Using Shared Decision Making to Improve Family Media Use Planning
Recruiting
Investigators will conduct a pilot randomized controlled trial assessing the efficacy and feasibility of the newly developed Family Media Check-In (FMC).
Gender:
ALL
Ages:
11 years and above
Trial Updated:
05/13/2025
Locations: Seattle Children's Research Institute, Seattle, Washington
Conditions: Adolescent Behavior
Yale Steroid Enhanced Versus Exparel Nerveblock TKA Part 2
Recruiting
The objective of this study is to investigate the efficacy of Dexamethasone sodium phosphate plus Methylprednisolone acetate in combination with plain bupivacaine ((B-DEX-MPA) compared with Liposomal Bupivacaine in combination with plain bupivacaine (B-LB) on post-surgical pain control among patients undergoing bilateral total knee arthroplasty (TKA) to asses if perineural B-DEX-MPA will result in superior analgesia efficacy as compared to B-LB. This study will also assess if perineural B-DEX-M... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/13/2025
Locations: Yale New Haven Hospital Saint Raphael Campus, New Haven, Connecticut +1 locations
Conditions: Total Knee Replacement, Knee Arthroplasty
IPH5201 and Durvalumab in Patients With Resectable Non-Small Cell Lung Cancer (MATISSE)
Recruiting
The study is intended to assess the safety and efficacy of neoadjuvant combination of IPH5201 and durvalumab in addition to standard chemotherapy and adjuvant combination of IPH5201 and durvalumab in untreated patients with resectable, early-stage (stage II to IIIA) non-small cell lung cancer (NSCLC).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/13/2025
Locations: St. Anthony's Hospital - BayCare Health System, Saint Petersburg, Florida +29 locations
Conditions: Non Small Cell Lung Cancer
Evaluation of Fractional Ablative Laser Treatment for Skin Conditions
Recruiting
Evaluate the safety and efficacy of the fractional ablative laser for treatment of skin laxity and tightening
Gender:
ALL
Ages:
Between 18 years and 85 years
Trial Updated:
05/13/2025
Locations: Sanctuary Plastic Surgery, Boca Raton, Florida
Conditions: Skin Laxity
Study of Sipuleucel-T With or Without Continuing New Hormonal Agents in Metastatic Prostate Cancer
Recruiting
This study is designed to test the hypothesis that using Sipuleucel-T (Provenge) in combination with new hormonal agents (NHA) (abiraterone, enzalutamide, apalutamide) for the treatment of participants with asymptomatic metastatic castration resistant prostate cancer (mCRPC) and no visceral metastases would enhance the activation of antigen presenting cells (APC) by sipuleucel-T.
Gender:
MALE
Ages:
18 years and above
Trial Updated:
05/13/2025
Locations: Moffitt Cancer Center, Tampa, Florida
Conditions: Prostate Cancer, Metastatic Prostate Cancer
Combined Dialectical Behavior Therapy and Digital Cognitive Behavioral Therapy for Insomnia for Adolescents at High Risk for Suicide
Recruiting
The proposed research addresses the urgent need to reduce suicide rates among teens. This will be the first study that the investigators know of that will examine the feasibility and preliminary effectiveness of augmenting a suicide-focused treatment (Dialectical Behavior Therapy, \[DBT\]) with an evidence-based treatment protocol for insomnia (a digital version of Cognitive Behavioral Therapy for Insomnia \[CBT-I\]). The goal of this clinical trial is to learn providing insomnia treatment in co... Read More
Gender:
ALL
Ages:
Between 12 years and 18 years
Trial Updated:
05/13/2025
Locations: Michele Berk, Stanford, California
Conditions: Suicide and Self-harm
Teen Mom Study Feasibility Trial
Recruiting
The proposed multicomponent digital health intervention has the potential to significantly impact the trajectory of maternal health in a rural, pregnant, Black adolescent population with the highest risks for cardiometabolic diseases worldwide. The proposed implementation strategy leverages mobile technologies which are ubiquitous across the socioeconomic gradient and proposes to train young adult WIC moms to deliver peer health coaching in a telehealth setting to address social barriers and sup... Read More
Gender:
FEMALE
Ages:
Between 15 years and 19 years
Trial Updated:
05/13/2025
Locations: University of Mississippi Medical Center, Jackson, Mississippi +1 locations
Conditions: Physical Activity, Sedentary Behavior, Gestational Weight Gain, Social Determinants of Health
Phase 1 Study Evaluating the Safety and PK of ADU-1805 in Advanced Solid Tumors
Recruiting
This first-in-human, open-label, multicenter, multi-arm dose-escalation study is designed to evaluate the safety, PK, and PD of ADU-1805, an anti- SIRPα monoclonal antibody, as monotherapy and in combination with pembrolizumab (anti-PD-1 antibody).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/13/2025
Locations: Henry Ford Cancer Institute, Detroit, Michigan +8 locations
Conditions: Solid Tumor, Adult, Metastatic Solid Tumor, Refractory Cancer
Quantitative Neuromuscular Monitoring and Gastric Bypass Surgery
Recruiting
This is a single site, prospective, non-blinded, non-randomized, before/after study. This study is designed to evaluate the impact of monitoring and reversal guidelines for neuromuscular blocking drugs on the post-operative outcomes for patients undergoing laparoscopic gastric bypass surgery.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/13/2025
Locations: UC Davis Medical Center, Sacramento, California
Conditions: Sugammadex
A Study to Evaluate Impact of Efanesoctocog Alfa on Long-term Joint Health in Participants With Hemophilia A
Recruiting
This is a prospective, observational, multi-center longitudinal cohort study to describe the real-world effectiveness, safety and treatment usage of efanesoctocog alfa in patients with hemophilia A treated per standard of care in the US and Japan. Patients will be enrolled in the study after the introduction of efanesoctocog alfa in the hemophilia treatment landscape in each study country. Decision to initiate treatment with commercially available efanesoctocog alfa will be made by the treating... Read More
Gender:
ALL
Ages:
All
Trial Updated:
05/13/2025
Locations: Banner MD Anderson Cancer Center- Site Number : 8400008, Gilbert, Arizona +26 locations
Conditions: Hemophilia A
A Study of DB-1311/BNT324 in Advanced/Metastatic Solid Tumors
Recruiting
This is a dose-escalation and dose-expansion Phase 1/2a trial to evaluate the safety and tolerability of DB-1311/BNT324 in subjects with advanced solid tumors.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/13/2025
Locations: Research Site 111, Tucson, Arizona +97 locations
Conditions: Advanced Solid Tumors
PET Adapted Brentuximab Vedotin and Pembrolizumab in Combination With Doxorubicin and Dacarbazine in Classic Hodgkin Lymphoma
Recruiting
To learn about the effects of brentuximab vedotin and pembrolizumab in combination with doxorubicin and dacarbazine when given to patients who have Stage II cHL with bulky mediastinal disease or advanced cHL (Stage III or IV) and who have not received treatment for the disease.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/13/2025
Locations: M D Anderson Cancer Center, Houston, Texas
Conditions: Hodgkin Lymphoma