Efficacy and Safety of IMVT-1402 in Adult Participants With Primary Sjogren's Disease With Moderate to Severe Systemic Disease Activity
NCT06979531
Recruiting
This is a Phase 2b, multicenter, randomized, double-blinded, placebo-controlled study to assess the efficacy and safety of IMVT-1402 in adult participants with moderate to severe systemic primary Sjogren's disease (SjD).
Gender:
ALL
Ages:
Between 18 years and 74 years
Trial Updated:
07/15/2025
Locations: Site Number - 1004, Tamarac, Florida +2 locations
Conditions: Primary Sjögren's Syndrome
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Beacon Tip Sizing Catheter and Slip-Cath Beacon Tip Catheter Study
NCT06986954
Recruiting
This prospective observational post-market clinical study will collect data in the United States to primarily support the re-launch of the re-designed Beacon Tip Sizing Catheter and Slip-Catheter Beacon Tip Catheter \& Shuttle Select Slip-Catheter (Visceral and Cerbral) for a Conformité Européenne (CE) Mark application in the European Union (EU). Additionally, the data from this study may be used to support regulatory approval in other countries/regions. The purpose of this clinical study is to... Read More
Gender:
ALL
Ages:
All
Trial Updated:
07/15/2025
Locations: Vascular Breakthroughs, Darien, Connecticut
Conditions: Stenosis, Bleed Intracranial, Stroke, TIA, Vascular Malformation, Pseudoaneurysm
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Real-world Experience Using Nemolizumab in the Treatment of Moderate-to-Severe Atopic Dermatitis in Adolescents & Adults
NCT06988605
Recruiting
The main aim of the study is to assess real-world effectiveness of nemolizumab in Atopic Dermatitis (AD) as measured by physician assessment and patient reported outcome (PRO) in clinical practice at Month 6.
Gender:
ALL
Ages:
12 years and above
Trial Updated:
07/15/2025
Locations: Galderma Investigational Site - 8893, Birmingham, Alabama +110 locations
Conditions: Atopic Dermatitis
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Effects of Aphasia Identification Cards on Service Workers' Comprehension of People With Aphasia
NCT06990997
Recruiting
The goal of this clinical trial is to learn whether healthy volunteers are more successful at understanding people with aphasia if they have first viewed an aphasia identification (ID) card. The main questions this study aims to answer are: * Does viewing an aphasia ID card improve healthy volunteers' understanding of the language errors made by people with aphasia? * Does viewing an aphasia ID card improve healthy volunteers' understanding of people with aphasia who make long pauses in their s... Read More
Gender:
ALL
Ages:
Between 18 years and 59 years
Trial Updated:
07/15/2025
Locations: UMass Amherst Henry M. Thomas III Center at Springfield, Springfield, Massachusetts
Conditions: Aphasia
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A Safety and Immunogenicity Study of CHIKV VLP Vaccine in Children.
NCT07003984
Recruiting
The goal of this multi-center, randomized, double-blind, placebo-controlled study is to evaluate the safety and immunogenicity of CHIKV VLP Vaccine in children 2 to \<12 years of age.
Gender:
ALL
Ages:
Between 2 years and 11 years
Trial Updated:
07/15/2025
Locations: ARK Clinical Research, LLC, Fountain Valley, California +8 locations
Conditions: Chikungunya Virus
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A Study to See How Well Lebrikizumab Works in Adults and Adolescents With Moderate Atopic Dermatitis (Eczema) and High Itch Burden
NCT07006792
Recruiting
The purpose of this study is to measure how well taking lebrikizumab alone works for participants with fewer places on the body with eczema (atopic dermatitis), but these places may be very itchy. Participation in this study will last up to approximately 38 weeks (9 and a half months) including 24 weeks (6 months) of treatment.
Gender:
ALL
Ages:
12 years and above
Trial Updated:
07/15/2025
Locations: Total Skin & Beauty Dermatology Center, PC DBA Total Dermatology, Birmingham, Alabama +74 locations
Conditions: Atopic Dermatitis
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Induction of Labor After Cesarean Using Foley Alone vs. Concurrent Foley and Oxytocin
NCT07006896
Recruiting
A randomized trial of patients undergoing a term (≥37 weeks) induction of labor with a history of one prior Cesarean delivery, wherein the provider intends to use a Foley catheter for cervical ripening. The investigators will be comparing Foley alone with concurrent Foley and Oxytocin use at the start of the induction. With this trial, the investigators aim to test our central hypothesis that concurrent Foley and Oxytocin will decrease time to delivery without increasing risks, compared to Foley... Read More
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
07/15/2025
Locations: Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania
Conditions: Labor Induction, Cesarean Delivery
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REGN7508 Versus Apixaban and Enoxaparin for Thromboprophylaxis After Total Knee Arthroplasty in Adults
NCT07015905
Recruiting
This study is researching an experimental drug called REGN7508 (called "study drug"). The study is focused on adults undergoing elective, unilateral (one side) total knee replacement surgery. The aim of the study is to see how effective the study drug is at preventing venous thromboembolism (VTE) and other related diseases after total knee replacement surgery. The study is looking at several other research questions, including: * What side effects may happen from taking the study drug * How m... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/15/2025
Locations: Phoenix Clinical Research, Tamarac, Florida
Conditions: Venous Thromboembolism (VTE)
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Inorganic Nitrate (NaNO3) Prevention of Contrast-Associated Acute Kidney Injury
NCT07016074
Recruiting
This pilot study is designed to test the logistics and recruitment of a trial testing the benefit of sodium nitrate in the prevention of contrast-associated kidney injury in a group of patients at high-risk.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/15/2025
Locations: University of Michigan, Ann Arbor, Michigan
Conditions: Kidney Injury, Acute
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A Phase 1/2a Study of VS-7375 in Patients With KRAS G12D-Mutated Solid Tumors
NCT07020221
Recruiting
This study will assess the safety and efficacy of VS-7375 alone and in combination in patients with advanced solid tumors harboring a KRAS G12D-mutation.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/15/2025
Locations: Massachusetts General Hospital, Boston, Massachusetts +4 locations
Conditions: Pancreatic Ductal Adenocarcinoma, Non Small Cell Lung Cancer, Colorectal Cancer, Solid Tumor, Adult, G12D Mutated KRAS
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4D Duke Microscope Integrated Optical Coherence Tomography in a Zeiss Artevo 800
NCT07024719
Recruiting
The study team will conduct the first in-human pilot studies using 4D MIOCT for imaging in the operating room. Building on the earlier integration and wet-lab validations, the researchers will assess the system's ease of use, safety, and visualization of intended structures during various anterior and posterior segment ophthalmic procedures.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/15/2025
Locations: Duke University Eye Center, Durham, North Carolina
Conditions: Corneal Diseases, Retinal Diseases, Ocular Diseases
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Minnesota RETAIN Phase 3
NCT07037927
Recruiting
MN RETAIN Phase 3 is a non-randomized trial to evaluate the impact of RETAIN program expansion and services on workforce retention and reduction of future workplace disability in the state of MN. The program is funded by US Department of Education (DOE). There will be collaboration between partners to implement best practices in early intervention to support injured or ill employees in stay-at-work and return-to-work. MN RETAIN involves a partnership between Mayo Clinic and MN Department of Empl... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/15/2025
Locations: Mayo Clinic Rochester, Rochester, Minnesota
Conditions: Injuries Related Work, Illness Related Work, Disability
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