Improving Clinician Capacity to Provide Interventions for Manual Wheelchair Users
NCT06294834
Recruiting
The objective of this study is to determine the effectiveness of remote manual wheelchair skills training program for clinicians. The study will use three-group approach: intervention with remote feedback (Group 1), control group (Group 2), and structured self-study (Group 3). This demonstrates how the intervention compares not only to a control, but also to the next "best alternative" - therapists sourcing web-based training materials and learning independently.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/14/2025
Locations: University of Pittsburgh / Rehab Neural Engineering Labs, Pittsburgh, Pennsylvania
Conditions: Paraplegia, Paralysis, Legs
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Global Paradise System US Post Approval Study
NCT06297291
Recruiting
The objective of the Global Paradise® System US Post Approval Study (US GPS) is to evaluate the real-world use of the Paradise Ultrasound Renal Denervation System indicated for patients who are unable to lower their blood pressure with lifestyle changes and medication. This system is comprised of a catheter, cable, balloon, and generator and has received FDA approval in the United States. Information collected in this study will be analyzed to better understand the long-term safety and effective... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/14/2025
Locations: Sutter Institute for Medical Research, Sacramento, California +25 locations
Conditions: Hypertension, Cardiovascular Diseases, Vascular Diseases
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A Study of Sepiapterin in Participants With Phenylketonuria (PKU)
NCT06302348
Recruiting
The main purpose of this trial is to evaluate the long-term efficacy of sepiapterin on preserving neurocognitive functioning in children with PKU when treatment is initiated in early childhood.
Gender:
ALL
Ages:
10 years and below
Trial Updated:
07/14/2025
Locations: Indiana University, Indianapolis, Indiana
Conditions: Phenylketonuria
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Pembrolizumab, INCB081776, and Radiation Therapy for Head and Neck Squamous Cell Carcinoma
NCT06308913
Recruiting
This study is evaluating INCB081776 when given in combination with the checkpoint inhibitor pembrolizumab and palliative radiation therapy in patients with metastatic or recurrent metastatic or recurrent head and neck squamous cell carcinoma (HNSCC). 12 participants will be enrolled and can expect to be on study for up to 12 months.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/14/2025
Locations: UW Carbone Cancer Center, Madison, Wisconsin
Conditions: Head and Neck Squamous Cell Carcinoma
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The Healthy Families Bright Futures Program
NCT06309134
Recruiting
The goal of this clinical trial is to learn about an online group program (Healthy Families Bright Futures program) for LGBTQ+ teens and their caregivers. The main question\[s\] it aims to answer are: • is this program acceptable, appropriate, and feasible for LGBTQ+ youth and their caregivers • does the program affect teen (alcohol use, dating violence, alcohol use refusal self-efficacy, healthy communication self-efficacy) and caregiver (accepting behaviors, parenting self-efficacy, parenting... Read More
Gender:
ALL
Ages:
Between 15 years and 18 years
Trial Updated:
07/14/2025
Locations: University of Colorado Colorado Springs, Colorado Springs, Colorado
Conditions: Alcohol Drinking, Violence in Adolescence
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Evaluating the Human Immune Response to the JYNNEOS Vaccine
NCT06366672
Recruiting
This study is designed to evaluate the magnitude and duration of the human adaptive immune response to the JYNNEOS Modified Vaccinia Ankara-Bavarian Nordic (MVA-BN) vaccine in the blood, lung mucosa, skin and bone marrow.
Gender:
ALL
Ages:
Between 18 years and 60 years
Trial Updated:
07/14/2025
Locations: Washington University in Saint Louis School of Medicine Emergency Care and Research Core, Saint Louis, Missouri
Conditions: Vaccinia, Virus Diseases
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A Phase 2/3 Study to Evaluate the Efficacy and Safety of Tinlarebant in Subjects With Stargardt Disease
NCT06388083
Recruiting
The goal of this clinical trial is to evaluate the safety, tolerability, and efficacy of tinlarebant in subjects with Stargardt Disease
Gender:
ALL
Ages:
Between 12 years and 20 years
Trial Updated:
07/14/2025
Locations: Belite Study Site - US08, Phoenix, Arizona +13 locations
Conditions: STGD1, Stargardt Disease 1
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CGM Academy for Youth With Type 1 Diabetes
NCT06408207
Recruiting
The goal of this randomized clinical trial is to compare the effects of a virtual education curriculum in blood glucose variation of youth with type 1 diabetes wearing continuous glucose monitoring (CGM) device. The main questions the study aims to answer are: * Do participants undertaking the proposed curriculum present improved glucose variation than participants of standard education? * Explore relationships between participant's glycemic outcomes with diabetes distress, diabetes family resp... Read More
Gender:
ALL
Ages:
Between 8 years and 18 years
Trial Updated:
07/14/2025
Locations: Children's Hospital Los Angeles, Los Angeles, California
Conditions: Type1 Diabetes
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Efficacy and Safety Study of BHV-7000 Monotherapy in Major Depression
NCT06419608
Recruiting
The purpose of this study is to determine the efficacy and safety of BHV-7000 in participants with Major Depressive Disorder (MDD)
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
07/14/2025
Locations: Reverie Mind, LLC, Chandler, Arizona +66 locations
Conditions: Major Depressive Disorder
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A Study to Evaluate the Efficacy and Safety of Golcadomide in Combination With Rituximab in Participants With Newly Diagnosed Advanced Stage Follicular Lymphoma
NCT06425302
Recruiting
The purpose of this study is to assess the efficacy and safety of golcadomide in combination with rituximab in participants with newly diagnosed advanced stage Follicular Lymphoma (FL).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/14/2025
Locations: Local Institution - 0152, Birmingham, Alabama +67 locations
Conditions: Lymphoma, Follicular
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Extracellular Vesicle Micro RNA Profiling in Congenital Heart Disease: Fetal-Maternal Regulation in Neonatal Thrombosis
NCT06434207
Recruiting
Newborns with congenital heart disease (CHD) are at increased risk of developing postpartum and postoperative blood clots after cardiac surgery. The molecular mechanisms that are responsible for the clotting profile predisposing children to blood clots in the early stages of life are currently not well described. The goal of this proposal is to prospectively collect plasma samples from ten (10) neonates with antenatal diagnosis of severe congenital heart disease (CHD) to better understand mecha... Read More
Gender:
ALL
Ages:
Between 1 day and 7 days
Trial Updated:
07/14/2025
Locations: Boston Children's Hospital, Boston, Massachusetts
Conditions: Congenital Heart Disease, Single-ventricle, Thrombosis
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Characterizing the Impact of Presbyphonia on Social Interaction
NCT06441136
Recruiting
The purpose of this study is to determine if presbyphonia, or voice disorder caused by age-related change in the larynx, is associated with change in social interaction. This proposal investigates the impact of voice impairment in older adults on social interaction, loneliness, social disconnectedness, and depression. A series of questionnaires, voice assessments, and interviews will be performed to improve our understanding of how voice disorders affect older adults and how treatment of voice i... Read More
Gender:
ALL
Ages:
65 years and above
Trial Updated:
07/14/2025
Locations: University of Iowa Hospitals & Clinics, Iowa City, Iowa
Conditions: Presbyphonia
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