All Clinical Trials in Canada

A listing of 3904 clinical trials actively recruiting volunteers for paid trials and research studies in various therapeutic areas.

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Patient Reported Outcomes Burdens and Experiences - Phase 3

NCT03549858

Recruiting

The PROBE Phase-3 study will collect data on patient reported outcomes, burdens, and experiences in patients living with hemophilia. The investigators will perform comparisons among countries, within country over time, within country against national normative data.

Gender:

ALL

Ages:

All

Trial Updated:

08/18/2025

Locations: McMaster University, Hamilton, Ontario

Conditions: Hemophilia, Chronic Disease

Learn More ›

Safety and Efficacy of EIK1001 in Combo With Pembro Versus Placebo and Pembro as First-Line Therapy in Patients With Advanced Melanoma.

NCT06697301

Recruiting

The study is for patients with advanced melanoma who are eligible for standard therapy with Pembrolizumab.

Gender:

ALL

Ages:

18 years and above

Trial Updated:

08/18/2025

Locations: Ironwood Cancer & Research Centers, Chandler, Arizona +56 locations

Ironwood Cancer & Research Centers, Chandler, Arizona

The Oncology Institution of Hope and Innovation, Los Angeles, California

Providence Medical Foundation, Santa Rosa, California

UCHealth Memorial Hospital Central, Colorado Springs, Colorado

Bioresearch Partner, Hialeah, Florida

Washington University School of Medicine in St. Louis, Saint Louis, Missouri

Gabrail Cancer Center Research LLC, Canton, Ohio

University of Pittsburgh Medical Center(UPMC)-Hillman Cancer Center, Pittsburgh, Pennsylvania

Cancer Care Wollongong, Wollongong, New South Wales

Icon Cancer Centre Chermside, Chermside, Queensland

Southern Adelaide Local Health Network Incorporated Flinders Medical Centre, Bedford Park, South Australia

Eastern Health, Box Hill, Victoria

Universitätsklinikum Graz, Graz, Styria

Universitair Ziekenhuis Antwerpen, Edegem, Antwerpen

Centre Hospitalier Universitaire Universite Catholique de Louvain - Site Godinne, Yvoir, Namur

Universitair Ziekenhuis Leuven - Campus Gasthuisberg, Leuven, Vlaams Brabant

Algemeen Ziekenhuis Groeninge - Campus Kennedylaan, Kortrijk, West-Vlaanderen

Cliniques Universitaires Saint-Luc, Brussels, Not set

Sunnybrook Research Ins<tute, Toronto, Ontario

Masaryk Memorial Cancer Institute, Brno, Not set

Aarhus Universitetshospital, Aarhus, Midtjylland

Aalborg University Hospital, Aalborg, Nord Jutland

Oulu University Hospital, Oulu, Not set

Centre Hospitalier Universitaire Grenoble Alpes, La Tronche, Isère

Centre Hospitalier Lyon-Sud, Pierre-Bénite, Rhone-Alpes

CHU Rouen, Rouen, Not set

Universitätsmedizin Mannheim, Mannheim, Baden-Württemberg

Universitätsklinikum Tübingen, Tübingen, Baden-Württemberg

Universitat Leipzig, Saxony, Leipzig

Elbe Kliniken Stade-Buxtehude, Buxtehude, Lower Saxony

Johannes Wesling Klinikum Minden, Minden, Nordrhein-Westfalen

University of Mainz Medical Center, Mainz, RLP

Universitätsklinikum Schleswig-Holstein - Campus Kiel, Kiel, Schleswig-Holstein

Universitätsklinikum Schleswig-Holstein - Campus Lübeck, Lübeck, Schleswig-Holstein

Soroka medical center, Be'er Sheva, Not set

Rabin Medical Center, Petach Tikva, Not set

Ella Lemelbaum Institute for Immuno-Oncology and Melanoma, Ramat Gan, Not set

Tel Aviv Medical Center, Tel Aviv, Not set

Auckland City Hospital, Auckland, Not set

Christchurch Public Hospital, Christchurch, Not set

Oslo University Hospital - The Norwegian Radium Hospital, Oslo, Not set

Hospital da Luz Lisboa, Lisboa, Not set

Cancercare Port Elizabeth - Langenhoven Drive Oncology Centre, Port Elizabeth, Eastern Cape

The Medical Oncology Centre of Rosebank, Saxonwold, Gauteng

Cape Town Oncology Trials, Cape Town, Western Cape

TASK Eden, George Central, Western Cape

Hospital Universitari Dexeus, Barcelona, Not set

Vall d' Hebron Institute of Oncology, Barcelona, Not set

Institut Català d'Oncologia Girona (ICO Girona), Girona, Not set

GenesisCare Madrid - Hospital San Francisco de Asís, Madrid, Not set

Hospital Universitario Virgen de la Victoria, Málaga, Not set

IVO - Fundacion Instituto Valenciano de Oncologia, Valencia, Not set

INCLIVA Instituto de Investigación Sanitaria, Valencia, Not set

Gävle Sjukhus, Gävle, Gävleborgs Län

Universitätsspital Zürich, Zürich, Not set

Guy's and St Thomas' NHS Foundation Trust, London, England

Sarah Cannon Research Institute London, London, England

Conditions: Advanced Melanoma

Learn More ›

Fibrosis Lessens After Metabolic Surgery

NCT06374875

Recruiting

Metabolic dysfunction-associated steatotic liver disease (MASLD), formerly known as non-alcoholic fatty liver disease (NAFLD), a major global public health concern, is commonly associated with obesity, diabetes, and dyslipidemia. MASLD is currently the most common cause of chronic liver disease affecting about 80% of people with obesity, ranging from simple fat deposits in the liver to Metabolic Dysfunction-Associated Steatohepatitis (MASH), cellular injury, advanced fibrosis, cirrhosis, or hepa... Read More

