All Clinical Trials in Canada

A listing of 3905 clinical trials actively recruiting volunteers for paid trials and research studies in various therapeutic areas.

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Cranial Nerve Neuromodulation to Improve Arm Function and Brain Plasticity in Stroke

NCT06386510

Recruiting

Following a stroke, persistent residual muscle weakness in the upper limb (UL) drastically impacts the individuals' quality of life and level of independence. Training interventions are recommended to promote UL motor recovery, and recent studies have shown that training must be tailored to each individual's recovery potential to maximise training gains. Complementary to training interventions, non-invasive brain stimulation devices (NIBS) can help support the provision of post-stroke care by mo... Read More

Gender:

ALL

Ages:

Between 18 years and 85 years

Trial Updated:

05/02/2025

Locations: CRIR/Feil/Oberfeld Research Center; Centre intégré de santé et de services sociaux de Laval; Jewish Rehabilitation Hospital, Laval, Quebec +2 locations

Conditions: Stroke

Learn More ›

A SMART Design to Optimize the Delivery of TEMPO for Men With Prostate Cancer and Their Caregivers

NCT06363266

Recruiting

Men with prostate cancer and their family caregivers face many physical and emotional challenges from the cancer itself and its treatment(s), which often lead to high anxiety. The pandemic has highlighted the importance of protecting our physical and mental health, and the complex responsibilities that caregivers have in supporting their loved ones. To improve the health of men with prostate cancer and of their caregivers, the research team developed TEMPO: a self-directed Tailored, wEb-based, psychosocial and physical activity self-Management PrOgram. TEMPO was developed with men with prostate cancer and their caregivers over the past 8 years. It also combines the investigators' research conducted over the past decade on providing the best support to those affected by cancer. Because the cancer care workforce is already overstretched, the research team designed TEMPO to be used without guidance from a health care professional. TEMPO is one-of-a kind in its support of both patients and caregivers, and the integration of coping skills training on a wide range of cancer challenges along with a home-based exercise program. Patients and caregivers who have used TEMPO said they improved their communication, learned new skills to cope with both physical and emotional challenges of cancer, and increased their physical activity. The present project builds on this work to further evaluate the cost and impact of TEMPO on men's and caregivers' health. Men with prostate cancer and their caregivers will be assigned by chance to one of two groups a) TEMPO or b) monitor their anxiety for 12 weeks. After 12 weeks, patients' and caregivers' needing more support will be identified based on an assessment of their anxiety level. For those already using TEMPO and needing more support, non-health care professional guidance might be offered. All those in the monitoring group needing more support will now have access to TEMPO. All participants complete surveys to determine whether TEMPO led to improved health outcomes. Read Less

Gender:

ALL

Ages:

18 years and above

Trial Updated:

05/01/2025

Locations: St. Mary's Research Centre, Montreal, Quebec +1 locations

Conditions: Cancer of the Prostate, Anxiety

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A Study on the Safety of TAK-279 and Whether it Can Reduce Inflammation in the Bowel of Participants With Moderately to Severely Active Crohn's Disease

NCT06233461

Recruiting

Crohn's disease (CD) is a long-lasting condition causing inflammation that can affect any part of the gut. The purpose of this study is to evaluate the efficacy and safety of TAK-279 versus placebo in participants with moderately to severely active Crohn's disease (CD). The main aim of this study is to learn if the 3 different doses of TAK-279 reduce bowel inflammation and ulcers in the bowel compared to the placebo after 12 weeks of treatment. Another aim is to compare any medical problems that... Read More

Gender:

ALL

Ages:

Between 18 years and 75 years

Trial Updated:

04/30/2025

Locations: GastroIntestinal BioSciences, Los Angeles, California +196 locations

GastroIntestinal BioSciences, Los Angeles, California

United Medical Doctors, Murrieta, California

UCI Health, Orange, California

West Central Gastroenterology, LLP, d/b/a/ Gastro Florida, Clearwater, Florida

Auzmer Research, Lakeland, Florida

Wellness Clinical Research, Miami Lakes, Florida

GI PROS, Inc., Naples, Florida

USF Health Morsani Center for Advanced Healthcare, Tampa, Florida

Emory University Hospital, The Emory Clinic, Atlanta, Georgia

Atlanta Center For Gastroenterology, P.C., Decatur, Georgia

The University of Iowa Hospitals & Clinics, Iowa City, Iowa

University Of Louisville, Louisville, Kentucky

Woodholme Gastroenterology Associates, Glen Burnie, Maryland

BVL Clinical Research, Liberty, Missouri

Las Vegas Medical Research, Las Vegas, Nevada

Icahn School of Medicine at Mount Sinai (ISMMS) - The Mount Sinai Hospital (MSH), New York, New York

