A Study of LBP-EC01 in the Treatment of Acute Uncomplicated UTI Caused by Drug Resistant E. Coli (ELIMINATE Trial)
NCT05488340
Recruiting
This is a Phase 2 superiority study of LBP-EC01, a recombinant bacteriophage cocktail, with an initial open-label 3-arm pharmacokinetic (PK) lead-in portion of 30 patients to evaluate the optimal dosing regimen to be used in the subsequent 288 patient blinded portion of the study which will be randomized 1:1 comparing LBP-EC01 + antibiotic versus placebo + antibiotic in patients with a history of prior urinary tract infection (UTI) cased by E. coli. All patients will be required to have an activ... Read More
Gender:
FEMALE
Ages:
Between 18 years and 75 years
Trial Updated:
02/24/2025
Locations: Research Site 115, Birmingham, Alabama +20 locations
Conditions: Urinary Tract Infections
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A Study of Spinraza (Nusinersen) Exposure in Pregnant Women With Spinal Muscular Atrophy (SMA) Within Existing SMA Registries
NCT05789758
Recruiting
The primary objectives of the study are to prospectively evaluate pregnancy complications and outcomes in participants with SMA, birth outcomes and adverse effects in infants born to participants with SMA, who were exposed to nusinersen up to 14 months prior to the first day of their last menstrual period (LMP) before conception, 14.5 months before the date of conception, and/or at any time during their pregnancy. The secondary objective of the study is to evaluate pregnancy outcomes in particip... Read More
Gender:
FEMALE
Ages:
Between 18 years and 54 years
Trial Updated:
02/24/2025
Locations: Research Site, Cambridge, Massachusetts +9 locations
Conditions: Muscular Atrophy, Spinal
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Cryocompression to Reduce Chemotherapy-induced Peripheral Neuropathy in Gynecologic Cancer - COHORT 2
NCT06139458
Recruiting
The investigators aim to determine the effect of cryotherapy wraps plus compression therapy (henceforth referred to as cryocompression) versus cryotherapy wraps alone on the incidence and degree of chemotherapy-induced peripheral neuropathy in patients with gynecologic cancer using a noninferiority design. The investigators also aim to determine the effect of cryocompression versus cryotherapy on patient tolerability and patient and staff satisfaction.
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
02/24/2025
Locations: Duke University Medical Center, Durham, North Carolina +1 locations
Conditions: Gynecologic Cancer, Chemotherapy-induced Peripheral Neuropathy
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Non-significant Risk (NSR) Study of [68Ga]-PSMA-11 (Illuccix) as a BgRT BioGuide on RefleXion X1
NCT06353321
Recruiting
To qualitatively determine the imaging performance of PET-CT imaging subsystem of the RefleXion X1 System Device in patients undergoing standard-of-care (SOC) \[68Ga\]-PSMA-11 PET-CT using Illuccix on the same day.
Gender:
MALE
Ages:
All
Trial Updated:
02/24/2025
Locations: Ut Southwestern Medical Center, Dallas, Texas
Conditions: Prostate Cancer
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OsciPulse D-dimer Pilot Trial
NCT06477016
Recruiting
Pilot, randomized, non-blinded clinical trial to generate preliminary data to evaluate the impact of the OsciPulse system on serum d-dimer levels compared to standard of care intermittent compression therapy for DVT prophylaxis in patients admitted in the neuro ICU or intermediate neurological care unit with acute ischemic stroke.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/24/2025
Locations: HUP Neurology Dept. of Stroke and Neurocritical Care- University of Pennsylvania, Philadelphia, Pennsylvania
Conditions: Ischemic Stroke
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A Modular Phase 1/2 Study with CT7439 in Participants with Solid Malignancies
NCT06600789
Recruiting
This modular, multi-part, multi-arm, Phase 1/2, FIH study allows the evaluation of the safety and tolerability of CT7439, dosed as a monotherapy and in combination with anticancer treatment in participants with solid malignancies.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/24/2025
Locations: Research site 03, Dallas, Texas +5 locations
Conditions: Solid Malignancies
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Door-Through-Door Companion Rideshare Technology for Individuals with Alzheimer's Disease and Related Dementias (AD/ADRD)
NCT06850870
Recruiting
The goal of this pilot randomized controlled trial is to assess the impact of D2D rideshare services with a trained companion driver on the rate of medical appointments for older adults and individuals with AD/ADRD. Participants will be assigned either door-through-door (D2D) rideshare or curb-to-curb (C2C) rideshare services. he main question it aims to answer is: Do D2D rideshare services reduce missed medical appointment rates compared to C2C rideshare services?