Gender:

ALL

Ages:

Between 18 years and 75 years

Trial Updated:

08/18/2025

Locations: Banner Health Center, Phoenix, Arizona +21 locations

Conditions: Metabolic Dysfunction-associated Steatotic Liver Disease (MASLD), Non-Alcoholic Fatty Liver Disease, Metabolic Dysfunction-Associated Steatohepatitis (MASH), Liver Fibrosis, Obesity

Learn More ›

Real-World Study of ABBV-951 Subcutaneous Infusion to Assess Change in Disease Activity in Adult Participants With Parkinson's Disease

NCT06107426

Recruiting

Parkinson's disease (PD) is a neurological condition, which affects the brain. PD gets worse over time, but how quickly it progresses varies a lot from person to person. Some symptoms of PD are tremors, stiffness, and slowness of movement. The purpose of this study is to evaluate how effective ABBV-951 is in treating adult participants with advanced PD in real world setting. ABBV-951 (foslevodopa/foscarbidopa) is an approved drug for the treatment of Parkinson's Disease. The main ROSSINI study... Read More

Gender:

ALL

Ages:

18 years and above

Trial Updated:

08/18/2025

Locations: University of Alabama at Birmingham - Main /ID# 253477, Birmingham, Alabama +64 locations

University of Alabama at Birmingham - Main /ID# 253477, Birmingham, Alabama

Banner Sun Health Research Institute /ID# 253461, Sun City, Arizona

Parkinson's Research Centers of America - Palo Alto /ID# 264703, Palo Alto, California

Georgetown University Hospital /ID# 259381, Washington, District of Columbia

Parkinson's Disease and Movement Disorders Center of Boca Raton /ID# 253465, Boca Raton, Florida

University of Florida College of Medicine /ID# 259383, Gainesville, Florida

University of Miami /ID# 259396, Miami, Florida

N1 Research, LLC /ID# 264221, Orlando, Florida

University of South Florida- Neuroscience Institute /ID# 253470, Tampa, Florida

Northwestern /ID# 266977, Chicago, Illinois

Ochsner Medical Center - Jefferson Highway /ID# 269764, New Orleans, Louisiana

Boston Medical Center Health System /ID# 269765, Brighton, Massachusetts

University of Minnesota - Minneapolis /ID# 268121, Minneapolis, Minnesota

Kansas City VA Medical Center /ID# 253466, Kansas City, Missouri

Cleveland Clinic Lou Ruvo Cent /ID# 259390, Las Vegas, Nevada

David L. Kreitzman, MD, PC /ID# 259397, Commack, New York

Northwell Health /ID# 253469, Lake Success, New York

Novant Health Neurology and Sleep /ID# 259391, Charlotte, North Carolina

Atrium Health Wake Forest Baptist Medical Center /ID# 259387, Winston-Salem, North Carolina

NeuroCare Center /ID# 259392, Canton, Ohio

The Movement Disorder Clinic of Oklahoma /ID# 253463, Tulsa, Oklahoma

Vanderbilt University Medical Center /ID# 253474, Nashville, Tennessee

Texas Movement Disorder Specialists /ID# 253473, Georgetown, Texas

Univ Texas HSC San Antonio /ID# 259394, San Antonio, Texas

University of Utah /ID# 253471, Salt Lake City, Utah

Inland Northwest Research /ID# 253460, Spokane, Washington

Kepler Universitaetsklinikum GmbH /ID# 262776, Linz, Oberoesterreich

Medizinische Universitaet Graz /ID# 262774, Graz, Steiermark

Medizinische Universitaet Innsbruck /ID# 262775, Innsbruck, Tirol

Klinik Ottakring /ID# 262773, Vienna, Wien

University of Calgary /ID# 262833, Calgary, Alberta

The Ottawa Hospital - General Campus /ID# 263315, Ottawa, Ontario

CHUM - Centre hospitalier de l'Universite de Montréal /ID# 269689, Montreal, Quebec

