Effect of VLCD on the Reduction of Liver Steatosis and Fibrosis in Subjects With Obesity and NAFLD
NCT04861571
Recruiting
Non-alcoholic fatty liver disease (NAFLD) is a common complication of obesity which can progress to deadly complications like end-stage liver disease and hepatocellular carcinoma. In the wake of the obesity epidemic, NAFLD is becoming the main etiology of liver transplantation in the US. Currently, there are no FDA approved pharmacological treatments for NAFLD. Weight loss through lifestyle modifications, pharmacotherapy and bariatric surgery can be effective strategies for the management of NAF... Read More
Gender:
ALL
Ages:
Between 18 years and 70 years
Trial Updated:
01/15/2025
Locations: University of Iowa Health Care, Iowa City, Iowa
Conditions: NAFLD
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Intraoperative Ansa Cervicalis Nerve (ACN) Stimulation
NCT05650710
Recruiting
Recently published data suggest that stimulation of the infrahyoid strap muscles increases pharyngeal patency in patients with obstructive sleep apnea, but the innervation of these muscles by the ansa cervicalis is variable. The investigators propose a study examining the anatomic variation of the ansa cervicalis and the effect of neurostimulation on muscle recruitment.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/15/2025
Locations: Vanderbilt University Medical Center, Nashville, Tennessee
Conditions: Head and Neck Cancer, Obstructive Sleep Apnea
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Investigation of the BrioVAD System for the Treatment of Left Ventricular Heart Failure
NCT06310031
Recruiting
The goal of this study is to evaluate the safety and efficacy of the BrioVAD System by demonstrating non-inferiority to the HeartMate 3 Left Ventricular Assist System when used for the treatment of advanced, refractory, left ventricular heart failure.
Gender:
ALL
Ages:
Between 18 years and 100 years
Trial Updated:
01/15/2025
Locations: Emory University, Atlanta, Georgia +6 locations
Conditions: Cardiovascular Diseases, Heart Diseases, Heart Failure
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Impact of Diaphragmatic Breathing Coaching on Deep Inspiration Breath Hold Reproducibility and Organ Protection
NCT06747533
Recruiting
To learn if coaching participants on diaphragmatic breathing will help participants to take larger, more reproducible breaths and feel less anxiety about their treatments.
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
01/15/2025
Locations: MD Anderson Cancer Center, Houston, Texas
Conditions: Breathing, Mouth
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Study of CD19-directed Allogeneic Memory T-cell Therapy for Relapsed/Refractory CD19+ Leukemia
NCT04881240
Recruiting
This is a Phase I clinical study evaluating the safety and maximum tolerated dose of a novel CAR T-cell product: allogeneic memory (CD45RA- negative) T-cells expressing a CD19-specific CAR 41BBz (CD19-CAR.CD45RA- negative T-cells) for the treatment of patients ≤ 21 years old with relapsed and/ or refractory CD19-positive leukemia. Primary Objective To determine the maximum tolerated dose (MTD) and characterize the safety profile and dose-limiting toxicities (DLTs) of treatment with allogeneic... Read More
Gender:
ALL
Ages:
21 years and below
Trial Updated:
01/15/2025
Locations: St. Jude Children's Research Hospital, Memphis, Tennessee
Conditions: Acute Lymphoblastic Leukemia, in Relapse, Acute Lymphoblastic Leukemia, Refractory, Pediatric ALL
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Vestibular Implantation to Treat Adult-Onset Bilateral Vestibular Hypofunction
NCT05674786
Recruiting
Although cochlear implants can restore hearing to individuals who have lost cochlear hair cell function, there is no widely available, adequately effective treatment for individuals suffering chronic imbalance, postural instability and unsteady vision due to bilateral vestibular hypofunction. Prior research focused on ototoxic cases has demonstrated that electrical stimulation of the vestibular nerve via a chronically implanted multichannel vestibular implant can partially restore vestibular ref... Read More
Gender:
ALL
Ages:
Between 22 years and 90 years
Trial Updated:
01/15/2025
Locations: Johns Hopkins School of Medicine, Baltimore, Maryland
Conditions: Other Disorders of Vestibular Function, Bilateral, Bilateral Vestibular Deficiency (BVD), Gentamicin Ototoxicity, Labyrinth Diseases, Vestibular Diseases, Sensation Disorders, Bilateral Vestibular Hypofunction, Bilateral Vestibulopathy, Aminoglycoside Ototoxicity
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Cooling Strategies for Older Adults in the Heat
NCT06349616
Recruiting
The earth's climate is warming, and the number of heat waves has increased in recent years. At the same time, the number of adults over the age of 65 is growing. Humans sweat and increase blood flow to the skin to cool their body when they get hot. Older adults do not do this as well as young adults. This makes it harder to safely be in warm and/or humid conditions. It is important to learn about cooling strategies for older adults to safely be in warm and/or humid conditions. There is compelli... Read More
Gender:
ALL
Ages:
Between 65 years and 100 years
Trial Updated:
01/15/2025
Locations: Noll Laboratory, University Park, Pennsylvania
Conditions: Aging
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The Use of Cyproheptadine in Pediatric Feeding Disorders
NCT06751290
Recruiting
The goal of this clinical trial is to learn if Cyproheptadine, an appetite stimulant, can improve eating habits in children with Pediatric Feeding Disorders. Pediatric Feeding Disorders is a broad term that describes disorders of eating-related behaviors that causes altered consumption of food and impairs physical or psychosocial health.
