A Real World Effectiveness Study of Pegcetacoplan in Patients With Paroxysmal Nocturnal Hemoglobinuria (PNH)
NCT05776472
Recruiting
This is a 36-month, long-term, multicenter, observational study designed to describe the real world effectiveness of pegcetacoplan in patients with PNH. Patients meeting the eligibility criteria will be enrolled in the study and followed prospectively for approximately 36 months. Patient data will be collected from start of pegcetacoplan treatment to end of follow-up. Retrospective data on pegcetacoplan will be captured from the time of pegcetacoplan treatment initiation. Pegcetacoplan treatment... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/09/2025
Locations: Liverpool Hospital, Liverpool, New South Wales +74 locations
Conditions: Paroxysmal Nocturnal Hemoglobinuria
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Anteroposterior Versus Anterolateral Electrode Position for Electrical Cardioversion of Atrial Fibrillation
NCT05511389
Recruiting
Atrial fibrillation is the most common heart rhythm disorder (arrhythmia) worldwide. Nearly 40 million people are affected by atrial fibrillation worldwide, and this number is expected to increase by over 50% by 2050. Atrial fibrillation can cause strokes, heart attacks, heart failure, poor quality of life and even death. Almost half a million deaths worldwide are expected to be related to atrial fibrillation by 2050, and many billions of dollars are spent on atrial fibrillation related healthca... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/08/2025
Locations: Hamilton Health Sciences, Hamilton, Ontario +1 locations
Conditions: Atrial Fibrillation, Atrial Flutter
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A Study Investigating the Efficacy and Safety of Intravitreal (IVT) Injections of ANX007 in Participants With Geographic Atrophy (GA)
NCT06510816
Recruiting
The primary purpose of the study is to determine if IVT injections of ANX007 every month reduce vision loss in participants with GA secondary to age-related macular degeneration (AMD).
Gender:
ALL
Ages:
50 years and above
Trial Updated:
05/08/2025
Locations: Retina Macula Institute of Arizona, Scottsdale, Arizona +116 locations
Conditions: Geographic Atrophy
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Women's Heart Attack Research Program: Stress Ancillary Study
NCT02914483
Recruiting
The Women's HARP study is a multi-center study focusing on women with clinical presentation of myocardial infarction (MI). Women will complete stress questionnaires following presentation to the medical center with elevated cardiac enzymes and abnormal electrocardiograms (ECGs). 2 months following MI, participants will be screened for the Stress Ancillary Study and enrolled if an elevated level of perceived stress is reported. After completing baseline assessments, participants will be randomize... Read More
Gender:
FEMALE
Ages:
Between 21 years and 99 years
Trial Updated:
05/08/2025
Locations: Cedars-Sinai Medical Center, Los Angeles, California +13 locations
Conditions: Myocardial Infarction
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A Study of DZD9008 Versus Platinum-Based Doublet Chemotherapy in Local Advanced or Metastatic Non-small Cell Lung Cancer (WU-KONG28)
NCT05668988
Recruiting
This is a phase 3, open-label, randomized, multi-center study assessing the efficacy and safety of DZD9008 versus platinum-based doublet chemotherapy in participants with locally advanced or metastatic NSCLC with EGFR Exon20ins mutation, who are newly diagnosed or have not received prior systemic therapy in advanced stage. Primary objective of this study is to assess the efficacy of DZD9008 versus platinum-based doublet chemotherapy using by BICR-assessed PFS per RECIST 1.1 as primary endpoint.... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/08/2025
Locations: OPN Healthcare, Inc., Glendale, California +159 locations
Conditions: Non-small Cell Lung Cancer
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Pre-Op THA Modelling
NCT05221554
Recruiting
Replacing diseased hip joints with prosthetic implants in a procedure called total hip arthroplasty (THA) is associated with high rates of patient satisfaction, pain relief, and functional improvement when the implant is appropriately placed. Incorrect implant size or placement may lead to a breadth of negative outcomes, which could result in the need for implant revision. It is difficult to assess the precise orientation of patient hips on the operating table, with one study revealing that only... Read More
Gender:
ALL
Ages:
40 years and above
Trial Updated:
05/08/2025
Locations: London Health Sciences Centre, London, Ontario
Conditions: Total Hip Arthroplasty, Computer-Assisted Surgery
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Safety, Tolerability, and Preliminary Efficacy of Psilocybin Oral Solution in Adults With Generalized Anxiety Disorder
NCT06969170
