Bronchiectasis can be congenital (meaning that the patient already had it before being born), or caused by lifestyle and environmental factors. Congenital bronchiectasis happens when the lungs develop abnormally in utero. With acquired, or environmental bronchiectasis, damages to the airways can begin during childhood; however, a person might not develop any symptoms until many years later. Some of the most common causes of bronchiectasis are:
What is Bronchiectasis?
ronchiectasis is a disease of the lungs that causes damaged airways to permanently dilate. This leads mucus build up in the patient’s lungs, making it harder to breathe and creating a viable environment for bacteria and infections. Bronchiectasis often happens after repeated damage to the airways and lungs, which may happen from chronic infections or autoimmune diseases. A fairly uncommon disease, there are about 139 cases per 100,000 adults in the United States, and it tends to affect women more often than it does men. Bronchiectasis is a chronic condition, meaning that there is no cure for it, however, there are treatments available that can help patients control and manage their symptoms. Bronchiectasis clinical trials are ongoing in the United States and around the world, with a variety of treatments being tested.
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What Causes Bronchiectasis?
How is Bronchiectasis Diagnosed?
When a patient has a persistent cough with large quantities of phlegm (mucus), the doctor may suspect bronchiectasis and order different types of tests. These tests include:
While most patients with bronchiectasis have chronic symptoms, a particularly severe episode is called an exacerbation. During an exacerbation, the patient experiences at least three of the following symptoms:
- Increase in sputum volume
- More breathing difficulty than usual
- Change in sputum color
- Weakness or fatigue
- Coughing up blood (hemoptysis)
- Increased coughing
Though there is no cure for bronchiectasis, treatments exist to alleviate symptoms and prevent exacerbations. Some of the treatments (including some clinical research) to prevent exacerbations include:
- Vaccines: doctors may recommend patients to get pneumococcal and flu vaccines in order to protect the lungs against the virus. Any virus that attacks or affects the airways can be extremely dangerous to a patient with bronchiectasis.
- Bronchodilators: these are medications that open the airways to allow breathing. Some bronchodilators that might be prescribed for patients with bronchiectasis include albuterol, formoterol, and levalbuterol.
- Antibiotics: patients with bronchiectasis experience repeated lung infections. A one to two-week antibiotic cycle is the treatment of choice to for these infections. Doctors also prescribe antibiotics during an exacerbation episode.
- Oxygen therapy: can be prescribed during exacerbations or in severe cases of bronchiectasis in order to increase blood oxygen levels.
- Surgery: a doctor may recommend surgery when the bronchiectasis is limited to one part of the airway or if severe bleeding occurs. During surgery, the doctor removes the damaged or affected area of the airway, or in severe cases, the patient may receive a lung transplant.
Bronchiectasis Clinical Trials
ClinicalTrials.gov: Recruiting Studies | Bronchiectasis | Last update posted in the last 300 days Studies found on ClinicalTrials.gov by a search of: Recruiting Studies | Bronchiectasis | Last update posted in the last 300 days
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Defining the Genetic Etiology of Suppurative Lung Disease in Children and Adults
on January 8, 2021 at 5:00 pm
Conditions: Primary Ciliary Dyskinesia; Primary Immune Deficiency; Kartagener SyndromeInterventions: Diagnostic Test: Genetic Testing for PCD or PID; Other: Unaffected Family Member Genetic TestingSponsors: University of North Carolina, Chapel Hill; Washington University School of Medicine; National Heart, Lung, and Blood Institute (NHLBI); Children's Hospital Colorado; Stanford University; Seattle Children's Hospital; The Hospital for Sick Children; McGill University; Children's Hospital Medical Center, CincinnatiRecruiting
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Effect of Long Term Clarithromycin for Prevention of Exacerbations in Non-cystic Fibrosis Bronchiectasis in Asian Populations
on December 8, 2020 at 5:00 pm
Condition: Bronchiectasis AdultInterventions: Drug: Clarithromycin; Drug: PlaceboSponsor: Chinese University of Hong KongRecruiting
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RHB-204 for the Treatment of Pulmonary Mycobacterium Avium Complex Disease
on November 5, 2020 at 5:00 pm
