Integrated Care and Treatment for Severe Infectious Diseases and Substance Use Disorders Among Hospitalized Patients
Recruiting
The goal of this clinical trial is to test the effectiveness of an integrated infectious disease/substance use disorder (SUD) clinical team intervention approach in patients hospitalized with severe injection-related infections (SIRI) who use drugs. The main question this study aims to answer is whether this intervention approach will be associated with lower mortality and fewer hospital readmissions. Participants will participate in the integrated SUD/ID care team intervention (SIRI Team). Rese... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/16/2025
Locations: University of Alabama at Birmingham, Birmingham, Alabama +5 locations
Conditions: Injection Site Infection, Substance Use Disorders
A Multicentre, Randomised, Double-blind, Parallel Group, Placebo-controlled, Time-to-first Asthma Exacerbation Phase III Efficacy and Safety Study of Benralizumab in Paediatric Patients With Severe Eosinophilic Asthma (DOMINICA)
Recruiting
A study to evaluate the efficacy and safety of benralizumab administered subcutaneously in patients ≥ 6 to \< 18 years of age with severe eosinophilic asthma, including a well-documented history of asthma exacerbations and uncontrolled asthma receiving high-dose inhaled corticosteroid (ICS) plus at least one additional controller medication.
Gender:
ALL
Ages:
Between 6 years and 18 years
Trial Updated:
07/16/2025
Locations: Research Site, Mobile, Alabama +86 locations
Conditions: Asthma
Resilience Mobile App for Teens and Young Adults With Cancer
Recruiting
The goal of this pilot trial is to examine whether a mobile app version of the Promoting Resilience in Stress Management (PRISM) intervention is acceptable, easy to use, and helps improve quality of life and mental health symptoms.
Gender:
ALL
Ages:
Between 12 years and 25 years
Trial Updated:
07/16/2025
Locations: Seattle Children's Hospital, Seattle, Washington
Conditions: Cancer
Studies of Human Inference Using On-line Testing
Recruiting
The investigators will record behavioral responses from human participants on crowdsourcing platform Prolific to identify the decision strategies humans apply short-term, long-term, and multi timescale (across both timescales) inference tasks. Participants will perform a Jar Switching Task (described in Research Strategy Aim 1- "Jar Switching Task") in which balls are drawn with replacement from one of two known jars. The current jar in use switches based on an underlying change rate across tria... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/16/2025
Locations: University of Colorado Boulder, Boulder, Colorado
Conditions: Behavior
A Study to Evaluate the Efficacy and Safety Study of Povorcitinib in Participants With Inadequately Controlled Moderate to Severe Asthma
Recruiting
The study is being conducted to evaluate the effect of 3 dosing regimens of povorcitinib on pulmonary function
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
07/16/2025
Locations: Allervie Clinical Research, Birmingham, Alabama +83 locations
Conditions: Moderate to Severe Asthma
Ventilatory and Perfusion Abnormalities in Individuals With Post-Acute Sequelae of SARS-CoV-2 Infection
Recruiting
Prospective cohort study to evaluate the utility of quantitative CT analysis to assess ventilation and perfusion defects in patients with Post-acute Sequelae of SARS-CoV-2 (PASC) and functional limitations
Gender:
ALL
Ages:
Between 18 years and 99 years
Trial Updated:
07/16/2025
Locations: Tufts Medical Center, Boston, Massachusetts
Conditions: Post-Acute COVID-19, Post COVID-19 Condition, Post Viral Fatigue, Dyspnea
Rapid Autopsy Protocol for Patients With Small Cell Lung Cancer
Recruiting
This is pilot study to establish a rapid autopsy program in Small Cell Lung Cancer (SCLC) at the Indiana University Simon Comprehensive Cancer Center and outline the components necessary for tumor tissue collection.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/16/2025
Locations: Indiana University Melvin and Bren Simon Comprehensive Cancer Center, Indianapolis, Indiana +2 locations
Conditions: Small Cell Lung Cancer
A Phase 1 Study of XL309 (ISM3091) Alone and in Combination in Patients With Advanced Solid Tumors
Recruiting
This is a FIH, multicenter, open-label Phase I study to investigate the safety, tolerability, preliminary antitumor activity, as well as PK and pharmacodynamics of XL309 (previously ISM3091) administered alone or in combination with olaparib in subjects with advanced solid tumors.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/16/2025
Locations: Exelixis Clinical Site #12, Fountain Valley, California +15 locations
Conditions: Advanced Solid Tumor
A Study Evaluating the Effect of Frozen-Section Directed Excision Surgery on Vulvar Dysplasia
Recruiting
The purpose of this study is to compare "Frozen-Section Directed Excision", which has been a proven method of surgery used in dermatology, versus the current, standard method called "Wide Local Excision" to treat high-grade vulvar dysplasia.
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
07/16/2025
Locations: Levine Cancer Institute, Charlotte, North Carolina
Conditions: Vulvar Neoplasm, Dysplasia Vulvar
ASK-PrEP (Assistance Services Knowledge-PrEP)
Recruiting
ASK-PrEP is a two-arm randomized controlled trial (RCT), with a Stepped Care approach, among HIV-negative trans women and men who have sex with men with a substance use disorder (SUD). Participants will be randomized (3:1) to the ASK-PrEP Stepped Care arm or Standard of Care (SOC). Participants in the ASK-PrEP Stepped Care arm will receive 5 PrEP navigation sessions, with weekly text-messaging support, delivered over 3 months, at which point they will be assessed for intervention response. Respo... Read More
Gender:
MALE
Ages:
18 years and above
Trial Updated:
07/16/2025
Locations: Friends Community Center, Los Angeles, California
Conditions: Substance Use Disorders, HIV
Telehealth Cognitive Behavioral Therapy for Youth at Risk for Psychosis
Recruiting
This study aims to evaluate the feasibility and effectiveness of telehealth interventions for individuals at clinical high risk for psychosis (CHR). Psychosis typically emerges during late adolescence or early adulthood, significantly impacting long-term functioning. While CHR programs have the potential to reduce illness severity, individuals often face barriers such as stigma and limited access to services. Telehealth interventions could address these barriers and improve treatment accessibili... Read More
Gender:
ALL
Ages:
Between 14 years and 25 years
Trial Updated:
07/16/2025
Locations: Icahn School of Medicine at Mount Sinai, New York, New York
Conditions: Clinical High Risk for Psychosis (CHR)
Personalized Health Self-Management Training for Colorectal Cancer Survivors
Recruiting
This is a Phase 2 prospective, randomized, controlled, double-arm study to assess personalized self-management training (PSMT) intervention efficacy and patient experiences compared to standardized self-management training (SSMT). A total of 120 colorectal cancer (CRC) patients will be enrolled and randomized 1:1 to complete a 6-week self-management training program (either PSMT or SSMT) to be carried out by licensed occupational therapists with doctoral training. This study aims to examine whe... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/16/2025
Locations: Cedars-Sinai Medical Center, Los Angeles, California +1 locations
Conditions: Colorectal Cancer, Healthy Lifestyle, Behavior, Health, Health Behavior