Gemcitabine and Carboplatin After Progression on Enfortumab Vedotin and Pembrolizumab in Advanced/Metastatic Urothelial Carcinoma
NCT07043972
Recruiting
The goal of this clinical trial is to learn if a chemotherapy combination called gemcitabine and carboplatin (GC) works to treat advanced urothelial cancer in people who have already been treated with enfortumab vedotin and pembrolizumab (EVP). It will also learn about the efficacy and safety of GC in these patients. The main questions it aims to answer are: * Does GC shrink the cancer or stop it from growing? * What medical side effects do participants have while receiving GC? Researchers w... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/15/2025
Locations: Fox Chase Cancer Center, Philadelphia, Pennsylvania +1 locations
Conditions: Urothelial Carcinoma
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Mississippi Community Engagement Alliance (MS CEAL): Fostering Community Solutions
NCT07071064
Recruiting
The Mississippi Community Engagement Alliance (MS CEAL) Team proposes to address the complexities of Mississippi's health issues and social determinants of health through its Fostering Community Solutions (FOCUS) Project, with two objectives: (1) advance the health and wellbeing of Mississippi's populations experiencing differing health outcomes; and (2) enhance the resilience and power within communities to disseminate and implement evidence-based interventions. This study's specific aims inclu... Read More
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
07/15/2025
Locations: Grace Episcopal Church, Canton, Mississippi +3 locations
Conditions: Nutrition Security
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Videos to Aid Decision Making for Fibroid Treatment
NCT07072364
Recruiting
Uterine fibroids are a common condition that can cause heavy and/or painful menstrual bleeding. There are many treatment options, but they vary in efficacy, side effects, short-term recovery and long-term implications for future fertility. Patients can have difficulty deciding between these options. In this study, the investigators will randomly assign patients seeking treatment for fibroids to receive an educational video on fibroids and their treatment, versus usual care (no video). The invest... Read More
Gender:
ALL
Ages:
Between 18 years and 55 years
Trial Updated:
07/15/2025
Locations: Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania
Conditions: Uterine Bleeding, Decision Aid
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Replacing Bone Marrow With Peripheral Blood in Cytopenia Patients
NCT07081087
Recruiting
This study aims to validate a novel, non-invasive diagnostic approach for blood and bone marrow malignancies using single-cell RNA sequencing of circulating hematopoietic stem and progenitor cells (cHSPCs) from peripheral blood. Building on prior work defining normal cHSPC profiles in healthy individuals, the study introduces a pipeline for identifying blood pathologies, with a focus on improving the diagnosis and subclassification of myelodysplastic syndromes (MDS). A multi-center clinical tria... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/15/2025
Locations: University of Miami, Miami, Florida
Conditions: Cytopenia
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Radiocaine Safety Study In Healthy Human Subjects
NCT07081217
Recruiting
This is a Phase 1, single-center, open-label study evaluating the safety, biodistribution, and radiation dosimetry of Radiocaine™, an investigational fluorine-18-labeled PET radiotracer designed to bind voltage-gated sodium channels in pain-related peripheral nerves. The study will enroll healthy adult volunteers and aims to inform future clinical development in pain imaging. Radiocaine™ is being developed as a potential imaging biomarker for the localization and quantification of pain.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/15/2025
Locations: Stanford University School of Medicine, Stanford, California
Conditions: Healthy Subjects
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Measurement-Based Peer Supervision App for Non-Specialist Providers
NCT07082010
Recruiting
The goal of this project is to enhance and evaluate the efficacy of a scalable digital solution designed to help train and support the work of non-specialist providers (NSPs), such as community health workers, to deliver therapy to individuals with anxiety and/or depression. The main questions this project aims to answer are: * Can a digital tool help NSPs feel more confident in counseling patients? * How can a digital tool be designed to optimally support the work of NSPs?