Centre de Recherche St-Louis /ID# 262746, Quebec City, Quebec

Bispebjerg Hospital /ID# 252032, Copenhagen, Hovedstaden

Rigshospitalet Glostrup /ID# 252035, Glostrup, Hovedstaden

Odense University Hospital /ID# 252036, Odense, Syddanmark

Parkinson-Klinik Ortenau GmbH&Co KG /ID# 252376, Wolfach, Baden-Wuerttemberg

Klinikum der Universitaet Muenchen Grosshadern /ID# 255574, Muenchen, Bayern

Klinikum Ernst von Bergmann /ID# 252375, Potsdam, Brandenburg

Klinikum Osnabrueck GmbH /ID# 252275, Osnabrueck, Niedersachsen

Krankenhaus Martha-Maria Halle-Doelau /ID# 260372, Halle (Saale), Sachsen-Anhalt

Kliniken Beelitz GmbH /ID# 252665, Beelitz-Heilstaetten, Not set

Knappschaftskrankenhaus Bottrop /ID# 252274, Bottrop, Not set

The Chaim Sheba Medical Center /ID# 254823, Ramat Gan, Tel-Aviv

Tel Aviv Sourasky Medical Center /ID# 254824, Tel Aviv, Tel-Aviv

Shaare Zedek Medical Center /ID# 257715, Jerusalem, Yerushalayim

Rambam Health Care Campus /ID# 260421, Haifa, Not set

Hadassah Medical Center-Hebrew University /ID# 257717, Jerusalem, Not set

Rabin Medical Center /ID# 257716, Petah Tikva, Not set

Spitalul Clinic Judetean de Urgenta Timisoara /Id# 252248, Timisoara, Timis

Spitalul Clinic Judetean de Urgenta Timisoara /Id# 252249, Timisoara, Timis

Spitalul Clinic Judetean de Urgenta Brasov /ID# 253308, Brasov, Not set

Spitalul Clinic Colentina /ID# 252250, Bucuresti, Not set

Spitalul Clinic Judetean de Urgenta Constanta /ID# 252251, Constanta, Not set

Spitalul Clinic Judetean de Urgenta Targu Mures /ID# 252247, Targu Mures, Not set

Complejo Hospitalario Universitario de Santiago (CHUS) /ID# 261402, Santiago de Compostela, A Coruna

Hospital General Universitario de Elche /ID# 254438, Elche, Alicante

Hospital Universitario Puerta de Hierro - Majadahonda /ID# 260921, Majadahonda, Madrid

Hospital Universitario Virgen de las Nieves /ID# 257588, Granada, Not set

Hospital Clinico San Carlos /ID# 260922, Madrid, Not set

Hospital Universitario Virgen del Rocio /ID# 254437, Sevilla, Not set

Centrum for neurologi /ID# 252118, Stockholm, Stockholms Lan

Uppsala University Hospital /ID# 252119, Uppsala, Uppsala Lan

Sahlgrenska Universitetssjukhuset /ID# 252115, Göteborg, Vastra Gotalands Lan

Conditions: Parkinson's Disease (PD)

Learn More ›

Transmural Healing and Disease-Modifying Effect of Guselkumab in Crohn's Disease Patients

NCT06408935

Recruiting

The purpose of this study is to evaluate the efficacy of guselkumab in healing of all layers of the digestive tract (transmural healing) with the help of a score called Magnetic Resonance Index of Activity (MaRIA) based on a scan at Week 48.

Gender:

ALL

Ages:

18 years and above

Trial Updated:

08/18/2025

Locations: Center for Colitis and Crohns Disease University of California, San Francisco, California +72 locations

Center for Colitis and Crohns Disease University of California, San Francisco, California

Washington University School Of Medicine, Saint Louis, Missouri

Medical University of South Carolina, Charleston, South Carolina

The Queen Elizabeth Hospital, Adelaide, Not set

Concord Repatriation General Hospital, Concord, Not set

Northern Hospital, Melbourne, Not set

Fiona Stanley Hospital, Murdoch, Not set

Mater Hospital Brisbane, South Brisbane, Not set

Cliged, Macae, Not set

Instituto Mederi de Pesquisa e Saude, Passo Fundo, Not set

NPCRS Nucleo de Pesquisa Clinica do Rio Grande do Sul, Porto Alegre, Not set

INTEGRAL Pesquisa e Ensino, Votuporanga, Not set

Foothills Hospital, Calgary, Alberta

Western University & London Health Sciences Centre, London, Ontario

Hopital du Sacre-Coeur de Montreal, Montreal, Quebec

Nemocnice Ceske Budejovice a s, Ceske Budejovice, Not set

Hepato-gastroenterologie HK, s.r.o., Hradec Kralove, Not set

ISCARE a.s., Praha 9, Not set

APHP - Hopital Bichat - Claude Bernard, Paris, Not set

Klinikum Augsburg, Augsburg, Not set

Charite Universitaetsmedizin Berlin, Berlin, Not set

Praxis Fur Gastroenteroligie, Berlin, Not set

Medizinisches Versorgungszentrum (MVZ) Dachau, Dachau, Not set

Universitatsklinikum Frankfurt/ Medizinische Klinik 1, Frankfurt, Not set

Universitatsmedizin Gottingen, Gottingen, Not set

BSF Studiengesellschaft, Halle, Not set

Medizinische Hochschule Hannover, Hannover, Not set

Universitatsklinikum Schleswig Holstein, Kiel, Not set

Staedtisches Klinikum Lueneburg, Luneburg, Not set

MVZ Portal 10, Munster, Not set

Siloah St Trudpert Klinikum, Pforzheim, Not set

Universitaetsklinikum Ulm, Ulm, Not set

Rambam Medical Center, Haifa, Not set

The Edith Wolfson Medical Center, Holon, Not set

Hadassah Medical Organization, Jerusalem, Not set

Galilee Medical Center, Nahariya, Not set

Rabin Medical Center, Petah Tikva, Not set

The Chaim Sheba Medical Center, Ramat Gan, Not set

Tel Aviv Sourasky Medical Center, Tel Aviv, Not set

Azienda Ospedaliera Policlinico S. Orsola-Malpighi, Bologna, Not set

IRCCS Ospedale San Raffaele, Milano, Not set

Universita Di Napoli Federico Ii, Napoli, Not set

Asst Rhodense - Ospedale Di Rho, Rho, Not set

Universita Campus Bio-Medico di Roma, Roma, Not set

Fondazione Policlinico Tor Vergata, Roma, Not set

Fondazione Policlinico Universitario A Gemelli IRCCS, Roma, Not set

IRCCS Humanitas Rozzano-IBD Center Malattie Infiammatorie Croniche Intestinali, Rozzano, Not set

