Nabilone for Agitation in Frontotemporal Dementia
NCT05742698
Recruiting
The primary goal of this study is to test the hypothesis that oral nabilone treatment will reduce agitation compared with placebo in patients with Frontotemporal Dementia (both behavioural variant frontotemporal dementia and primary progressive aphasia). The study population is defined as patients with probable Frontotemporal Dementia that meet the International Psychogeriatric Association criteria for agitation in cognitive disorders.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/11/2025
Locations: University of British Columbia, St Paul's Hospital, Vancouver, British Columbia +6 locations
Conditions: Frontotemporal Dementia, Frontotemporal Dementia, Behavioral Variant, Primary Progressive Aphasia, bvFTD, PPA, FTD
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Hairy Cell Leukemia Patient Data Registry
NCT02560883
Recruiting
The overall objective is to develop a clinical data registry that can be used to facilitate research with the ultimate goal of reducing the morbidity and/or mortality and improving the quality of life of patients diagnosed or living with hairy cell leukemia. With approximately 1,000 new cases of this rare disease identified in the US each year, HCL represents 2% of all cases of leukemia in adults. Considering the rarity of this chronic leukemia, the Hairy Cell Leukemia Foundation (HCLF), in part... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/11/2025
Locations: University of Miami/Soffer Clinical Research Center, Miami, Florida +5 locations
Conditions: Leukemia, Other
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Kimel Family Centre for Brain Health and Wellness
NCT06933667
Recruiting
Participants (n=450; aged 50+; without a diagnosis of dementia; sufficiently fluent in English to complete the assessments and engage in programming) receive a comprehensive dementia risk assessment, including nonmodifiable and modifiable risk factors, from which they receive a Personalized Dementia Risk Report and Program Strategy, indicating their health conditions increasing and their risk level in five modifiable risk domains: physical activity, brain- healthy eating, cognitive engagement, s... Read More
Gender:
ALL
Ages:
50 years and above
Trial Updated:
04/10/2025
Locations: Baycrest, Toronto, Ontario
Conditions: Prevention, Dementia
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The Effects of Cold-water Immersion on Exercise Performance Recovery and Postprandial Plasma Aminoacidemia
NCT06698237
Recruiting
In order to optimize sports performance, high-level athletes are required to manage conflicting training objectives, which often result in periods of high-volume training. These athletes need to perform heavy resistance training sessions to promote physiological adaptations, which consequently induce fatigue. Yet, they need to minimize fatigue to perform subsequent high-quality training sessions often within the same day. To support these training endeavours, a high-quality dietary regimen and a... Read More
Gender:
ALL
Ages:
Between 18 years and 40 years
Trial Updated:
04/10/2025
Locations: McGill University, Montreal, Quebec
Conditions: Sport Recovery, Aminoacidemia, Cold-water Immersion
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A Study of Ficlatuzumab in Combination With Cetuximab in Participants With Recurrent or Metastatic (R/M) HPV Negative Head and Neck Squamous Cell Carcinoma
NCT06064877
Recruiting
The purpose of this study is to compare the efficacy and safety of ficlatuzumab plus cetuximab compared to placebo plus cetuximab in participants with recurrent/metastatic (R/M) HPV-negative Head and Neck Cancer. The primary hypothesis is that ficlatuzumab combined with cetuximab is superior to cetuximab alone in terms of progression-free survival and/or overall survival.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/10/2025
Locations: Banner MD Anderson Cancer Center, Gilbert, Arizona +109 locations
Conditions: Metastatic Head-and-neck Squamous-cell Carcinoma, Recurrent Head and Neck Squamous Cell Carcinoma
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Evaluation of the SIMBA Capsule for Small Intestinal Dysbiosis
NCT05633706
Recruiting
The SIMBA Capsule is a small, single-use, ingestible capsule that allows for the non-invasive sampling of small bowel contents using purely mechanical means. The study will compare the microbial and metabolomics analysis from the sample collected with the capsule series, to same-participant symptom questionnaires and stool microbial analysis.