Rochester Clinical Research, Rochester, New York

Great Lakes Gastroenterology Research, LLC, Mentor, Ohio

Hightower Clinical - SSM Health, Oklahoma City, Oklahoma

University Gastroenterology Providence, Providence, Rhode Island

Gastroenterology Associates, PA, Greenville, South Carolina

Novel Research, LLC, Bellaire, Texas

TDDC - Baylor University Medical Center Gaston Ave, Dallas, Texas

Texas Digestive Disease Consultants, PLLC d/b/a GI Alliance, Fort Worth, Texas

TDDC dba Alliance Research, Mansfield, Texas

Southern Star Research Institute, LLC, San Antonio, Texas

Tyler Research Institute, LLC, Tyler, Texas

Tidewater Gastroenterology, P.L.L.C. d/b/a Gastroenterology Associates of Tidewater, Chesapeake, Virginia

University of Washington Medical Center, Seattle, Washington

Nepean Clinical School, Kingswood, New South Wales

Concord Repatriation General Hospital, Sydney, New South Wales

Mater Cancer Care Centre-Mater Health Services, South Brisbane, Queensland

Central Adelaide Local Health Network - Royal Adelaide Hospital, Adelaide, South Australia

Flinders Medical Centre, Bedford Park, South Australia

The Queen Elizabeth Hospital, Woodville, South Australia

Western Health/Footscray Hospital, Melbourne, Victoria

Harry Perkins Medical Research Institute Fiona Stanley Hospital, Murdoch, Western Australia

Royal Perth Hospital, Perth, Western Australia

Northern Hospital Epping, Epping, Not set

Sir Charles Gairdner Hospital (SCGH) - Comprehensive Cancer Centre, Nedlands, Not set

Hopital Universitaire de Bruxelles/ Academisch Ziekenhuis Brussel, Brussels, Anderlecht / Region Capitale De Bruxelles/ Brussel

CHU Saint-Pierre - Porte de Hal, Bruxelles, Not set

Universitair Ziekenhuis Leuven, Leuven, Not set

Centre Hospitalier Universitaire (CHU) de Liege - Domaine Universitaire du Sart Tilman, Liege, Not set

UMBAL Kaspela, Plovdiv, Not set

Multi-Profile Hospital for Active Treatment (MHAT) Hadji Dimitar, Sliven, Not set

Acibadem City clinic Tokuda hospital, Sofia, Not set

Diagnostic-Consultative Center Aleksandrovska EOOD, Sofia, Not set

University Hospital Tsaritsa Yoanna - Isul (University Hospital Queen Giovanna), Sofia, Not set

Acibadem City Clinic Mladost Hospital, Sofia, Not set

Heritage Medical Research Clinic - University Of Calgary, Calgary, Alberta

Fraser Clinical Trials, New Westminster, British Columbia

(G.I.R.I) GI Research Institute Foundation, Vancouver, British Columbia

Nova Scotia Health Authority - Queen Elizabeth II Heath Sciences Centre, Halifax, Nova Scotia

London Health Sciences Centre - University Hospital, London, Ontario

London Health Sciences Centre - Victoria Hospital, London, Ontario

University of Toronto - Mount Sinai Hospital - The Lunenfeld-Tanenbaum Research Institute, Toronto, Ontario

Centre Hospitalier de l'Universite de Montreal, Montreal, Quebec

The Research Institute of the McGill University Health Center, Montreal, Quebec

Chongqing General Hospital, Chongqing, Chongqing Sheng

Zhongshan Hospital Xiamen University, Xiamen, Fujian

Sun Yat-sen University (SYSU) - The First Affiliated Hospital, Guangzhou, Guangdong

The Second Xiangya Hospital of Central South University, Changsha, Hunan

China Medical University (CMU) - Shengjing Hospital (The Second Affiliated Hospital) - Huaxiang Campus, Shenyang, Liaoning Sheng