IRCCS Ospedale Casa Sollievo della Sofferenza, San Giovanni Rotondo, Not set

NZOZ Centrum Medyczne KERmed, Bydgoszcz, Not set

Centrum Medyczne Medyk, Rzeszow, Not set

GASTROMED Sp. z o.o., Torun, Not set

WIP Warsaw IBD Point Profesor Kierkus, Warszawa, Not set

Melita Medical Sp. z o.o., Wroclaw, Not set

Centrum Medyczne Oporow, Wroclaw, Not set

EuroMediCare Szpital Specjalistyczny z Przychodnia, Wroclaw, Not set

ETG Zamosc, Zamosc, Not set

FNsP F.D.R. Banska Bystrica, Banska Bystrica, Not set

Cliniq s.r.o., Bratislava, Not set

ENDOMED s.r.o, Kosice, Not set

KM Management spol. s r.o., Nitra, Not set

GASTRO I. s.r.o., Presov, Not set

Hosp. Gral. Univ. Dr. Balmis, Alicante, Not set

Hosp Reina Sofia, Cordoba, Not set

Complejo Hosp Univ. de Ferrol, Ferrol, Not set

Hosp. Univ. de La Paz, Ferrol, Not set

Hosp. Univ. de La Princesa, Madrid, Not set

Hosp. Univ. Pta. de Hierro Majadahonda, Madrid, Not set

Hosp. Clinico Univ. de Valencia, Valencia, Not set

Hosp. Alvaro Cunqueiro, Vigo, Not set

Chang-Hua Christian Hospital, Changhua, Not set

Far Eastern Memorial Hospital, New Taipei, Not set

National Taiwan University Hospital, Taipei, Not set

Taipei Veterans General Hospital, Taipei, Not set

Conditions: Crohn's Disease

Learn More ›

A Phase III Trial Comparing Tisagenlecleucel to Standard of Care (SoC) in Adult Participants With r/r Follicular Lymphoma

NCT05888493

Recruiting

This trial will compare tisagenlecleucel to standard of care in adult participants with relapsed or refractory (r/r) follicular lymphoma.

Gender:

ALL

Ages:

Between 18 years and 100 years

Trial Updated:

08/18/2025

Locations: TRIHEALTH Good Samarithan Hospital, Cincinnati, Ohio +35 locations

TRIHEALTH Good Samarithan Hospital, Cincinnati, Ohio

VA Tennessee Valley Healthcare System, Nashville, Tennessee

Novartis Investigative Site, Camperdown, New South Wales

Novartis Investigative Site, Clayton, Victoria

Novartis Investigative Site, Melbourne, Victoria

Novartis Investigative Site, Nedlands, Western Australia

Novartis Investigative Site, Linz, Not set

Novartis Investigative Site, Salzburg, Not set

Novartis Investigative Site, Toronto, Ontario

Novartis Investigative Site, Montreal, Quebec

Novartis Investigative Site, Ostrava, Poruba

Novartis Investigative Site, Budapest, Not set

Novartis Investigative Site, Seoul, Not set

Novartis Investigative Site, Gliwice, Slaskie

Novartis Investigative Site, Poznan, Wielkopolskie

Novartis Investigative Site, Gdansk, Not set

Novartis Investigative Site, Lodz, Not set

Novartis Investigative Site, Bucharest, Not set

Novartis Investigative Site, Singapore, Not set

Novartis Investigative Site, Bratislava, Not set

Novartis Investigative Site, Hospitalet de LLobregat, Barcelona

Novartis Investigative Site, Santander, Cantabria

Novartis Investigative Site, Salamanca, Castilla Y Leon

Novartis Investigative Site, Barcelona, Catalunya

Novartis Investigative Site, Santiago De Compostela, Galicia

Novartis Investigative Site, El Palmar, Murcia

Novartis Investigative Site, Barcelona, Not set

Novartis Investigative Site, Cordoba, Not set

Novartis Investigative Site, Madrid, Not set

Novartis Investigative Site, Kaohsiung, Not set

Novartis Investigative Site, Taichung, Not set

Novartis Investigative Site, Taipei, Not set

Conditions: Follicular Lymphoma (FL)

Learn More ›

A Study in Adult Patients With Paroxysmal Nocturnal Hemoglobinuria (PNH) to Evaluate How Safe Long-term Treatment With Pozelimab + Cemdisiran Combination Therapy is and How Well it Works

NCT05744921

Recruiting

This study is researching an experimental treatment combination with two experimental drugs called pozelimab and cemdisiran. The study is focused on people with paroxysmal nocturnal hemoglobinuria (PNH). The aim of this study is to see how safe and effective the pozelimab + cemdisiran combination is for people with PNH in the long term. The pozelimab + cemdisiran combination may be referred to as "study drugs" in this section. This study is looking at several other research questions, including... Read More

Gender:

ALL

Ages:

18 years and above

Trial Updated:

08/18/2025

Locations: Toronto General Hospital, Toronto, Ontario +35 locations

Toronto General Hospital, Toronto, Ontario

Semmelweis University/Semmelweis Egyetem, Budapest, Not set

Rajiv Gandhi Cancer Institute & Research Center (RGCIRC) - Rohini Campus, New Delhi, Delhi

Amrita Institute of Medical Sciences (AIMS) and Research Centre Aims, Kochi, Kerala

