UNIty-Based MR-Linac Guided Adaptive RadioThErapy for High GraDe Glioma-3 (UNITED-3)
NCT05720078
Recruiting
The goal of this study is to test whether an adaptive radiation therapy (RT), two-phase approach in participants with glioblastoma impacts local control compared to standard non-adaptive RT approach. The main questions of the study are to see how this adaptive, two-phase RT approach compares to standard RT in terms of: * Local control * Overall and progression-free survival * Patterns of failure * Toxicity, Neurological Function, and Quality of Life
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/12/2025
Locations: Sunnybrook Health Sciences Centre, Toronto, Ontario
Conditions: Glioblastoma Multiforme, Adult
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Promoting Intensive Transitions for Children and Youth With Medical Complexity From Pediatric to Adult Care
NCT06093386
Recruiting
Medical advances have allowed many more children and youth with medical complexity (CMC) to survive well into adulthood. However, this has not been matched with increases in knowledge of complex conditions or the availability of supports as they transition into the adult care system. The goal of this randomized control trial is to compare intensive transition support from a transition team, led by an advance practice nurse, during transition to adult care for 2 years, with usual care in CMC. Par... Read More
Gender:
ALL
Ages:
Between 210 months and 213 months
Trial Updated:
05/12/2025
Locations: The Hospital for Sick Children, Toronto, Ontario
Conditions: Children and Youth With Medical Complexity
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Effectiveness of Penthrox vs Placebo in Sinus Procedures, a Clinical Trial
NCT06750302
Recruiting
The goal of this randomized controlled trial is to evaluate the effectiveness of inhaled methoxyflurane (Penthrox) as an analgesic for patients undergoing minor rhinology and sinus procedures, specifically comparing it to a placebo control. The primary question the study aims to answer is: Does methoxyflurane provide superior pain relief compared to placebo during minor sinus procedures, as measured by the Visual Analog Scale (VAS)? If there is a comparison group: Researchers will compare the e... Read More
Gender:
ALL
Ages:
19 years and above
Trial Updated:
05/12/2025
Locations: St Paul's Sinus Centre, Vancouver, British Columbia
Conditions: Chronic Rhinosinusitis (CRS)
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Objective Concussion Assessment Using MRI and Metabolomics
NCT05993351
Recruiting
Mild traumatic brain injury (mTBI), also referred to as concussions, affect millions of people around the world and can cause harmful long term effects. Unfortunately, concussions can be hard to diagnose and many people have lasting post-concussion symptoms such as headaches, difficulty concentrating, and light sensitivity. Recent studies have shown that advanced magnetic resonance imaging (MRI) techniques can identify subtle brain changes caused by a concussion. This study aims to track concuss... Read More
Gender:
ALL
Ages:
Between 9 years and 50 years
Trial Updated:
05/12/2025
Locations: Imaging Research Center at St. Joseph's Healthcare Hamilton, Hamilton, Ontario
Conditions: Concussion, Brain
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A Pilot Study Investigating Upfront Adaptive Immunotherapy Approach in Children, Adolescent and Young Adult (CAYA) Patients With Replication-Repair Deficient (RRD) High-Grade Gliomas (HGG)
NCT06519682
Recruiting
This is open label, multicentre, single arm, pilot study of upfront nivolumab in patients with RRD-glioblastoma with favorable immune/genomic biomarkers. The purpose of the study is to use upfront immune checkpoint inhibitor (ICI) to delay/avoid radiation for patients with RRD-glioblastoma with favorable clinical (Gross total resection (GTR) or near total resection (NTR)) and biological (RRD, hypermutation, immune activation) biomarkers. At progression, patients will be undergoing surgery/biopsy... Read More
Gender:
ALL
Ages:
Between 12 months and 25 years
Trial Updated:
05/12/2025
Locations: Hospital for Sick Children, Toronto, Ontario
Conditions: High Grade Glioma, Replication Repair Deficient
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SPECT-CT Guided ELEctive Contralateral Neck Treatment for Patients With Lateralized Oropharyngeal Cancer
NCT05451004
Recruiting
This study is being done to answer the following question: Is the chance of cancer spreading or returning the same if radiotherapy to the neck is guided, by using a special imaging study called lymph node mapping (lymphatic mapping) Single Photon Emission Computed Tomography (SPECT-CT), compared to the usual treatment when radiotherapy is given to both sides of the neck?