Shanghai Jiao Tong University School of Medicine - Ruijing hospital, Shanghai, Shanghai

Xinhua Hospital Affiliated To Shanghai Jiaotong University School of Medicine, Shanghai, Shanghai

Renji Hospital Shanghai Jiao Tong University School of Medicine, Shanghai, Shanghai

The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang

Sun Yat-sen University - The Sixth Affiliated Hospital (Guangdong Gastrointestinal Hospital), Guangzhou, Not set

Zhejiang University School of Medicine - Sir Run Run Shaw Hospital (SRRSH), Hangzhou, Not set

Shanghai Pudong New District Zhoupu Hospital, Shanghai, Not set

NH Hospital, Horovice, Stredocesky

SurGal Clinic SRO, Brno, Not set

Vojenska Nemocnice Brno, Brno, Not set

University Hospital Brno, Brno, Not set

Nemocnice Ceske Budejovice, a.s., Ceske Budejovice, Not set

Hepato-Gastroenterologie HK, s.r.o., Hradec Kralove, Not set

Fakultni Nemocnice Ostrava (FNO), Ostrava-Poruba, Not set

EndoArt, Ostrava, Not set

Gastromedic s.r.o, Pardubice, Not set

Axon Clinical s.r.o., Praha 5, Not set

Endohope Clinic, Praha, Not set

Masaryk Hospital, Usti nad Labem, Not set

Odense Universitetshospital (OUH) (Odense University Hospital), Odense, Syddanmark

Aalborg Hospital, Aalborg, Not set

Sydvestjysk Region/Esbjerg Hospital, Esbjerg, Not set

Hillerod Hospital, Hilleroed Sygehus, Hillerod, Not set

Hvidovre Hospital Medicinsk Gastroenterologisk Afdeling, Hvidovre, Not set

Region Sjaelland Sygehus Nord, Koge Sygehus, Koge, Not set

Centre Hospital Regional Et Universitaire De Tours (Chru Tours) - Houpital Trousseau, Chambray-les-Tours, Not set

CHU De Clermont Ferrand - Hopital Estaing, Clermont-Ferrand, Not set

Centre Hospitalier Universitaire de Montpellier - Hopital Saint Eloi, Montpellier, Not set

Hopital l'Archet 2, Nice Cedex 3, Not set

Hopital Nord Chu Saint-Etienne, Saint Etienne, Not set

Centre Hospitalier Universitaire (CHU) de Toulouse - Hopital Rangueil, Toulouse cedex 09, Not set

Centre Hospitalier Universitaire (CHU) de Toulouse - Hopital Rangueil, Toulouse, Not set

Centre Hospitalier Regional Universitaire de Nancy, Hopital Brabois, Vandoeuvre les Nancy, Not set

Agaplesion Markus Krankenhaus, Frankfurt Am Main, Not set

Universitaetsklinik Frankfurt, Frankfurt, Not set

Hamburger Forschungsinstitut Fuer Chronisch Entzuendliche Darmerkrankungen (HaFCED e.K.), Hamburg, Not set

Universitaetsklinikum Schleswig-Holstein, UKSH-Campus Kiel, Kiel, Not set

St. Marien- und St. Annastiftskrankenhaus, Ludwigshafen, Not set

Universitaetsklinikum Mannheim GmbH, Mannheim, Not set

Universitaetsklinikum Tuebingen, Tuebingen, Not set

University Hospital Of Ulm, Universitatsklinikum Ulm, Ulm, Not set

University General Hospital of Patras, Patras, Achaia

Evangelismos Hospital, Athens, Attiki

University of Athens School of Medicine, Alexandra General Hospital, Athens, Attiki

University Hospital of Heraklion, Heraklion, Crete

Sotiria General Hospital of Athens, Athens, Not set

G.N.A. Gennimatas, Athens, Not set

Clinexpert, Budapest, Not set

Semmelweis Egyetem, Budapest, Not set

Pannonia Maganorvosi Centrum Kft., Budapest, Not set

Mohacsi Korhaz, Mohacs, Not set

Soroka Mc, Beer-Sheva, Not set

Digestive Disease Institute, Shaare Zedek Medical Center, Jerusalem, Not set

Meir Medical Center, Kfar-Saba, Not set

The Chaim Sheba Medical Center - The Edmond and Lily Safra Children's Hospital, Ramat Gan, Not set

