A Study to Evaluate Pharmacokinetics of LY3209590 in Pediatric Participants With Type 2 Diabetes Mellitus
NCT06362265
Recruiting
The main purpose of this study is to evaluate how much of LY3209590 gets into the blood stream after a single dose and how long it takes the body to remove it in pediatric participants with Type 2 Diabetes Mellitus (T2DM). The study will last for approximately 100 days.
Gender:
ALL
Ages:
Between 10 years and 17 years
Trial Updated:
03/25/2025
Locations: Honor Health Research Institute, Scottsdale, Arizona +10 locations
Conditions: Type 2 Diabetes Mellitus
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Mindful Motivation for Reducing Binge Eating
NCT06528067
Recruiting
The aim of this study is to test how acceptable and feasible a new eating intervention is in people with overweight and binge eating. This intervention combines mindful eating with motivational interviewing to target binge eating. The main questions this clinical trial aims to answer are: How well do participants accept the new intervention (acceptability)? Is the intervention practical and easy to implement (feasibility)? In this trial researchers will compare the new eating intervention (mot... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/25/2025
Locations: University of California, San Francisco, San Francisco, California
Conditions: Binge Eating, Psychological, Health Behavior, Weight, Body
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BSB-1001 in Patients Undergoing HLA-Matched Allogenic Hematopoietic Stem Cell Transplant for AML, ALL or MDS
NCT06704152
Recruiting
The goal of this clinical trial is to test BSB-1001 which is a new type of cellular therapy to treat blood cancers (AML, ALL and MDS). It will evaluate the safety of BSB-1001 and also determine whether it works to prevent relapse of your cancer.
Gender:
ALL
Ages:
Between 18 years and 70 years
Trial Updated:
03/25/2025
Locations: City of Hope National Medical Center, Duarte, California +4 locations
Conditions: AML, Adult Recurrent, ALL, Recurrent, Adult, MDS
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Collaborative Care Model for Perinatal Wellness Support Services - Population-Level Equity-Centered Systems Change
NCT06849869
Recruiting
The collaborative care model (CCM) is a health services intervention that integrates mental health care in primary care settings. The goal of this study is to adapt the CCM to the perinatal care context, including community co-designed adaptations to enhance health equity (COMPASS+). The main objectives of the study are to: 1. Evaluate the effect of COMPASS+ on depression symptom outcomes. Specifically we will evaluate population-level depression symptom trajectories and the prevalence of suici... Read More
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
03/25/2025
Locations: Women and Infants Hospital, Providence, Rhode Island
Conditions: Perinatal Mental Health
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Ponatinib Hydrochloride as Second Line Therapy in Treating Patients With Chronic Myeloid Leukemia in Chronic Phase Resistant or Intolerant to Imatinib Mesylate, Dasatinib, or Nilotinib
NCT01746836
Recruiting
This phase II trial studies how well ponatinib hydrochloride works as second line therapy in treating patients with chronic myeloid leukemia in chronic phase that has not responded to initial treatment (first line) with imatinib mesylate, dasatinib, or nilotinib or cannot tolerate imatinib mesylate, dasatinib, or nilotinib. Ponatinib hydrochloride may stop or control the growth of cancer cells by blocking a protein needed for cell growth.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/24/2025
Locations: M D Anderson Cancer Center, Houston, Texas
Conditions: Chronic Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive, Philadelphia Chromosome Positive, BCR-ABL1 Positive Chronic Myelogenous Leukemia, Recurrent Chronic Myelogenous Leukemia, BCR-ABL1 Positive
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Edwards PASCAL CLASP IID/IIF Pivotal Clinical Trial
NCT03706833
Recruiting
To establish the safety and effectiveness of the Edwards PASCAL Transcatheter Valve Repair System in patients with degenerative mitral regurgitation (DMR) who have been determined to be at prohibitive risk for mitral valve surgery by the Heart Team, and in patients with functional mitral regurgitation (FMR) on guideline directed medical therapy (GDMT)
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/24/2025
Locations: The University of Alabama at Birmingham, Birmingham, Alabama +101 locations
Conditions: Degenerative Mitral Valve Disease, Mitral Regurgitation, Mitral Insufficiency, Functional Mitral Regurgitation
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A Framework for Linking Sequential Pattern Rules in DLD: Perception in Toddlers
NCT04531514
Recruiting
This broad aim of this clinical study is to assess the hypothesis that morphological and phonological deficits are linked by a broader deficit in sequential pattern learning. This hypothesis applies to learning in general, but is especially critical as an avenue for developing earlier assessments and more powerful interventions for children with developmental language disorder (DLD; AKA specific language impairment). Other populations, such as at-risk toddlers, may also benefit from this new app... Read More
Gender:
ALL
Ages:
Between 19 months and 36 months
Trial Updated:
03/24/2025
Locations: University of Arizona, Tucson, Arizona +1 locations
Conditions: Developmental Language Disorder, Speech Sound Disorder, Specific Language Impairment
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Virtual Neuro-Navigation System for Personalized Community Based TMS
NCT04956081
Recruiting
Phase I study of a virtual neuro-navigation package with built-in support for identifying specific "surface-based" targets to optimze TMS treatment.
