PROPULSION SANTE: Inflammometry to Improve the Diagnostic Trajectory in Situations of Suspected Asthma in Children and Adults
NCT06981169
Recruiting
The objective of this observational study is to assess the relevance of inflammometry (based on the measurement of fractional exhaled nitric oxide (FeNO) and blood eosinophil count (BEC)) as a tool for prioritizing respiratory diagnostic tests. The study will evaluate the role of inflammometry (FeNO and BEC) in prioritizing diagnostic respiratory tests. It will include patients aged six and older with suspected asthma, referred by non-pulmonologists for diagnostic asthma testing (spirometry or... Read More
Gender:
ALL
Ages:
6 years and above
Trial Updated:
05/12/2025
Locations: CHU Sainte-Justine, Montreal, Quebec +2 locations
Conditions: Asthma, Inflammation, Asthma in Children
Register for Updates
Objective Concussion Assessment Using MRI and Metabolomics
NCT05993351
Recruiting
Mild traumatic brain injury (mTBI), also referred to as concussions, affect millions of people around the world and can cause harmful long term effects. Unfortunately, concussions can be hard to diagnose and many people have lasting post-concussion symptoms such as headaches, difficulty concentrating, and light sensitivity. Recent studies have shown that advanced magnetic resonance imaging (MRI) techniques can identify subtle brain changes caused by a concussion. This study aims to track concuss... Read More
Gender:
ALL
Ages:
Between 9 years and 50 years
Trial Updated:
05/12/2025
Locations: Imaging Research Center at St. Joseph's Healthcare Hamilton, Hamilton, Ontario
Conditions: Concussion, Brain
Register for Updates
Midodrine for the Early Liberation of Vasopressor Support in the ICU (LIBERATE Multi-Site)
NCT05058612
Recruiting
Vasopressors are medications that are given intravenously to increase the blood pressure of patients with illnesses that cause dangerous blood pressure drops. When a doctor prescribes a vasopressor, they ask that the dose be adjusted to achieve a specific blood pressure. This kind of medical support with intravenous (IV) vasopressors are usual treatments in intensive care unit (ICU) settings. Oral vasopressors, such as midodrine, have been historically used to maintain blood pressure in non-crit... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/12/2025
Locations: University of Alberta Hospital, Edmonton, Alberta
Conditions: Vasoplegia
Register for Updates
SPECT-CT Guided ELEctive Contralateral Neck Treatment for Patients With Lateralized Oropharyngeal Cancer
NCT05451004
Recruiting
This study is being done to answer the following question: Is the chance of cancer spreading or returning the same if radiotherapy to the neck is guided, by using a special imaging study called lymph node mapping (lymphatic mapping) Single Photon Emission Computed Tomography (SPECT-CT), compared to the usual treatment when radiotherapy is given to both sides of the neck?
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/12/2025
Locations: City of Hope Comprehensive Cancer Center, Duarte, California +26 locations
Conditions: Oropharyngeal Cancer
Register for Updates
Pilot Study of Vinblastine and Tovorafenib in Pediatric Patients With Recurrent/Progressive RAF Altered Low Grade Gliomas
NCT06381570
Recruiting
This is a Pilot, multicenter, open-label study of patients less than or equal to 25 years, with recurrent or progressive LGG harboring a CRAF or BRAF alteration, including BRAF V600 mutations and KIAA1549: BRAF fusions. Patients with BRAF or CRAF alterations will be identified through molecular assays as routinely performed at Clinical Laboratory Improvement Amendments (CLIA) of 1988 or other similarly certified laboratories. The study will be conducted in two sequential phases: Phase A: A Fea... Read More
Gender:
ALL
Ages:
Between 0 weeks and 25 years
Trial Updated:
05/12/2025
Locations: The Hospital for Sick Children, Toronto, Ontario
Conditions: Low-grade Glioma
Register for Updates
Vomiting Prevention in Children With Cancer
NCT06886451
Recruiting
The goal of this single arm trial is to learn if a machine learning (ML) model predicting the risk of vomiting within the next 96 hours will impact vomiting outcomes in inpatient cancer pediatric patients. The main questions it aims to answer are whether an ML model predicting the risk of vomiting within the next 96 hours will: Primary 1. Reduce the proportion with any vomiting within the 96-hour window Secondary 1. Reduce the number of vomiting episodes 2. Increase the proportion receiving... Read More
Gender:
ALL
Ages:
All
Trial Updated:
05/12/2025
Locations: The Hospital for Sick Children, Toronto, Ontario
Conditions: Chemotherapy Induced Nausea and Vomiting, Quality of Life (QOL), Pediatric Cancer