The Chaim Sheba Medical Centre, Tel Aviv, Not set

IRCCS - AOU di Bologna - SantOrsola Malpighi, Bologna, Not set

Fondazione IRCCS Ospedale Maggiore Policlinico Mangiagalli e Regina Elena - Clinica Mangiagalli, Milano, Not set

Ospedale San Raffaele (HSR) Instituto Scientifico Universitario San Raffaele, Milano, Not set

Azienda Ospedaliera Ospedali Riuniti Villa Sofia Cervello, Palermo, Not set

A. Gemelli University Hospital, Catholic University of the Sacred Heart, Roma, Not set

Azienda Ospedaliera San Camillo Forlanini, Rome, Not set

IRCCS Istituto clinico humanitas - Humanitas Mirasole spa, Rozzano, Not set

Sapporo Medical University Hospital, Sapporo, Hokkaido

Hyogo Medical University Hospital, Nishinomiya-city, Hyogo

Iwate Medical University Uchimaru Medical Center, Morioka, Iwate

Tohoku University Hospital, Sendai, Miyagi

Kansai Medical University Hospital, Hirakata, Osaka

Osaka Medical College Hospital, Takatsuki-shi, Osaka

Hamamatsu University Hospital, Hamamatsu city, Shizuoka

The Jikei University Hospital, Minato, Tokyo

Kyorin University Hospital, Mitaka-City, Tokyo

Tsujinaka Hospital Kashiwanoha, Chiba, Not set

Fukuoka University Hospital, Fukuoka, Not set

Institute of Science Tokyo Hospital, Tokyo, Not set

Toyama University Hospital, Toyama, Not set

Yonsei University Wonju Severance Christian Hospital, Wonju, Gangwon

Inje University Haeundae Paik Hospital, Busan, Not set

Kosin University Gospel Hospital, Busan, Not set

Keimyung University Dongsan Hospital, Daegu, Not set

Severance Hospital, Yonsei University Health System, Seoul, Not set

Asan Medical Center (AMC), Seoul, Not set

Samsung Medical Center, Seoul, Not set

Chung-Ang University Hospital, Seoul, Not set

Zuyderland Medisch Centrum - Sittard-Geleen, Geleen, Limburg

Amsterdam University Medical Center (Amsterdam UMC), Vrije University Medical Center (VUMC), Amsterdam, Not set

St. Elisabeth Ziekenhuis, Tilburg, Not set

Vestre Viken HF - Baerum Sykehus, Drammen, Akershus

Akershus University Hospital, Lorenskog, Akershus

Oslo Univeristy Hospital Ulleval Hospital, Oslo, Not set

Centrum Medyczne Melita Medical, Wroclaw, Dolnoslaskie

PlanetMed Sp. z o.o., Wroclaw, Dolnoslaskie

Gastromed Kopon, Zmudzinski i Wspolnicy Sp.j. Specjalistyczne Centrum Gastrologii i Endoskopii Specjalistyczne Gabinety Lekarskie, Torun, Kujawsko-pomo

AmiCare Sp. z o.o. Sp. k., Lodz, Lodzkie

Medicome Sp. z o.o., Oswiecim, Malopolskie

Panstwowy Instytut Medyczny MSWiA, Warszawa, Mazowieckie

Twoja Przychodnia - Szczecinskie Centrum Medyczne, Szczecin, Zachodniopomorskie

Manermed Sp. z o.o - CM Medis, Bydgoszcz, Not set

Oddzial Kliniczny Gastroenterologii Ogolnej i Onkologicznej SPZOZ Uniwersytecki Szpital Kliniczny Nr 1 im. Barlickiego Uniwersytetu Medycznego w Lodzi, Lodz, Not set

Centrum Medyczne Med-Gastr, Lodz, Not set

Medrise sp. z o.o, Lublin, Not set

Centrum Medyczne Medyk Sp. z o.o. Sp. K., Rzeszow, Not set

Korczowski Bartosz, Gabinet Lekarski, Rzeszow, Not set

H-T. Centrum Medyczne Sp. z o.o. Sp.k., Tychy, Not set

Wojskowy Instytut Medyczny, Warsaw, Not set

WIP Warsaw IBD Point Profesor Kierkus, Warsaw, Not set

Centrum Badan Klinicznych, Wroclaw, Not set

ETG Zamosc, Zamosc, Not set

Policlinica Algomed: Centrul De Gastroenterologie Dr. Goldis, Timisoara, Jud Timis

