A Study to Evaluate the Long-term Safety of Inclacumab Administered to Participants With Sickle Cell Disease
NCT05348915
Recruiting
This study is an open-label study to evaluate the safety of long-term administration of inclacumab in participants with sickle cell disease (SCD). Participants in this study will have completed a prior study of inclacumab.
Gender:
All
Ages:
12 years and above
Trial Updated:
11/29/2023
Locations: Arkansas Children's Hospital, Little Rock, Arkansas
Conditions: Sickle Cell Disease, Vaso-occlusive Crisis, Vaso-occlusive Pain Episode in Sickle Cell Disease
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A Study of Retatrutide (LY3437943) in Participants Who Have Obesity or Overweight
NCT05929066
Recruiting
The purpose of this study is to evaluate the efficacy and safety of retatrutide in participants who have obesity or overweight (J1I-MC-GZBJ master protocol) including subsets of participants who have knee osteoarthritis (OA) (J1I-MC-GOA1) or who have obstructive sleep apnea (OSA) (J1I-MC-GSA1). This study will last about 89 weeks and will include up to 24 visits.
Gender:
All
Ages:
18 years and above
Trial Updated:
10/18/2023
Locations: Medical Investigations, Little Rock, Arkansas
Conditions: Obesity, Overweight, Knee Pain Chronic, Knee Osteoarthritis, Obstructive Sleep Apnea
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Evaluation of Efficacy and Safety of VX-548 for Acute Pain After a Bunionectomy
NCT05553366
Recruiting
The purpose of this study is to evaluate the efficacy and safety of VX-548 for acute pain after a bunionectomy.
Gender:
All
Ages:
Between 18 years and 80 years
Trial Updated:
10/13/2023
Locations: Woodland International Research Group, Little Rock, Arkansas
Conditions: Acute Pain
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Pharmacokinetics, Pharmacodynamics, and Safety Profile of Understudied Drugs Administered to Children Per Standard of Care (POPS)
NCT04278404
Recruiting
The study investigators are interested in learning more about how drugs, that are given to children by their health care provider, act in the bodies of children and young adults in hopes to find the most safe and effective dose for children. The primary objective of this study is to evaluate the PK of understudied drugs currently being administered to children per SOC as prescribed by their treating provider.
Gender:
All
Ages:
Between 0 years and 20 years
Trial Updated:
09/21/2023
Locations: Arkansas Children's Hospital Research Institute, Little Rock, Arkansas
Conditions: Coronavirus Infection (COVID-19), Pulmonary Arterial Hypertension, Urinary Tract Infections in Children, Hypertension, Pain, Hyperphosphatemia, Primary Hyperaldosteronism, Edema, Hypokalemia, Heart Failure, Menorrhagia, Insomnia, Pneumonia, Skin Infection, Arrythmia, Asthma in Children, Bronchopulmonary Dysplasia, Adrenal Insufficiency, Fibrinolysis; Hemorrhage, Hemophilia, Attention Deficit Hyperactivity Disorder, Multisystem Inflammatory Syndrome in Children (MIS-C), Kawasaki Disease, Coagulation Disorder, Down Syndrome
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The RESET Clinical Trial: SPRINT® Peripheral Nerve Stimulation for the Treatment of Back Pain
NCT04246281
Recruiting
The purpose of this study is to compare standard of care treatments for back pain to electrical stimulation. Stimulation is delivering small amounts of electricity to the nerves in your low back. This study will use a device called the SPRINT Peripheral Nerve Stimulation (PNS) System. The device is cleared by the FDA for up to 60 days of use for the relief of chronic or acute pain (including back pain)
Gender:
All
Ages:
Between 21 years and 75 years
Trial Updated:
09/06/2023
Locations: University of Arkansas for Medical Sciences, Little Rock, Arkansas
Conditions: Low Back Pain, Back Pain
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Optimizing the Use of Ketamine to Reduce Chronic Postsurgical Pain
NCT05037123
Recruiting
The study utilizes a 3-arm placebo-controlled RCT to study the effectiveness of ketamine in reducing chronic post-mastectomy pain. Participants randomized to the first arm will receive a 0.35 mg/kg dose after induction, followed by a 0.25 mg/kg/hr infusion during surgery (up to a maximum of 6 hours) and continued for 2 hours postoperatively. Participants in the second arm will receive a single dose of 0.6 mg/kg of ketamine in the post-anesthesia care unit, and the final group will serve as the c... Read More
Gender:
Female
Ages:
18 years and above
Trial Updated:
08/07/2023
Locations: University of Arkansas, Little Rock, Arkansas
Conditions: Chronic Postsurgical Pain
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Epigenetic Mechanisms and Symptom Clusters Associated With Resolution of Pain Following Spinal Cord Stimulation
NCT04960592
Recruiting
Spinal cord stimulation (SCS) is indicated for selected patients with chronic pain who have not responded to conventional medical management. Forty (40) patients indicated for SCS placement and presenting to the University of Arkansas for Medical Sciences (UAMS) Interventional Pain Management Clinic in Little Rock, Arkansas will be recruited for this study. Prior to temporary stimulator placement, patients will complete symptom-related questionnaires and provide a blood sample. Demographic and... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
05/08/2023
Locations: University of Arkansas for Medical Sciences, Little Rock, Arkansas
Conditions: Spinal Cord Stimulation, Chronic Pain
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Pilot Study on the Effects of Low-Level Laser Therapy Treatment for Acute and Persistent Discomfort
NCT04774783
Recruiting
This study will examine the effectiveness of Low-Level Laser Therapy (LLLT) for the management of pain in various locations of the body. All subjects selected for participation in the study will be assigned to a LLLT treatment group for a duration of 12 sessions.
Gender:
All
Ages:
18 years and above
Trial Updated:
02/24/2021
Locations: Arkansas Colleges of Health Education, Fort Smith, Arkansas
Conditions: Chronic Pain, Acute Pain
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