCU Massey Comprehensive Cancer Center, Richmond, Virginia

ThedaCare Regional Cancer Center, Appleton, Wisconsin

HSHS Sacred Heart Hospital, Eau Claire, Wisconsin

Saint Vincent Hospital Cancer Center Green Bay, Green Bay, Wisconsin

Saint Vincent Hospital Cancer Center at Saint Mary's, Green Bay, Wisconsin

Froedtert Menomonee Falls Hospital, Menomonee Falls, Wisconsin

Medical College of Wisconsin, Milwaukee, Wisconsin

Drexel Town Square Health Center, Oak Creek, Wisconsin

Saint Vincent Hospital Cancer Center at Sturgeon Bay, Sturgeon Bay, Wisconsin

Froedtert West Bend Hospital/Kraemer Cancer Center, West Bend, Wisconsin

Conditions: Recurrent Head and Neck Squamous Cell Carcinoma, Recurrent Hypopharyngeal Squamous Cell Carcinoma, Recurrent Laryngeal Squamous Cell Carcinoma, Recurrent Oral Cavity Squamous Cell Carcinoma, Recurrent Oropharyngeal Squamous Cell Carcinoma

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Clinical and Genetic Studies of Li-Fraumeni Syndrome

NCT01443468

Recruiting

Background: - Li-Fraumeni syndrome (LFS) is a genetic condition that increases the risk for some types of cancer. LFS may lead to cancer of the bone or connective tissue, breast, and brain. It may also increase the risk for certain types of leukemia and other cancers. The only known cause of LFS is a change (called a mutation ) in a gene known as TP53. However, not all people with LFS have a TP53 mutation. Researchers want to study other possible genetic causes of LFS, and factors that may increase or decrease cancer risk in people with the syndrome. Objectives: * To learn more about the types of cancers that occur in individuals with LFS. * To study the role of the TP53 gene in the development of cancer. * To look for other possible genes that cause LFS * To study the effect of LFS diagnosis on families. * To determine if environmental factors or other genes can change a person s cancer risk associated with LFS. Eligibility: * Individuals with a family or personal medical history of cancers consistent with LFS. * Individuals with a family or personal medical history of cancers that does not meet the diagnosis of LFS, but the history is suggestive for LFS (meets the diagnosis for the so-called Li-Fraumeni like syndrome) * Individuals with certain rare cancers * Individuals with a family or personal history of a TP53 gene mutation, with or without related cancer(s). Design: * Participants will fill out a medical history questionnaire and a family history questionnaire. * Blood samples will be collected for DNA and for storage. Cheek cell samples may be collected if blood cannot be obtained for DNA. Participants can choose to have or not have cancer screening with blood tests, imaging studies, and other exams. * Participants will complete questionnaires about their worries about cancer, stress levels, and coping strategies. Diet and physical activity questionnaires will also be given. Other psychological tests may be given as needed. * Participants will be monitored for several years, with regular followup visits to the National Institutes of Health, if indicated. Any changes in health or cancer status will be recorded. Read Less

Gender:

ALL

Ages:

All

Trial Updated:

08/21/2025

Locations: National Cancer Institute - Shady Grove, Bethesda, Maryland +1 locations

Conditions: Li-Fraumeni Syndrome, Neoplasms, Tp53 Mutations

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A Study of Zolbetuximab Together With Pembrolizumab and Chemotherapy in Adults With Gastric Cancer