Clinical Hospital Colentina-Spitalul Clinic Colentina, Bucharest, Not set

Clinica Medicum, Bucharest, Not set

Spital Clinic Dr I Cantacuzino, Bucharest, Not set

Institutul Clinic Fundeni, Bucuresti, Not set

Spitalul Euroclinic, Bucuresti, Not set

Fakultna nemocnica F. D. Roosevelta, Banska Bystrica, Not set

Cliniq s. r. o., Bratislava, Not set

Endomed, Kosice, Not set

Fakultna Nemocnica s poliklinikou Nove Zamky, Nove Zamky, Not set

Accout Center, s.r.o.- Gastroenterologicka ambulancia, Sahy, Not set

Hospital Juan Ramon Jimenez, Huelva, Not set

Hospital Dr. Negrin, Las Palmas De Gran Canaria, Not set

University Hospital Basel, Basel, Not set

Intesto - Gastroenterologische Praxis & Crohn-Colitis-Zentrum Bern, Bern, Not set

Changhua Christian Hospital, Changhua City, Changhua County

National Taiwan University Hospital, Taipei City, Zhongzheng District

Kaohsiung Medical University Chung-Ho Memorial Hospital, Kaohsiung, Not set

Chang Gung Medical Foundation Koahsiung Chang Gung Memorial Hospital, Kaohsiung, Not set

China Medical University Hospital, Taichung City, Not set

Chang Gung Memorial Foundation Linkou Chang Gung Memorial Hospital, Taoyuan City, Not set

Addenbrooke's Hospital - Cambridge University Hospitals NHS Foundation Trust, Cambridge, Cambridgeshire

Wingate Institute for Neurogastroenterology, Wingate Clinical Trials Facility, Barts Health NHS Trust, London, E1 2at

South Eastern Health and Social Care Trust - The Ulster Hospital, Belfast, Not set

St Thomas' Hospital - Guy's & St Thomas' NHS Foundation Trust, London, Not set

Conditions: Crohn's Disease

Learn More ›

"Extended" (Alternate Day) Antipsychotic Dosing

NCT04478838

Recruiting

The study wishes to examine whether "extended" antipsychotic treatment, in this case, antipsychotic treatment every other day, is as effective as daily treatment. It is also evaluating whether there may be differences in terms of side effects. Participants will be randomly assigned to either the treatment as usual group (i.e., taking antipsychotic daily) or the extended dosing group (i.e., taking antipsychotic one day on, one day off). That means, like flipping a coin, there is a 50/50 chance t... Read More

Gender:

ALL

Ages:

18 years and above

Trial Updated:

04/30/2025

Locations: Centre for Addiction and Mental Health, Toronto, Ontario

Conditions: Schizophrenia and Related Disorders, Drug Administration Schedule, Drug Therapy, Antipsychotic Agents

Learn More ›

Imaging the Effects of Serotonin 2A Receptor Modulation on Synaptic Density in Treatment-resistant Depression (SYNVEST)

NCT06512220

Recruiting

Limit: 5000 characters. Psilocybin, the chemical component of "magic mushrooms", has been administered with psychotherapy in several randomized clinical trials (RCTs) showing large and sustained antidepressant effects. In healthy volunteers, the psychedelic effects of psilocybin have been shown to be blocked by administration of certain medications such as risperidone. The purpose of this study is to use an established SV2A radiotracer produced at our Centre to determine the feasibility of inte... Read More

Gender:

ALL

Ages:

Between 18 years and 65 years

Trial Updated:

04/30/2025

Locations: Centre for Addiction and Mental Health, Toronto, Ontario

Conditions: Treatment Resistant Depression

Learn More ›

Effect of Switching From Intermittently Scanned to Real-time Continuous Glucose Monitoring on Diabetes Management in Adults With Type 2 Diabetes (Switch CGM T2D)

