The Biomarkers in the Hyperbaric Oxygen Brain Injury Treatment Trial (BioHOBIT)
Recruiting
There are no therapeutic agents that have been shown to improve outcomes from severe traumatic brain injury (TBI). Critical barriers to progress in developing treatments for severe TBI are the lack of: 1) monitoring biomarkers for assessing individual patient response to treatment; 2) predictive biomarkers for identifying patients likely to benefit from a promising intervention. Currently, clinical examination remains the fundamental tool for monitoring severe TBI patients and for subject select... Read More
Gender:
ALL
Ages:
Between 16 years and 65 years
Trial Updated:
03/31/2025
Locations: UCSD Medical Center - Hillcrest Hospital, San Diego, California +10 locations
Conditions: Traumatic Brain Injury
Adaptive Optics Imaging of Outer Retinal Diseases
Recruiting
The objective of the study is to collect adaptive optics (AO) retinal images from human subjects with outer retinal diseases (diseases of the outer retina including photoreceptor, retinal pigment epithelium (RPE), basement membrane or choroidal pathologies) to develop new diagnostic methods, biomarkers, and clinical endpoints.
Gender:
ALL
Ages:
21 years and above
Trial Updated:
03/31/2025
Locations: NIH Clinical Center, Bethesda, Maryland +1 locations
Conditions: Retinal Degeneration, Age-Related Macular Degeneration, Retinitis Pigmentosa, Hydroxychloroquine Retinopathy, Usher Syndromes, Late-Onset Retinal Degeneration, Cone Dystrophy, Cone Rod Dystrophy, Rod Cone Dystrophy, Rod Dystrophy
The ECMO-Free Trial
Recruiting
Decannulation from venovenous extracorporeal membrane oxygenation (VV-ECMO) at the earliest and safest time would be expected to improve outcomes and reduce cost. Daily assessments for readiness to liberate from therapies have demonstrated success in other realms of critical care. A recent single-center study demonstrated that a protocolized daily assessment of readiness for liberation from VV-ECMO was feasible and did not raise any major safety concerns, but the effect of this protocolized dail... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/31/2025
Locations: Hennepin County Medical Center, Minneapolis, Minnesota +1 locations
Conditions: Extracorporeal Membrane Oxygenation Complication
NIBP Validation Study
Recruiting
The purpose of this study is to compare measurements of blood pressure (BP) between the Philips non-invasive blood pressure (NIBP) system (including NIBP cuff and portable patient monitor) and invasive radial arterial line (A-line) in critical care patients.
Gender:
ALL
Ages:
All
Trial Updated:
03/31/2025
Locations: Mayo Clinic Jacksonville, Jacksonville, Florida +4 locations
Conditions: Critical Illness
StuDy AimED at Increasing AlCohol AbsTinEnce
Recruiting
The goal of this clinical trial is to test the feasibility \& acceptability of an integrated CM-PST intervention (in K99 phase) and preliminary efficacy (in R00 phase), vs. CM alone, to improve treatment efficacy and inform about neural mechanisms of treatment effects in young adults with Alcohol Use Disorder (AUD). The aims are as follows: K99 Aim: Test feasibility \& acceptability of a developed CM-PST, by meeting these benchmarks: 2a Feasibility: enroll 20 participants in the new CM-PST in... Read More
Gender:
ALL
Ages:
Between 18 years and 24 years
Trial Updated:
03/31/2025
Locations: University of Illinois at Chicago, Chicago, Illinois
Conditions: Alcohol Use Disorder
REZILIENT3 (REsearching ZIpaLertinib In Egfr Non-small Cell Lung Cancer Tumors)
Recruiting
The purpose of this study is to evaluate the safety and efficacy of zipalertinib in combination with standard first-line platinum-based chemotherapy compared to chemotherapy alone, in patients with locally advanced or metastatic NSCLC with EGFR ex20ins mutations.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/31/2025
Locations: Comprehensive Cancer Centers of Nevada - Henderson, Henderson, Nevada +113 locations
Conditions: Advanced or Metastatic NSCLS With Exon 20 Insertion Mutation