NCT06901531

Recruiting

Zolbetuximab is being studied in people with cancer in and around the stomach or where the food pipe (esophagus) joins the stomach, called gastroesophageal junction (GEJ) cancer. Zolbetuximab with chemotherapy may be used to treat stomach and GEJ cancer when the cancer cells do not have a protein called HER2 (human epidermal growth factor receptor 2) on their surface (HER2-negative) but do have a protein called Claudin 18.2 (Claudin 18.2-positive). Zolbetuximab is thought to work by attaching to the Claudin 18.2 protein in their tumor, which switches on the body's immune system to attack the tumor. Certain stomach and GEJ cancers may be treated with immunotherapy, which helps the body's immune system fight cancer. This study will give more information about how well zolbetuximab works when given with an immunotherapy medicine called pembrolizumab and chemotherapy. In this study, adults with stomach cancer or GEJ cancer will either be given zolbetuximab with pembrolizumab and chemotherapy or a placebo with pembrolizumab and chemotherapy. A placebo looks like zolbetuximab but doesn't have any medicine in it. The main aim of the study is to check how long people with stomach cancer and GEJ cancer live after treatment with zolbetuximab with pembrolizumab and chemotherapy compared to placebo with pembrolizumab and chemotherapy. Adults with locally advanced unresectable or metastatic stomach cancer or GEJ cancer can take part. Locally advanced means the cancer has spread to nearby tissue. Unresectable means the cancer cannot be removed by surgery. Metastatic means the cancer has spread to other parts of the body. A tumor sample (biopsy) of their cancer will have the Claudin 18.2 protein, PD-L1 protein, and be HER2-negative. They may have been previously treated with certain standard therapies. People cannot take part if they need to take medicines to suppress their immune system, have blockages or bleeding in their gut, have specific uncontrollable cancers such as symptomatic or untreated cancers in the nervous system, or have a specific heart condition, or infections. The study treatments are either zolbetuximab with pembrolizumab and chemotherapy, or placebo with pembrolizumab and chemotherapy. People who take part will receive just 1 of the study treatments by chance. The people in the study and the study doctors will not know who takes which of the study treatments. Study treatment will be given in 6-week (42-day) cycles. The study treatment is mainly given to people slowly through a tube into a vein. This is called an infusion. People will receive study treatment as follows: Zolbetuximab or placebo: 1 infusion every 2 or 3 weeks (2 or 3 infusions in a cycle) together with: Chemotherapy (1 of the following types of chemotherapy): 1. CAPOX (capecitabine and oxaliplatin): 1 infusion of oxaliplatin every 3 weeks (2 infusions in a cycle). People will also take 1 tablet of capecitabine twice a day for 2 weeks (14 days) at the start of each cycle (Day 1) and again in the middle of each cycle (Day 22). After 8 study treatments people will receive capecitabine only. 2. Modified FOLFOX6 or mFOLFOX6 (5-fluorouracil, folinic acid and oxaliplatin): 1 infusion every 2 weeks (3 infusions in a cycle). After 12 study treatments people will receive folinic acid and fluorouracil only, instead of mFOLFOX6. Pembrolizumab: 1 infusion every 3 or 6 weeks (1 or 2 infusions in a cycle). People can be in the study and will receive study treatment until their cancer worsens, they cannot tolerate the study treatment, or they need to start another cancer treatment. People may receive pembrolizumab for up to 2 years. People will visit the clinic on certain days to receive their study treatment and have health checks. The study doctors will check if people had any medical problems from taking zolbetuximab or the other study treatments. On some visits they will have scans to check for any changes in their cancer. People will have the option of giving a tumor sample if they stop treatment because their cancer has worsened. People will visit the clinic after they stop their study treatment. People will be asked about any medical problems and will have a health check. People will continue to have scans every 9 or 12 weeks to check for any changes in their cancer. They will have telephone health checks every 3 months. The number of visits and checks done at each visit will depend on the health of each person and whether they completed their study treatment or not. Read Less

Gender:

ALL

Ages:

18 years and above

Trial Updated:

08/21/2025

Locations: Metro Minnesota Community Oncology Research Consortium (MMCORC), Saint Louis Park, Minnesota +21 locations

Conditions: Locally Advanced Unresectable Gastroesophageal Junction (GEJ) Adenocarcinoma or Cancer, Locally Advanced Unresectable Gastric Adenocarcinoma or Cancer, Metastatic Gastric Adenocarcinoma or Cancer, Metastatic Gastroesophageal Junction (GEJ) Adenocarcinoma

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A Study to Assess the Efficacy and Safety of Ruxolitinib Cream in Children and Adolescents (6 to <18 Years Old) With Moderate Atopic Dermatitis

NCT06832618

Recruiting

The purpose of the study is to assess the efficacy and safety of ruxolitinib cream in children and adolescents (6 to \<18 Years Old) with moderate atopic dermatitis.

