A Pilot Presurgical Trial of REGN5678 (Anti-PSMA x CD28) in Patients With High-risk, Localized Prostate Cancer Followed by Radical Prostatectomy
Recruiting
To learn about the safety and effects of a drug called REGN5678 when it is given to patients with high-risk prostate cancer.
Gender:
MALE
Ages:
18 years and above
Trial Updated:
01/16/2025
Locations: M D Anderson Cancer Center, Houston, Texas
Conditions: Prostate Cancer, Radical Prostatectomy
The Heart Outcomes in Pregnancy Expectations for Mom and Baby Study
Recruiting
This is a prospective, observational study which is evaluating the obstetrical, neonatal, and cardiovascular outcomes of 1000 pregnant people with known heart disease to define how best to structure cardio-obstetrics care to optimize outcomes.
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
01/16/2025
Locations: Saint Luke's Hospital of Kansas City, Kansas City, Missouri
Conditions: Pregnancy Complications, Cardiovascular
A Phase 1/2 Study of DCC-3116 in Patients With RAS/MAPK Pathway Mutant Solid Tumors
Recruiting
This is a Phase 1/2, multicenter, open label, first in human (FIH) study of DCC-3116 as monotherapy, and in combination with trametinib, binimetinib, or sotorasib in patients with advanced or metastatic solid tumors with RAS/MAPK pathway mutation. The study consists of 2 parts, a dose-escalation phase, and an expansion phase.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/16/2025
Locations: Massachusetts General Hospital, Boston, Massachusetts +9 locations
Conditions: Non-Small Cell Lung Cancer, Advanced Solid Tumor, Metastatic Solid Tumor
Remote Smoking Cessation in Hospitalized Cardiac Patients
Recruiting
The investigators are proposing to examine new strategies for helping patients hospitalized for an acute coronary event adhere to recommendations to quit smoking. The investigators are interested to see whether offering financial incentives for smoking cessation, combined with medications to ameliorate withdrawal, can significantly reduce smoking in a population for which continued smoking has disproportionately negative health effects. The proposed trial can provide significant knowledge for pr... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/16/2025
Locations: University of Vermont Medical Center, Burlington, Vermont
Conditions: Smoking Cessation
Using Augmented Reality to Promote Physical Activity in Children With Cerebral Palsy
Recruiting
Children with cerebral palsy (CP), Gross Motor Functional Classification Scale (GMFCS) I-II will be recruited to participate in a home based physical activity intervention for 4 weeks. Demographic data will be collected, and validated surveys assessing baseline physical activity level and mobility will be completed. Participants will have an exercise program assigned and will be given a logbook to record their exercise adherence. They will be assigned to the Augment Reality (AR) app group. The A... Read More
Gender:
ALL
Ages:
Between 5 years and 18 years
Trial Updated:
01/16/2025
Locations: Jackie and Gene Autry Orthopedic Center, CHLA, Los Angeles, California
Conditions: Cerebral Palsy, Mobile Phone Use, Pediatric ALL, Physical Disability, Physical Inactivity
Prediction of Anxiety and Memory State
Recruiting
The purpose of this study is to look at how signals in the brain, body, and behavior relate to anxiety and memory function. This project seeks to develop the CAMERA (Context-Aware Multimodal Ecological Research and Assessment) platform, a state-of-the-art open multimodal hardware/software system for measuring human brain-behavior relationships. The R61 portion of the project is designed to develop the CAMERA platform, which will use multimodal, passive sensor data to predict anxiety-memory stat... Read More
Gender:
ALL
Ages:
Between 18 years and 55 years
Trial Updated:
01/16/2025
Locations: Columbia University, New York, New York
Conditions: Anxiety, Memory, Epilepsy
Acalabrutinib in CNSL
Recruiting
This research study is a Phase 1/2 clinical trial testing the safety, tolerance and efficacy of the drug Acalabrutinib for people with recurrent or refractory central nervous system lymphoma (CNSL).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/16/2025
Locations: Brigham and Women's Hospital, Boston, Massachusetts +1 locations
Conditions: Central Nervous System Lymphoma, Refractory Central Nervous System Lymphoma, Recurrent Central Nervous System Lymphoma
Workplace Fall Prevention Through Slip Recovery Training
Recruiting
The goal of this clinical trial is to evaluate the feasibility of applying slip recovery training, a novel balance training exercise intervention, to workers who are at increased risk of slip-induced falls. This will be done via field studies with industrial partners. Note that the slip recovery training is not a device or drug. It is a detailed exercise regimen that aims to improve the the ability to recover balance after slipping. The main specific aims are are: * To investigate the feasibil... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
01/16/2025
Locations: Virginia Tech, Blacksburg, Virginia
Conditions: Accidental Fall
A Study to Evaluate the Efficacy and Safety of Subcutaneous Amlitelimab Monotherapy Compared With Placebo in Participants Aged 12 Years and Older With Moderate-to-severe Atopic Dermatitis
Recruiting
This is a parallel group, Phase 3, multinational, multicenter, randomized, double blind, placebo-controlled, 3-arm monotherapy study for treatment of participants diagnosed with moderate to severe atopic dermatitis (AD), whose disease is not adequately controlled with topical prescription therapies or when those therapies are not advisable. The purpose of this study is to measure the efficacy and safety of treatment with amlitelimab solution for SC injection compared with placebo in participant... Read More
Gender:
ALL
Ages:
12 years and above
Trial Updated:
01/16/2025
Locations: Scottsdale Clinical Trials- Site Number : 8401149, Scottsdale, Arizona +147 locations
Conditions: Dermatitis Atopic
Modified Multi-Platform Trial Assessing Multiple CAMPs and SOC vs SOC Alone in the Treatment of DFU and VLUs
Recruiting
This is a multicenter, prospective, randomized controlled modified multi-platform (matriarch) trial evaluating several cellular, acellular, and matrix-like products (CAMPs) and standard of care versus standard of care alone in the management of nonhealing diabetic foot and venous leg ulcers.
Gender:
ALL
Ages:
21 years and above
Trial Updated:
01/16/2025
Locations: Cutting Edge Research, Circleville, Ohio
Conditions: Diabetic Foot Ulcer, Venous Leg Ulcer, Ulcer Foot, Leg Ulcer
Oral Aromatase Inhibitors Modify the Gut Microbiome
Recruiting
The purpose of this research is to study the bacteria in participants' gut before receiving a medicine called an aromatase inhibitor for breast cancer and after participants receive medicine for breast cancer.
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
01/16/2025
Locations: Wake Forest Baptist Health Sciences, Winston-Salem, North Carolina
Conditions: Breast Cancer
Neoantigen-based Personalized DNA Vaccine With Retifanlimab PD-1 Blockade Therapy in Patients With Newly Diagnosed, Unmethylated Glioblastoma
Recruiting
This is a single institution, open-label, multi-arm, phase I study assessing the safety and immunogenicity of a personalized neoantigen-based personalized DNA vaccine combined with PD-1 blockade therapy in subjects with newly diagnosed, MGMT promoter unmethylated glioblastoma (GBM). Immune checkpoint blockade, specifically those targeting the PD-1/PD-L1 pathways, has shown efficacy in multiple solid and hematologic malignancies. Furthermore, as has been demonstrated in metastatic melanoma, comb... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/16/2025
Locations: Washington University School of Medicine, Saint Louis, Missouri
Conditions: Unmethylated Glioblastoma