Conditions: Pulmonary Mycobacterium Avium Complex Infection; Bronchiectasis; Lung DiseasesInterventions: Drug: RHB-204; Drug: PlaceboSponsor: RedHill Biopharma LimitedRecruiting
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The Ear-Nose-Throat (ENT) Prospective International Cohort of PCD Patients (EPIC-PCD)
on November 2, 2020 at 5:00 pm
Conditions: Primary Ciliary Dyskinesia; Kartagener SyndromeIntervention: Sponsors: University of Bern; Bicetre Hospital; Centre Hospitalier Intercommunal Creteil; University Hospital Southampton NHS Foundation Trust; Universitaire Ziekenhuizen Leuven; VU University Medical Center; University of Cyprus; Hacettepe University; Marmara University; Hospital Universitario La Fe; University Hospital Inselspital, BerneRecruiting
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A Series of N-of-1 Trials of Traditional Chinese Medicine Based on Bayesian Method
on October 26, 2020 at 4:00 pm
Conditions: Bronchiectasis; Quality of Life; Traditional Chinese Medicine; Sputum; Symptoms; IndividualityInterventions: Drug: Individualized Decoction; Drug: placebo; Drug: Tested drug minus heat-clearing herbsSponsors: Shanghai University of Traditional Chinese Medicine; Guangzhou University of Traditional Chinese MedicineRecruiting
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A Study to Assess the Efficacy, Safety, and Tolerability of Brensocatib in Participants With Non-Cystic Fibrosis Bronchiectasis
on October 20, 2020 at 4:00 pm
Condition: Non-Cystic Fibrosis BronchiectasisInterventions: Drug: Brensocatib 10 mg; Drug: Brensocatib 25 mg; Drug: PlaceboSponsor: Insmed IncorporatedRecruiting
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Lung Ultrasound Artefact Analysis for Exclusion of Acute Rejection in Lung Transplant Recipients
on October 9, 2020 at 4:00 pm
Condition: Post-Lung Transplantation BronchiectasisIntervention: Diagnostic Test: Lung ultrasoundSponsor: Mayo ClinicRecruiting
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A Prospective Study of Factors Related to Exacerbation and Mortality of Non-cystic Fibrosis Bronchiectasis in Hong Kong
on September 4, 2020 at 4:00 pm
Condition: Bronchiectasis AdultIntervention: Sponsor: Chinese University of Hong KongRecruiting
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Identification of Microbiome of Bronchiectasis in Chinese Population.
on July 29, 2020 at 4:00 pm
Condition: BronchiectasisIntervention: Sponsor: Shanghai Pulmonary Hospital, Shanghai, ChinaRecruiting
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COVID-19 Phobia in Patients With Bronchiectasis During Covid-19 Pandemic
on July 27, 2020 at 4:00 pm
Conditions: Covid19; BronchiectasisIntervention: Sponsor: Hacettepe UniversityRecruiting
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Lung Damage Caused by SARS-CoV-2 Pneumonia (COVID-19)
on June 17, 2020 at 4:00 pm
Conditions: COVID; Pneumonia, Viral; Barotrauma; Interstitial Lung Disease; Bronchiectasis Adult; EmphysemaIntervention: Sponsor: University of Milano BicoccaRecruiting
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Mucus Solids Concentration in Patients With Bronchiectasis
on March 17, 2020 at 4:00 pm
Condition: BronchiectasisIntervention: Other: No interventionSponsors: Universidad San Jorge; Hospital Clínic de Barcelona; Asociación Murciana de Fibrosis Quistica; University of North CarolinaRecruiting
- Learn to recognize what might trigger an exacerbation event so you are always prepared and able to act fast.
- Try to quit smoking if you smoke. Smoking affects your lungs and can cause further damage.
- Avoid strong smells and lung irritants such as dust, smoke, and fumes.
- If you are feeling overwhelmed, talk to someone. Talking about your feelings, fears, and concerns with people who are going through the same as you can be very helpful. There are several online and in-person support groups for patients with bronchiectasis.
- Make sure your loved one seeks treatment for his/her bronchiectasis, especially during a severe exacerbation.
- Be patient with your loved one, chronic lung conditions can be very frightening and uncomfortable. Offer to help whenever you can and be understanding of their condition.
- Try to keep the environment around your loved one clean and free of dust and other contaminants that might make their condition worse.
- Patients with chronic lung diseases are more prone to emotional problems such as anxiety and depression. If you think your loved one might be struggling with his/her condition reach out and encourage them to seek expert help.
Match to Bronchiectasis Clinical Trials
- Access to cutting-edge treatments
- Latest clinical trials
- Find trials in your area