NCT06805786

Recruiting

The goal of this prospective study is to evaluate diabetes outcomes and patient experience following a switch from second generation intermittently scanned continuous glucose monitor (isCGM) to real-time continuous glucose monitor (rtCGM) compared with participants with continued isCGM use among adults with insulin-treated type 2 diabetes (T2D) in a specialist endocrinology clinic setting in Canada. The study aims include: Primary outcome - Evaluate change in percent time in range (TIR) at 3-6... Read More

Gender:

ALL

Ages:

18 years and above

Trial Updated:

04/30/2025

Locations: LMC Diabetes & Endocrinology Ltd., Toronto, Ontario

Conditions: Type 2 Diabetes

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Combination Nicotine Replacement Therapy, Cytisine, or Varenicline for Smoking Cessation

NCT06832085

Recruiting

The purpose of this trial is to test whether clients of Sun Life are willing to join in a quit smoking program that offers counselling and tobacco cessation products to all participants over a 12-month period. The study team will track the safety and usage of 3 types of cessation products as well as the effectiveness of a virtual pharmacy (i.e. cessation products delivered to participants directly from a pharmacy) over a 12-week treatment period. The purpose of this study is to look at 3 approv... Read More

Gender:

ALL

Ages:

18 years and above

Trial Updated:

04/30/2025

Locations: University of Ottawa Heart Institute, Ottawa, Ontario

Conditions: Tobacco

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Albumin To Enhance Recovery After Acute Kidney Injury

NCT04705896

Recruiting

Study objectives: To determine whether, in critically ill patients with Acute Kidney Injury requiring renal replacement therapy (AKI-RRT), randomization to receive intravenous hyperoncotic albumin 20-25% (100 mL X two doses) compared to control/placebo normal saline boluses (100 mL X two doses) given during RRT sessions, leads to: 1. An increase in organ support-free days (primary outcome) at 28 days following randomization; and 2. An increase in RRT-free days (principal secondary outcome) at... Read More

Gender:

ALL

Ages:

18 years and above

Trial Updated:

04/30/2025

Locations: The Governors of the University of Calgary, Calgary, Alberta +15 locations

Conditions: Acute Kidney Injury, Renal Replacement Therapy, Hypotension, Critical Illness

Learn More ›

Real-world Effects of Using Intermittently Scanned Continuous Glucose Monitoring and Pharmacist-led Coaching on the Management of Type 2 Diabetes Among Adults Not Using Insulin (REAL isCGM T2D)

NCT06837103

Recruiting

The goal of this prospective study is to evaluate diabetes outcomes after initiating second generation intermittently scanned continuous glucose monitoring (isCGM) plus one pharmacist consultation session compared with capillary blood glucose (CBG) monitoring among insulin-naïve adults with type 2 diabetes (T2D) in a specialist endocrinology clinical setting in Canada. Primary Outcome - To evaluate change in HbA1c at 3-6 months follow-up after initiating isCGM plus one pharmacist consultation (... Read More

Gender:

ALL

Ages:

18 years and above

Trial Updated:

04/30/2025

Locations: LMC Diabetes & Endocrinology Ltd., Toronto, Ontario

Conditions: Type 2 Diabetes

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Single Dose of Antenatal Corticosteroids for Pregnancies at Risk of Preterm Delivery (SNACS)

NCT05114096

Recruiting

Antenatal corticosteroids (ACS) reduce the risks of neonatal death and morbidities in preterm infants, such as respiratory distress syndrome. The standard of care for pregnant people at risk of preterm birth includes 2 doses of Celestone (for a total of 24 mg in Canada, or 22.8 mg in Australia) to accelerate fetal lung maturity. The investigators plan to conduct a randomized controlled trial to determine whether half the usual dose (12 mg in Canada, or 11.4 mg in Australia) of Celestone is non... Read More

Gender:

FEMALE

Ages:

Between 18 years and 55 years

Trial Updated:

04/30/2025

Locations: University of Calgary, Cumming School of Medicine, Calgary, Alberta +23 locations

University of Calgary, Cumming School of Medicine, Calgary, Alberta

Alberta Health Services; University of Alberta, Edmonton, Alberta

Royal Columbian Hospital, New Westminster, British Columbia

Fraser Health, University of British Columbia; Jim Pattison Outpatient Care and Surgery Centre, Surrey, British Columbia