Gender:
ALL
Ages:
60 years and above
Trial Updated:
02/24/2025
Locations: Onward Health HQ, San Leandro, California
Conditions: Alzheimer Disease or Associated Disorder, Dementia, Cognitive Decline
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Anticoagulation in ICH Survivors for Stroke Prevention and Recovery
NCT03907046
Recruiting
Primary Aim: To determine if apixaban is superior to aspirin for prevention of the composite outcome of any stroke (hemorrhagic or ischemic) or death from any cause in patients with recent ICH and atrial fibrillation (AF). Secondary Aim: To determine if apixaban, compared with aspirin, results in better functional outcomes as measured by the modified Rankin Scale.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/24/2025
Locations: University of Alabama Hospital, Birmingham, Alabama +169 locations
Conditions: Intracerebral Hemorrhage, Atrial Fibrillation
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Atorvastatin ± Aspirin in Lynch Syndrome Syndrome
NCT04379999
Recruiting
The goal of this study is to investigate that a common cholesterol lowering agent (atorvastatin) alone or combining with a nonsteroidal anti-inflammatory drug (aspirin) would reduce the risk of colorectal cancer (CRC) in high-risk individuals with Lynch syndrome.
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
02/24/2025
Locations: Fox Chase Cancer Center, Philadelphia, Pennsylvania
Conditions: Lynch Syndrome
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TBI Evaluation and Management (TEaM)
NCT04576715
Recruiting
The purpose of this study is to evaluate a multi-disciplinary, multi-setting intervention with the goal of improving outcomes for children who have experienced a mild traumatic brain injury (mTBI). The project aims to improve and support mTBI diagnosis and management, and improve critical decision making by clinicians during their interaction with the injured child, their family, and their school.
Gender:
ALL
Ages:
5 years and above
Trial Updated:
02/24/2025
Locations: Children's Healthcare of Atlanta (CHOA) - Egleston Emergency Department, Atlanta, Georgia +2 locations
Conditions: Mild Traumatic Brain Injury
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US Study of ECT-001-CB in Pediatric and Young Adult Patients With High-Risk Myeloid Malignancies
NCT04990323
Recruiting
Cord blood (CB) transplants are an option for patients lacking an HLA identical donor but are hampered by low cell dose, prolonged aplasia and high transplant related mortality. UM171, a novel and potent agonist of hematopoietic stem cell self renewal could solve this major limitation, allowing for CB's important qualities as lower risk of chronic GVHD and relapse to prevail. In previous trials (NCT02668315, NCT03913026, NCT04103879, and NCT03441958), the CB expansion protocol using the ECT-001-... Read More
Gender:
ALL
Ages:
Between 0 years and 21 years
Trial Updated:
02/24/2025
Locations: Memorial Sloan Kettering Cancer Center, New York, New York
Conditions: High Risk Myeloid Malignancies, Cord Blood Transplant
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Enfortumab Vedotin and Pembrolizumab in People with Bladder Cancer
NCT05239624
Recruiting
This study will test whether enfortumab vedotin combined with pembrolizumab is an effective treatment for people with bladder cancer (urothelial carcinoma) involving the lymph nodes who are going to have surgery to remove their cancer (cystectomy). The researchers will look at whether treatment with enfortumab vedotin and pembrolizumab before surgery can get rid of cancer within the lymph nodes. They will also try to find out if this combination of drugs is effective at shrinking participants' c... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/24/2025
Locations: Baptist Alliance MCI, Miami, Florida +9 locations
Conditions: Urothelial Carcinoma
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