Time Restricted Eating for Metabolic and Psychological Optimization
NCT05997316
Recruiting
Obesity and related metabolic comorbidities have been associated with more than a 4-fold increased risk of incident cognitive impairment, including Alzheimer's disease and related dementias (ADRD). Dysfunctional metabolic flexibility is increasingly recognized as a critical mechanism linking metabolic risk factors to risk of cognitive impairment, although few studies portable behavioral strategies to enhance metabolic function among individuals at risk for ADRD. The present study will examine th... Read More
Gender:
ALL
Ages:
Between 65 years and 80 years
Trial Updated:
10/17/2024
Locations: University of North Carolina, Chapel Hill, North Carolina
Conditions: Mild Cognitive Impairment, Obesity
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Intravenous Gammaglobulin for Sickle Cell Pain Crises
NCT01757418
Recruiting
The purpose of this study is to determine whether intravenous immune globulin is safe and effective in the acute treatment of pain crises in sickle cell disease. Funding Source: Food and Drug Administration (FDA), Office of Orphan Products Development (OOPD)
Gender:
ALL
Ages:
Between 6 years and 65 years
Trial Updated:
10/17/2024
Locations: Montefiore Medical Center, Bronx, New York
Conditions: Sickle Cell Disease, Pain
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Gabapentin & Ketamine for Prevention/Treatment of Acute/Chronic Pain in Locally Advanced Head and Neck Cancer
NCT05156060
Recruiting
This is a study to establish a safe and feasible dose for prophylactic use of a combination of gabapentin and ketamine in head and neck cancer patients undergoing chemoradiation.
Gender:
ALL
Ages:
21 years and above
Trial Updated:
10/17/2024
Locations: Vanderbilt-Ingram Cancer Center, Nashville, Tennessee
Conditions: Head and Neck Cancer, Locally Advanced Head and Neck Carcinoma
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Audio-based Mental Health Intervention Study
NCT05555745
Recruiting
This is a study on an audio-based digital intervention designed to reduce symptoms of depression. Participants who experience at least moderate symptoms of depression will be invited to participate in the study. Participants will be randomly assigned to receive one of two audio-based digital interventions. The experimental intervention based on behavioral activation treatment for depression. The control intervention is based on self-monitoring. Depression symptoms and related mental health sympt... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/17/2024
Locations: The Pennsylvania State University, University Park, Pennsylvania
Conditions: Depressive Symptoms
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A Mechanistic Trial of the Neurobiology of Extinction Learning and Intraparietal Sulcus Stimulation
NCT06234969
Recruiting
This study will be the first of its kind to explore the impact of continuous theta burst stimulation (cTBS) to the intraparietal sulcus (IPS) on arousal symptoms among patients with posttraumatic stress disorder (PTSD). The investigators will demonstrate that IPS cTBS results in significant reduction in arousal (measured by startle response) compared to sham cTBS, that IPS cTBS interacts with extinction training to further improve arousal, and that there is a dose/response effect of cTBS on arou... Read More
Gender:
ALL
Ages:
Between 18 years and 60 years
Trial Updated:
10/17/2024
Locations: Center for the Treatment and Study of Anxiety, University of Pennsylvania, Philadelphia, Pennsylvania
Conditions: Posttraumatic Stress Disorder
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Magnetic Apnea Prevention(MAGNAP) Device to Treat Obstructive Sleep Apnea:First-In-Human Study of Feasibility and Safety
NCT02431507
Recruiting
The purpose of this study is to determine the safety and feasibility of the Magnap magnetic device in the treatment of obstructive sleep apnea (OSA).
Gender:
ALL
Ages:
Between 21 years and 70 years
Trial Updated:
10/17/2024
Locations: University of California San Francisco/Mount Zion Hospital, San Francisco, California
Conditions: Obstructive Sleep Apnea
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MiSight 1 Day Safety Post-Approval Study
NCT05285527
Recruiting
The purpose of this post-approval study is to confirm the safety of daily disposable soft contact lens wear among the intended patient population for the MiSight 1 Day lens in the US.