University of British Columbia; BC Women's Hospital, Vancouver, British Columbia

Victoria General Hospital, Victoria, British Columbia

University of Manitoba, Health Sciences Centre, Winnipeg, Manitoba

University of Manitoba; St. Boniface General Hospital, Winnipeg, Manitoba

Dr. Everett Chalmers Regional Hospital, Fredericton, New Brunswick

The Moncton Hospital, Horizon Health Network, Moncton, New Brunswick

Memorial University, Eastern Health, St. John's, Newfoundland and Labrador

Dalhousie University; Izaak Walton Killam Health, Halifax, Nova Scotia

McMaster University, Hamilton, Ontario

Queen's University, Kingston General Hospital Health Sciences Centre, Kingston, Ontario

Western University; London Health Sciences Centre, Victoria Hospital, London, Ontario

University of Ottawa; The Ottawa Hospital, Ottawa, Ontario

Mount Sinai Hospital, Toronto, Ontario

Sunnybrook Health Sciences Center, Toronto, Ontario

McGill University, McGill University Health Center, Royal Victoria Hospital, Montréal, Quebec

Sir Mortimer B. Davis Jewish General Hospital; McGill University, Montréal, Quebec

The Centre Hospitalier Universitaire Sainte-Justine, Université de Montréal, Montréal, Quebec

Université Laval, Centre de recherche du CHU de Québec, Québec City, Quebec

(CIUSSS de l'Estrie-CHUS); Université de Sherbrooke, Sherbrooke, Quebec

University of Saskatchewan, Regina General Hospital, Saskatoon, Saskatchewan

Conditions: Preterm Birth, Premature Birth, Complication of Prematurity, Obstetric Labor, Premature, Pregnancy Complications

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Anxiolysis for Laceration Repair in Children

NCT05383495

Recruiting

This is a 3-arm adaptive clinical trial to the optimal light sedative for reducing distress during laceration repair in children. The investigators will compare intranasal (IN) dexmedetomidine, IN midazolam, and nitrous oxide (N20). The primary outcome is the Observational Scale of Behavioral Distress - Revised (OSBD-R).

Gender:

ALL

Ages:

Between 2 years and 12 years

Trial Updated:

04/29/2025

Locations: London Health Sciences Centre, London, Ontario

Conditions: Laceration of Skin, Distress, Emotional

Learn More ›

Transcutaneous Electrical Stimulation for Apnea Detected by Capnography

NCT06823661

Recruiting

After surgery, patients often recover in a special area called the Post Anesthesia Care Unit (PACU). Patients may receive pain medications either during the surgery or afterward in the PACU. While these medications are important for controlling pain, some of them can slow down breathing. To ensure patients' breathing remains safe, the nurses in the PACU monitor respiratory rate (how many breaths a patient takes per minute) and oxygen levels using standard monitoring equipment. This is the usual way they check for breathing concerns. If these monitors show that a patient's breathing has slowed down too much, nurses may wake the patient up or stimulate them using their voice or gentle physical touch to encourage deeper breaths. What is this study about? This research is testing a new approach that uses an additional monitor called capnography. Capnography helps detect slowing or stopping of breathing by measuring the carbon dioxide (CO2) exhaled by patients. If the monitor shows slowed or stopped breathing (called apnea, lasting at least 10 seconds), this study will test using a technology called transcutaneous electrical stimulation (TES) to encourage normal breathing. How does TES work? TES provides a slight, annoying sensation on the patient's skin-enough to wake them up without causing pain. This has been used in other studies to safely restore breathing after surgery. In this study, the researchers are testing whether a new automated device can deliver TES when the capnography monitor detects breathing issues. The goal is to test the feasibility (can this system work in the PACU?) and acceptability (how do patients feel about this approach?) of this technology. Who can join this study? Adults aged 18 or older who received general anesthesia and medications (opioids) for pain control during or after surgery are eligible. Patients recovering from surgery in the PACU at Toronto General Hospital may be invited to participate. Why is this study important? The study aims to reduce the risk of opioid-related breathing problems after surgery, making recovery safer and more comfortable for patients. Read Less

Gender:

ALL

Ages:

18 years and above

Trial Updated:

04/29/2025

Locations: Toronto General Hospital, Toronto, Ontario +1 locations

Conditions: Respiratory Depression, Opioids

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