Evaluating Innovative Technologies and Approaches to Addressing Cervical Cancer in Gaza and Maputo Cidade Provinces in Mozambique
Recruiting
The goal of this operational research study is to develop, implement and test integrated CCS\&PT and voluntary FP service delivery models to evaluate whether integrated service delivery can optimize uptake and health impact of both services. The study objectives and learning questions are listed below, along with key outcomes that will be measured.
Gender:
FEMALE
Ages:
Between 30 years and 49 years
Trial Updated:
05/09/2025
Locations: M D Anderson Cancer Center, Houston, Texas
Conditions: Cervical Cancer
Image-Guided Biopsies to Identify Mechanisms of Resistance in Patients With Metastatic Castration Resistant Prostate Cancer Treated With 177Lu-PSMA Radioligand Therapy
Recruiting
This clinical trial studies mechanisms of resistance to 177-lutetium prostate specific membrane antigen (177Lu-PSMA) radioligand therapy using image-guided biopsies in patients with castrate-resistant prostate cancer that had spread to other places in the body (metastatic). Diagnostic procedures, such as image guided biopsies, may help in learning how well 177Lu-PSMA works to kill tumor cells and allow doctors to plan better treatment.
Gender:
MALE
Ages:
All
Trial Updated:
05/09/2025
Locations: UCLA / Jonsson Comprehensive Cancer Center, Los Angeles, California
Conditions: Castration-Resistant Prostate Carcinoma, Metastatic Prostate Carcinoma, Stage IV Prostate Cancer American Joint Committee on Cancer (AJCC) v8, Stage IVA Prostate Cancer AJCC v8, Stage IVB Prostate Cancer AJCC v8
Partial Breast Re-irradiation Using Ultra Hypofractionation (PRESERVE)
Recruiting
Breast-conserving surgery followed by re-irradiation with partial breast irradiation (rPBI) has recently been found to be a safe alternative to mastectomy for women who have undergone prior whole breast radiation. By reducing the volume of tissue receiving radiation, rPBI has been associated with less toxicity and improved cosmetic outcomes. For many women with early-stage breast cancer, shorter 1-week (5-fraction) courses of breast radiation (ultra-fractionation) have been found to be equivalen... Read More
Gender:
FEMALE
Ages:
Between 18 years and 99 years
Trial Updated:
05/09/2025
Locations: NYU Langone Health, New York, New York +9 locations
Conditions: Breast Cancer, Breast Cancer Recurrent
Assessment of Functional and Symptom Outcomes for Survivors of Paranasal Sinus, Nasopharyngeal and Skull Base Tumors
Recruiting
To learn about the symptoms and changes our patients experience while receiving treatment for sinonasal or nasopharyngeal cancer
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/09/2025
Locations: M D Anderson Cancer Center, Houston, Texas
Conditions: Tumors
The Long COVID-19 Wearable Device Study
Recruiting
To further characterize Long COVID-19 by collecting data from individuals who already own wearable devices or are provided with a wearable device along with basic and enhanced educational materials to determine if both can improve Long COVID-19 symptom management and post-exertional malaise.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/09/2025
Locations: Scripps Research, La Jolla, California
Conditions: Long COVID, Postural Orthostatic Tachycardia Syndrome, Dysautonomia, Myalgic Encephalomyelitis, Chronic Fatigue Syndrome, Long Covid19
A Study of Magnesium and Bladder Spasms Following Ambulatory Urologic Procedures
Recruiting
This research is being done to find out whether intravenous magnesium is effective in the treatment of bladder spasms after urologic surgery.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/09/2025
Locations: Mayo Clinic in Minnesota, Rochester, Minnesota
Conditions: Bladder Spasms
Long Term Efficacy and Safety of Orlistat for Type 1 Hyperlipoproteinemia
Recruiting
Type I hyperlipoproteinemia (T1HLP, also known as familial chylomicronemia syndrome or FCS) is a rare diseasewhere the blood triglycerides (fats) are very high. It is caused by lack of certain enzymes and proteins in the bodythat are important in disposing circulating fats from blood. Treatment of T1HLP patients who have very high levels of blood fats (≥ 1,000 mg/dL) is challenging as conventional triglyceride-lowering medications, such as fibrates and fishoil, are ineffective. The purpose of t... Read More
Gender:
ALL
Ages:
8 years and above
Trial Updated:
05/09/2025
Locations: UT southwestern Medical Center, Dallas, Texas
Conditions: Type 1 Hyperlipoprotenemia
Efficacy and Safety of Magnesium Vitamin B6 in First Episode Bipolar Disorder
Recruiting
This is a randomized, double-blind, placebo-controlled proof-of-concept clinical trial to assess the efficacy and safety of Magnesium-vitamin B6in combination with treatment as usual for treating symptoms of depression, stress, and anxiety in patients with first episode bipolar I disorder.
Gender:
ALL
Ages:
Between 18 years and 50 years
Trial Updated:
05/09/2025
Locations: McLean Hospital, Belmont, Massachusetts
Conditions: Bipolar I Disorder, Depression, Anxiety, Stress
AntiThrombotic Therapy to Ameliorate Clinical Complications in Community Acquired Pneumonia
Recruiting
This is an international, open-label, stratified randomized controlled trial with Bayesian adaptive stopping rules to compare the effects of therapeutic-dose heparin vs. usual care pharmacological thromboprophylaxis on outcomes in patients admitted to hospital with community acquired pneumonia (CAP).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/09/2025
Locations: University of Chicago, Chicago, Illinois +61 locations
Conditions: Community-acquired Pneumonia
Evaluating and Monitoring Immune and Clinical Responses in Early-Stage Triple Negative Breast Cancer Undergoing Neoadjuvant Chemo-immunotherapy With Pembrolizumab
Recruiting
This research study is a prospective, single arm, pilot study, designed to evaluate the correlation between the immune and clinical responses of subjects with untreated Stage II-III triple negative breast cancer (TNBC) undergoing standard of care neoadjuvant chemo- immunotherapy.
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
05/09/2025
Locations: Emory University/Winship Cancer Institute, Atlanta, Georgia
Conditions: Breast Cancer Triple Negative, Breast Cancer Stage II, Breast Cancer Stage III, Breast Cancer Invasive
Reducing Blood Pressure in Patients With High Cardiovascular Risk
Recruiting
BP-REACH is a study of a team-based (pharmacist and health coach) program for lowering blood pressure for people with a prior stroke or heart attack in the Los Angeles Department of Health Services healthcare system. The goal of this clinical trial is to test if this team based program is better at helping people reduce their blood pressure than usual care for people with prior heart attack or stroke. The main questions it aims to answer are: * Do people in the REACH BP program have lower bloo... Read More
Gender:
ALL
Ages:
35 years and above
Trial Updated:
05/09/2025
Locations: Rancho Los Amigos National Rehabilitation Center, Downey, California +3 locations
Conditions: Myocardial Infarction, Hypertension, Stroke
Use of Hand-held Dynamometry to Obtain Objective Measures of Lower Extremity Force Production With Chronic Stroke
Recruiting
This study wants to know if using handheld dynamometry (HHD) to test leg strength in persons who have had a stroke, will reduce mistakes and give therapists better information to use for therapy. This study will collect normal values of leg muscle peak force production, cumulative peak force production, and sustained peak force production in patients with chronic stroke.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/09/2025
Locations: Vanderbilt University Medical Center, Nashville, Tennessee
Conditions: Chronic Stroke, Weakness, Muscle