Nabilone for Agitation in Frontotemporal Dementia
NCT05742698
Recruiting
The primary goal of this study is to test the hypothesis that oral nabilone treatment will reduce agitation compared with placebo in patients with Frontotemporal Dementia (both behavioural variant frontotemporal dementia and primary progressive aphasia). The study population is defined as patients with probable Frontotemporal Dementia that meet the International Psychogeriatric Association criteria for agitation in cognitive disorders.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/11/2025
Locations: University of British Columbia, St Paul's Hospital, Vancouver, British Columbia +6 locations
Conditions: Frontotemporal Dementia, Frontotemporal Dementia, Behavioral Variant, Primary Progressive Aphasia, bvFTD, PPA, FTD
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At-home Breast Oncology Care Delivered With E-health Solutions
NCT05989477
Recruiting
The COVID-19 pandemic has significantly impacted healthcare service delivery, highlighting the need for high quality virtual patient care. Our team has developed a multi-dimensional remote eHealth solution for newly diagnosed breast cancer patients and their practitioners to use during the diagnostic and follow-up period. The ABODE study involved development of a Breast Cancer Treatment Application (app) which will facilitate virtual consultations, deliver patient education material, and collect... Read More
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
04/11/2025
Locations: Tulin Cil, Toronto, Ontario
Conditions: Patient Engagement, Patient Activation, Patient Reported Outcome Measures
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Kimel Family Centre for Brain Health and Wellness
NCT06933667
Recruiting
Participants (n=450; aged 50+; without a diagnosis of dementia; sufficiently fluent in English to complete the assessments and engage in programming) receive a comprehensive dementia risk assessment, including nonmodifiable and modifiable risk factors, from which they receive a Personalized Dementia Risk Report and Program Strategy, indicating their health conditions increasing and their risk level in five modifiable risk domains: physical activity, brain- healthy eating, cognitive engagement, s... Read More
Gender:
ALL
Ages:
50 years and above
Trial Updated:
04/10/2025
Locations: Baycrest, Toronto, Ontario
Conditions: Prevention, Dementia
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A Study of Ficlatuzumab in Combination With Cetuximab in Participants With Recurrent or Metastatic (R/M) HPV Negative Head and Neck Squamous Cell Carcinoma
NCT06064877
Recruiting
The purpose of this study is to compare the efficacy and safety of ficlatuzumab plus cetuximab compared to placebo plus cetuximab in participants with recurrent/metastatic (R/M) HPV-negative Head and Neck Cancer. The primary hypothesis is that ficlatuzumab combined with cetuximab is superior to cetuximab alone in terms of progression-free survival and/or overall survival.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/10/2025
Locations: Banner MD Anderson Cancer Center, Gilbert, Arizona +109 locations
Conditions: Metastatic Head-and-neck Squamous-cell Carcinoma, Recurrent Head and Neck Squamous Cell Carcinoma
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The Effects of Cold-water Immersion on Exercise Performance Recovery and Postprandial Plasma Aminoacidemia
NCT06698237
Recruiting
In order to optimize sports performance, high-level athletes are required to manage conflicting training objectives, which often result in periods of high-volume training. These athletes need to perform heavy resistance training sessions to promote physiological adaptations, which consequently induce fatigue. Yet, they need to minimize fatigue to perform subsequent high-quality training sessions often within the same day. To support these training endeavours, a high-quality dietary regimen and a... Read More
Gender:
ALL
Ages:
Between 18 years and 40 years
Trial Updated:
04/10/2025
Locations: McGill University, Montreal, Quebec
Conditions: Sport Recovery, Aminoacidemia, Cold-water Immersion
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Evaluation of the SIMBA Capsule for Small Intestinal Dysbiosis
NCT05633706
Recruiting
The SIMBA Capsule is a small, single-use, ingestible capsule that allows for the non-invasive sampling of small bowel contents using purely mechanical means. The study will compare the microbial and metabolomics analysis from the sample collected with the capsule series, to same-participant symptom questionnaires and stool microbial analysis.