Gender:

ALL

Ages:

Between 6 years and 17 years

Trial Updated:

08/21/2025

Locations: Clinical Research Center of Alabama, Birmingham, Alabama +94 locations

Clinical Research Center of Alabama, Birmingham, Alabama

Saguaro Dermatology, Phoenix, Arizona

National Jewish Health, Denver, Colorado

Cleaver Medical Group, Cumming, Georgia

Treasure Valley Medical Research, Boise, Idaho

Sneeze Wheeze and Itch Associates Llc, Normal, Illinois

Kindred Hair and Skin Center, Marriottsville, Maryland

Henry Ford Health System, Detroit, Michigan

University of Mississippi Medical Center, Jackson, Mississippi

Medisearch Clinical Trials, Saint Joseph, Missouri

Nyu Langone Health - Nyu Otolaryngology Associates, New York, New York

University of Rochester Medical Center, Rochester, New York

Cincinnati Childrens Hospital Medical Center, Cincinnati, Ohio

University of Texas Physicians - Bellaire Station, Bellaire, Texas

Medical College of Wisconsin, Milwaukee, Wisconsin

Cliniques Universitaires Ucl Saint-Luc, Brussels, Not set

Az Sint-Lucas, Gent, Not set

Universitair Ziekenhuis Gent, Gent, Not set

Les Viviers, Gilly, Not set

Centre Hospitalier Universitaire de Liege - Sart Tilman, Liege, Not set

Dermatologie Maldegem, Maldegem, Not set

Medical Centre 'Asklepii', Ood, Dupnitsa, Not set

Mhat Dr. Tota Venkova Ad, Gabrovo, Not set

Dcc 'Alexandrovska', Eood, Sofia, Not set

Diagnostic Consultative Center Xxviii, Sofia, Not set

Medical Center Assoc. Prof. Vasilev, Sofia, Not set

Dermatology Research Institute Inc., Calgary, Alberta

Laster Rejuvenation Clinics Edmonton D.T. Inc., Edmonton, Alberta

University of British Columbia (Ubc) - British Columbia Children'S Hospital (Bc Children'S Hospital), Vancouver, British Columbia