Bhagwan Mahaveer Cancer Hospital and Research Centre (BMCHRC), Jaipur, Not set

Aou Careggi, Firenze, Florence

SC Hematology, AOU Città della Salute e della Scienza di Torino, Torino, Not set

University of Tsukuba Hospital, Tsukuba, Ibaraki

Ajou University Medical Center, Suwon-si, Gyeonggi-do

St. Vincent Hospital, Suwon, Gyeonggi

Gachon University Gil Medical Center, Incheon, Namdong-Gu

Pusan National University Hospital, Busan, Not set

Severance Hospital Yonsei University Health System, Seoul, Not set

Samsung Medical Center, Seoul, Not set

Ewha Womans University Mokdong Hospital, Seoul, Not set

Hospital Tg Ampuan Afzan, Kuantan, Pahang

Hospital Queen Elizabeth, Kota Kinabalu, Sabah

Hospital Ampang, Ampang, Selangor

Clinica San Felipe, Lima, Not set

St Lukes Medical Center, Quezon City, National Capital Region

Szpital Uniwersytecki Nr2 Bydgoszcz, Bydgoszcz, Not set

Prof Dr Ion Chiricuta Cancer Institute, Cluj Napoca, Cluj

National University Hospital, Singapore, Not set

Hospital Universitario Basurto, Bilbao, Bizkaia

Hospital Clinic de Barcelona, Barcelona, Not set

Chang Gung Memorial Hospital - Linkou Branch, Taoyuan, Hunan Province

Hualien Tzu Chi Hospital, Hualien City, Not set

China Medical University Hospital, Taichung, Not set

Tri-Service General Hospital, Taipei City, Not set

National Taiwan University Hospital, Taipei, Not set

Prince Of Songkla Hospital, Prince Of Songkhla University, Hat-Yai, Songkhla

King Chulalongkorn Memorial Hospital, Bangkok, Not set

Chiang Mai University, Chiang Mai, Not set

Srinagarind Hospital, Khon Kaen, Not set

Ege University Faculty of Medicine, Bornova, Izmir

Leeds Teaching Hospitals NHS Trust - St. James Institute of Oncology, Leeds, Not set

Conditions: Paroxysmal Nocturnal Hemoglobinuria

Learn More ›

ORKA-001 Versus Placebo in Patients With Moderate-to-Severe Plaque Psoriasis

NCT07090330

Recruiting

This is a multicenter, randomized, double-blinded, placebo-controlled, proof-of-concept study to evaluate the efficacy, safety, tolerability, and pharmacokinetics of ORKA-001 in adult participants with moderate-to-severe plaque psoriasis.

Gender:

ALL

Ages:

18 years and above

Trial Updated:

08/18/2025

Locations: Oruka Therapeutics Investigative Site, Fountain Valley, California +15 locations

Conditions: Plaque Psoriasis

Learn More ›

Study to Evaluate the Efficacy and Safety of [177Lu]Lu-DOTA-TATE in Patients With Grade 1 and Grade 2 Advanced GEP-NET

NCT06784752

Recruiting

The purpose of the current study is to evaluate the efficacy and safety of \[177Lu\]Lu-DOTA-TATE plus octreotide long-acting release (LAR) versus octreotide LAR alone in newly diagnosed patients with somatostatin receptor positive (SSTR+), well differentiated Grade1 and Grade 2 (G1 and G2) (Ki-67 \<10%) advanced gastroenteropancreatic neuroendocrine tumors (GEP-NETs) with high disease burden

Gender:

ALL

Ages:

Between 12 years and 100 years

Trial Updated:

08/18/2025

Locations: Highlands Oncology Group, Fayetteville, Arkansas +13 locations

Conditions: Somatostatin Receptor Positive (SSTR+), Gastroenteropancreatic Neuroendocrine Tumor (GEP-NET)

Learn More ›

ELEMENT-MDS: A Study to Compare the Efficacy and Safety of Luspatercept in Participants With Myelodysplastic Syndrome (MDS) and Anemia Not Receiving Blood Transfusions

NCT05949684

Recruiting

The purpose of the study is to compare the efficacy and safety of Luspatercept vs epoetin alfa in the treatment of anemia in adults due to IPSS-R very low, low, intermediate-risk MDS in ESA-naïve participants who are non-transfusion dependent (NTD).

Gender:

ALL

Ages:

18 years and above

Trial Updated:

08/18/2025

Locations: Community Cancer Institute, Clovis, California +168 locations

Community Cancer Institute, Clovis, California

Compassionate Cancer Care Medical Group, Fountain Valley, California

Local Institution - 0095, Fresno, California

Cancer and Blood Specialty Clinic, Los Alamitos, California

UCLA Hematology/Oncology - Westwood (Building 200 Suite 120), Los Angeles, California

St. Joseph Hospital, Orange, California

Ventura County Hematology Oncology Specialists, Oxnard, California

John Muir Health - Behring Pavilion, Walnut Creek, California

Local Institution - 0098, Fort Collins, Colorado

Hartford Hospital (HH), Hartford, Connecticut

Yale-New Haven Hospital, New Haven, Connecticut

Halifax Health Medical Center, Daytona Beach, Florida

Local Institution - 0230, Daytona Beach, Florida

Florida Cancer Specialists - South, Fort Myers, Florida

Baptist MD Anderson Cancer Center, Jacksonville, Florida

D&H Cancer Research Center LLC, Margate, Florida

BRCR Global, Plantation, Florida

Florida Cancer Specialists - North, Saint Petersburg, Florida

Advanced Research, Tamarac, Florida

Moffitt Cancer Center, Tampa, Florida

Local Institution - 0240, Honolulu, Hawaii

Northwestern Memorial Hospital, Chicago, Illinois

Orchard Healthcare Research Inc., Skokie, Illinois

Northwest Cancer Centers, P.C., Dyer, Indiana

Local Institution - 0232, Pikeville, Kentucky

Our Lady of the Lake RMC, Baton Rouge, Louisiana

Pontchartrain Cancer Center, Covington, Louisiana

Local Institution - 0097, New Orleans, Louisiana

American Oncology Partners of Maryland, PA, Bethesda, Maryland

Metro-Minnesota Community Clinical Oncology, Saint Louis Park, Minnesota

Hattiesburg Clinic Hematology/Oncology, Hattiesburg, Mississippi

John Theurer Cancer Center at Hackensack University Medical Center, Hackensack, New Jersey

