Oxidative Stress in Microvascular Dysfunction Following Gestational Diabetes
NCT05946785
Recruiting
The purpose of this investigation is to examine the role of oxidative stress in aberrant microvascular function in otherwise healthy women with a history of GDM.
Gender:
FEMALE
Ages:
Between 18 years and 50 years
Trial Updated:
05/07/2025
Locations: University of Iowa, Iowa City, Iowa
Conditions: Gestational Diabetes, Vascular Endothelial Function
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Role of NADPH Oxidase in Microvascular Dysfunction Following GDM
NCT05946798
Recruiting
The purpose of this investigation is to examine NADPH oxidase as a source of reactive oxygen species contributing to aberrant microvascular function in otherwise healthy women with a history of GDM.
Gender:
FEMALE
Ages:
Between 18 years and 50 years
Trial Updated:
05/07/2025
Locations: University of Iowa, Iowa City, Iowa
Conditions: Gestational Diabetes, Oxidative Stress, Vascular Endothelial Function
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Project 4: Ambulatory Biofeedback and Voice Therapy for Patients With Vocal Hyperfunction
NCT05970562
Recruiting
Vocal hyperfunction (VH) is the most commonly treated class of voice disorders by speech-language pathologists and voice therapy is the primary curative treatment. Patients and clinicians report that generalizing improved voicing into daily life is the most significant barrier to successful therapy. We will test if extending biofeedback into the patient's daily life using ambulatory voice monitoring will significantly improve generalization during therapy and if individual patient factors, like... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
05/07/2025
Locations: Massachusetts General Hospital, Boston, Massachusetts +1 locations
Conditions: Voice Disorders, Vocal Fold Polyp, Vocal Nodules in Adults, Muscle Tension Dysphonia
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Remote Cardiac Rehab for Adolescents With Congenital Heart Disease
NCT06015191
Recruiting
The goal of this randomized controlled trial is to evaluate the effectiveness of video conferencing for the delivery of live-supervised, real-time cardiac rehabilitation (CR) exercise training to groups of adolescents with congenital heart disease (CHD) in their homes. Participants will be randomized to either the remote cardiac rehab (RCR) group or active control group. The RCR group will participate in live, group-based exercise training (3-5 participants per exercise session), in their homes... Read More
Gender:
ALL
Ages:
Between 12 years and 19 years
Trial Updated:
05/07/2025
Locations: Children's Mercy Kansas City, Kansas City, Missouri
Conditions: Congenital Heart Disease in Children
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A Study About the Long-Term Safety of TAK-881 in People With Primary Immunodeficiency Diseases
NCT06076642
Recruiting
The main aim of this study is to learn if TAK-881 is safe and well tolerated during long-term use in adults and children with PIDD who are eligible and completed study TAK-881-3001 (NCT05755035). The participants will receive the first dose of TAK-881 immunoglobulin (IgG) infusion at the same dosage as the last dose administered in study TAK-881-3001 (NCT05755035). After the first TAK-881 infusion in study TAK-881-3002, the dosing interval (can be adjusted by participant/caregiver) and/or the d... Read More
Gender:
ALL
Ages:
2 years and above
Trial Updated:
05/07/2025
Locations: Central Georgia Infectious Disease Consultants, Macon, Georgia +4 locations
Conditions: Primary Immunodeficiency Diseases (PID)
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A Natural History Study in Participants With Congenital Myasthenic Syndromes (CMS) Due to Mutations in DOK7, MUSK, AGRN, or LRP4
NCT06078553
Recruiting
Participants will attend up to 4 study visits to collect clinical assessments. The assessments will evaluate participants' symptoms and quality of life to understand disease activity in patients with CMS due to mutations in DOK7, MUSK, AGRN, or LRP4.
Gender:
ALL
Ages:
2 years and above
Trial Updated:
05/07/2025
Locations: UC Davis Health - UC Davis Health Midtown Ambulatory Care Center, Sacramento, California +9 locations
Conditions: Congenital Myasthenic Syndrome
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The Effect of Synaquell™ in Contact Sport Athletes
NCT06104670
Recruiting
This research is being done to investigate the dietary supplement, Synaquell (TM), for effects on brain function in youth contact sport athletes.
Gender:
ALL
Ages:
Between 13 years and 19 years
Trial Updated:
05/07/2025
Locations: Mayo Clinic in Rochester, Rochester, Minnesota
Conditions: Healthy
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Using Novel Imaging to More Safely Treat Neuroendocrine Tumors
NCT06122610
Recruiting
The goal of this research is to determine if DetectnetTM PET/CT can be used to make Lutathera therapy safer for patients with neuroendocrine cancer. Participants will: * Complete two phases involving 6 visits * Undergo additional research PET/CT, and possibly SPECT/CT scans
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/07/2025
Locations: University of Wisconsin - Madison, Madison, Wisconsin
Conditions: Neuroendocrine Tumors, Somatostatin Receptor-positive Neuroendocrine Tumor
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A Study to Determine if BHV-7000 is Effective and Safe in Adults With Refractory Focal Onset Epilepsy
NCT06132893
Recruiting
The purpose of this study is to determine whether BHV-7000 is effective in the treatment of refractory focal epilepsy.
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
05/07/2025
Locations: Barrow Neurological Institute, Phoenix, Arizona +123 locations
Conditions: Focal Epilepsy
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Community Care Intervention to Decrease COVID-19 Vaccination Inequities
NCT06156254
Recruiting
The purpose of this study is to find out if a community health workers (CHW) intervention conducted in Federally Qualified Health Centers (FQHCs) can increase the number of adults with chronic illnesses who are up-to-date with their COVID-19 and influenza vaccines.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/07/2025
Locations: Morris Heights Health Center, Bronx, New York +3 locations
Conditions: COVID-19 Vaccination
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Effect of Chlorhexidine Gluconate Bladder Instillations in Patients With Chronic Suprapubic Catheters on Unplanned Healthcare Encounters and Quality of Life
NCT06163469
Recruiting
The goal of this clinical trial is to evaluate the feasibility and tolerability of 0.05% Chlorhexidine Gluconate (CGH) bladder instillations in an outpatient setting at the time of suprapubic catheter (SPC) exchange in patients with history of recurrent urinary tract infections (UTI). The main questions are: 1. is instillation of 150mL of CGH for five-minute duration at the time of SPC exchange feasible in an outpatient setting and tolerable for patients. 2. does this protocol decrease the rate... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/07/2025
Locations: Yale New Haven Health, New Haven, Connecticut
Conditions: Neurogenic Bladder, Urinary Retention
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Reducing the Risk of Chronic Hypertension and Improving Vascular Function Following Preeclampsia
NCT06220721
Recruiting
The long-term goal of our work is to evaluate the effect of intensive postpartum blood pressure control on maternal cardiovascular health, risk of chronic hypertension, and reversal of vascular dysfunction generated by hypertensive disorders of pregnancy, thus attenuating the lifelong trajectory of cardiovascular disease risk.
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
05/07/2025
Locations: Northwestern University, Chicago, Illinois +1 locations
Conditions: Hypertension, Pregnancy-Induced
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