Weight Inclusive and Adaptive Strategies to Enhance Cardiometabolic Health in Black Adults
Recruiting
The proposed 6-month pilot Sequential Multiple Assignment Randomize Trial (SMART) has two aims. The first and primary aim is to determine the feasibility of conducting a full-scale SMART to compare weight-focused (i.e., weight loss) and weight-neutral (i.e., weight loss is not an explicit goal) adaptive biobehavioral interventions for improving cardiometabolic health in Black adults with overweight or obesity (BMI ≥27 kg/m2) plus at least one weight-related cardiometabolic condition (high blood... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/23/2025
Locations: University of Alabama at Birmingham, Birmingham, Alabama
Conditions: Obesity, Prehypertension, Hypertension, PreDiabetes, Type 2 Diabetes, Dyslipidemia
Retinal Vascular Changes During Pregnancy
Recruiting
The goal of this study is to better understand how the back part of the eye-called the retina and the choroid-changes during pregnancy. Specialized photos of the eye will be taken at three different timepoints: early in pregnancy (first or second trimester), late in pregnancy (third trimester), and after delivery. This imaging is non-invasive and does not require contact with the surface of the eye. The photos taken will allow assessment of specific parameters, like blood flow and the health of... Read More
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
04/23/2025
Locations: Vanderbilt University Medical Center, Nashville, Tennessee
Conditions: Pregnancy
Surgical Approach to Uterine Septum
Recruiting
The objective of this study is to determine if the use of scissors without electrosurgery is superior to bipolar electrosurgery for resection of uterine septum. The investigators will be comparing procedure-level variables such as operative time, complications, and need for additional procedures.
Gender:
FEMALE
Ages:
Between 22 years and 44 years
Trial Updated:
04/23/2025
Locations: Northwestern Medicine Prentice Women's Hospital, Chicago, Illinois
Conditions: Uterine Septum, Surgical Complication, Septum; Uterus, Treatment Side Effects, Treatment
A Study Evaluating the Safety and Efficacy of Inhaled AP01 in Participants With Progressive Pulmonary Fibrosis
Recruiting
A randomized, double-blind, placebo-controlled clinical study to evaluate the safety and efficacy of 2 doses of inhaled pirfenidone (AP01) versus placebo on top of standard of care in participants with PPF over 52 weeks.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/23/2025
Locations: University of Alabama at Birmingham, Birmingham, Alabama +117 locations
Conditions: Progressive Pulmonary Fibrosis
Integrated Treatment for Enhancing Growth in Recovery During Adolescence
Recruiting
This is a Phase II parallel group randomized controlled trial with 294 adolescents (age: 14-21 years) with alcohol and other drug \[AOD\] use disorder (hereafter substance use disorder), that compares two different active psychosocial interventions designed to address adolescent substance use disorder. Participants are recruited from our clinical settings and the community at two sites: one in the metro Boston, Massachusetts (MA) area and the other in the metro Farmington, Connecticut (CT), area... Read More
Gender:
ALL
Ages:
Between 14 years and 21 years
Trial Updated:
04/23/2025
Locations: UConn Health, Farmington, Connecticut +1 locations
Conditions: Alcohol Use Disorder, Cannabis Use Disorder
A Phase I Study of Decitabine, Lisaftoclax, and Olverembatinib in Patients With Advanced Chronic Myeloid Leukemia and Philadelphia Chromosome-Positive Acute Myeloid Leukemia
Recruiting
To find the recommended doses of lisaftoclax and olverembatinib that can be given in combination with decitabine to participants with advanced CML and Ph+ AML.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/23/2025
Locations: MD Anderson Cancer Center, Houston, Texas
Conditions: Advanced Chronic Myeloid Leukemia, Philadelphia Chromosome-Positive Acute Myeloid Leukemia
Standard Versus High Dose ED-Initiated Buprenorphine Induction
Recruiting
This study is a multisite double-blind, double-dummy, randomized clinical trial enrolling ED patients with untreated moderate to severe opioid use disorder (OUD) to compare Standard Dose Induction (SDI) and High Dose Induction (HDI) on rates of participation in OUD treatment within 10 days post randomization, and opioid withdrawal symptoms, opioid craving, and use of illicit and non-prescribed drugs.
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
04/23/2025
Locations: Highland Hospital, Oakland, California +4 locations
Conditions: Opioid Use Disorder
MBC Physical Activity Study
Recruiting
This clinical trial evaluates the impact of a tailored physical activity program on physical activity in patients with breast cancer that has spread from where it first started to other places in the body (metastatic). It has been shown that decreased physical activity contributes to poor performance and quality of life. Evidence has also shown that exercise could improve physical fitness, physical functioning, quality of life, and cancer-related fatigue, however, there is concern that it may no... Read More
Gender:
FEMALE
Ages:
Between 18 years and 120 years
Trial Updated:
04/23/2025
Locations: Thomas Jefferson University Hospital, Philadelphia, Pennsylvania
Conditions: Anatomic Stage IV Breast Cancer AJCC v8, Metastatic Breast Carcinoma
Jackson Heart Study Women's Hypertension Study
Recruiting
High blood pressure is a powerful risk factor for heart disease. Black women are more likely to have high blood pressure than white women or Hispanic women. Even when they are aware they have high blood pressure, many people struggle to keep their blood pressure controlled. Research shows a connection between life stress and high blood pressure and heart disease outcomes. Mindfulness training programs can help people regulate their emotions and cope with stress. Research shows that mindfulness p... Read More
Gender:
FEMALE
Ages:
Between 18 years and 99 years
Trial Updated:
04/23/2025
Locations: University of Mississippi Medical Center, Jackson, Mississippi
Conditions: Hypertension
Auricular Vagus Nerve Stimulation (aVNS) in Chronic Spinal Cord Injuries (SCI)
Recruiting
The purpose of this research is to test if Auricular Vagal Nerve Stimulation (aVNS) is safe in persons with spinal cord injury (SCI).
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
04/23/2025
Locations: University of Miami, Miami, Florida
Conditions: Spinal Cord Injuries
Ear-Seizure Detection (EarSD) Study
Recruiting
The proposed study is an investigator-initiated study that aims to measure the accuracy of a wearable seizure detection and prediction device (Ear-Seizure Detection Device (EarSD)) by simultaneous recording with conventional video-EEG (Electroencephalogram) on patients with epileptic seizures in the Epilepsy Monitoring Unit of the hospital.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/23/2025
Locations: Ummmc-Memorial Campus, Worcester, Massachusetts +1 locations
Conditions: Seizures, Epilepsy
Contrast-enhanced Ultrasound in the Treatment of Acute Spinal Cord Injury
Recruiting
Patients with traumatic spinal cord injury (tSCI) often suffer from spinal cord swelling inside the thecal sac, which contains the spinal cord and surrounding fluid, leading to increased pressure on the spinal cord tissue and decreased spinal cord blood flow at the site of injury. The combination of increased pressure and decreased blood flow causes vascular hypoperfusion of the spinal cord and exacerbates the severity of injury. This is also referred to as secondary injury. Thus, knowledge of s... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/23/2025
Locations: University of Washington Harborview Medical Center, Seattle, Washington
Conditions: Acute Spinal Cord Injury