The James Cancer Hospital and Solove Research Institute at The Ohio State University Comprehensive Cancer Center, Columbus, Ohio

University of Tennessee Medical Center, Knoxville, Tennessee

University of Texas MD Anderson Cancer Center, Houston, Texas

VCU Health Adult Outpatient Pavillion, Richmond, Virginia

Blue Ridge Cancer Care, Roanoke, Virginia

Kadlec Clinic Hematology and Oncology, Kennewick, Washington

Local Institution - 0213, Seattle, Washington

Centro Medico Barrio Parque, Buenos Aires, Not set

Hospital Británico de Buenos Aires, Buenos Aires, Not set

Instituto Alexander Fleming, Ciudad Autónoma de Buenos Aires, Not set

Blacktown Hospital, Blacktown, New South Wales

Royal Prince Alfred Hospital, Camperdown, New South Wales

Coffs Harbour Health Campus, Coffs Harbour, New South Wales

Pindara Private Hospital, Gold Coast, Queensland

Monash Health, Clayton, Victoria

Austin Health, Heidelberg, Victoria

Hospital Universitario Walter Cantidio, Fortaleza, Ceará

Hospital São Lucas da PUCRS, Porto Alegre, Rio Grande Do Sul

HEMORIO, Rio de Janeiro, Not set

Hospital das Clinicas FMUSP, São Paulo, Not set

Arthur J.E. Child Comprehensive Cancer Centre, Calgary, Alberta

St. Paul's Hospital, Vancouver, British Columbia

Victoria Hospital & Children's Hospital - London Health Sciences Centre, London, Ontario

Sunnybrook Health Sciences Centre, Toronto, Ontario

Enroll SpA, Santiago, Región Metropolitana De Santiago

FALP, Santiago, Región Metropolitana De Santiago

Clínica Inmunocel, Santiago, Región Metropolitana De Santiago

Bradfordhill, Santiago, Región Metropolitana De Santiago

Anhui Provincial Hospital, Hefei, Anhui

Peking University People's Hospital, Beijing, Beijing

Beijing Peking Union Medical College Hospital, Beijing, Beijing

Local Institution - 0223, Chongqing, Chongqing

Local Institution - 0096, Fuzhou Fujian, Fujian

Local Institution - 0220, Xiamen, Fujian

Local Institution - 0031, Guangzhou, Guangdong

The Second Afilliated Hospital of Hebei Medical University, Shijiazhuang, Hebei

The First Hospital of Harbin, Harbin, Heilongjiang

People's Hospital of Henan Province, Zhengzhou, Henan

Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei

Xiangya Hospital Central South University, Changsha, Hunan

Jiangsu Province Hospital, Nanjing, Jiangsu

The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu

The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi

Local Institution - 0043, Changchun, Jilin

The First Hospital of China Medical University, Shenyang, Liaoning

The Affiliated Hospital of Qingdao University, Qingdao, Shandong

Shanghai Sixth People's Hospital, Shanghai, Shanghai

Shaanxi provincial people's hospital, Xi'an, Shanxi

Local Institution - 0075, Cheng Du, Sichuan

Institute of hematology&blood disease hospital, Tianjin, Tianjin

The first Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang

Local Institution - 0281, Ningbo, Zhejiang

The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang

Hospital Pablo Tobon Uribe, Medellin, Antioquia

Sociedad De Oncologia Y Hematologia Del Cesar, Valledupar, Cesar

Fundación Cardiovascular de Colombia, Piedecuesta, Santander

Oncomédica S.A.S, Montería, Not set

Fakultní nemocnice Brno Bohunice, Brno, Brno-město

Fakultni nemocnice Ostrava, Ostrava, Moravskoslezský Kraj

Vseobecna fakultni nemocnice v Praze, Praha 2, Not set

Centre Hospitalier Universitaire de Nice - Hôpital l'Archet, Nice, Alpes-Maritimes

CHU Bordeaux Haut-Leveque, Pessac, Aquitaine

Centre Hospitalier Régional Universitaire de Tours - Hôpital Bretonneau, Tours, Indre-et-Loire

Chu Grenoble Alpes, La Tronche, Isère

Centre Hospitalier Régional Universitaire de Nancy - Hôpitaux de Brabois, Vandoeuvre lès Nancy, Lorraine

Centre Hospitalier Universitaire d'Angers, Angers, Maine-et-Loire

Gustave Roussy, Villejuif, Val-de-Marne

Hôpital Saint-Louis, Paris, Not set

Institut Universitaire du Cancer Toulouse - Oncopole - CHU de TOULOUSE, Toulouse, Not set

Onkologie Erding, Erding, Bayern

Local Institution - 0250, Kempten, Bayern

Gemeinschaftspraxis für Hämatologie und Onkologie Münster, Münster, Nordrhein-Westfalen