Register for Updates
The Dragon PLC Trial (DRAGON-PLC)
NCT06914648
Recruiting
The goal of the DRAGON PLC clinical trial is to determine whether portal vein embolization (PVE) combined with hepatic vein embolization (HVE) improves resectability and overall survival in patients with initially unresectable primary liver cancer compared to standard PVE alone. This trial specifically focuses on patients with hepatocellular carcinoma and cholangiocarcinoma. The main questions this trial aims to answer are whether combined PVE and HVE increases the proportion of patients who be... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/12/2025
Locations: Yale School of Medicine Hospital, New Haven, Connecticut +54 locations
Conditions: Primary Liver Cancer, Hepatocellular Carcinoma (HCC), Cholangiocarcinoma
Register for Updates
Ferric Derisomaltose (Iron Isomaltoside) Versus Iron Sucrose for Treatment of Iron Deficiency in Pregnancy
NCT05251493
Recruiting
Ion deficiency anemia (IDA) is associated with poor neonatal outcomes and maternal morbidity. Iron replacement may be done with oral iron or intravenous iron, with intravenous iron being utilized later in pregnancy or if there is an inadequate response to oral iron in the first trimester. In Canada, iron sucrose has been used, however iron isomaltoside is as safe as other formulations of IV iron but can replete iron stores with a single visit. Replenishing iron stores reduces both maternal and n... Read More
Gender:
FEMALE
Ages:
Between 18 years and 50 years
Trial Updated:
05/12/2025
Locations: Regina General Hospital, Regina, Saskatchewan
Conditions: Iron Deficiency Anaemia in Childbirth
Register for Updates
Phase I Master Protocol of Novel Combination Therapy for Patients With Relapsed or Refractory Aggressive B-Cell Lymphoma
NCT04161248
Recruiting
The purpose of this study is to find the highest dose of a new drug, in combination with standard drugs, which can be tolerated without causing very severe side effects. The study treatment is new agents in combination with R-GDP or an equivalent regimen.
Gender:
ALL
Ages:
Between 16 years and 65 years
Trial Updated:
05/12/2025
Locations: BCCA - Vancouver, Vancouver, British Columbia +3 locations
Conditions: Lymphoma, B-Cell
Register for Updates
Bupivacaine and Epinephrine Injection Study
NCT06456255
Recruiting
Endoscopic sinus surgery (ESS) is a common otolaryngologic procedure that aims to remove the partitions that separate the sinus cavities, remove inflamed tissue, and optimize the sinuses for topical medication use. In this procedure, the surgeon will inject a combination of drugs, local anesthetics, and vasoconstrictors, to reduce bleeding and improve visualization. However, previous studies have shown similar results when injected with only saline. In this study, investigators want to determine... Read More
Gender:
ALL
Ages:
19 years and above
Trial Updated:
05/12/2025
Locations: St.Paul's Hospital Sinus Center, Vancouver, British Columbia
Conditions: Sinus Disease, Anesthesia, Bleeding
Register for Updates
I-CARE: A Pilot Study of Cognitive Behavioural Therapy(CBT) for Mood and Anxiety Disorders
NCT06532500
Recruiting
The goal of this clinical trial is to learn if CBT(Cognitive Behavioural Therapy)-MyOWL(Optimizing Wellness through Literature) is feasible, leads to better patient retention, and has high acceptability by youth psychiatric outpatients with mood and/or anxiety disorder aged 14-19. The main questions it aims to answer are: Primary Objective (feasibility): To determine whether a clinically meaningful proportion of youth complete a full course of CBT-MyOWL / CBT-as-usual. Primary Objective (accep... Read More
Gender:
ALL
Ages:
Between 14 years and 19 years
Trial Updated:
05/12/2025
Locations: Sunnybrook Health Sciences Centre, Toronto, Ontario
Conditions: Mood Disorders, Anxiety Disorders
Register for Updates
Viral Dynamics and Transmission of Influenza, RSV and SARS-CoV-2 in Children
NCT06640387
Recruiting
Viral respiratory tract infections are very common in children. They contribute to missed time in school, work disruption for caregivers and can also cause severe illness requiring hospitalization and rarely death. In the 2022-2023, influenza, RSV and SARS-CoV-2 viruses infected a large number of children which strained the pediatric healthcare system in many jurisdictions. Unfortunately, there continues to be limited data on duration of infectiousness and transmission risk of these viruses to i... Read More
Gender:
ALL
Ages:
1 day and above
Trial Updated:
05/12/2025
Locations: The Hospital for Sick Children (SickKids), Toronto, Ontario
Conditions: SARS CoV 2 Infection, RSV Infection, Influenza
Register for Updates