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/12/2025
Locations: City of Hope Comprehensive Cancer Center, Duarte, California +26 locations
Conditions: Oropharyngeal Cancer
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The Dragon PLC Trial (DRAGON-PLC)
NCT06914648
Recruiting
The goal of the DRAGON PLC clinical trial is to determine whether portal vein embolization (PVE) combined with hepatic vein embolization (HVE) improves resectability and overall survival in patients with initially unresectable primary liver cancer compared to standard PVE alone. This trial specifically focuses on patients with hepatocellular carcinoma and cholangiocarcinoma. The main questions this trial aims to answer are whether combined PVE and HVE increases the proportion of patients who be... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/12/2025
Locations: Yale School of Medicine Hospital, New Haven, Connecticut +54 locations
Conditions: Primary Liver Cancer, Hepatocellular Carcinoma (HCC), Cholangiocarcinoma
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Bupivacaine and Epinephrine Injection Study
NCT06456255
Recruiting
Endoscopic sinus surgery (ESS) is a common otolaryngologic procedure that aims to remove the partitions that separate the sinus cavities, remove inflamed tissue, and optimize the sinuses for topical medication use. In this procedure, the surgeon will inject a combination of drugs, local anesthetics, and vasoconstrictors, to reduce bleeding and improve visualization. However, previous studies have shown similar results when injected with only saline. In this study, investigators want to determine... Read More
Gender:
ALL
Ages:
19 years and above
Trial Updated:
05/12/2025
Locations: St.Paul's Hospital Sinus Center, Vancouver, British Columbia
Conditions: Sinus Disease, Anesthesia, Bleeding
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Vomiting Prevention in Children With Cancer
NCT06886451
Recruiting
The goal of this single arm trial is to learn if a machine learning (ML) model predicting the risk of vomiting within the next 96 hours will impact vomiting outcomes in inpatient cancer pediatric patients. The main questions it aims to answer are whether an ML model predicting the risk of vomiting within the next 96 hours will: Primary 1. Reduce the proportion with any vomiting within the 96-hour window Secondary 1. Reduce the number of vomiting episodes 2. Increase the proportion receiving... Read More
Gender:
ALL
Ages:
All
Trial Updated:
05/12/2025
Locations: The Hospital for Sick Children, Toronto, Ontario
Conditions: Chemotherapy Induced Nausea and Vomiting, Quality of Life (QOL), Pediatric Cancer
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Patients With Rectal Cancer: a "Wait-and-see" Approach
NCT03001362
Recruiting
Patients with histologically proven adenocarcinoma of the rectum will receive pelvic radiotherapy to a dose of 45Gy in 25 fractions with a tumor boost to a dose of 9Gy in 5 fractions (thus total of 54Gy/30Fx to the primary tumor), combined with radio sensitizing chemotherapy. Patients will then be closely monitored, through endoscopy and imaging, for response to treatment and relapse. Salvage oncologic surgery to be offered if there is failure to achieve complete clinical response or in the even... Read More
Gender:
ALL
Ages:
Between 18 years and 90 years
Trial Updated:
05/12/2025
Locations: McGill University Health Centre- Cedars Cancer Centre, Montreal, Quebec +1 locations
Conditions: Colorectal Carcinoma
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Midodrine for the Early Liberation of Vasopressor Support in the ICU (LIBERATE Multi-Site)
NCT05058612
Recruiting
Vasopressors are medications that are given intravenously to increase the blood pressure of patients with illnesses that cause dangerous blood pressure drops. When a doctor prescribes a vasopressor, they ask that the dose be adjusted to achieve a specific blood pressure. This kind of medical support with intravenous (IV) vasopressors are usual treatments in intensive care unit (ICU) settings. Oral vasopressors, such as midodrine, have been historically used to maintain blood pressure in non-crit... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/12/2025
Locations: University of Alberta Hospital, Edmonton, Alberta
Conditions: Vasoplegia
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Phase I Master Protocol of Novel Combination Therapy for Patients With Relapsed or Refractory Aggressive B-Cell Lymphoma
NCT04161248
Recruiting
The purpose of this study is to find the highest dose of a new drug, in combination with standard drugs, which can be tolerated without causing very severe side effects. The study treatment is new agents in combination with R-GDP or an equivalent regimen.
Gender:
ALL
Ages:
Between 16 years and 65 years
Trial Updated:
05/12/2025
Locations: BCCA - Vancouver, Vancouver, British Columbia +3 locations
Conditions: Lymphoma, B-Cell
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