The state of Alabama currently has 5 active clinical trials seeking participants for Epilepsy research studies. These trials are conducted in various cities, including Birmingham, Mobile, Huntsville and Anniston.
A Study to Evaluate the Efficacy, Safety, and Tolerability of Brivaracetam as Monotherapy in Patients 2 to 25 Years of Age With Childhood Absence Epilepsy or Juvenile Absence Epilepsy
NCT04666610
Recruiting
The purpose of the study is to test the efficacy, safety and tolerability of brivaracetam monotherapy in study participants 2 to 25 years of age inclusive with childhood absence epilepsy (CAE) or juvenile absence epilepsy (JAE).
Gender:
All
Ages:
Between 2 years and 25 years
Trial Updated:
06/20/2024
Locations: N01269 115, Birmingham, Alabama
Conditions: Childhood Absence Epilepsy, Juvenile Absence Epilepsy
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RNS System LGS Feasibility Study
NCT05339126
Recruiting
To generate preliminary safety and effectiveness data for brain-responsive neurostimulation of thalamocortical networks as an adjunctive therapy in reducing the frequency of generalized seizures in individuals 12 years of age or older with Lennox Gastaut Syndrome (LGS) who are refractory to antiseizure medications. The intent is to determine the feasibility and the optimal design of a subsequent pivotal study in order to expand the indication for use for the RNS System as a treatment for patien... Read More
Gender:
All
Ages:
12 years and above
Trial Updated:
06/20/2024
Locations: University of Alabama at Birmingham, Birmingham, Alabama
Conditions: Epilepsy, Lennox Gastaut Syndrome, Lennox-Gastaut Syndrome, Intractable, Seizures, Seizures, Generalized
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Exercise for Memory Rehabilitation in Epilepsy
NCT04959019
Recruiting
The purpose of this study is to determine how effective a 6-week exercise program is for improving memory compared to a no-intervention control group, investigate the brain changes that may be responsible for memory improvements, and determine if the memory benefits and brain changes are retained 6 weeks after completing the exercise intervention in people with Idiopathic generalized epilepsy (IGE).
Gender:
All
Ages:
Between 18 years and 55 years
Trial Updated:
02/13/2024
Locations: University of Alabama at Birmingham, Birmingham, Alabama
Conditions: Epilepsy, Generalized, Memory Impairment
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Stimulation-Induced Changes in Fronto-Limbic Network
NCT05854160
Recruiting
The purpose of this research is to better understand how emotion processing unfolds in the brain using stereoelectroencephalography (sEEG) and direct brain stimulation. This study will use standard behavioral emotion processing tasks combined with neural recording and direct brain stimulation to assess different aspects of emotion processing. Stimulation pulses during pre and post-test periods will assess the effects of stimulation before and after conditioning, the results of which will be comb... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
09/22/2023
Locations: Epilepsy Monitoring Unit UAB Hospital, Birmingham, Alabama
Conditions: Epilepsy, Mental Disorders
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Stopping TSC Onset and Progression 2B: Sirolimus TSC Epilepsy Prevention Study
NCT05104983
Recruiting
This trial is a Phase II randomized, double-blind, placebo controlled multi-site study to evaluate the safety and efficacy of early sirolimus to prevent or delay seizure onset in TSC infants. This study is supported by research funding from the Office of Orphan Products Division (OOPD) of the US Food and Drug Administration (FDA).
Gender:
All
Ages:
Between 1 day and 6 months
Trial Updated:
08/21/2023
Locations: University of Alabama at Birmingham, Birmingham, Alabama
Conditions: Tuberous Sclerosis Complex, Epilepsy
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