Gender:
ALL
Ages:
Between 8 years and 12 years
Trial Updated:
10/17/2024
Locations: Experts on Sight LLC., Gilbert, Arizona +46 locations
Conditions: Myopia
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Anti-inflammatory Drugs and Serum Prostate-Specific Antigen Test
NCT05629494
Recruiting
Prostate cancer is the most frequently diagnosed cancer in men in the Unites States. Nearly 1 million prostate biopsy procedures are performed in the United States annually and elevated prostate-specific antigen (PSA) level is the primary reason for prostate biopsy in \> 90% of cases. However, at the PSA levels which trigger prostate biopsy, often no cancer is found in prostate biopsy specimens. PSA test can be elevated due to reasons other than cancer such as inflammation or natural variation i... Read More
Gender:
MALE
Ages:
Between 18 years and 80 years
Trial Updated:
10/17/2024
Locations: University of Chicago Medical Center, Chicago, Illinois +2 locations
Conditions: Prostate Cancer, Prostate Inflammation, PSA
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The BEE-Power Study (Boosting Exercise for Excellent Pediatric Blood Pressure)
NCT06444464
Recruiting
The goal of this study is to compare two types of exercises, isometric exercise (like squats and planks) and aerobic exercise (such as running), to see which one is more effective at improving blood pressure in teenagers aged 13 to 17.5 years. The main question the study aims to answer is: - Do the effects of one session of isometric exercise on the blood pressure of adolescents compare to the effects of one session of aerobic exercise? Adolescents diagnosed with high blood pressure may quali... Read More
Gender:
ALL
Ages:
Between 13 years and 17 years
Trial Updated:
10/17/2024
Locations: Arkansas Children's Nutrition Center, Little Rock, Arkansas
Conditions: High Blood Pressure, Overweight and Obesity, Adolescent Obesity, Exercise
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Executive Function in Early Childhood
NCT03713125
Recruiting
Despite the fact that a substantial number of school age children struggle with both reading and math acquisition, the brain mechanisms of the overlapping aspects of reading and math skills, thought in part to be linked via executive functions (EF), have not been unpacked. This project will use a longitudinal design, following children from Kindergarten through 1st grade, to understand how the brain networks associated with reading, math, and EF interact to predict academic outcomes and, in thos... Read More
Gender:
ALL
Ages:
Between 4 years and 9 years
Trial Updated:
10/17/2024
Locations: Vanderbilt University, Nashville, Tennessee
Conditions: Reading Disability
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MiSight 1 Day Post-Approval Study for Effectiveness and Visual Symptoms
NCT05285553
Recruiting
The purpose of this post-approval study is to confirm the effectiveness of the MiSight 1 Day lens in clinical practices within the US and to assess the stability of the myopia reduction over one-year post-treatment.
Gender:
ALL
Ages:
Between 8 years and 12 years
Trial Updated:
10/17/2024
Locations: University of Alabama School of Optometry, Birmingham, Alabama +29 locations
Conditions: Myopia
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Social Determinants of Sleep and Obesity
NCT05698693
Recruiting
African American adults sleep less and obtain worse quality sleep compared to the national average, and emerging evidence links inadequate sleep with greater morbidity and mortality from chronic diseases such as diabetes, obesity, and cancer. To address this public health concern, the proposed research seeks to use a multi-method approach to adapt a sleep intervention for African American adults with overweight/obesity not meeting national sleep duration or physical activity recommendations. The... Read More
Gender:
ALL
Ages:
Between 21 years and 65 years
Trial Updated:
10/17/2024
Locations: University of Minnesota, Minneapolis, Minnesota
Conditions: Insufficient Sleep, Physical Inactivity, Sedentary Behavior, Obesity
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