The state of Alabama currently has 11 active clinical trials seeking participants for Parkinson's Disease research studies. These trials are conducted in various cities, including Birmingham, Mobile, Huntsville and Anniston.
Early Parkinson's Disease Monotherapy With CVN424
Recruiting
This is a multicenter, 12-week, placebo-controlled clinical trial of CVN424 150 milligrams (mg) tablets in early, untreated Parkinson's Disease (PD). Participants will be randomized in a 1:1 ratio to CVN424 150 mg or placebo at the Baseline Visit. The purpose of this study is to measure effect on motor features with CVN424 compared to placebo in early, untreated Parkinson's Disease (PD) and to evaluate the potential of CVN424 to improve motor and non-motor functions in participants with early PD... Read More
Gender:
All
Ages:
30 years and above
Trial Updated:
02/22/2024
Locations: University of Alabama at Birmingham, Birmingham, Alabama
Conditions: Parkinson Disease
Study in Parkinson Disease of Exercise
Recruiting
This study is a Phase 3 multi-site, randomized, evaluator-masked, study of endurance treadmill exercise on changes in the Movement Disorder Society-Unified Parkinson Disease Rating Scale (MDS-UPDRS) Part III score at 12 months among persons with early stage Parkinson disease. 370 participants will be randomly assigned to 2 groups: 1)60-65% HRmax or 2)80-85% HRmax 4 times per week. The primary objective is to test whether the progression of the signs of Parkinson's disease is attenuated at 12 mon... Read More
Gender:
All
Ages:
Between 40 years and 80 years
Trial Updated:
02/20/2024
Locations: University of Alabama at Birmingham, Birmingham, Alabama
Conditions: Parkinson Disease
A Study to Investigate The Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of RO7486967 in Participants With Early Idiopathic Parkinson's Disease
Recruiting
This is a multi-center, randomized, double blind, adaptive, parallel-group, placebo controlled Phase 1b study to evaluate the safety, tolerability, pharmacokinetic (PK) and pharmacodynamics of RO7486967 in participants with idiopathic PD at the early stage of the disease (modified H&Y stage ≤2.5) who are either treatment-naïve or on stable treatment with symptomatic therapy (levodopa and/or pramipexole, ropinirole, rotigotine).
Gender:
All
Ages:
Between 40 years and 85 years
Trial Updated:
02/15/2024
Locations: University of Alabama at Birmingham, Birmingham, Alabama
Conditions: Parkinson Disease
Stimulus-Evoked Directional Field Potentials to Guide Subthalamic and Pallidal DBS for PD
Recruiting
The purpose of the study is to determine whether new deep brain stimulation (DBS) device technologies can generate and record brain rhythms to reveal the best location for clinical stimulation.
Gender:
All
Ages:
18 years and above
Trial Updated:
01/12/2024
Locations: University of Alabama at Birmingham, Birmingham, Alabama
Conditions: Parkinson Disease
PPMI Clinical - Establishing a Deeply Phenotyped PD Cohort
Recruiting
The Parkinson Progression Marker Initiative (PPMI) is a longitudinal, observational, multi-center natural history study to assess progression of clinical features, digital outcomes, and imaging, biologic and genetic markers of Parkinson's disease (PD) progression in study participants with manifest PD, prodromal PD, and healthy controls. The overall goal of PPMI is to identify markers of disease progression for use in clinical trials of therapies to reduce progression of PD disability.
Gender:
All
Ages:
30 years and above
Trial Updated:
12/13/2023
Locations: University of Alabama at Birmingham, Birmingham, Alabama
Conditions: Parkinson Disease
Automated Imaging Differentiation of Parkinsonism
Recruiting
The purpose of this study is to test the performance of the AID-P across 21 sites in the Parkinson Study Group. Each site will perform imaging, clinical scales, diagnosis, and will upload the data to the web-based software tool. The clinical diagnosis will be blinded to the diagnostic algorithm and the imaging diagnosis will be compared to the movement disorders trained neurologist diagnosis.
Gender:
All
Ages:
Between 40 years and 80 years
Trial Updated:
11/13/2023
Locations: University of Alabama at Birmingham, Birmingham, Alabama
Conditions: Parkinson Disease, Multiple System Atrophy, Parkinson Variant, Progressive Supranuclear Palsy
Investigating Inhibitory Control Networks in Parkinson's Disease
Recruiting
The purpose of this study is to investigate the brain activity associated with non-motor symptoms of movement disorders, including Parkinson's disease and essential tremor. These movement disorders commonly have significant non-motor features also, including depression, cognitive impairment, decreased attention, and slower processing speeds. The investigators are interested in the brain activity associated with these symptoms, and perform recordings of the surface of the brain, in addition to th... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
11/01/2023
Locations: University of Alabama at Birmingham, Birmingham, Alabama
Conditions: Parkinson Disease
Combining VNS With PT Interventions for Individuals With PD
Recruiting
The purpose of this study is to evaluate the combined effects of non-invasive neuromodulation (specifically transauricular Vagus Nerve Stimulation) with exercise interventions to improve physical function and quality of life in individuals with Parkinson's Disease.
Gender:
All
Ages:
Between 35 years and 80 years
Trial Updated:
09/18/2023
Locations: WHARF, Birmingham, Alabama +1 locations
Conditions: Parkinson Disease
Sensory Filtering in the Human Basal Ganglia as a Mechanism of Parkinson's Disease
Recruiting
The investigators are investigating the brain activity associated with sensory information in movement disorders in order to improve treatment of these symptoms beyond what is currently available.
Gender:
All
Ages:
Between 18 years and 89 years
Trial Updated:
08/07/2023
Locations: The University of Alabama at Birmingham Hospital, Birmingham, Alabama
Conditions: Parkinson Disease
Optimizing Protein Patterns for Skeletal Muscle Preservation and Sleep in the Medical Management of Parkinson Disease
Recruiting
The purpose of this pilot study is to generate preliminary data on the impact of the dietary protein pattern on markers of skeletal muscle health and drug efficacy in Parkinson disease.
Gender:
All
Ages:
Between 45 years and 99 years
Trial Updated:
06/22/2023
Locations: University of Alabama at Birmingham, Birmingham, Alabama
Conditions: Parkinson Disease
The University of Alabama at Birmingham (UAB) Neuroinflammation in Parkinson's Disease-TSPO- Positron Emission Tomography (PET) Substudy
Recruiting
The primary objective of this substudy is to measure the concentration and the regional brain distribution of activated brain microglia/macrophages using the PET (Positron Emission Tomography) ligand Fluorodeoxyglucose dimethylpyrazolo ([18F]DPA-714) in participants enrolled in the UAB Neuroinflammation in Parkinsons Disease (PD) study. The PET tracer [18F]DPA-714 binds to the 18 kilodaltons (kDa) translocator protein (TSPO, also known as the peripheral benzodiazepine receptor) in the mitochondr... Read More
Gender:
All
Ages:
30 years and above
Trial Updated:
02/07/2023
Locations: UAB Advanced Imaging Facility, Birmingham, Alabama
Conditions: Parkinson Disease