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
04/10/2025
Locations: Nimble Science, Calgary, Alberta
Conditions: Irritable Bowel Syndrome, Crohn Disease, Celiac Disease, Ulcerative Colitis, Functional Dyspepsia, Type 2 Diabetes, Healthy
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Music Intervention for Brain-Heart Disease in Myotonic Dystrophy Type 1 (DM1)
NCT06809049
Recruiting
The goal of this interventional study is to demonstrate the feasibility and tolerability of Dalcroze music intervention for children with congenital DM1, while providing indications of its effectiveness in improving brain and heart symptoms of DM1. Additionally, information from the collection of biological samples and wearable devices (accelerometer, EEG headband and ECG chest strap) will be used to identify brain-heart biomarkers and outcome measures for use in future research and trials. Res... Read More
Gender:
ALL
Ages:
Between 6 years and 18 years
Trial Updated:
04/09/2025
Locations: Children's Hospital of Eastern Ontario, Ottawa, Ontario
Conditions: Myotonic Dystrophy, Congenital, Myotonic Dystrophy, Type 1 (DM1), Myotonic Dystrophy Type 1, Myotonic Dystrophy Type 1 (DM1)
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Non-invasive Brain Stimulation Paired With FES Cycling Post SCI
NCT05975606
Recruiting
This project is randomized controlled trial which will explore the effect of pairing repetitive Transcranial Magnetic Stimulation (rTMS) with Functional Electrical Stimulation (FES) Cycling on lower extremity function in people with incomplete spinal cord injury and compare the effects to each one of these interventions alone.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/09/2025
Locations: Parkwood Institute, London, Ontario
Conditions: Incomplete Spinal Cord Injury
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Breast 3DUS ABUS System Comparison
NCT06118996
Recruiting
This comparative study will recruit 30 females who are scheduled for mammography and ultrasound assessment. The clinical 2D ultrasound is performed routinely, and the research portion of this study will add a few extra 3-D ultrasound images during the procedure. The ultrasound imaging laboratory under the direction of Dr. Aaron Fenster has developed a customized device designed to acquire 3D ultrasound of the breast using a commercial ultrasound machine. The purpose is to see how well 3-dimensio... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/09/2025
Locations: St. Joseph's Hospital, London, Ontario
Conditions: Breast Diseases
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Long-term Follow-up Study to Evaluate Durability of Treatment Response in Previous Bepirovirsen Study Participants (B-Sure)
NCT04954859
Recruiting
This is a global multi-center, long-term follow-up study to assess durability of efficacy, as measured by maintenance of treatment response from the parent study, in participants who participated in a previous bepirovirsen study and achieved a complete or partial response. Eligible participants will be enrolled in this study after completing the end of study (EoS) visit in the respective parent bepirovirsen studies (studies B-Clear \[209668: NCT04449029\], B-Together \[209348: NCT04676724\], B-F... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/09/2025
Locations: GSK Investigational Site, Sacramento, California +50 locations
Conditions: Hepatitis B
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Effect of Extracellular Calcium on Carbetocin Mediated Contractility in Human Myometrium
NCT06930391
Recruiting
Postpartum hemorrhage (PPH) continues to be an increasing problem globally. Uterotonics play an essential role in the pharmacological management of uterine atony. Carbetocin, a long acting analog of oxytocin has been recommended as a first line uterotonic for PPH prophylaxis at cesarean delivery. Considering many woman have associated comorbidities and are at high risk of PPH, finding alternative pharmacological agents is essential. Calcium is a key factor for myometrial contractions and calcium... Read More
Gender:
FEMALE
Ages:
Between 18 years and 40 years
Trial Updated:
04/09/2025
Locations: Mount Sinai Hospital, Toronto, Ontario
Conditions: Postpartum Hemorrhage (Primary)
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The Thoracic Peri-Operative Integrative Surgical Care Evaluation Trial - Stage III
NCT04871412
Recruiting
Despite enormous advances in thoracic surgery and oncology, two critical issues concern patients undergoing curative-intent surgery for lung, gastric and esophageal cancer: first, a majority (\~60%) of patients experience minor and major adverse events occurring during and in the days following surgery; second, patients worry about the significant risk of cancer recurrence and mortality months to years after surgery. These issues, combined with side effects of chemotherapy and radiation, have de... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/09/2025
Locations: The Ottawa Hospital, Ottawa, Ontario +1 locations
Conditions: Lung Cancer, Gastric Cancer, Esophageal Cancer
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