Hypotensive Anesthesia for Orthognathic Surgery
Recruiting
The overall objective of this double blinded, randomized controlled trial (RCT) is to compare specific outcomes of three medications (Dexmedetomidine, Nicardipine, and Labetalol) which are routinely used to lower blood pressure used during general anesthesia for orthognathic (jaw) surgery. The outcome measures for the study will be surgical field visibility, estimated blood loss, hemodynamic parameters, operation time, and adverse events. The specific objectives of this study are to compare: 1... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/31/2025
Locations: Boston Medical Center, Boston, Massachusetts
Conditions: Hypotensive Anesthesia, Orthognathic Surgery
Genomic Medicine Risk Assessment Care for Everyone - Implementation Phase
Recruiting
The "Genomic medicine Risk Assessment Care for Everyone" (GRACE)" intervention project will develop a scalable end-to-end solution for risk assessment and management that meets the needs of those populations living in low resource settings. The long-term goal is to increase access to and uptake of risk-informed evidence-based guidelines that will improve population health through better patient outcomes, higher quality of life, and decreased costs. The three primary aims are: Aim 1: Develop a s... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/31/2025
Locations: UF Health Family Medicine - Lem Turner, Jacksonville, Florida +3 locations
Conditions: Cardiovascular Diseases, Cancer, Liver Diseases, Hyperthermia
Acellular Dermal Matrix Investigation in Breast Reconstruction
Recruiting
Prospective, multi-center, dual-arm non-randomized clinical study in females undergoing a two-stage breast reconstruction using a pre-pectoral technique.
Gender:
FEMALE
Ages:
22 years and above
Trial Updated:
03/31/2025
Locations: University of Colorado, Aurora, Colorado +5 locations
Conditions: Breast Reconstruction
Study to Compare an Oral Weekly Islatravir/Lenacapavir Regimen With Bictegravir/Emtricitabine/Tenofovir Alafenamide in Virologically Suppressed People With HIV-1
Recruiting
The goal of this clinical study is to learn about the safety and efficacy of switching to once weekly tablet of islatravir/lenacapavir (ISL/LEN) regimen versus continuing standard treatment of bictegravir/emtricitabine/tenofovir alafenamide (B/F/TAF) in people with human immunodeficiency virus (PWH) who are virologically suppressed (HIV-1 RNA levels \< 50 copies/mL) on B/F/TAF for ≥ 6 months prior to screening. The primary objective is to evaluate the efficacy of switching to oral weekly ISL/LE... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/31/2025
Locations: University of Alabama at Birmingham, Birmingham, Alabama +105 locations
Conditions: HIV-1-infection
Improving Sympathetic Activity, Hot Flashes, and Sleep in Midlife Women Using Inspiratory Muscle Strength Training
Recruiting
The purpose of this research is to understand how training the muscles used for breathing (inhalation) affects menopausal hot flashes, sympathetic nerve activity and sleep.
Gender:
FEMALE
Ages:
Between 45 years and 60 years
Trial Updated:
03/31/2025
Locations: Mayo Clinic in Rochester, Rochester, Minnesota
Conditions: Menopause, Hot Flashes, Blood Pressure Regulation
Incorporating Narrative Into the Treatment of Youth With Anorexia Nervosa
Recruiting
The goal of this clinical trial is to evaluate whether a narrative medicine (NM) curriculum can enhance self-expression, reflection, and resilience in adolescents and young adults with anorexia nervosa. The main questions it aims to answer are: * Does participation in an NM curriculum improve self-expression and reflection in individuals with anorexia nervosa? * Does engaging in creative writing and group discussion promote resilience and emotional processing in this population? Participants... Read More
Gender:
ALL
Ages:
Between 16 years and 25 years
Trial Updated:
03/31/2025
Locations: UCSF Nancy Friend Pritzker Psychiatry Building, San Francisco, California
Conditions: Anorexia Nervosa