Gender:
ALL
Ages:
Between 18 years and 60 years
Trial Updated:
03/24/2025
Locations: Columbia Docs, New York, New York
Conditions: Treatment Resistant Depression
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Special Care Patterns for Elderly HNSCC Patients Undergoing Radiotherapy
NCT05337631
Recruiting
The number of elderly head-and-neck squamous cell carcinoma (HNSCC) patients is increasing; however, the evidence regarding the ideal treatment for this often vulnerable and frail patient cohort is limited. Although the benefit of concomitant chemotherapy has been reported to decrease in elderly HNSCC patients based on the MACH-NC meta-analysis, it remains unknown whether state-of-the art radiotherapy techniques such as intensity-modulated radiotherapy (IMRT), modern supportive treatments and al... Read More
Gender:
ALL
Ages:
65 years and above
Trial Updated:
03/24/2025
Locations: Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland +17 locations
Conditions: HNSCC, Oral Cavity Cancer, Oropharynx Cancer, Hypopharynx Cancer, Larynx Cancer
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Evaluation of GeoHAI Implementation
NCT05612672
Recruiting
Geographic Information Systems (GIS) and spatial analysis have become important tools in public health informatics but have rarely been applied to the hospital setting. In this study we apply these tools to address the challenge of Hospital Acquired Infections (HAIs) by building, implementing, and evaluating a new computer application which incorporates mapping and geographic data to assist hospital epidemiologists in identifying HAI clusters and assessing transmission risk. We expect that incor... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/24/2025
Locations: The Ohio State University, Columbus, Ohio
Conditions: Clostridioides Difficile Infection, Healthcare Associated Infection
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MDMA-Assisted Therapy for Veterans with Moderate to Severe Post Traumatic Stress Disorder
NCT05790239
Recruiting
This randomized, double-blind, single-site phase II 2-arm study will investigate the safety and preliminary efficacy of MDMA-assisted therapy compared with low dose d-amphetamine-assisted therapy on the severity of PTSD symptoms in participants aged 18 years and older with PTSD of at least moderate severity.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/24/2025
Locations: VA Greater Los Angeles Healthcare System, Westwood campus, Los Angeles, California +1 locations
Conditions: Post Traumatic Stress Disorder
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NG101 AAV Gene Therapy in Subjects with Wet Age-Related Macular Degeneration
NCT05984927
Recruiting
This study will evaluate the safety, tolerability, and preliminary efficacy of NG101 AAV gene therapy administered by subretinal injections into a single selected eye as a single selected dose for patients with wet age-related macular degeneration (wAMD).
Gender:
ALL
Ages:
Between 50 years and 89 years
Trial Updated:
03/24/2025
Locations: Cincinnati Eye Institute, Cincinnati, Ohio +3 locations
Conditions: Age-Related Macular Degeneration
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