Efficacy and Safety of Depemokimab Compared With Mepolizumab in Adults With Relapsing or Refractory Eosinophilic Granulomatosis With Polyangiitis (EGPA)
NCT05263934
Recruiting
This study aims to investigate the efficacy and safety of depemokimab compared with mepolizumab in adults with relapsing or refractory EGPA receiving SoC therapy.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/16/2025
Locations: GSK Investigational Site, Denver, Colorado +80 locations
Conditions: Eosinophilic Granulomatosis With Polyangiitis
Register for Updates
Fecal Microbiota Transplantation for Chronic Granulomatous Disease-Associated Colitis
NCT05333471
Recruiting
Background: Chronic granulomatous disease (CGD) weakens the body's defense against germs. CGD can also damage the colon. It can cause inflammation (colitis) that disrupts the good bacteria. Placing good bacteria from donor stool into the intestine of a person with CGD (called fecal microbiota transplantation, or FMT) may help. Objective: To see if FMT can reduce inflammation in the colon. Eligibility: People aged 10-60 who have CGD and colitis, and the treatments they have tried are not hel... Read More
Gender:
ALL
Ages:
Between 10 years and 60 years
Trial Updated:
07/16/2025
Locations: National Institutes of Health Clinical Center, Bethesda, Maryland
Conditions: Chronic Granulomatous Disease-associated Colitis
Register for Updates
Testing of Tazemetostat in Combination With Topotecan and Pembrolizumab in Patients With Recurrent Small Cell Lung Cancer
NCT05353439
Recruiting
This phase I trial tests the safety, side effects, and best dose of tazemetostat in combination with topotecan and pembrolizumab in treating patients with small cell lung cancer that has come back after a period of improvement (recurrent). Tazemetostat may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Chemotherapy drugs, such as topotecan, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/16/2025
Locations: Keck Medicine of USC Koreatown, Los Angeles, California +13 locations
Conditions: Extensive Stage Lung Small Cell Carcinoma, Limited Stage Lung Small Cell Carcinoma, Platinum-Resistant Lung Small Cell Carcinoma, Platinum-Sensitive Lung Small Cell Carcinoma, Recurrent Lung Small Cell Carcinoma, Recurrent Extensive Stage Lung Small Cell Carcinoma
Register for Updates
A Study of XMT-1660 in Participants With Solid Tumors
NCT05377996
Recruiting
A Study of XMT-1660 in Solid Tumors
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/16/2025
Locations: UC Irvine Health-Chao Family Comprehensive Cancer Center, Orange, California +21 locations
Conditions: Triple Negative Breast Cancer, Breast Cancer, Endometrial Cancer, Ovarian Cancer, Fallopian Tube Cancer, Primary Peritoneal Cavity Cancer, Adenoid Cystic Carcinoma
Register for Updates
Development of a Lifestyle Physical Activity Intervention to Reduce Risk for Perinatal Cannabis Use
NCT05528380
Recruiting
This study will recruit 20 women who are high risk for prenatal cannabis use for a 12-week program of using the tracker and receiving a Lifestyle Physical Activity program. The primary outcomes will be self reported percent days of cannabis use and physical activity. Secondary outcomes include self -reported measures of depression and anxiety symptoms, adaptive coping, and self-efficacy for cannabis abstinence.
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
07/16/2025
Locations: Butler Hospital, Providence, Rhode Island
Conditions: Pregnancy, Cannabis
Register for Updates
Acupuncture Therapy and Hypertension
NCT05530512
Recruiting
Acupuncture therapy will be provided to reduce blood pressure in hypertensive patients. The mild to moderate hypertensive patients will be either on or off hypertensive medications. The course last for 8 weeks and the frequency is once a week.