InVO Institut für Versorgungsforschung in der Onkologie, Koblenz, Rheinland-Pfalz

Universitätsklinikum Leipzig, Leipzig, Sachsen

Universitätsklinikum Jena, Jena, Thüringen

Praxis fur Hamatologie und Onkologie, Berlin, Not set

Local Institution - 0028, Berlin, Not set

Universitaetsklinikum Duesseldorf, Düsseldorf, Not set

Local Institution - 0255, Lübeck, Not set

Kliniken Ostalb, Stauferklinikum, Mutlangen, Not set

Gemeinschaftspraxis Dres. med. Björn Schöttker & Dominik Pretscher, Würzburg, Not set

Local Institution - 0242, Patras, Achaḯa

University Hospital of Patras, Patras, Achaḯa

General Hospital of Athens "G. Gennimatas", Athens, Attikí

General Hospital of Athens "Laiko", Athens, Attikí

Attikon General University Hospital, Chaidari, Attikí

University Hospital of Alexandroupolis, Alexandroupolis, Not set

Local Institution - 0034, Hksar, Not set

Heves Vármegyei Markhot Ferenc Oktatókórház és Rendelőintézet, Eger, Heves

Szabolcs Szatmár Bereg Vármegyei Oktatókórház, Nyiregyhaza, Szabolcs-Szatmár-Bereg

Semmelweis Egyetem, Budapest, Not set

All India Institute of Medical Sciences, New Delhi, Delhi

Rajiv Gandhi Cancer Institute And Research Centre, New Delhi, Delhi

Hemato Oncology Clinic, Ahmedabad, Gujarat

Local Institution - 0273, Ahmedabad, Gujarat

Local Institution - 0177, Bengaluru, Karnataka

Institute of Medical Sciences and Sum Hospital, Bhubaneswar, Odisha

Local Institution - 0185, Hyderabad, Not set

Local Institution - 0186, New Delhi, Not set

Fondazione Policlinico Tor Vergata, Rome, Lazio

Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico, Milano, Lombardia

ASST Grande Ospedale Metropolitano Niguarda, Milan, Milano

Humanitas, Rozzano, Milano

Azienda Ospedaliera Ordine Mauriziano di Torino, Torino, Piemonte

Azienda Ospedaliera Universitaria Careggi, Firenze, Toscana

IRCCS Azienda Ospedaliero-Universitaria di Bologna, Policlinico di Sant'Orsola, Bologna, Not set

Grande Ospedale Metropolitano - Presidio Morelli, Reggio Calabria, Not set

Fondazione Policlinico Universitario Agostino Gemelli IRCCS - Università Cattolica del Sacro Cuore, Roma, Not set

Azienda Ospedaliera Universitaria Integrata Verona - Ospedale Borgo Roma, Verona, Not set

Local Institution - 0123, Kitakyushu-shi, Fukuoka

Local Institution - 0117, Sapporo, Hokkaido

Local Institution - 0126, Amagasaki, Hyogo

Local Institution - 0120, Sagamihara, Kanagawa

Local Institution - 0118, Sendai-shi, Miyagi

Local Institution - 0125, Osaka-sayama, Osaka

Local Institution - 0121, Shimotsuga, Tochigi

Local Institution - 0124, Nagasaki, Not set

Local Institution - 0122, Osaka, Not set

Local Institution - 0119, Tokyo, Not set

Centro de Investigacion Clinica de Oaxaca, Oaxaca de Juarez, Oaxaca

Hematológica Alta Especialidad SC, consultorio 830, Huixquilucan, Not set

Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Not set

Unidad Médica Onco-hematológica, Puebla, Not set

Specjalistyczny Szpital im. dra Alfreda Sokołowskiego w Wałbrzychu, Wałbrzych, Dolnośląskie

Uniwersyteckie Centrum Kliniczne, Gdańsk, Not set

Pratia Onkologia Katowice, Katowice, Not set

MTZ Clinical Research powered by Pratia, Warsaw, Not set

Auxilio Mutuo Cancer Center, San Juan, Not set

Local Institution - 0237, San Juan, Not set

Hospital Universitari Vall d'Hebron, Barcelona, Barcelona [Barcelona]

Institut Català d'Oncologia - L'Hospitalet, L'Hospitalet de Llobregat, Catalunya [Cataluña]

Hospital Clinico de Valencia, Valencia, Valenciana, Comunitat

Hospital Universitario Virgen Nieves, Granada, Not set

Hospital La Princesa, Madrid, Not set

Hospital Universitario Central de Asturias, Oviedo, Not set

Hospital Universitario de Salamanca - Complejo Asistencial Universitario de Salamanca, Salamanca, Not set

Hospital Universitario Virgen Del Rocio, Sevilla, Not set

Conditions: Myelodysplastic Syndromes

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Rhu-pGSN for Acute Respiratory Distress Syndrome (ARDS)

NCT05947955

Recruiting

BTI-203 is a randomized, double-blind, placebo-controlled, multicenter, Phase 2 proof-of-concept (POC) study to evaluate the efficacy and safety of rhu-pGSN plus standard of care (SOC) in subjects with moderate-to-severe ARDS (P/F ratio ≤150) due to pneumonia or other infections. Potential subjects hospitalized with pneumonia or other infections are to be screened within 24 hours of diagnosis of ARDS.