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/15/2025
Locations: Baylor Scott & White Health, Dallas, Texas
Conditions: Training of Mental Health Professionals, Training of Frontline Health Workers
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Feasibility and Potential Efficacy of Herbs and Spices for Improving Dietary Quality in College Students: A Pilot Study
NCT07082348
Recruiting
The goal of this single-arm feasibility, pilot study is to assess the feasibility, acceptability, and potential effectiveness of the Herbs and Spices Nutrition Education Program (HSNP-focusing on incorporating herbs and spices into the diet for adherence to the DGA's) for determining the scalability of implementing this intervention for a larger scale, more comprehensive study The main questions it aims to answer are: * What is the feasibility and acceptability of incorporating herbs and spices... Read More
Gender:
ALL
Ages:
Between 18 years and 39 years
Trial Updated:
07/15/2025
Locations: Department of Kinesiology and Nutrition Sciences, Las Vegas, Nevada, Las Vegas, Nevada
Conditions: Dietary Quality, Feasibility Studies, College Student, Dietary Guidelines for Americans, Gut Microbiome, Lipid Profiles, Herbs and Spices, Acceptability, Inflammation Biomarkers, Body Composition, Anthropometrics
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External Carotid Blood Flow in Individuals With Post-Bariatric Hypoglycemia
NCT07082478
Recruiting
This is a pilot study (small-scale study) that aims to understand more about how blood flow changes in people who have low blood sugar after bariatric surgery (post-bariatric hypoglycemia) compared to those who have had surgery without hypoglycemia, those who have hypoglycemia without surgery, or those who do not experience low blood sugar. This study has two phases. This is the first phase, and the purpose is to test comfort and feasibility of a novel in-ear wearable device (Lumia Health) that... Read More
Gender:
ALL
Ages:
Between 18 years and 70 years
Trial Updated:
07/15/2025
Locations: Joslin Diabetes Center, Boston, Massachusetts
Conditions: Hypoglycemia, Cerebral Blood Flow
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Dominantly Inherited Alzheimer Network (DIAN)
NCT00869817
Recruiting
The purpose of this study is to identify potential biomarkers that may predict the development of Alzheimer's disease in people who carry an Alzheimer's mutation.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/14/2025
Locations: Mayo Clinic Jacksonville, Jacksonville, Florida +24 locations
Conditions: Alzheimer's Disease
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Diagnostic and Therapeutic Applications in Microarrays in Organ Transplantation
NCT01299168
Recruiting
The current standard for biopsy-based diagnoses of dysfunction of kidney transplants is the Banff Classification which represents arbitrary international consensus. Recent data-driven approaches using molecular and conventional technologies indicate that mere consensus produces frequently incorrect diagnoses with potential harm to patients due to inappropriate treatment. To address this unmet need and improve diagnostics in the area of organ transplantation, the Alberta Transplant Applied Genomi... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/14/2025
Locations: University of Alabama, Birmingham, Alabama +25 locations
Conditions: Validation Study of Molecular Diagnostic System, Development of Reporting System for Molecular Diagnosis, Incorporate Molecular Diagnosis Into Diagnostic Standards
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Generation of Heart Muscle Cells From Blood or Skin Cells of Breast Cancer Patients
NCT02772367
Recruiting
The purpose of this study is to investigate whether cells from a biopsy taken from the patient skin can be transformed into cardiomyocytes the changes in cardiomyocyte (heart muscle cells) when grown in a special culture medium outside of the body. The structure and function of these cells will then be studied to determine why some patients with breast cancer who are treated with chemotherapy including anthracycline (e.g. Doxorubicin) and anti-HER2 therapy (e.g. Herceptin) develop decreased hear... Read More
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
07/14/2025
Locations: Memorial Sloan-Kettering Cancer Center, New York, New York
Conditions: Breast Cancer
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Observation or Radiation Therapy in Treating Patients With Newly Diagnosed Grade II Meningioma That Has Been Completely Removed by Surgery
NCT03180268
Recruiting
This randomized phase III trial studies how well radiation therapy works compared with observation in treating patients with newly diagnosed grade II meningioma that has been completely removed by surgery. Radiation therapy uses high energy x-rays to kill tumor cells and shrink tumors.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/14/2025
Locations: University of Alabama at Birmingham Cancer Center, Birmingham, Alabama +208 locations
Conditions: Intracranial Meningioma, Grade 2 Meningioma
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