Gender:
ALL
Ages:
Between 45 years and 75 years
Trial Updated:
07/16/2025
Locations: Susan Samueli Integrative Health Institute, Irvine, California +1 locations
Conditions: Mild to Moderate Hypertension
Register for Updates
Sleep Disordered Breathing With Opioid Use
NCT05589753
Recruiting
There is an increased risk for sleep disordered breathing (SDB), sleep-related hypoventilation and irregular breathing in individuals on chronic prescription opioid medications. Almost 30% of a veteran sleep clinic population had opioid-associated central sleep apnea (CSA). The proposal aims to identity whether oxygen and acetazolamide can be effective in reducing unstable breathing and eliminating sleep apnea in chronic opioid use via different mechanisms. We will study additional clinical para... Read More
Gender:
ALL
Ages:
Between 18 years and 89 years
Trial Updated:
07/16/2025
Locations: John D. Dingell VA Medical Center, Detroit, MI, Detroit, Michigan
Conditions: Sleep Apnea, Opioid Use, Sleep Disordered Breathing
Register for Updates
Immune Mechanisms of Vitamin D to Reduce Chronic Pain After Burn
NCT05619289
Recruiting
The goal of this pilot clinical trial is to learn whether vitamin D is able to prevent chronic pain following burn injury and to determine what biological mechanisms are engaged by Vitamin D following burn injury. The main question\[s\] it aims to answer are: * Is the clinical trial protocol feasible? * Is Vitamin D administration following burn injury safe? * How does vitamin D cause changes in the immune system in the aftermath of burn injury? Following informed consent, participants will be... Read More
Gender:
ALL
Ages:
Between 18 years and 70 years
Trial Updated:
07/16/2025
Locations: University Of North Carolina, Chapel Hill, North Carolina
Conditions: Burn Injury, Chronic Pain
Register for Updates
Fruit and Vegetable Biomarker Discovery
NCT05621863
Recruiting
The purpose of this research is to find a set of markers in the blood and/or urine that can be linked to consumption of specific fruits and vegetables. This will allow for better understanding of the link between diet and health-related outcomes. Furthermore, the results of this study will lead to the development of new methods to evaluate the nutritional status of individuals in both community and clinical settings. Food frequency questionnaires and diaries/recalls can be affected by intentiona... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/16/2025
Locations: USDA ARS Western Human Nutrition Research Center, Davis, California
Conditions: Biomarkers
Register for Updates
Myocardial Perfusion Imaging Galmydar Rest/Stress
NCT05625490
Recruiting
A single center, phase 0/1 clinical imaging study designed to assess the role of \[68Ga\]Galmydar PET/CT imaging in human subjects.
Gender:
ALL
Ages:
Between 18 years and 99 years
Trial Updated:
07/16/2025
Locations: Washington University School of Medicine, Saint Louis, Missouri
Conditions: Coronary Artery Disease
Register for Updates
Adolescent Vaping Characterization and Parent Views on Adolescent Vaping Protocol
NCT05669716
Recruiting
Background: The use of electronic cigarettes (vaping) has increased among adolescents over the past decade. Vaping raises many health concerns. People who vape inhale toxic chemicals. Vaping is also linked with mental health issues, such as depression and suicide risk. In one survey, 85% of young adults reported that they used both vaping and tobacco products; the primary reason they cited for using these products was stress. Objective: This natural history study will survey adolescents and t... Read More
Gender:
ALL
Ages:
Between 13 years and 120 years
Trial Updated:
07/16/2025
Locations: National Institute on Drug Abuse, Baltimore, Maryland
Conditions: Healthy Volunteers, Vaping Teens
Register for Updates
Observational, Non-Interventional Study Supporting Validation of VO2Max Estimation Methods Using Results in Patients Receiving Standard of Care Cardiopulmonary Exercise Tests (CPET)
NCT05678530
Recruiting
In this study, the hypothesis being explored is that VO2Max and other CPET parameters can be accurately estimated from biosignals (namely, motion from accelerometers and cardiopulmonary variables from EKG) collected during activities of daily living using wearable biosensors worn by study participants. This study will aim to collect development and validation data for a machine learning algorithm and to evaluate the performance of the algorithm. A total of 300 participants will be enrolled inclu... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/16/2025
Locations: Mayo Clinic Arizona, Scottsdale, Arizona +13 locations
Conditions: Cardiopulmonary
Register for Updates