Gender:

ALL

Ages:

18 years and above

Trial Updated:

08/17/2025

Locations: University of California Irvine Medical Center, Irvine, California +66 locations

University of California Irvine Medical Center, Irvine, California

Cedars-Sinai Medical Center, Los Angeles, California

Wellstar MCG Augusta University, Augusta, Georgia

Northwestern University - Pulmonary and Critical Care Medicine, Chicago, Illinois

University of Louisville Hospital - Jewish Hospital, Louisville, Kentucky

University of Louisville-Jewish Hospital, Louisville, Kentucky

Mayo Clinic, Rochester, Minnesota

Hannibal Regional Hospital, Hannibal, Missouri

Bryan Medical Center, Lincoln, Nebraska

Penn State Health - Milton S. Hershey Medical Center, Hershey, Pennsylvania

McGovern Medical School - UT Physicians Pulmonary Medicine - Texas Medical Center, Houston, Texas

Baylor Scott & White Health, Temple, Texas

HUB - Hôpital Erasme, Brussels, Not set

CHU Charleroi Marie Curie Hospital, Charleroi, Not set

Centre Hospitalier Regional de la Citadelle, Liege, Not set

Clinique Saint-Pierre Ottignies, Ottignies, Not set

Acibadem City Clinic UMHAT Tokuda - Sofia, Sofia, Not set

Military Medical Academy, Sofia, Not set

UMHAT "Alexandrovska" EAD, Sofia, Not set

Foothills Medical Centre, Calgary, Alberta

Royal Alexandra Hospital, Edmonton, Alberta

Lions Gate Hospital, North Vancouver, British Columbia

University Health Network (UHN)-Toronto General Hospital (TGH), Toronto, Ontario

McGill University Health Centre - Royal Victoria Hospital (MUHC-RVH), Montreal, Quebec

Centre intégré universitaire de santé et services sociaux du nord de l'île de Montréal-Hôpital du Sacré de Montréal (CIUSSS-NÎM-HSCM), Montreal, Quebec

Peter Lougheed Centre, Calgary, Not set

Rocky View General Hospital, Calgary, Not set

South Health Campus, Calgary, Not set

St. Anne's University Hospital, Brno, Not set

University Hospital Královské Vinohrady, Prague, Not set

General University Hospital, Prague, Not set

Centre Hospitalier Departemental (CHD) Vendee, La Roche-sur-Yon, Not set

Hôpital du Kremlin Bicêtre, APHP, Le Kremlin Bicêtre, Not set

Centre Hospitalier de Melun-Senart, Melun, Not set

CHU Nantes, Nantes, Not set

Centre Hospitalier Lyon Sud, Oullins-Pierre-Bénite, Not set

Tenon Hospital, Paris, Not set

Nouvel Hopital Civil, Strasbourg, Not set

Saarland University Hospital, Homburg, Not set

Jena University Hospital, Jena, Not set

University Hospital LMU Munich, Munich, Not set

National Institute of Pulmonology, Budapest, Not set

Petz Aladár University Teaching Hospital, Gyor, Not set

Szent Damján Greek Catholic Hospital, Kisvarda, Not set

Szabolcs-Szatmar-Bereg County Teaching Hospital, Andras Josa Hospital, Nyiregyhaza, Not set

Hospital of Siofok, Siófok, Not set

Teaching Hospital of Vas County, Szombathely, Not set

Ferenc Csolnoky Hospital of Veszprem County, Veszprém, Not set

Asst-Spedali Civili di Brescia, Brescia, Not set

Fondazione Policlinico A. Gemelli IRCCS, Rome, Not set

Jeroen Bosch Ziekenhuis, 's-Hertogenbosch, Not set

Gelre Hospitals, Department of ICU, Apeldoorn, Not set

Gelderse Vallei Hospital, Ede, Not set

Medisch Spectrum Twente, Enschede, Not set

Canisius Wilhelmina Ziekenhuis, Nijmegen, Not set

Spital Universitar de Urgenta ELIAS (University Emergency Hospital Elias), Bucharest, Not set

County Clinical Hospital Tirgu Mures, Targu Mures, Not set

Clinical County Hospital Timisoara, Timisoara, Not set

Hospital Clínic Barcelona, Barcelona, Not set

Bellvitge University Hospital, Barcelona, Not set

Hospital Universitario 12 de Octubre, Madrid, Not set

Hospital Universitario de Getafe, Madrid, Not set

Clínico San Carlos, Madrid, Not set

Hospital Universitari de Tarragona Joan XXIII, Tarragona, Not set

University Hospital of Wales, Cardiff, Not set

Derriford Hospital (University Hospitals Plymouth Hospital Trust), Plymouth, Not set

Pinderfields Hospital (Mid Yorkshire Teaching NHS Trust), Wakefield, Not set

Conditions: Acute Respiratory Distress Syndrome, Infections

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Effect of Music on Surgical Performance During Artificial Intelligence-Based Simulation Training

NCT07111481

Recruiting

At the Neurosurgical Simulation and Artificial Intelligence Learning Centre, we seek to provide surgical trainees with innovative technologies that allow them to improve their surgical technical skills in risk-free environments, potentially improving patient operative outcomes. The Intelligent Continuous Expertise Monitoring System (ICEMS), a deep learning application that assesses and trains neurosurgical technical skill and provides continuous intraoperative feedback, is one such technology th... Read More

Gender:

ALL

Ages:

18 years and above

Trial Updated:

08/17/2025

Locations: Neurosurgical Simulation and Artificial Intelligence Learning Centre, Montreal, Quebec

Conditions: Surgical Education

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