Recruiting
This Phase 2a clinical trial is designed to evaluate the safety, tolerability, and preliminary efficacy of a 3 mg dose of psilocybin oral solution for the treatment of Generalized Anxiety Disorder (GAD). The study consists of three sequential phases: Screening Phase (up to 4 weeks), Open-label Run-in Phase (4 weeks), Double-blind Treatment Phase (4 weeks) Screening Phase During the Screening Visit, participants will provide informed consent and undergo a comprehensive medical evaluation, inclu... Read More
Gender:
ALL
Ages:
Between 18 years and 60 years
Trial Updated:
05/08/2025
Locations: Kingston General Health Research Institute, Kingston, Ontario
Conditions: Generalized Anxiety Disorder (GAD)
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A Trial of a Next Generation COVID-19 Vaccine Delivered by Inhaled Aerosol
NCT06381739
Recruiting
The goal of this clinical trial is to study the safety of a new inhaled vaccine to prevent COVID infection and learn about the immune responses that are made in the lungs and the blood after vaccination. Participants will be randomized (like the toss of a coin) to receive the experimental vaccine or a placebo (a look-alike solution that contains no vaccine). To be in the study participants will have to have already had three doses of a messenger ribonucleic acid (mRNA) COVID vaccine and be gene... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
05/07/2025
Locations: Health Sciences Centre, Hamilton, Ontario
Conditions: COVID-19 Infection
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Observing Metabolism of EPA With Consideration of Genetics And Sex
NCT06975241
Recruiting
The goal of this clinical study is to learn how fast EPA is converted to other molecules, including DHA, with consideration of biological sex and genetics in healthy humans. The main questions it aims to answer are: * How fast is EPA converted to DHA in blood, and is the conversion rate affected by sex and a specific genotype we previously identified? * How do sex and the specific genotypes affect blood DHA levels and other products of DHA in response to dietary EPA? * How fast does dietary EP... Read More
Gender:
ALL
Ages:
Between 18 years and 35 years
Trial Updated:
05/07/2025
Locations: Clinical Nutrition and Risk Factor Modification Centre, Toronto, Ontario
Conditions: Healthy, Omega 3, Metabolism, Lipids
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Biospecimen Collection to Identify Gene Mutations for High Risk Pancreatic Cancer in Pediatric Patients, INSPPIRE 2 Study
NCT06651580
Recruiting
This clinical trial collects blood, saliva, urine, or stool samples to help identify possible genetic mutations that may increase a person's chance at developing pancreatic cancer. Finding genetic markers among pediatric patients with acute recurrent pancreatitis and chronic pancreatitis may help identify patients who are at risk of pancreatic cancer.
Gender:
ALL
Ages:
17 years and below
Trial Updated:
05/07/2025
Locations: Children's Hospital Los Angeles, Los Angeles, California +25 locations
Conditions: Chronic Pancreatitis, Exocrine Pancreas Carcinoma, Recurrent Acute Pancreatitis
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Rare Embryonal Tumors of the Central Nervous System: International Registry
NCT05711992
Recruiting
Central nervous system (CNS) tumors are the most common solid malignancies among children. Although some types of CNS tumors like medulloblastomas and low-grade gliomas are widespread and well-studied, there is a huge number of rare diseases that need further research. This international registry aims to establish a large multicenter database of pediatric and young adult patients with rare embryonal tumors of the central nervous system and describe the clinical presentations, diagnostics, treatm... Read More
Gender:
ALL
Ages:
Between 1 day and 25 years
Trial Updated:
05/07/2025
Locations: Hematology Center named after prof. R. Yeolyan, Yerevan, Not set +10 locations
Conditions: Embryonal Tumor
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Systemic Therapy With a Loco-regional Treatment in Patients With Locally Advanced Pancreatic Cancer
NCT04276857
Recruiting
Background Pancreatic cancer is one the leading causes of cancer-related death in Canada. Approximately 40 percent of patients with pancreatic cancer present with locally advanced pancreatic cancer and are not candidate for curative surgery. The optimal management of patients with locally advanced pancreatic cancer remains unknown. Most patients are treated with chemotherapy alone and role of local treatment such as radiation is not well defined. Other conventional ablative therapies such as th... Read More
Gender:
ALL
Ages:
All
Trial Updated:
05/07/2025
Locations: Allan Blair Cancer Center, Regina, Saskatchewan +1 locations
Conditions: Locally Advanced Pancreatic Cancer, Irreversible Electroporation
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