Gender:
ALL
Ages:
Between 2 years and 6 years
Trial Updated:
01/15/2025
Locations: University of Miami Department of Pediatric Gastroenterology, Miami, Florida
Conditions: Pediatric Feeding Disorder, Chronic, Avoidant Restrictive Food Intake Disorder
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The Healthy Elderly Longevity Cohort
NCT01004133
Recruiting
With the completion of the human genome project, investigators can now explore new questions in human biology. Previously human genetics focused on highly penetrant, Mendelian traits; however, now rare and common variants can be discovered that affect "common" diseases that have multi-gene architecture with variable penetrance such as breast cancer, diabetes mellitus, and coronary artery disease. This change took place because investigators now have the tools to illuminate the whole genome at on... Read More
Gender:
ALL
Ages:
80 years and above
Trial Updated:
01/15/2025
Locations: Scripps Translational Science Institute, La Jolla, California
Conditions: Healthy
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Reducing Pregnancy Risks: The Mastery Lifestyle Intervention
NCT05012072
Recruiting
This randomized controlled trial will test an intervention called the Mastery Lifestyle Intervention (the MLI) that was developed from data of 1000+pregnant Hispanic women related to risks of preterm birth. The investigators will deliver a psychoeducational intervention that is manualized over 6 group sessions. The investigators will also have a usual care group that receives standard prenatal care. The investigators plan to enroll 238 pregnant women and start the study with them at 14-20 weeks... Read More
Gender:
FEMALE
Ages:
Between 18 years and 45 years
Trial Updated:
01/15/2025
Locations: Anthony Chavez, MD, Houston, Texas
Conditions: Mental Health Wellness 1, Preterm Birth
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Long-term Follow-up After Adoptive Transfer of Genetically Modified Cell Products
NCT05713214
Recruiting
Human gene therapy products are designed to achieve therapeutic effect through genetic modifications of human cells using retroviral or lentiviral vectors, resulting in permanent or long-acting changes in the human body. With this genetic modification comes risk of undesirable adverse events. Due to this risk, the Food and Drug Administration (FDA) and the Center for Biologics Evaluation and research (CBER) require long-term follow-up (15 years) of participants that receive investigational gene... Read More
Gender:
ALL
Ages:
All
Trial Updated:
01/15/2025
Locations: St. Jude Children's Research Hospital, Memphis, Tennessee
Conditions: Relapsed Hematologic Malignancy, Refractory Hematologic Malignancy
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Study to Evaluate the Efficacy and Safety of Subcutaneous Sonelokimab Compared with Placebo in Adult Participants with Moderate to Severe Hidradenitis Suppurativa
NCT06411379
Recruiting
This is a study to evaluate the clinical efficacy and safety of sonelokimab administered subcutaneously compared with placebo in the treatment of adult participants with moderate to severe hidradenitis suppurativa. Participants will be randomized 2:1 to either sonelokimab or matching placebo up to Week 16.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/15/2025
Locations: Clinical Site, Birmingham, Alabama +95 locations
Conditions: Hidradenitis Suppurativa
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