Winnipeg Clinic, Winnipeg, Manitoba

Leader Research, Hamilton, Ontario

Facet Dermatology, Toronto, Ontario

Centre de Recherche Saint-Louis, Montreal, Quebec

Chu Sainte-Justine, Montreal, Quebec

Skinsense Medical Research, Saskatoon, Saskatchewan

K. Papp Clinical Research, Ontario, Not set

Chu de Québec-Université Laval, Quebec, Not set

Skincare Studio Dermatology Centre, St. John's, Not set

Bordeaux Chu Hopital Saint - Andre, Bordeaux, Not set

Polyclinique Reims-Bezannes, Reims, Not set

Hopitaux Drome Nord, Romans-sur-isère, Not set

Fachklinik Bad Bentheim Dermatologie, Bad Bentheim, Not set

St. Josef-Hospital Universitaetsklinikum, Bochum, Not set

Universitatsklinikum Bonn Aoer, Bonn, Not set

Drk Krankenhaus Chemnitz-Rabenstein, Chemnitz, Not set

Universitaetsklinikum Carl Gustav Carus Tu Dresden, Dresden, Not set

Universitatsklinikum Frankfurt, Frankfurt, Not set

Universitatsmedizin Goettingen, Goettingen, Not set

Universitaetsklinikum Schleswig-Holstein - Campus Kiel, Kiel, Not set

Universitatsmedizin Der Johannes Gutenberg-Universitat Mainz Iii, Mainz, Not set

Universitatsklinikum Munster, Muenster, Not set

Clinexpert Kft., Budapest, Not set

Obudai Egeszsegugyi Centrum Kft., Budapest, Not set

Geomedical Orvosi Kft., Budapest, Not set

Semmelweis Egyetem, Budapest, Not set

Debreceni Egyetem Klinikai Kozpon Belgyogy Klinika, Debrecen, Not set

Bacs-Kiskun Varmegyei Oktatokorhaz, Kecskemet, Not set

Pecsi Tudomanyegyetem, Pecs, Not set

Szegedi Tudomanyegyetem Aok Szent-Gyorgyi Albert Klinikai Kozpont, Szeged, Not set

Azienda Ospedaliero Universitaria Policlinico G.Rodolico San Marco, Catania, Not set

Fondazione Irccs Ca Granda Ospedale Maggiore, Milano, Not set

Azienda Ospedaliera Universitaria Federico Ii, Napoli, Not set

Azienda Ospedale-Università Di Padova, Padova, Not set

Fondazione Policlinico Universitario Agostino Gemelli Irccs, Rome, Not set

Umc Utrecht, Utrecht, Not set

Centrum Badan Klinicznych Pi-House Sp. Z O.O., Gdansk, Not set

Gyncentrum Sp. Z O.O., Katowice, Not set

Centrum Medyczne All-Med Badania Kliniczne, Krakow, Not set

Diamond Clinic Sp. Z O.O., Krakow, Not set

Dermoklinika, Lodz, Not set

Clinical Best Solutions Sp. Z O.O. Sp. K., Lublin, Not set

Dermodent Centrum Medyczne Czajkowscy S.C., Osielsko, Not set

Twoja Przychodnia - Szczecinskie Centrum Medyczne, Szczecin, Not set

Mics Centrum Medyczne Toruń, Torun, Not set

Etg Warszawa, Warsaw, Not set

Mics Centrum Medyczne Warszawa Chlodna, Warszawa, Not set

High-Med Przychodnia Specjalistycza, Warszawa, Not set

Centrum Medyczne Evimed, Warszawa, Not set

Dermmedica Sp. Z O.O., Wrocław, Not set

Hospital General Unviersitario de Alicante, Alicante, Not set

Hospital de La Santa Creu I Sant Pau, Barcelona, Not set

Hospital Sant Joan de Deu, Esplugues de Llobregat, Not set

Hospital Universitario Virgen de Las Nieves, Granada, Not set

Hospital Universitario 12 de Octubre, Madrid, Not set

Hospital Universitario de La Paz, Madrid, Not set

Hospital Universitario Puerta de Hierro de Majadahonda, Majadahonda, Not set

Hospital Regional Universitario de Malaga, Malaga, Not set

Hospital de Manises, Manises, Not set

Complejo Hospitalario Universitario de Santiago, Santiago de Compostela, Not set

West Glasgow Ambulatory Care Hospital, Glasgow, Not set

St John'S Institute of Dermatology, London, Not set

University of Nottingham Health Service, Nottingham, Not set

Sheffield Childrens Hospital, Sheffield, Not set

Walsall Manor Hospital, Walsall, Not set

The Adam Practice, Wirral, Not set

Conditions: Atopic Dermatitis

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Binimetinib for People With Relapsed/Refractory BRAF Wild Type Hairy Cell Leukemia and Variant

NCT04322383

Recruiting

Background: Most people with hairy cell leukemia have a BRAF gene mutation. They can be treated with BRAF inhibitors, drugs that target this mutation. For people who do not have this mutation, BRAF inhibitors are not a treatment option. We found that in hairy cell leukemia, when BRAF is not mutated, the MEK gene frequently is. Binimetinib is a MEK inhibitor which targets MEK. It is important to determine if this drug can be a good treatment option in those who cannot benefit treatment with BRAF... Read More

Gender:

ALL

Ages:

18 years and above

Trial Updated:

08/21/2025

Locations: National Institutes of Health Clinical Center, Bethesda, Maryland

Conditions: Hairy Cell Leukemia

Learn More ›