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
04/10/2025
Locations: Nimble Science, Calgary, Alberta
Conditions: Irritable Bowel Syndrome, Crohn Disease, Celiac Disease, Ulcerative Colitis, Functional Dyspepsia, Type 2 Diabetes, Healthy
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Three-level Model of DBT-informed Care for Youth With and/or at Familial Risk for Bipolar Disorder (DB3)
NCT05153369
Recruiting
This study seeks to bridge the knowledge-to-action gap regarding psychosocial treatment "dosing" for youth with and/or at familial risk for bipolar disorder (BD). In psychiatry, pragmatic collaborative decisions between patient and care provider about pharmacological titrations and tapers are common. Less frequently are there considerations made regarding the pragmatic dosing of psychosocial interventions. Whereas some youth clearly require full/"high-dose" treatment, others may benefit from "lo... Read More
Gender:
ALL
Ages:
Between 13 years and 23 years
Trial Updated:
04/09/2025
Locations: Centre for Addiction and Mental Health, Toronto, Ontario
Conditions: Bipolar Disorder
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Long-term Follow-up Study to Evaluate Durability of Treatment Response in Previous Bepirovirsen Study Participants (B-Sure)
NCT04954859
Recruiting
This is a global multi-center, long-term follow-up study to assess durability of efficacy, as measured by maintenance of treatment response from the parent study, in participants who participated in a previous bepirovirsen study and achieved a complete or partial response. Eligible participants will be enrolled in this study after completing the end of study (EoS) visit in the respective parent bepirovirsen studies (studies B-Clear \[209668: NCT04449029\], B-Together \[209348: NCT04676724\], B-F... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/09/2025
Locations: GSK Investigational Site, Sacramento, California +50 locations
Conditions: Hepatitis B
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Pragmatic Patient-oriented Extension Study of Dialectical Behavior Therapy Booster Sessions for Youth With and/or at Familial Risk for Bipolar Disorder
NCT05627492
Recruiting
The study intervention is DBT adapted for youth with and/or at familial risk for bipolar disorder. Participants will have completed one full year of DBT in a previous study. This study is examining use of booster sessions. It is delivered in the form of individual sessions and skills sessions, based on the preference of the study participant. The study participant may also receive skills coaching via phone. There is no standard reference therapy/comparator against which the study intervention is... Read More
Gender:
ALL
Ages:
Between 14 years and 25 years
Trial Updated:
04/09/2025
Locations: Centre for Addiction and Mental Health, Toronto, Ontario
Conditions: Bipolar Disorder
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Mycophenolate Mofetil in Systemic Sclerosis With Subclinical Interstitial Lung Disease
NCT05785065
Recruiting
The goal of this pilot study is to assess the feasibility of a larger study on the efficacy of mycophenolate mofetil in people diagnosed with systemic sclerosis with mild lung involvement. Participants will be recruited over 12 months at 3 academic centers and assigned randomly to receive either mycophenolate mofetil or placebo, a look-alike substance that contains no active drug, for 96 weeks.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/09/2025
Locations: Centre hospitalier de l'Université de Montréal (CHUM), Montreal, Quebec +2 locations
Conditions: Systemic Sclerosis With Lung Involvement, Systemic Sclerosis, Interstitial Lung Disease
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Effect of Extracellular Calcium on Carbetocin Mediated Contractility in Human Myometrium
NCT06930391
Recruiting
Postpartum hemorrhage (PPH) continues to be an increasing problem globally. Uterotonics play an essential role in the pharmacological management of uterine atony. Carbetocin, a long acting analog of oxytocin has been recommended as a first line uterotonic for PPH prophylaxis at cesarean delivery. Considering many woman have associated comorbidities and are at high risk of PPH, finding alternative pharmacological agents is essential. Calcium is a key factor for myometrial contractions and calcium... Read More
Gender:
FEMALE
Ages:
Between 18 years and 40 years
Trial Updated:
04/09/2025
Locations: Mount Sinai Hospital, Toronto, Ontario
Conditions: Postpartum Hemorrhage (Primary)
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Breast 3DUS ABUS System Comparison
NCT06118996
Recruiting
This comparative study will recruit 30 females who are scheduled for mammography and ultrasound assessment. The clinical 2D ultrasound is performed routinely, and the research portion of this study will add a few extra 3-D ultrasound images during the procedure. The ultrasound imaging laboratory under the direction of Dr. Aaron Fenster has developed a customized device designed to acquire 3D ultrasound of the breast using a commercial ultrasound machine. The purpose is to see how well 3-dimensio... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/09/2025
Locations: St. Joseph's Hospital, London, Ontario
Conditions: Breast Diseases
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